|
The complete 2000 annual report can be
downloaded as a PDF as can individual sections of this report from the
links below. The table of contents is given below.
For annual reports from previous years click here.
Physics, Biophysics, and Modeling [PDF]
Rutherford, the Curies, and Radon
David J. Brenner
The
Potential Impact of the Bystander Effect on Radiation Risks on a Mars
Mission
David J Brenner and Carl D. Elliston
A
Quantitative Model of the Bystander Effect in Radiation Oncogenesis
David J. Brenner, J.B. Little , and R.K. Sachs
Microbeam Studies [PDF]
The Bystander Effect in Radiation Oncogenesis: Oncogenic Transformation
Can be Initiated in the Unirradiated Neighbors of Irradiated Cells
Satin Sawant, Gerhard Randers-Pehrson, Charles R. Geard, David J.
Brenner, and Eric J. Hall
Adaptive Response and The Bystander Effect
Satin G. Sawant, Gerhard Randers-Pehrson, and Eric J. Hall, in
collaboration with Noelle F. Metting
Studies of a Bystander Mutagenic Effect in Mammalian Cells Using a
Charged-Particle Microbeam
Hongning Zhou, Gerhard Randers-Pehrson, Charles A. Waldren , James E.
Trosko , Eric J. Hall, and Tom K. Hei
Mutagenicity of Cytoplasmic Irradiation in Mammalian Cells: Role of
Peroxynitrite Anions
An Xu, Gerhard Randers-Pehrson, and Tom K. Hei
Investigation of the Bystander Effect in Known Irradiated and
Non-Irradiated Normal Human Fibroblasts
Brian Ponnaiya, Gloria Jenkins-Baker, Gerhard Randers-Pehrson, and
Charles R. Geard
Bystander Cell Responses in Normal Human Fibroblasts as a Function of
Hit-Cell Fraction
Charles R. Geard, Brian Ponnaiya, Gloria Jenkins-Baker, and Gerhard
Randers-Pehrson
Cytoplasmic Irradiation of Normal Human Fibroblasts
Charles R. Geard, Brian Ponnaiya, Gloria Jenkins-Baker, and Gerhard
Randers-Pehrson
Microbeam Irradiation of Intercellular Medium Between Normal Human
Fibroblasts
Charles R. Geard, Brian Ponnaiya, Gloria Jenkins-Baker, and Gerhard
Randers-Pehrson
p53 Modulation and Microbeam Responses: Studies with MCF-7 and MCF-7/E6
Cells
Charles R. Geard, Gloria Jenkins-Baker, Gerhard Randers-Pehrson, and
David Boothman
Microbeam Studies with Lifespan-Extended Human Retinal Pigmented
Epithelial Cells
Charles R. Geard, Brian Ponnaiya, Gloria Jenkins-Baker, and Gerhard
Randers-Pehrson
Single-Cell RT-PCR for Early-Response Genes
Brian Ponnaiya, Gloria Jenkins-Baker, and Charles R. Geard
SCGE Detection of DNA Damage in Human Nuclei Induced by Mirobeam
Irradiation Using Alpha Particles
Adayabalam S. Balajee, Brian Ponnaiya, M. Prakash Hande, T.S.
Kumaravel and Althaf Lohani, Gerhard Randers-Pehrson, Stephen A. Marino,
and Charles R. Geard
Cellular Studies [PDF]
Routine Mammographic Screening and Breast Cancer Induction
Satin G. Sawant, Stephen A. Marino, Charles R. Geard, and David J.
Brenner, in collaboration with Zugen Fu
Malignant Transformation of Human Bronchial Epithelial Cells with
Tobacco-Specific Nitrosamine, 4-Methynitrosamine-1-3Pyridyl-1-Butanone (NNK)
Hongning Zhou and Tom K. Hei
Induction and Mutant-Spectrum Analysis of CD59 Mutations in Human
Hamster Hybrid Cells by Crocidolite Asbestos and Hydrogen Peroxide:
Implications for Mechanisms of Fiber Mutagenesis
An Xu and Tom K. Hei
Effects of Irradiated Medium on Chromatid Aberrations and Mutagenesis in
Mammalian Cells: Studies Using Double-Mylar Dishes
Masao Suzuki, Hongning Zhou, Charles R. Geard, and Tom K. Hei
Mutagenicity of Cadmium in Mammalian Cells
Fei Sung, Stephanie Stern (Intern), and Tom K. Hei
Quantitative Measurement of Superoxides and Hydroxyl Radicals Generated
in Arsenite-Treated Cells Using ESR Spectroscopy
Su-Xian Liu, Istvan Lippai, Mohammed Athar , and Tom K. Hei
Extension of Lifespan in Primary Human Bronchial Epithelial Cells by
Expressing Telomerase
Chang Q. Piao, Yong L. Zhao, and Tom K. Hei
Markers in Progression of Human Breast Epithelial Cells Transformed by
Estrogens and High-LET Radiation
Gloria M. Calaf and Tom K. Hei
Neoplastic Progression of Benzo(a)pyrene-Treated Breast Epithelial Cells
Gloria M. Calaf and Tom K. Hei
Karyotype Analysis in Tumorigenic Human Bronchial Epithelial Cells
Transformed by Crysolite Asbestos Using Chemically Induced PCC Technique
Masao Suzuki, Chang Q. Piao, and Tom K. Hei
High-Energy Ions and Genomic Instability
Chang Q. Piao, Tom K. Hei, and Eric J. Hall
Cytogenetic Studies [PDF]
Induction and Recovery of Cytotoxic and Chromatic Damage in Primary
Human Bronchial Epithelial Cells Irradiated with 56Fe Ions
Masao Suzuki, Chang-Qing Piao, and Tom K. Hei
Conservation of Chromosome-Specific Telomere Length in Mammalian Cells
Andrei Tchirkov and Elizabeth Chavez, M. Prakash Hanke, and Peter
Lansdorp (TFL)
Chromosome Aberrations Induced by a Particles and Soft X-Rays in Human
Primary Fibroblasts
M. Prakash Hande, Satin G. Sawant, Brian Ponnaiya, Sonu Dhar, Stephen
A. Marino, Adayabalam S. Balajee, Charles R. Geard, and David J. Brenner
Use of Chromosome-Arm-Specific Probes in the Detection of
Radiation-Induced Inter-Arm Exchanges
M. Prakash Hande, Sonu Dhar, Adayabalam S. Balajee, Charles R. Geard,
and David J. Brenner
Molecular Studies [PDF]
S. pombe rad9 and its Human Homologue Have a BH3-Like Domain and Can
Promote Apoptosis in Human
Howard B. Lieberman, Kevin M. Hopkins, and Haiying Hang, in
collaboration with Hong-Gang Wang and Kiyoshi Komatsu
Construction and Analyses of Mrad9 Knockout Cells and Mice
Howard B. Lieberman, Kevin M. Hopkins, and Haiying Hang, in
collaboration with Wojtek Auerbach and Alexandra L. Joyner
Effect of Human HRAD9 Overexpression on Cell Survival, Growth, and
Checkpoint Control
Haiying Hang and Howard B. Lieberman
ATM Gene Proeuct is Not Required for DNA-Damage-Dependent Redistribution
of PCNA Complex in Human Cells
Adayabalam S. Balajee, M. Prakash Hande, and Charles R. Geard
A Common Target Gene for p53 and Rb Functions in Apoptosis
Yuxin Yin, Yan Jin, and Eric J. Hall
The Catalytic Subunit of Telomerase is Expressed in Developing Brain
Neurons and Serves a Cell-Survival-Promoting Function
Weiming Fu, Michael Killen, and Carten Culmsee, Sonu Dhar, Tej K.
Pandita, and Mark P. Mattson
Regulation of the hTERT Telomerase Catalytic Subunit by the c-Abl
tyrosine
Kinasem S. Kharbanda and V. Kumar, Sonu Dhar, P. Pandy, C. Chen, P.
Majumder, and Z-M. Yuan, Y. Whang, W. Strauss, Tej K. Pandita, and D.
Weaver and D. Kufe
Chronic Activation of Damage-Responsive Functions is Reduced by a-Lipoic
Acid in Ataxia Telangiectasia Cells
Magtouf Gatei, Dganit Shkedy, Tej K. Pandita, Martin F. Lavin, and
Galit Rotman
Meiotic Telomere Distribution and Sertoli-Cell Nuclear Architecture is
Altered in Atm- and Atm/p53-Deficient Mice
Harry Scherthan and Martin Jerratsch, Sonu Dhar, Y. Alan Wang,
Stephen P. Goff, and Tej K. Pandita
Characterization of Ataxia Telangiectasia Fibroblasts with Extended
Lifespan through Telomerase Expression
Lauren D. Wood and Tanya L. Halvorsen , Sonu Dhar, Joseph A. Baur,
Raj K. Pandita, Woodring E. Wright, M. Prakash Hande, Gloria M. Calaf,
Tom K. Hei, Fred Levine, Jerry W. Shay, Jean J.Y. Wang, and Tej K.
Pandita
Adenovirus-Mediated Antisense ATM Gene Transfer Sensitizes Prostate
Cancer Cells to Ionizing Radiation
Zuoheng Fan and Prabir Chakravarty, Alan Alfieri, Tej K. Pandita, and
Bhadrasain Vikram and Chandan Guha
Regulation of DNA-Dependent Protein Kinase Activity by
Ionizing-Radiation-Activated Abl Kinase is an ATM-dependent Process
Sanjeev Shangary, Kevin D. Brown and Aaron W. Adamson, Scott
Edmonson, Bobby Ng, Tej K. Pandita, Jack Yalowich, Guillermo E. Taccioli,
and R. Baskaran
High Frequency of Hypermethylation at the 14-3-3sLocus to Gene Silencing
in Breast Cancer
Anne T. Ferguson, Ella Evron, Christopher Umbricht , Tej K. Pandita,
Timothy A. Chan and Heiko Hermeking (JHOC), Jeffrey Marks, Aouk R.
Lambers and P. Andrew Futreal , Martha R. Stampfer , and Saraswati
Sukumar (JHOC)
Inactivation of 14-3-3s Influences Telomere Behavior and
Ionizing-Radiation-Induced Chromosomal Instability
Sonu Dhar, Jeremy A. Squire, M. Prakash Hande, Raymund J. Wellinger,
and Tej K. Pandita
Telomerase-Associated Protein TEP1 is Not Essential for Telomerase
Activity or Telomere-Length Maintenance In Vivo
Yie Liu and Bryan E. Snow, M. Prakash Hande, Gabriela Baerlocher,
Valerie Kickhoefer, David Yeung, Drew Wakeham and Annick Itie, David
Siderovski, Peter Lansdorp, Murray O. Robinson, and Lea Harrington
A Few Percent of the Population May Be Genetically Predisposed to
Radiation-Induced Cancer
Lubomir B. Smilenov, Eric J. Hall, and David J. Brenner
Differentially Expressed Genes in Asbestos-Induced Tumorigenic Human
Bronchial Epithelial Cells
Yong L. Zhao, Chang Q. Piao, and Tom K. Hei
Antisense ATM Gene Therapy: A Strategy to Increase the Radiosensitivity
of Human Tumors
C. Guha, U. Guha, and S. Tribius, A. Alfieri, D. Casper and P.
Chakravarty (AECOM), W. Mellado, Tej K. Pandita, and B. Vikram (AECOM)
Identification of a Defined Region with Allelic Loss in Chromosome 11
During Radiation
Debasish Roy, Gloria M. Calaf, and Tom K. Hei
Vitamin D Receptor Gene in a High-LET-Radiation- and Estrogen-Treated
Breast Cancer Model
Debasish Roy, Gloria M. Calaf, and Tom K. Hei
Studies
Related to Radiation Therapy [PDF]
Towards Optimal External-Beam Fractionation for Prostate Cancer
David J. Brenner
Adjuvant Radiotherapy for DCIS – Pyrrhic or Low Risk?
David J. Brenner, with Peter B. Schiff and Lydia B. Zablotska
The Radiological Research Accelerator Facility an NIH-Supported
Resource Center [PDF]
Dir, David J Brenner, PhD, DSc; Chief Physicist, Randers-Pehrson, PhD;
Mnger, Stephen A Marino, MS
The Radiation Safety Office [PDF] |
