Meador

Jarah A. Meador, Ph.D.

Contact Information

Center for Radiological Research
VC 11-239
630 W. 168th St.
New York, NY 10032

Tel: (212) 342-6838
Fax: (212) 305-3229
email: jam2194@columbia.edu

Research Interests

DNA damage induction and repair

Low dose ionizing radiation
Ultraviolet radiation
Nucleoside analog adducts
Epigenetic effects and chromatin structure
Cell cycle checkpoints

Academic Training
Undergraduate:	B.S., Texas State University, 1997
Graduate:	M.S., Texas State University, 1999 Ph.D., The University of Texas-Houston Health Science Center, MD Anderson Cancer Center, 2004
Post-Doctoral:	NASA/Johnson Space Center-Universities Space Research Association, 2006

Current Academic and Professional Appointments

Associate Research Scientist, Center for Radiological Research, College of Physicians & Surgeons of Columbia University Medical Center

Current Research

We study the role of phosphatidylinositol-3 kinase like kinase (PIKK) and mitogen activated protein kinase (MAPK) mediated cell signaling pathways in the response to low dose (low LET) ionizing radiation in 2D and 3D cell systems.

A second area of research involves collaboration with the Columbia University Skin Disease Research Center to study responses of adult skin stem cells, primary keratinocytes and melanocytes to ionizing and ultraviolet radiation (UVR) both in mono and co-culture. We are interested in cell type specific differences in epigenetic modifications of chromatin following DNA damage and during repair.

A third research focus is nucleoside analog adduct formation in cancer cells. Our aim is to sensitize cancer cells by targeting and inhibiting adduct repair processes leading to additional genomic instability that can be further exploited through combination of radiation and chemotherapeutics.

Selected Publications

Meador JA, Su Y, Ravanat JL and Balajee AS. DNA dependent protein kinase (DNA-PK) deficient human glioblastoma cells are preferentially sensitized by Zebularine. Carcinogenesis. 2009 Nov 23. [Epub ahead of print] [abstract]

Meador JA, Baldwin AJ, Catala P, Jeffrey WH, Joux F, Moss JA, Dean Pakulski J, Stevens R and Mitchell DL. Sunlight-induced DNA damage in marine micro-organisms collected along a latitudinal gradient from 70 degrees N to 68 degrees S. Photochem Photobiol 85:412-20, 2009. [abstract]

Su Y, Meador JA, Geard CR, Balajee AS. Analysis of ionizing radiation-induced DNA damage and repair in three-dimensional human skin model system. Exp Dermatol. 2009 Jul 23. [Epub ahead of print] [abstract]

Wen G, Partridge MA, Calaf GM, Meador JA, Hu B, Echiburu-Chau C, Hong M and Hei TK. Increased susceptibility of human small airway epithelial cells to apoptosis after long term arsenate treatment. Sci Total Environ. 407:1174-81, 2009. [abstract]

Meador JA, Zhao M, Su Y, Narayan G, Geard CR and Balajee AS. Histone H2AX is a critical factor for cellular protection against DNA alkylating agents. Oncogene 27:5662-71, 2008. [abstract]

Matallana-Surget S, Meador JA, Joux F and Douki T. Effect of the GC content of DNA on the distribution of UVB-induced bipyrimidine photoproducts. Photochem Photobiol Sci 7:794-801, 2008. [abstract]

Pakulski JD, Kase JP, Meador JA and Jeffrey WH. Effect of stratospheric ozone depletion and enhanced ultraviolet radiation on marine bacteria at Palmer Station, Antarctica in the early austral spring. Photochem Photobiol 84:215-21, 2008. [abstract]

Hada M, Meador JA, Cucinotta FA, Gonda SR and Wu H. Chromosome aberrations induced by dual exposure of protons and iron ions. Radiat Environ Biophys 46:125-9, 2007. [abstract]

Wu H, Hada M, Meador J, Hu X, Rusek A and Cucinotta FA. Induction of micronuclei in human fibroblasts across the Bragg curve of energetic heavy ions. Radiat Res 166:583-9, 2006. [abstract]

Wilhelm SW, Jeffrey WH, Dean AL, Meador J and Mitchell DL. (2003) Ultraviolet radiation induced DNA damage in marine viruses along a latitudinal gradient. Aquat Microb Ecol. 31: 1-8.

Meador J, Jeffrey WH, Kase JP, Pakulski JD, Chiarello S and Mitchell DL. Seasonal fluctuation of DNA photodamage in marine plankton assemblages at Palmer Station, Antarctica. Photochem Photobiol 75:266-71, 2002. [abstract]

Mitchell DL, Meador J, Paniker L, Gasparutto D, Jeffrey WH and Cadet J. Development and application of a novel immunoassay for measuring oxidative DNA damage in the environment. Photochem Photobiol 75:257-65, 2002. [abstract]

Mitchell DL, Meador JA, Byrom M and Walter RB. Resolution of UV-induced DNA damage in Xiphophorus fishes. Mar Biotechnol (NY) 3:S61-71, 2001. [abstract]

Meador JA, Walter RB and Mitchell DL. Induction, distribution and repair of UV photodamage in the platyfish, Xiphophorus signum. Photochem Photobiol 72:260-6, 2000. [abstract]