2009 Annual Report
Table of Contents

CRR Director: David J. Brenner
Editor: Howard B. Lieberman
Asst Editor: Jinshuang Lu



This is our most recent published annual report. The complete 2009 annual report can be downloaded as a PDF as can individual sections of this report from the links below. Individual studies can be browsed as HTML.

For annual reports from previous years click here.

Microbeam Development and Experimental Studies [PDF]

Microbeam Writing on a Cell at RARAF
Alan W Bigelow, Helen C Turner, Yanping Xu, Gerhard Randers-Pehrson and David J Brenner

Formation of DNA Repair Foci using RARAF’s UV Microspot Irradiator
Alan W Bigelow, Charles R Geard, Gerhard Randers-Pehrson and David J Brenner

UV Microspot Resolution: Columbia University Crown Logo
Alan W Bigelow, Helen C Turner, Guy Y Garty, Yanping Xu, Gerhard Randers-Pehrson and David J Brenner

Proton Induced Soft X-ray Microbeam at RARAF
Andrew Harken, Gerhard Randers-Pehrson and David J Brenner

Preliminary Studies of Flow-And-Shoot Technology (FAST) for the Microbeam
Guy Garty, Michael Grad, Brian K Jones, Yanping Xu, Jie Xu, Gerhard Randers-Pehrson, Daniel Attinger and David J Brenner

Neutron Microbeam
Yanping Xu, Gerhard Randers-Pehrson, Stephen A Marino and David J Brenner

Simultaneous Immersion Mirau Interferometry
Oleksandra V Lyulko, Gerhard Randers-Pehrson and David J Brenner

Microbeam Induced Stress Response in the C elegans Nematode
Antonella Bertucci, Roger D J Pocock, Guy Garty and David J Brenner

Bystander Studies [PDF]

Radiation-induced Bystander Signaling Pathways in Human Skin Fibroblasts: A Role for ATM and IL-33 in the Signal Transmission
Vladimir N Ivanov, Hongning Zhou, Shanaz A Ghandhi, Sally A Amundson and Tom K Hei

Mutations in Succinate Dehydrogenase Subunit C Increase Radiosensitivity and Bystander Responses
Hongning Zhou and Tom K Hei

Role of Bystander Cells after Irradiation with a Low a Dose of Alpha Particles
Alexandre V Mezentsev and Sally A Amundson

Cell Communication Is a Significant Component of the Early Gene Expression Response in Bystanders
Shanaz A Ghandhi and Sally A Amundson

Induction of Bystander Responses by Si490 Ions
Brian Ponnaiya, Masao Suzuki, Chirzuru Tsuruoka, Yukio Uchihori and Tom K Hei

Genomic Instability in Single Cell Derived Clones Following Exposure to Si490 Ions
Brian Ponnaiya, Tom K Hei and Charles R Geard

Molecular Studies [PDF]

DNMT1 Knockdown in Prostate Cancer Cells Reduces HRAD9 Expression and Tumor Formation in Nude Mice
Aiping Zhu, Xiangyuan Wang and Howard B Lieberman

DNMT3B siRNA Downregulates HRAD9 Expression in Prostate Cancer Cells
Corinne Leloup, Aiping Zhu and Howard B Lieberman

Radiosensitivity to High Energy Iron Ions is Influenced by Heterozygosity for ATM, RAD9 and BRCA1
Lubomir B Smilenov, Guangming Zhou, Howard B Lieberman, Thomas Ludwig and Eric J Hall

Transforming Growth Factor-β Induced Protein (TGFBI) Suppresses Mesothelioma Progression through the Akt/mTOR Pathway
Gengyun Wen, Mei Hong, Bingyan Li, Michael A Partridge, Burong Hu, Gloria M Calaf and Tom K Hei

TGFBI Deficiency Leads to Aberrant CREB and Cyclin D1 Activations by Enhanced Protein Kinase an Activity
Ping Lu, Ye Zhang, Tom K Hei and Yongliang Zhao

Alterations in Gene Expression Levels in Individual Cells in Response to Ionizing Radiation
Brian Ponnaiya, Sally A Amundson, Shanaz A Ghandhi, Lubomir B Smilenov, Charles R Geard and David J Brenner

Histone Gene Expression in Irradiated Cells
Jarah A Meador and Sally A Amundson

DNA Repair in Human Adipose Tissue-derived Stem Cells
Jarah A Meador and Adayabalam S Balajee

Hypoxia-Induced Radioresistance is Associated with 53BP1 Upregulation and Facilitated Turnover
Alexander V Kofman, Jarah A Meador and Charles R Geard

Mitochondria-derived Reactive Intermediate Species Mediate Asbestos-induced Nuclear DNA Mutagenesis and Oxidative Stress-Responsive Signaling Pathways
Sarah XL Huang, Michael A Partridge, Shanaz A Ghandhi, Evelyn Hernandez-Rosa, Mercy M Davidson, Sally A Amundson, Sindu Krishna and Tom K Hei

Asbestos Induces Mitochondrial DNA Mutation and Functional Alteration: Potential Source of Intracellular Oxidants and Implications for Mechanism of Mutagenicity
Sarah XL Huang, Michael A Partridge, Evelyn Hernandez-Rosa, Mercy M Davidson and Tom K Hei

Cellular Studies [PDF]

Human Endothelial Cells in 3D Model Vessel Systems: Differential Effects of High and Low LET Space Radiations
Peter Grabham, Burong Hu, Preety Sharma and Charles R Geard

Catechol Estrogen as a Biomarker for Mammary Gland Cancer
Gloria M Calaf and Fernando Garrido

Population-Based Radiology or Radiotherapy Oriented Studies [PDF]

Cancer Risks after Radiation Exposure in Middle Age: Mechanisms and Societal Implications
Igor Shuryak, Rainer K Sachs and David J Brenner

A Model of Interactions between Radiation-Induced Oxidative Stress, Protein and DNA Damage in Deinococcus Radiodurans
Igor Shuryak and David J Brenner

Radiation Dose Measurements in Phantom from Coronary CT Angiography Performed with First Generation Volume Scanner
Carl D Elliston, Andrew J Einstein, Andrew E Arai, Marcus Y Chen, Rich Mather, Gregory D Pearson, Robert L DeLaPaz, Edward L Nickoloff, Ajoy Dutta and David J Brenner

Center for High-Throughput Minimally-Invasive Radiation Biodosimetry (U19) [PDF]

The Columbia Center for High-Throughput Minimally-Invasive Radiation Biodosimetry
David J Brenner

High-Throughput mBAND
Alan W Bigelow, Guy Y Garty, Antonella Bertucci, Charles R Geard and David J Brenner

Evaluation of Effect of Genotoxic Drugs on Peripheral Blood Gene Expression Profiling for Radiation Biodosimetry with Cancer Patients
Sunirmal Paul and Sally A Amundson

Optimizing the γ-H2AX Assay for High Throughput Automated Biodosimetry
Helen C Turner, David J Brenner, Youhua Chen, Antonella Bertucci, Jian Zhang, Hongliang Wang, Oleksandra V Lyulko, Yanping Xu, Julia Schäfer, Nabil Simaan, Gerhard Randers-Pehrson, Y Lawrence Yao, Sally A Amundson and Guy Garty

An Online PC Cluster for High Performance Computing of Bio-Physics Project
Yanping Xu and Helen C Turner

Upgrades to Rapid Automated Biodosimetry Technology (RABIT)
Youhua Chen, Jian Zhang, Hongliang Wang, Guy Garty, Gary W Johnson, Nabil Simaan, Y Lawrence Yao and David J Brenner

A Rapid Autofocus System for High Speed Imaging
Guy Garty, Nina Bahar, Gerhard Randers-Pehrson and David J Brenner

Automated Image Analysis for Micronuclei Assay in RABIT
Oleksandra V Lyulko, Guy Garty, Helen C Turner, Gerhard Randers-Pehrson and David J Brenner

Development of a Button-Type Personal Dosimeter
Stephen A Marino, Gary W Johnson and David J Brenner

The Radiological Research Accelerator Facility an NIH-Supported Resource Center [PDF]
Dir., David J. Brenner, PhD, DSc; Assoc. Dir. Gerhard Randers-Pehrson, PhD; Mnger., Stephen A. Marino, MS


Updated 10/22/2010


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