2001 Annual Report
Table of Contents

CRR Director: Eric J. Hall
Editor: Charles R. Geard
Asst Editors: Mary T. Coady
                    Moshe Y. Friedman

 

The complete 2001 annual report can be downloaded as a PDF as can individual sections of this report from the links below. The table of contents is given below.

For annual reports from previous years click here.

Physics, Biophysics, and Modeling [PDF]

Laser Ion Source Development for the Columbia University Microbeam
Alan W Bigelow, Gerhard Randers-Pehrson, and David J Brenner

Are there Geometric Associations between Different Human Chromosomes?
David J Brenner, in collaboration with Karin M Greulich-Bode, Martina Brückner, Michael N Cornforth, Bradford Lucas and Rainer K Sachs

Biomarkers Specific to Densely-Ionizing (High-LET) Radiations
David J Brenner, M Prakash Hande and Charles R Geard, with Nadia Okladnikova, Ludmilla Burak and Tamara Azizova 

Do Low Dose-Rate Bystander Effects Influence Domestic Radon Risks?
David J Brenner, in collaboration with Rainer K Sachs

Microbeam & Bystander Studies [PDF]

Induction of p21/WAF1 in Microbeam Irradiated and Bystander Normal Human Fibroblasts
Brian Ponnaiya, Gloria Jenkins-Baker, Mutian Zhang, Alan Bigelow, Gerhard Randers-Pehrson, & Charles R Geard

Intra-Nuclear Dynamics of Mre11 in Human Cells Following Microbeam Irradiation with a-Particles
Adayabalam S Balajee and Charles R Geard

SCGE Detection of DNA Strand Breaks and Oxidized Base Lesions Induced by Microbeam Irradiation of Human Nuclei with Defined Number of Alpha Particles
Adayabalam S Balajee, Brian Ponnaiya, Manoor P Hande, Gloria Jenkins-Baker, Stephen Marino, Gerhard Randers-Pehrson and Charles R Geard

Modulation of Adaptive Response in Alpha Particle Induced Bystander Mutagenesis
Hongning Zhou, Gerhard Randers-Pehrson, Eric J Hall and Tom K Hei

Novel Approaches with Track Segment Alpha Particles and Cell Co-Cultures in Studies of Bystander Effects
Charles R Geard, Gloria Jenkins-Baker, Stephen A Marino, Gary Johnson and Brian Ponnaiya

Investigation of a Radiation-Induced Bystander Effect Using Co-Culturing Protocols
Brian Ponnaiya, Gloria Jenkins-Baker, Mutian Zhang, Alan Bigelow, Stephen Marino and Charles R Geard

Investigation of the Role of Cell Type Specificity in the Induction of a Bystander Effect
Brian Ponnaiya, Gloria Jenkins-Baker, Mutian Zhang, Alan Bigelow, Stephen Marino and Charles R Geard

Induction of Chromosomal Aberrations in γ-Irradiated and Bystander Fibroblasts
Brian Ponnaiya, Gloria Jenkins-Baker, Mutian Zhang, Alan Bigelow, Stephen Marino and Charles R Geard

Detection of Chromosomal Instability in Co-Cultured g-Irradiated and Bystander Human Fibroblasts
Brian Ponnaiya, Gloria Jenkins-Baker, Mutian Zhang, Alan Bigelow, Stephen Marino and Charles R Geard

Induction of DNA Repair and Signal Transduction Proteins Triggered by Ionizing Radiation in Bystander Cells
Adayabalam S Balajee and Charles R Geard

Cellular Studies [PDF]

Ataxia Telangiectasia Fibroblasts with Extended Lifespan through Telomerase Expression Retain Their Cellular Characteristics
Tej K Pandita, Sonu Dhar and Arun Gupta, with Lauren D Wood, Fred Levine, Jerry W Shay and Jean J Y Wang

Spontaneously Immortalized Cell Lines Obtained from Adult ATM Null Mice Retain Sensitivity to Ionizing Radiation and Exhibit a Mutational Pattern Suggestive of Oxidative Stress
Sonu Dhar, Girdha G Sharma and Tej K Pandita, in collaboration with BM Gage, D Alroy, CY Shin, ON Ponomareva, MJ Thayer and MS Turker

Extension of Lifespan by Transfection of hTERT in Normal Human Mammary Epithelial Cells
Li Liu, Yong L Zhao, Chang Q Piao and Tom K Hei

Immortalization of Primary Human Bronchial Epithelial Cells by Overexpression of Human Telomerase Catalytic Subunits (hTERT)
Chang Q Piao, Yong L Zhao, Li Liu and Tom K Hei

Monitoring Tumor Progression in a Radiation and Estrogen-Induced Breast Cancer Model
Gloria M Calaf, Debasish Roy and Tom K Hei

Effect of Retinol on Radiation and Estrogen-Induced Neoplastic Transformation of Human Breast Epithelial Cells
Gloria M Calaf and Tom K Hei, in collaboration with Nancy J Emenaker

Susceptibility of Human Breast Tissue to Neoplastic Changes Induced by Organophosphorous Pesticides
Gloria M Calaf and Tom K Hei, in collaboration with Gertrudis Cabello

Arsenic Induces Oxidative DNA Damage in Mammalian Cells
Su Xian Liu, An Xu and Tom K Hei, in collaboration with Maris Kessel and Regina Santella

Role of Mitochondrial Oxidants as Regulators of Mutagenicity of Arsenite in Mammalian Cells
Su Xian Liu and Tom K Hei

Development of a Flow Cytometric Assay for the Quantification of CD59 Mutations in Human-Hamster Hybrid (AL) Cells
An Xu, Haiying Hang, Hongning Zhou, Raheel Ansari and Tom K Hei

Extranuclear Targets in the Genotoxicity of Asbestos in Mammalian Cells
An Xu, Suxian Liu and Tom K Hei

Mutagenicity of Crocidolite Asbestos in Mammalian Cells is Associated with Nitric Oxide Production
An Xu and Tom K Hei

Cytogenetic Studies [PDF]

Use of Multicolor Fluorescence in Situ Hybridization (m-FISH) to Detect Radiation-Induced Chromosome Aberrations in Human Cells
M Prakash Hande and David J Brenner

Radiation Induced Inter-Arm Exchanges Detected by Fluorescence in Situ Hybridization Using Chromosome Single Arm-Specific Probes
M Prakash Hande, Adayabalam S Balajee, Charles R Geard and David J Brenner

Aberrant Hrad9 Expression Influences Telomere Behavior and Ionizing Radiation-Induced Chromosomal Instability
Sonu Dhar, Wei Zheng, Girdhar G Sharma, Kevin M, Hopkins, Howard B Lieberman and Tej K Pandita

Extra-Chromosomal Telomeric DNA in Cells from Atm-/- Mice and Patients with Ataxia-Telangiectasia
M Prakash Hande and Adayabalam S Balajee, in collaboration with Andrei Tchirkov, Anthony Wynshaw-Boris and Peter M Lansdorp

Molecular Studies [PDF]

Mrad9 Knockout Mouse ES Cells are Sensitive to Ionizing Radiation
Howard B Lieberman and Kevin M Hopkins, in collaboration with Alexandra L Joyner and Wojtek Auerbach

Identification and Characterization of a Paralogue of Human Cell Cycle Checkpoint Gene HUS1
Haiying Hang and Howard B Lieberman, in collaboration with Yuzhu Zhang and Roland L Dunbrack, Jr

hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase
Tej K Pandita, in collaboration with Homayoun Vaziri, Scott K Dessain, Elinor Ng Eaton, Shin-Ichiro Imai, Roy A Frye, Leonard Guarente and Robert A Weinberg

Influence of PTEN on Telomere Stability and Telomerase Activity
Girdhar G Sharma, Janusz Puc, Sonu Dhar, Ramon Parson and Tej K Pandita

hTERT Association with Telomeres Correlates with Reduction in Spontaneous Chromosome Damage and Enhancement of DNA Repair
Girdhar G Sharma, Arun Gupta, Sonu Dhar and Tej K Pandita

14-3-3s Influences Telomere Stability and ATM Kinase Activity
Arun Gupta, Sonu Dhar and Tej K Pandita, in collaboration with Dea-Sick Lim and Michael B Kastan

ECK Protein Kinase as a Transcriptional Target of P53 in Signaling Apoptosis and Tumor Suppression
Cynthia Y Liu and Yuxin Yin

Overexpression of Betaig-H3 Gene Suppresses Tumorigenicity in Radiation Induced Tumorigenic Human Bronchial Epithelial Cells
Yong Liang Zhao, Chang Piao and Tom K Hei

Mutation(s) at Exon 3 of b-Catenin Preventing b-Catenin-GSK-3bInteraction: A possible Role in Radiation-Induced Breast Cancer Progression
Debasish Roy, Gloria M Calaf and Tom K Hei

Radiology and Radiation Therapy Oriented Studies [PDF]

Risks of Radiation-Induced Cancer from Pediatric CT
David J Brenner, Carl D Elliston, Eric J Hall and Walter E Berdon

The Radiological Research Accelerator Facility an NIH-Supported Resource Center [PDF]
Dir, David J Brenner, PhD, DSc; Chief Physicist, Randers-Pehrson, PhD; Mnger, Stephen A Marino, MS

The Radiation Safety Office [PDF]

 

Updated 10/06/2010

 

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