2008 Annual Report
Table of Contents

CRR Director: David J. Brenner
Editor: Howard B. Lieberman
Asst Editor: Jinshuang Lu



The complete 2008 annual report can be downloaded as a PDF as can individual sections of this report from the links below. The table of contents is given below.

For annual reports from previous years click here.

Microbeam Development and Experimental Studies [PDF]

Under-Dish Detector for the Microbeam at Columbia University
Guy Garty, Andrew D Harken, Gerhard Randers-Pehrson and David J Brenner

The Permanent Magnet Microbeam at Columbia University
Guy Garty, Andrew D Harken, Yanping Xu, Gerhard Randers-Pehrson and David J Brenner

Applications for the Microbeam-Integrated Multiphoton Imaging System at RARAF
Alan W Bigelow, Charles R Geard, Gerhard Randers-Pehrson and David J Brenner

Immersion Mirau Interferometry Developments
Oleksandra V Lyulko, Gerhard Randers-Pehrson and David J Brenner

Point-and-Shoot: Charged-Particle Microbeam Irradiation Targeting Through Beam Deflection
Andrew D Harken, Gerhard Randers-Pehrson and David J Brenner

Proton Induced Soft X-ray Microbeam at RARAF
Andrew D Harken, Gerhard Randers-Pehrson and David J Brenner

Neutron Microbeam
Yanping Xu, Gerhard Randers-Pehrson, Stephen A Marino and David J Brenner

Microbeam Irradiation of Living Animals
Antonella Bertucci, Roger D J Pocock, Wendy Kuhne, Gerhard Randers-Pehrson, William Dynan, Oliver Hobert and David J Brenner

Bystander Studies [PDF]

Mitochondrial Function Modulates Cytoplasmic Irradiation Induced Bystander Effect
Hongning Zhou, Masao Suzuki, Mei Hong, Vladimir Ivanov, Michael Partridge, Alan Bigelow, Gerhard Randers-Pehrson and Tom K Hei

Role of Succinate Dehydrogenase C in Radiation Induced Bystander Effect
Hongning Zhou, Vladimir N Ivanov and Tom K Hei

A Role of IGFBP3 in Modulation of α-radiation-induced Bystander Signaling Pathways Followed by TRAIL-Mediated Apoptosis in Human Skin Fibroblasts
Vladimir N Ivanov, Hongning Zhou and Tom K Hei

Differential Expression of p53 Related Genes in Irradiated and Bystander Cell Populations
Shanaz A Ghandhi and Sally A Amundson


Molecular Studies [PDF]

TGFBI Deficiency Predisposes Mice to Spontaneous Tumor Development
Ye Zhang, Gengyun Wen, Genze Shao, Chyuansheng Lin, Adayabalam S Balajee Govind Bhagat, Tom K Hei and Yongliang Zhao

Betaig-h3 Expression Reduces In Vitro and In Vivo Metastatic Ability in Lung and Breast Tumor Cells
Gengyun Wen, Michael A Partridge, Mei Hong, Bingyan Li, Gloria M Calaf, Yongliang Zhao, Tian Liu, Jun Zhou, Zengli Zhang and Tom K Hei

DNA Demethylating Agent Zebularine Preferentially Sensitizes Human Glioblastoma Cells Deficient in DNA-Dependent Protein Kinase (DNA-PK)
Jarah A Meador, Yanrong Su, Jean-Luc Ravanat, Charles R Geard and Adayabalam S Balajee

DNA-PK Plays a Regulatory Role in Cisplatin Induced Toxicity in Human Brain Tumor Cells
Patricia de Oliveira Carminati, Jarah A Meador, Charles R Geard and Adayabalam S Balajee

Combined Heterozygosity for DNA Repair Genes Has Significant Effect on Radiation Response
Lubomir B Smilenov, Guangming Zhou, Howard B Lieberman and Eric J Hall

Alteration of p53-Binding Protein 1 Kinetics in Hypoxic Cells
Alexander V Kofman, Burong Hu and Charles R Geard

Use of geNorm to Identify Appropriate Endogenous Controls for Normalization of Gene Expression in a Macro Array
Shanaz A Ghandhi and Sally A Amundson

Agilent One Color Low RNA Input Linear Amplification Microarrays: Modified Protocol and Evaluation of Expression Profiling Quality Control Measurements
Sunirmal Paul and Sally A Amundson

HRAD9 Overexpression in Prostate Cancer Cell Line-DU145 is Caused by Aberrant DNA Methylation
Aiping Zhu, Kevin M Hopkins, Xiaojian Wang and Howard B Lieberman

Mrad9B Is Expressed in the Brain of Mouse Embryos
Corinne Leloup, Xiang Yuan Wang, Kevin M Hopkins, Aiping Zhu, Debra J Wolgemuth and Howard B Lieberman

Human RAD9 Can Activate Transcription of the Cox-2 Promoter after Ionizing Radiation Exposure
Xiaojian Wang, Chuanxin Huang, Wenhong Shen, Yuxin Yin and Howard B Lieberman

Characterization of Mrad1 Deficient Mouse Embryos
Kevin M Hopkins, Xiangyuan Wang, Haiying Hang and Howard B Lieberman

A Signaling Pathway Involving 4-HNE and COX-2 in Cytoplasmic Irradiation-induced Genotoxic Effect
Mei Hong, Hongning Zhou, Gerhard Randers-Pehrson, and Tom K Hei

Identification of DUSP1 as a p53 Target during the Cellular Response to Oxidative Stress
Yu-Xin Liu, Jianli Wang, Jianfen Guo, Jingjing Wu, Howard B Lieberman and Yuxin Yin


Cellular Studies [PDF]

Human Endothelial Cells in 3D Model Vessel Systems; Differential Effects of High and Low LET
Space Radiations
Peter Grabham, Burong Hu, Alan Bigelow and Charles R Geard

Effect of Organophosphorus Pesticides and Estrogen on Mammary Carcinogenesis
Gloria M Calaf and Carlos EchiburĂș-Chau

Population-Based Radiology or Radiotherapy Oriented Studies [PDF]

Protons for Radiotherapy: A 1946 Proposal
Eric J Hall

Integrating Short- and Long-Term Mechanistic Models of Radiation-Induced Carcinogenesis I: Rationale and Methods
Igor Shuryak, Philip Hahnfeldt, Lynn Hlatky, Rainer K Sachs and David J Brenner

Integrating Short- and Long-Term Mechanistic Models of Radiation-Induced Carcinogenesis
II: Second Cancer Risk Estimation
Igor Shuryak, Philip Hahnfeldt, Lynn Hlatky, Rainer K Sachs and David J Brenner

Center for High-Throughput Minimally-Invasive Radiation Biodosimetry (U19) [PDF]

Triage of Medically Significant Radiation Exposures Using Gene Expression Signatures in Human PBL
Sally A Amundson and Sunirmal Paul

The Rabit: A Rapid Automated Biodosimetry Tool for Radiological Triage
Guy Garty and David J Brenner

Sample Collection for High Throughput Radiation Biodosimetry
Guy Garty, Helen C Turner, Gerhard Randers-Pehrson and David J Brenner

Adaptation of MN and γ-H2AX Assays for Automated Processing
Helen C Turner, Guy Garty, Oleksandra V Lyulko, Antonella Bertucci, Julia SchÀfer, Gerhard Randers-Pehrson and David J Brenner90

High-Throughput Image Acquisition and Analysis for Rapid Automated Biodosimetry Tool
Oleksandra V Lyulko, Guy Garty, Helen C Turner, Gerhard Randers-Pehrson and David J Brenner

Immunoassays to Detect Paracrine Signaling Molecules Induced by Radiation Exposure:
Developing an in vivo Proof of Principle Animal Model
Michael A Partridge

Expression of Activated Checkpoint Kinase 2 and Histone 2AX in Exfoliative Oral Cells after
Exposure to Ionizing Radiation
Angela J Yoon, Jing Shen, Hui-Chen Wu, Christos Angelopoulos, Steven R Singer,
Rongzhen Chen and Regina M Santella

Radiation-Induced Mitochondrial DNA Damage: A Dosimeter for Radiation Exposure
Hongning Zhou, Michael Partridge, Sarah Huang, Yu-Chin Lien and Tom K Hei

Remodeling of Interphase Chromosome Domains in Response to Radiation Damage
Michael N Cornforth

Minimally Invasive High-Throughput Radiation Biodosimetry Using a Finger Prick Blood Cytokinesis-Block Micronucleus Assay Microculture System
Michael Fenech

miRNA Based Dosimetry for Irradiation Exposure
Lubomir B Smilenov

Development of a Button-Type Personal Dosimeter
Stephen A Marino

Stability of Expression of Endogenous Controls in Single and Multiple Cells by qRT-PCR
Brian Ponnaiya, Sally A Amundson, Shanaz A Ghandhi, Lubomir B Smilenov, Charles R Geard and David J Brenner

On-Line Breath Gas Analysis for Non-Invasive High-Throughput Radiation Biodosimetry
Uwe Oeh, Lothar Keck, Claudia Brunner, Mattia Fredrigo and Herwig G Paretzke

Human DNA Repair Variation and Radiation Exposure Biomarkers
Bruce Demple

Integrated Microfluidic Visualization on a Microchip for Ultrahigh-Throughput Low-Cost Radiation Biodosimetry
Robin Muller, Michael Grad, Chee Wei Wong, Samuel K Sia and Daniel Attinger

Potential Application of γ-H2AX and TUNEL Assays in Hair Follicle Cells for High-Throughput Minimally-Invasive Biodosimetry in the 2-8 Gy Dose Range
Yuanlin Peng and Joel S Bedford

Quantitative Microarray Flow-Channel Assay for Use with a Hand-Held Fluorescent Reader
Matthew Coleman

The Radiological Research Accelerator Facility an NIH-Supported Resource Center [PDF]
Dir., David J. Brenner, PhD, DSc; Assoc. Dir. Gerhard Randers-Pehrson, PhD; Mnger., Stephen A. Marino, MS

The Radiation Safety Office [PDF]


Updated 10/05/2010


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