Projects

Reference Ability Neural Networks (RANN) - Four primary “reference abilities” are thought to underlie performance on a wide-range of cognitive tasks: episodic memory, fluid ability, perceptual speed, and vocabulary. This study uses fMRI to identify distinct networks of brain activity associated with each of the reference cognitive abilities. Healthy adults are recruited from each decade from 20 to 80 (PI: Yaakov Stern)

  • Identification of univariate and multivariate neural networks and statistical inference of construct validity
  • Christian Habeck
  • Interval timing and cognitive aging
  • Brian Rakitin
  • Contextual Analysis of Psychomotor Vigilance
  • Brian Rakitin
  • White matter integrity and cognition
  • Yunglin Gazes
  • Resting-State Bold fMRI and Cognitive Aging
  • Ray Razlighi
  • Mediation and moderation models of aging, cognition, and functional imaging
  • Jason Steffener

    Imaging of Cognition, Learning, and Memory in Aging -  The goal of this study is to understand the neural basis of Cognitive Reserve (CR). CR is thought to mediate the relationship between age- or AD-related neuropathology and the functional or clinical consequences of this pathology. Various imaging and analytic approaches are used to model the relationship between age-related neural changes, CR, and cognition.

  • Multimodal and multivariate image analyses
  • Jason Steffener
  • ApoE, cortical thickness and cognitive change
  • Lyndsey Collins-Praino
  • Resting-State Bold fMRI and Cognitive Aging; Region Based Spatial Normalization of fMRI data
  • Ray Razlighi
  • Resting-State Bold fMRI: functional connectivity and temporal variability and their diagnostic and prognostic potential; optimization of pre-processing to minimize false-positives, false-negatives and statistical variability using the NPAIRS framework
  • Christian Habeck
  • Response Conflict in Task Switching
  • Brian Rakitin
  • Functional network of task-switching
  • Yunglin Gazes

    Washington/Hamilton Heights Inwood Columbia Aging Project (WHICAP) – a community-based longitudinal study of over 5,500 Northern Manhattan residents over age 65, ongoing since 1988. Participants include individuals with and without dementia. (PI: Richard Mayeux)

  • Cross-cultural neuropsychology
  • Jennifer Manly
  • Cross-sectional and longitudinal neuroimaging
  • Adam Brickman
  • Scale construction and leisure activities
  • Robert Feio
  • Biomarkers, cognition and structural change
  • Lyndsey Collins-Praino
  • ApoE status and cortical thickness/volume
  • Lyndsey Collins-Praino
  • Nutritional epidemiology of dementia and brain aging
  • Nikolaos Scarmeas, Yian Gu
  • Localization of Amyloid PET image using FreeSurfer
  • Ray Razlighi

    The Predictors Study – a multi-center, clinic-based study of predictors of progression of Alzheimer’s disease. Over 500 prevalent cases were followed longitudinally. The current Predictors cohort comprises incident AD cases identified through WHICAP. (PI: Yaakov Stern)

  • Predictive models of AD progression
  • Ray Razlighi
  • Body mass index and nutrition
  • Yian Gu
  • Behavioral and psychological symptoms
  • Laura Zahodne
  • Social cognition and metacognition
  • Stephanie Cosentino
  • Healthcare utilization
  • Caroline Zhu
  • Subjective language complaints and social behavior
  • Meagan Farrell
  • Caregiver burden
  • Katherine Ornstein

    African American Genetics Study – a multi-center study of matched African American Alzheimer’s disease cases and controls. Data collected include neuropsychological and genetic profiles, MRI, and biomarkers related to subclinical cardiovascular disease. (PI: Jennifer Manly)

  • Mood-cognition associations
  • Jamie Hamilton

    Offspring Study – This study evaluates racial differences in the relationship of risk factors for cognitive decline among middle-aged people whose parents do and do not have Alzheimer’s Disease (AD). Neuropsychological function, cardiovascular health, and biomarkers are being evaluated among offspring of participants in the Washington/Hamilton Heights Inwood Columbia Aging Project. (PI: Jennifer Manly)

    Early AD Detection with Arterial Spin Labeling Use of Arterial Spin Labeling to identify early Alzheimer’s markers in cross-sectional and longitudinal analyses involving healthy elderly controls, subjects with Mild Cognitive Impairment and early Alzheimer’s Disease  (PI: Chris Habeck)

  • Univariate and multivariate blood-flow  pattern underlying early Alzheimer’s disease
  • Chris Habeck
  • Construction of multivariate and multi-modal disease markers using blood-flow and brain-structure information from our study, as well as FDG-PET data and structural data from the Alzheimer’s Disease Neuroimaging Initiative
  • Chris Habeck

    Analyzing Age-related Changes of Brain Activation – This is a pilot study investigating the effect of subject task difficulty in the observed age-related difference in brain activations during delayed letter recognition task. (PI: Ray Razlighi)

  • Region-based spatial normalization
  • Ray Razlighi
  • Effective measure of subjective task difficulty
  • Ray Razlighi

    White Matter Hyperintensities in Aging and Dementia – This study examines the contribution of white matter abnormalities to cognitive aging and dementia, its antecedents and its modifiers (PI: Adam Brickman)

  • Regional progression of white matter hyperintensities
  • Adam Brickman
  • Vascular markers of aging
  • Jamie Hamilton
  • Neuroinflammation and white matter hyperintensities
  • Lyndsey Collins-Praino
  • Interaction of small vessel cerebrovascular disease and AD biomarkers
  • Irene Meier

    Neuroimaging Guided Histopathological Examination of White Matter Abnormalities in Aging and Dementia – This project uses postmortem MRI to guide the histopathological analysis of radiologically normal and abnormal white matter tissue (PI: Adam Brickman)

  • Histological correlates of white matter disease
  • Adam Brickman
  • Interaction of white matter pathology with AD pathology
  • Lyndsey Collins-Praino

    Hemodynamics, Small Vessel Disease, and Alzheimer’s – This project looks at the autoregulation, white matter abnormalities, and AD biomarkers (PI: Adam Brickman)

  • Autoregulation, white matter hyperintensities, and amyloid
  • Adam Brickman

    Early Indicators of Frontotemporal Dementia (FTD) – This newly funded, family-based study seeks to identify the earliest indicators of FTD in presymptomatic MAPT mutation carriers and to characterize potential effects of lifestyle factors on symptom onset and course. As part of this study, we are conducting longitudinal assessments including neuroimaging, cognitive testing, behavioral characterization, plasma and cerebrospinal fluid collection, and psychiatric evaluation. (PIs: Ted Huey & Stephanie Cosentino)

    Frontotemporal Dementia (FTD) Study – This clinic-based, cross-sectional study examines a range of cognitive and behavioral symptoms in individuals diagnosed with FTD. Assessment includes a broad neuropsychological battery with particular focus on language abilities, as well as several experimental cognitive and metacognitive tasks.   (PIs: Ted Huey & Stephanie Cosentino)

  • Language and disordered behavior
  • Meagan Farrell

    Metacognition in Alzheimer’s Disease – This project examines the measurement of memory awareness in AD, the cognitive and neural substrates of disordered memory awareness, and the everyday effects of this metacognitive deficit related to decision making and quality of life.  (PI: Stephanie Cosentino)

  • Objective versus subjective assessment of awareness
  • Sarah Cines
  • Cognitive correlates of metamemory in AD
  • Danielle Shaked & Meagan Farrell

    Long Life Family Study – This project examines the genetic and environmental factors that contribute to exceptional aging.  (PI: Richard Mayeux).

  • Cognitive functioning in long-lived families
  • Stephanie Cosentino

    Cognitive and Exercise Interventions for Cognition – This study examines the influence of aerobic training on specific aspects of cognitive function in young (25-40) and young-old (50-65) adults. The neural basis of cognitive improvement is explored via structural MRI, resting cerebral blood flow scans (arterial spin labeling) and cognitive activation fMRI studies

  • Executive functions
  • Anna MacKay-Brandt
  • Changes in white matter integrity
  • Yunglin Gazes
  • Functional imaging changes
  • Chris Habeck, Jason Steffener

    Genetics and Pathophysiology of Motor Disorders (PI: Brian Rakitin)

  • Interval Timing in Genetic Variants of Parkinson’s Disease
  • Brian Rakitin
  • Interval Timing, Motor Control and Function in Huntington’s Disease
  • Brian Rakitin
  • Protein aggregation, cell death pathways and cognition in Parkinson’s disease
  • Lyndsey Collins-Praino