Nikolaos Scarmeas, M.D., M.Sc.
Associate Professor of Neurology, Cognitive Neuroscience Division Taub Institute
Division of Aging and Dementia Department of Neurology
630 West 168th St, P&S 16
New York, NY 10032
Phone: 212.342.1350
Fax: 212.342.1838
Email: ns257@columbia.edu
Ongoing Research:
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Lifestyle, nutrition and Dementia – Alzheimer's disease. Exploration of the association between intellectual-social activities, exercise and dietary habits and risk for development cognitive impairment. Consideration of different methodological approaches including that of dietary pattern analyses. Investigation of biological mechanisms of association between nutrition and cognition with use of imaging and other biomarkers.
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Cognitive Reserve. Interested in understanding the variability of clinical response to brain pathology (Alzheimer's disease in particular) which is related to different inherent or acquired abilities. Such abilities, which are considered to affect each individual's cognitive reserve include IQ, education, and intellectual-social-physical life activities. These associations are explored with use of either epidemiological data or imaging studies.
- Predictors of progression in Dementia - Alzheimer's disease. Interested in understanding the variability of clinical response to brain pathology (Alzheimer's disease in particular) which is related to different inherent or acquired abilities. Such abilities, which are considered to affect each individual's cognitive reserve include IQ, education, and intellectual-social-physical life activities. These associations are explored with use of either epidemiological data or imaging studies.
- Epilepsy and Dementia. Investigation of characteristics, frequency and predictive information of seizures in dementia and Alzheimer's disease.
Representative Publications
Scarmeas N., Levy G., Tang M., Manly J., Stern Y.: Influence of leisure activity on the incidence of Alzheimer's disease. Neurology 2001; 57: 2236-2242..
Scarmeas N., Zarahn E., Anderson K., Habeck C., Hilton J., Flynn J., Marder K., Bell K., Sackeim H., Van Heertum R., Moeller J., Stern Y.: Association of life activities with cerebral blood flow in Alzheimer's disease: Implications for the cognitive reserve hypothesis. Archives of Neurology 2003; 60: 359-365.
Scarmeas N., Stern Y., Tang MX. Mayeux R., Luchsinger JA. Mediterranean diet and risk for Alzheimer's disease. Annals of Neurology 2006; 59: 912-921.
Scarmeas N., Luchsinger J., Schupf N., Brickman A., Cosentino S., Tang M., Stern Y. Physical activity, diet and risk of Alzheimer's disease. JAMA 2009; 302 (6): 627 – 637.
Scarmeas N.,Honig L., Choi H., Cantero J., Brandt J., Blacker D., Albert M., Amatniek J., Marder K., Bell K., Hauser A., Stern Y. Seizures in Alzheimer's disease: who, when, and how common? Archives of Neurology 2009; 66 (8):992-997.
Scarmeas N., Luchsinger J., Stern Y., Gu Y., He J., DeCarli C., Brown T., Brickman A.M. Mediterranean diet and magnetic resonance imaging – assessed cerebrovascular disease. Annals of Neurology 2011; 69 (2): 257 -268.
Scarmeas N., Luchsinger J.A., Brickman A.M., Cosentino S., Schupf N., Xin-Tang M., Gu Y., Stern Y. Physical activity and Alzheimer's disease course. American Journal of Geriatric Psychiatry 2011; 19 (5): 471 – 481.