CUMC
Department of Radiation Oncology

Education

Residency Training Program

CHI ZHANG

RESIDENT PROFILES
CHI ZHANG, MD, PhD

Undergraduate: University of Science & Technology of China, Hefei, Anhui, China
Graduate: Texas A&M University, College Station TX – PhD, Biology
Medical School: University of Miami, Miami FL
Internship: Jackson Memorial Hospital, Miami FL
Residency NYPH/ Columbia University College of P&S, New York, NY

Abstracts and Publications (Selected):

Huang XP, Lee KJ, Beth R, Zhang C, Lemanski LF, Walker JW. Thyroid hormone regulates ssTnI inactivation in cTnI deficient mouse hearts. J. Mol. Cell. Cardiol. 32:2221-2228, 2000.

Lemanski LF, Meng F, Lemanski SL, Dawson N, Zhang C, Li Q, Nakatsugawa M, Dube DK, Huang X. Creation of chimeric mutant axolotls: a model to study early embryonic heart development in Mexican axolotls. Anat. Embryol. 203: 335-342, 2001.

Huang X, Li J, Zhang C, Foster D, Lemanski SL, Dube DK, Lemanski LF. Protein kinase C- mediated desmin phosphorylation is related to myofibril disarray in cardiomyopathic hamster heart. Exp Biol Med (Maywood) 227(11):1039-46, 2002.

Meng, F, Huang X, Zhang C, Zajdel RW, Foster D, Dawson N, Lemanski SL, Zawieja D, Dube DK, Lemanski LF. Relationship between cardiac protein tyrosine phosphorylation and myofibrillogenesis during axolotl heart development. Tissue&Cell 35: 133-142, 2003.

Zhang C, LaFrance SM, Lemanski LF, Huang X, Dube DK, Lemanski LF. Sheep Heart RNA Stimulates Myofibril Formation and Beating in Cardiac Mutant Axolotl Hearts in Organ Culture. Anat. Embryol., 206(6):495-506, 2003.

Zhang C, Huang X, Lemanski SL, Meng F, Foster D, Reidel B, Dube DK, Lemanski LF. A point mutation in bioactive RNA results in RNA secondary structure alteration and failure of mutant heart correction in Mexican axolotls. Anat. Embryol., 206(6): 419-27, 2003.

Zhang C, Meng F, Huang X, Zajdel R, Lemanski S, Li Q, Foster D, Erginel-Unaltuna N, Dube DK. Lemanski LF. Downregulation of N1 gene expression by liposome-mediated delivery of anti- sense oligonucleotides inhibits the initial heartbeat in axolotls. Tissue&Cell, 36:71-81, 2004.

Zhang C, Osinska H, Lemanski S, Lemanski LF. Changes in myofibrils and cytoskeleton of neonatal hamster cardiomyocytes in vitro: an immunofluorescent study. Tissue&Cell. 37(6):435-45, 2005.

Du J, Zhang C , Liu L, Sidky C, Huang XP. A point mutation (R192H) in the C-terminus of human cardiac troponin I causes diastolic dysfunction in transgenic mice. Arch Biochem Biophys.15;456(2):143-50. 2006.

Zhang C, Pietras K, Huang, Lemanski SL, Lemanski LF. Immunohistochemical and molecular analyses of cardiac troponin T gene during the cardiac development of Mexican axolotls, Ambystoma mexicanum. J. Cell. Biochem. 100(1):1-15, 2007.

Sferrazza GF, Zhang C , Jia P, Lemanski SL, Athauda G, Stassi A, Halager K, Maier JA, Rueda- de-Leon E, Gupta A, Dube S, Huang X, Prentice HM, Dube DK, Lemanski LF. Role of myofibril-inducing RNA in cardiac TnT expression in developing Mexican axolotl. Biochem Biophys ResCommun. 357(1):32-7. 2007.

Liu J, Du J, Zhang C, Walker JW, Huang X. Progressive Troponin I Loss Impairs Cardiac Relaxation and Causes Heart Failure in Mice. Am J Physiol Heart Circ Physiol. 293(2):H1273-81., 2007.

Du J, Nan C, Huang JJ, Zhang C , Liu J, Jia P, Abers M, Huang XP. Functional characterization of mouse fetal TnI gene promoters in myocardial cells. J Biomed Sci. 15(5):605-13. 2008.

Du J, Liu J, Feng HZ, Hossain, Gobara N, Zhang C, Li Y, Jean-Charles PY, Jin JP, Huang XP. Impaired relaxation is the main manifestation in transgenic mice expressing a restrictive cardiomyopathy mutation, R193H, in cardiac TnI. Am J Physiol Heart Circ Physiol. 294(6):H2604-13. 2008.

Jia P, Zhang C, Poda M, Akbas F, Lemanski SL, Erginel-Unaltuna N, Lemanski LF. A Novel Protein Involved in Heart Development in Ambystoma mexicanum is Localized in Endoplasmic Reticulum, J. Biomed. Sci. 15(6):789-99. 2008.

Zhang C, Jia P, Athauda G, Sferrazza GF, Lemanski SL, Rueda-de-Leon D, Maier JA, Stassi AK, Dube S, Dube DK, Lemanski LF. Myofibril-Inducing RNA (MIR) is Essential for Sarcomeric Tropomyosin Expression and the Initiation of Cardiac Contractile Function in Developing Axolotl Heart. J. Biomed. Sci. 16:81. 2009.

Zhang C, Jia P, Huang X, Webster KA, Lemanski LF.Methionine Sulfoxide Reductase A (MsrA) protects cultured mouse embryonic stem cells from H2O2-mediated oxidative damage. J. Cell. Biochem. 111(1):94-103, 2010 (Selected as a “Feature Article” in the journal).

Zhang C, Jia P, Li Y, Huang X, Lemanski LF. Hypoxia and Acidosis Selectively Regulate the Gene Expression of Methionine Sulfoxide Reductases in Mouse Embryonic Stem Cells. J. Cell. Biochem. 112(1):98-106, 2011 (Selected as a “Feature Article” in the journal).

Jia P, Zhang C, Jia Y, Webster KA, Huang X, Kochegarov AA, Lemanski SL, Lemanski LF. Identification of a truncated form of Methionine Sulfoxide Reductase A expressed in mouse embryonic stem cells. J Biomed Sci. 18(1):18-46, 2011.

Denz C, Zhang C, Jia P, Du J, Huang X, Dube S, Thomas A, Dube DK. Absence of mutation at the 5’-upstream promoter region of the TPM4 gene from cardiac mutant axolotl (Ambystoma mexicanum). Cardiovasc Toxicol. 11(3):235-43, 2011.

Rueda-de-Leon E, Kochegarov A, Lian W, Athauda G, Zhang C, Maier J, Huang X, Achary MP, Moses A, Meyer J, Arms JD, Burlbaw SR, Lemanski SL, Lemanski LF. Human heart RNA promotes tropomyosin synthesis and myofibrillogenesis in mutant axolotl hearts. MD-Medical Data, 3(3): 223-227, 2011.

Ng J, Zhang C, Gidea-Addeo D, Saif MW. Locally advanced pancreatic adenocarcinoma: update and progress. J. of the Pancreas. 13(2):155-8, 2012.

Spratt DE, Zhang C, Zumsteg ZS, Pei X, Zhang Z, Zelefsky MJ. Metformin and prostate cancer: benefit for development of castration-resistant disease and prostate cancer mortality. Eur Urol. 63(4):709-16, 2013.

Wang T, Zhang C, Wei Y, Horowitz DP, Connolly EP, Cheng SK, Feng W, Chao KS, Deutsch I. Comparison of effect of rectal volume delineation methods on dose constraint endpoints in the treatment of prostate cancer with intensity-modulated radiation therapy. J. Radiat. Oncol. 2: 303-308, 2013.

Wang T, Riaz N, Tam M., Zhang C Youssef, B., Hong, J. C., Born,H., Wolden S., Rao, S. and Lee, N. Y. Patterns of failure after salvage re-irradiation for recurrent head and neck cancer: implications for field design and consolidation therapy. Accepted by J. Radiot Oncol. December 2013.

Zhang C, Wang T, Horowitz D, Jain A, Chao KS, Connolly EP. Pattern of care and role of definitive radiation therapy in pediatric craniopharyngioma, the updated Surveillance Epidemiology and End Results (SEER) database analysis. Submitted to IJROBP, 2014.

Zhang C, Wang T, Yan SX, Crockford S, Gidea-Addeo D, Chao KS, Connolly EP. Triple negative breast cancer is associated with higher rate of locoregional recurrence for patient achieving less than a pCR following neoadjuvant chemotherapy, surgery and radiotherapy. Submitted to Journal of the National Cancer Institute (JNCI), 2014.

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