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The complete 2001 annual report can be
downloaded as a PDF as can individual sections of this report from the
links below. The table of contents is given below.
For annual reports from previous years click here.
Physics, Biophysics, and Modeling [PDF]
Laser Ion Source Development for the
Columbia University Microbeam
Alan W Bigelow, Gerhard Randers-Pehrson, and David J Brenner
Are there Geometric Associations between
Different Human Chromosomes?
David J Brenner, in collaboration with Karin M Greulich-Bode, Martina
Brückner, Michael N Cornforth, Bradford Lucas and Rainer K Sachs
Biomarkers Specific to Densely-Ionizing
(High-LET) Radiations
David J Brenner, M Prakash Hande and Charles R Geard, with Nadia
Okladnikova, Ludmilla Burak and Tamara Azizova
Do Low Dose-Rate Bystander Effects
Influence Domestic Radon Risks?
David J Brenner, in collaboration with Rainer K Sachs
Microbeam & Bystander Studies [PDF]
Induction of p21/WAF1 in Microbeam
Irradiated and Bystander Normal Human Fibroblasts
Brian Ponnaiya, Gloria Jenkins-Baker, Mutian Zhang, Alan Bigelow,
Gerhard Randers-Pehrson, & Charles R Geard
Intra-Nuclear Dynamics of Mre11 in Human
Cells Following Microbeam Irradiation with a-Particles
Adayabalam S Balajee and Charles R Geard
SCGE Detection of DNA Strand Breaks and
Oxidized Base Lesions Induced by Microbeam Irradiation of Human Nuclei
with Defined Number of Alpha Particles
Adayabalam S Balajee, Brian Ponnaiya, Manoor P Hande, Gloria
Jenkins-Baker, Stephen Marino, Gerhard Randers-Pehrson and Charles R
Geard
Modulation of Adaptive Response in Alpha
Particle Induced Bystander Mutagenesis
Hongning Zhou, Gerhard Randers-Pehrson, Eric J Hall and Tom K Hei
Novel Approaches with Track Segment Alpha
Particles and Cell Co-Cultures in Studies of Bystander Effects
Charles R Geard, Gloria Jenkins-Baker, Stephen A Marino, Gary Johnson
and Brian Ponnaiya
Investigation of a Radiation-Induced
Bystander Effect Using Co-Culturing Protocols
Brian Ponnaiya, Gloria Jenkins-Baker, Mutian Zhang, Alan Bigelow,
Stephen Marino and Charles R Geard
Investigation of the Role of Cell Type
Specificity in the Induction of a Bystander Effect
Brian Ponnaiya, Gloria Jenkins-Baker, Mutian Zhang, Alan Bigelow,
Stephen Marino and Charles R Geard
Induction of Chromosomal Aberrations in
γ-Irradiated and Bystander
Fibroblasts
Brian Ponnaiya, Gloria Jenkins-Baker, Mutian Zhang, Alan Bigelow,
Stephen Marino and Charles R Geard
Detection of Chromosomal Instability in
Co-Cultured g-Irradiated and Bystander Human Fibroblasts
Brian Ponnaiya, Gloria Jenkins-Baker, Mutian Zhang, Alan Bigelow,
Stephen Marino and Charles R Geard
Induction of DNA Repair and Signal
Transduction Proteins Triggered by Ionizing Radiation in Bystander Cells
Adayabalam S Balajee and Charles R Geard
Cellular Studies [PDF]
Ataxia Telangiectasia Fibroblasts with
Extended Lifespan through Telomerase Expression Retain Their Cellular
Characteristics
Tej K Pandita, Sonu Dhar and Arun Gupta, with Lauren D Wood, Fred
Levine, Jerry W Shay and Jean J Y Wang
Spontaneously Immortalized Cell Lines
Obtained from Adult ATM Null Mice Retain Sensitivity to Ionizing
Radiation and Exhibit a Mutational Pattern Suggestive of Oxidative
Stress
Sonu Dhar, Girdha G Sharma and Tej K Pandita, in collaboration with
BM Gage, D Alroy, CY Shin, ON Ponomareva, MJ Thayer and MS Turker
Extension of Lifespan by Transfection of
hTERT in Normal Human Mammary Epithelial Cells
Li Liu, Yong L Zhao, Chang Q Piao and Tom K Hei
Immortalization of Primary Human Bronchial
Epithelial Cells by Overexpression of Human Telomerase Catalytic
Subunits (hTERT)
Chang Q Piao, Yong L Zhao, Li Liu and Tom K Hei
Monitoring Tumor Progression in a Radiation
and Estrogen-Induced Breast Cancer Model
Gloria M Calaf, Debasish Roy and Tom K Hei
Effect of Retinol on Radiation and
Estrogen-Induced Neoplastic Transformation of Human Breast Epithelial
Cells
Gloria M Calaf and Tom K Hei, in collaboration with Nancy J Emenaker
Susceptibility of Human Breast Tissue to
Neoplastic Changes Induced by Organophosphorous Pesticides
Gloria M Calaf and Tom K Hei, in collaboration with Gertrudis Cabello
Arsenic Induces Oxidative DNA Damage in
Mammalian Cells
Su Xian Liu, An Xu and Tom K Hei, in collaboration with Maris Kessel
and Regina Santella
Role of Mitochondrial Oxidants as
Regulators of Mutagenicity of Arsenite in Mammalian Cells
Su Xian Liu and Tom K Hei
Development of a Flow Cytometric Assay for
the Quantification of CD59 Mutations in Human-Hamster Hybrid (AL) Cells
An Xu, Haiying Hang, Hongning Zhou, Raheel Ansari and Tom K Hei
Extranuclear Targets in the Genotoxicity
of Asbestos in Mammalian Cells
An Xu, Suxian Liu and Tom K Hei
Mutagenicity of Crocidolite Asbestos in
Mammalian Cells is Associated with Nitric Oxide Production
An Xu and Tom K Hei
Cytogenetic Studies [PDF]
Use of Multicolor Fluorescence in Situ
Hybridization (m-FISH) to Detect Radiation-Induced Chromosome
Aberrations in Human Cells
M Prakash Hande and David J Brenner
Radiation Induced Inter-Arm Exchanges
Detected by Fluorescence in Situ Hybridization Using Chromosome Single
Arm-Specific Probes
M Prakash Hande, Adayabalam S Balajee, Charles R Geard and David J
Brenner
Aberrant Hrad9 Expression Influences
Telomere Behavior and Ionizing Radiation-Induced Chromosomal Instability
Sonu Dhar, Wei Zheng, Girdhar G Sharma, Kevin M, Hopkins, Howard B
Lieberman and Tej K Pandita
Extra-Chromosomal Telomeric DNA in Cells
from Atm-/- Mice and Patients with Ataxia-Telangiectasia
M Prakash Hande and Adayabalam S Balajee, in collaboration with
Andrei Tchirkov, Anthony Wynshaw-Boris and Peter M Lansdorp
Molecular Studies [PDF]
Mrad9 Knockout Mouse ES Cells are Sensitive
to Ionizing Radiation
Howard B Lieberman and Kevin M Hopkins, in collaboration with
Alexandra L Joyner and Wojtek Auerbach
Identification and Characterization of a
Paralogue of Human Cell Cycle Checkpoint Gene HUS1
Haiying Hang and Howard B Lieberman, in collaboration with Yuzhu
Zhang and Roland L Dunbrack, Jr
hSIR2SIRT1 Functions as an NAD-Dependent
p53 Deacetylase
Tej K Pandita, in collaboration with Homayoun Vaziri, Scott K Dessain,
Elinor Ng Eaton, Shin-Ichiro Imai, Roy A Frye, Leonard Guarente and
Robert A Weinberg
Influence of PTEN on Telomere Stability and
Telomerase Activity
Girdhar G Sharma, Janusz Puc, Sonu Dhar, Ramon Parson and Tej K
Pandita
hTERT Association with Telomeres Correlates
with Reduction in Spontaneous Chromosome Damage and Enhancement of DNA
Repair
Girdhar G Sharma, Arun Gupta, Sonu Dhar and Tej K Pandita
14-3-3s Influences Telomere Stability and
ATM Kinase Activity
Arun Gupta, Sonu Dhar and Tej K Pandita, in collaboration with Dea-Sick
Lim and Michael B Kastan
ECK Protein Kinase as a Transcriptional
Target of P53 in Signaling Apoptosis and Tumor Suppression
Cynthia Y Liu and Yuxin Yin
Overexpression of Betaig-H3 Gene Suppresses
Tumorigenicity in Radiation Induced Tumorigenic Human Bronchial
Epithelial Cells
Yong Liang Zhao, Chang Piao and Tom K Hei
Mutation(s) at Exon 3 of b-Catenin
Preventing b-Catenin-GSK-3bInteraction: A possible Role in
Radiation-Induced Breast Cancer Progression
Debasish Roy, Gloria M Calaf and Tom K Hei
Radiology and Radiation Therapy Oriented Studies
[PDF]
Risks of Radiation-Induced Cancer from
Pediatric CT
David J Brenner, Carl D Elliston, Eric J Hall and Walter E Berdon
The Radiological Research Accelerator Facility an NIH-Supported
Resource Center [PDF]
Dir, David J Brenner, PhD, DSc; Chief Physicist, Randers-Pehrson, PhD;
Mnger, Stephen A Marino, MS
The Radiation Safety Office [PDF] |
