Adayabalam Balajee, Ph.D.

Center for Radiological Research           Email: ab836@columbia.edu
630 West 168th Street, VC 11-239        Tel: 212-342-6838
New York, N.Y. 10032                                Fax: 212-305-3229
 

Research Interests

  • Role of PI-3 kinase like kinase mediated signal transduction pathways in cellular response to low dose radiation exposure

  • Targeting epigenome for cancer treatment

  • Role of DNA repair pathways in genomic instability, aging and cancer

     Academic Training  
 

Master's Degree:

University of Madras, Madras, India, 1982

Master of Philosophy:

Bharathiar University, Coimbatore, India, 1983

Doctoral Degree:

Banaras Hindu University, Varanasi, India, 1991


   Current Academic and Professional Appointments  

  • Research Scientist, Center for Radiological Research, College of Physicians & Surgeons, Columbia University

   Select Publications  

If you do not find what you are looking for below, try searching for Adayabalam Balajee on PubMed.

  • Meador JA, Zhao M, Su Y, Narayan G, Geard CR and Balajee AS. Histone H2AX is a critical factor for cellular protection against DNA alkylating agents. Oncogene 27:5662-71, 2008. [abstract]

  • Sakamoto-Hojo ET and Balajee AS. Targeting poly (ADP) ribose polymerase I (PARP-1) and PARP-1 interacting proteins for cancer treatment. Anticancer Agents Med Chem. 8:402-16, 2008. [abstract]

  • Shao G, Balajee AS, Hei TK and Zhao Y. p16INK4a downregulation is involved in immortalization of primary human prostate epithelial cells induced by telomerase. Mol Carcinog. 47:775-83, 2008.[abstract]

  • Baskar R, Balajee AS, Geard CR and Hande MP. Isoform-specific activation of protein kinase c in irradiated human fibroblasts and their bystander cells. Int J Biochem Cell Biol. 40:125-34, 2008. [abstract]

  • Baskar R, Balajee AS and Geard CR. Effects of low and high LET radiations on bystander human lung fibroblast cell survival. Int J Radiat Biol. 83:551-9, 2007. [abstract]

  • Shen WH*, Balajee AS*, Wang J, Wu H, Eng C, Pandolfi PP, Yin Y. Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell 128:157-70, 2007. [abstract] (Shared first author)

  • Sharma S, Stumpo DJ, Balajee AS, Bock CB, Lansdorp PM, Brosh RM Jr, Blackshear PJ. RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability. Mol Cell Biol. 27:1784-94, 2007.[abstract]

  • Poonepalli A, Balakrishnan L, Khaw AK, Low GK, Jayapal M, Bhattacharjee RN, Akira S, Balajee AS and Hande MP. Lack of poly(ADP-ribose) polymerase-1 gene product enhances cellular sensitivity to arsenite. Cancer Res. 65:10977-83, 2005. [abstract]

  • Piao CQ, Liu L, Zhao YL, Balajee AS, Suzuki M and Hei TK. Immortalization of human small airway epithelial cells by ectopic expression of telomerase. Carcinogenesis 26:725-31, 2005. [abstract]

  • Balajee AS and Geard CR. Replication protein A and gamma-H2AX foci assembly is triggered by cellular response to DNA double-strand breaks. Exp Cell Res 300:320-34, 2004. [abstract]

  • Balajee AS, Ponnaiya B, Baskar R and Geard CR. Induction of replication protein A in bystander cells. Radiat Res 162:677-86, 2004. [abstract]

  • van Hoffen A, Balajee AS, van Zeeland AA and Mullenders LH. Nucleotide excision repair and its interplay with transcription. Toxicology 193:79-90, 2003. [abstract]

  • Proietti De Santis L, Balajee AS, Lorenti Garcia C, Pepe G, Worboys AM and Palitti F. Inhibition of p53, p21 and Bax by pifithrin-alpha does not affect UV induced apoptotic response in CS-B cells. DNA Repair (Amst) 2:891-900, 2003. [abstract]

  • Proietti De Santis L, Garcia CL, Balajee AS, Latini P, Pichierri P, Nikaido O, Stefanini M and Palitti F. Transcription coupled repair efficiency determines the cell cycle progression and apoptosis after UV exposure in hamster cells. DNA Repair (Amst) 1:209-23, 2002. [abstract]

  • Balajee AS and Geard CR. Chromatin-bound PCNA complex formation triggered by DNA damage occurs independent of the ATM gene product in human cells. Nucleic Acids Res 29:1341-51, 2001. [abstract]

  • Proietti De Santis L, Garcia CL, Balajee AS, Brea Calvo GT, Bassi L and Palitti F. Transcription coupled repair deficiency results in increased chromosomal aberrations and apoptotic death in the UV61 cell line, the Chinese hamster homologue of Cockayne's syndrome B. Mutat Res 485:121-32, 2001. [abstract]

  • Hande MP, Balajee AS, Tchirkov A, Wynshaw-Boris A and Lansdorp PM. Extra-chromosomal telomeric DNA in cells from Atm(-/-) mice and patients with ataxia-telangiectasia. Hum Mol Genet 10:519-28, 2001. [abstract]

  • Sunesen M, Selzer RR, Brosh RM, Jr., Balajee AS, Stevnsner T and Bohr VA. Molecular characterization of an acidic region deletion mutant of Cockayne syndrome group B protein. Nucleic Acids Res 28:3151-9, 2000. [abstract]

  • Balajee AS, Proietti De Santis L, Brosh RM, Jr., Selzer R and Bohr VA. Role of the ATPase domain of the Cockayne syndrome group B protein in UV induced apoptosis. Oncogene 19:477-89, 2000. [abstract]

  • Balajee AS, May A and Bohr VA. DNA repair of pyrimidine dimers and 6-4 photoproducts in the ribosomal DNA. Nucleic Acids Res 27:2511-20, 1999. [abstract]

  • Cooper MP, Balajee AS and Bohr VA. The C-terminal domain of p21 inhibits nucleotide excision repair In vitro and In vivo. Mol Biol Cell 10:2119-29, 1999. [abstract]

  • Balajee AS, Dianova I and Bohr VA. Oxidative damage-induced PCNA complex formation is efficient in xeroderma pigmentosum group A but reduced in Cockayne syndrome group B cells. Nucleic Acids Res 27:4476-82, 1999. [abstract]

  • Balajee AS, Machwe A, May A, Gray MD, Oshima J, Martin GM, Nehlin JO, Brosh R, Orren DK and Bohr VA. The Werner syndrome protein is involved in RNA polymerase II transcription. Mol Biol Cell 10:2655-68, 1999. [abstract]

  • Brosh RM, Jr., Balajee AS, Selzer RR, Sunesen M, Proietti De Santis L and Bohr VA. The ATPase domain but not the acidic region of Cockayne syndrome group B gene product is essential for DNA repair. Mol Biol Cell 10:3583-94, 1999. [abstract]

  • Bouayadi K, van der Leer-van Hoffen A, Balajee AS, Natarajan AT, van Zeeland AA and Mullenders LH. Enzymatic activities involved in the DNA resynthesis step of nucleotide excision repair are firmly attached to chromatin. Nucleic Acids Res 25:1056-63, 1997. [abstract]

  • Balajee AS, May A, Dianov GL, Friedberg EC and Bohr VA. Reduced RNA polymerase II transcription in intact and permeabilized Cockayne syndrome group B cells. Proc Natl Acad Sci U S A 94:4306-11, 1997. [abstract]

  • Hande MP, Balajee AS and Natarajan AT. Induction of telomerase activity by UV-irradiation in Chinese hamster cells. Oncogene 15:1747-52, 1997. [abstract]

  • Kruk PA, Balajee AS, Rao KS and Bohr VA. Telomere reduction and telomerase inactivation during neuronal cell differentiation. Biochem Biophys Res Commun 224:487-92, 1996. [abstract]

 

 

Updated 07/21/09

 

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