Peter W. Grabham, Ph.D.

      Center for Radiological Research
      630 West 168th Street, VC 11-243
      New York, N.Y. 10032

      Email: pwg2@columbia.edu
      Tel: 212-305-0845 / Fax: 212-305-3229 

   Current Position

• Associate Research Scientist, Center for Radiological Research, College of Physicians & Surgeons of Columbia University Medical Center.

   Research Interests  

1. Effects of ionizing radiation on the structure and function of 3-dimensional vessel models.

2. Bystander response in vessel tissue models.

3. Effects of ionizing radiation on cell motility and the cytoskeleton.

Image of a vessel model stained for filamentous actin (green) and nuclei (red).

   Selected Publications  

• Grabham PW, Seale GE, Bennecib M, Goldberg DJ and Vallee RB. Cytoplasmic dynein and LIS1 are required for microtubule advance during growth cone remodeling and fast axonal outgrowth. J Neurosci 27:5823-34, 2007. [Abstract]

• Grabham PW, Wu F, Schacher S and Goldberg DJ. Initiating morphological changes associated with long-term facilitation in Aplysia is independent of transcription or translation in the cell body. J Neurobiol 64:202-12, 2005. [Abstract]

• Rybin VO, Grabham PW, Elouardighi H and Steinberg SF. Caveolae-associated proteins in cardiomyocytes: caveolin-2 expression and interactions with caveolin-3. Am J Physiol Heart Circ Physiol 285:H325-32, 2003. [Abstract]

• Grabham PW, Foley M, Umeojiako A and Goldberg DJ. Nerve growth factor stimulates coupling of beta1 integrin to distinct transport mechanisms in the filopodia of growth cones. J Cell Sci 113 ( Pt 17):3003-12, 2000. [Abstract]

• Goldberg DJ, Foley MS, Tang D and Grabham PW. Recruitment of the Arp2/3 complex and mena for the stimulation of actin polymerization in growth cones by nerve growth factor. J Neurosci Res 60:458-67, 2000. [Abstract]

• Goldberg DJ and Grabham PW. Braking news: calcium in the growth cone. Neuron 22:423-5, 1999.

• Grabham PW and Goldberg DJ. Nerve growth factor stimulates the accumulation of β1 integrin at the tips of filopodia in the growth cones of sympathetic neurons. J Neurosci 17:5455-65, 1997. [Abstract]

• Grabham PW, Wu D-Y and Goldberg DJ. Protein tyrosine phosphorylation in the growth cone. In: Nerve Growth and Guidance, ed. C. McCaig, Portland Press, pp. 7-19, 1996.

• Grand RJ, Turnell AS and Grabham PW. Cellular consequences of thrombin-receptor activation. Biochem J 313 ( Pt 2):353-68, 1996.

• Grabham P and Cunningham DD. Thrombin receptor activation stimulates astrocyte proliferation and reversal of stellation by distinct pathways: involvement of tyrosine phosphorylation. J Neurochem 64:583-91, 1995. [Abstract]