2000 Annual Report
Table of Contents

CRR Director: Eric J. Hall
Editor: Charles R. Geard
Asst Editors: Micaela J. Delegtianis
                    Mary T. Coady


The complete 2000 annual report can be downloaded as a PDF as can individual sections of this report from the links below. The table of contents is given below.

For annual reports from previous years click here.

Physics, Biophysics, and Modeling [PDF]

Rutherford, the Curies, and Radon
David J. Brenner

The Potential Impact of the Bystander Effect on Radiation Risks on a Mars Mission
David J Brenner and Carl D. Elliston

A Quantitative Model of the Bystander Effect in Radiation Oncogenesis
David J. Brenner, J.B. Little , and R.K. Sachs

Microbeam Studies [PDF]

The Bystander Effect in Radiation Oncogenesis: Oncogenic Transformation Can be Initiated in the Unirradiated Neighbors of Irradiated Cells
Satin Sawant, Gerhard Randers-Pehrson, Charles R. Geard, David J. Brenner, and Eric J. Hall

Adaptive Response and The Bystander Effect
Satin G. Sawant, Gerhard Randers-Pehrson, and Eric J. Hall, in collaboration with Noelle F. Metting

Studies of a Bystander Mutagenic Effect in Mammalian Cells Using a Charged-Particle Microbeam
Hongning Zhou, Gerhard Randers-Pehrson, Charles A. Waldren , James E. Trosko , Eric J. Hall, and Tom K. Hei

Mutagenicity of Cytoplasmic Irradiation in Mammalian Cells: Role of Peroxynitrite Anions
An Xu, Gerhard Randers-Pehrson, and Tom K. Hei

Investigation of the Bystander Effect in Known Irradiated and Non-Irradiated Normal Human Fibroblasts
Brian Ponnaiya, Gloria Jenkins-Baker, Gerhard Randers-Pehrson, and Charles R. Geard

Bystander Cell Responses in Normal Human Fibroblasts as a Function of Hit-Cell Fraction
Charles R. Geard, Brian Ponnaiya, Gloria Jenkins-Baker, and Gerhard Randers-Pehrson

Cytoplasmic Irradiation of Normal Human Fibroblasts
Charles R. Geard, Brian Ponnaiya, Gloria Jenkins-Baker, and Gerhard Randers-Pehrson

Microbeam Irradiation of Intercellular Medium Between Normal Human Fibroblasts
Charles R. Geard, Brian Ponnaiya, Gloria Jenkins-Baker, and Gerhard Randers-Pehrson

p53 Modulation and Microbeam Responses: Studies with MCF-7 and MCF-7/E6 Cells
Charles R. Geard, Gloria Jenkins-Baker, Gerhard Randers-Pehrson, and David Boothman

Microbeam Studies with Lifespan-Extended Human Retinal Pigmented Epithelial Cells
Charles R. Geard, Brian Ponnaiya, Gloria Jenkins-Baker, and Gerhard Randers-Pehrson

Single-Cell RT-PCR for Early-Response Genes
Brian Ponnaiya, Gloria Jenkins-Baker, and Charles R. Geard

SCGE Detection of DNA Damage in Human Nuclei Induced by Mirobeam Irradiation Using Alpha Particles
Adayabalam S. Balajee, Brian Ponnaiya, M. Prakash Hande, T.S. Kumaravel and Althaf Lohani, Gerhard Randers-Pehrson, Stephen A. Marino, and Charles R. Geard

Cellular Studies [PDF]

Routine Mammographic Screening and Breast Cancer Induction
Satin G. Sawant, Stephen A. Marino, Charles R. Geard, and David J. Brenner, in collaboration with Zugen Fu

Malignant Transformation of Human Bronchial Epithelial Cells with Tobacco-Specific Nitrosamine, 4-Methynitrosamine-1-3Pyridyl-1-Butanone (NNK)
 Hongning Zhou and Tom K. Hei

Induction and Mutant-Spectrum Analysis of CD59 Mutations in Human Hamster Hybrid Cells by Crocidolite Asbestos and Hydrogen Peroxide: Implications for Mechanisms of Fiber Mutagenesis
An Xu and Tom K. Hei

Effects of Irradiated Medium on Chromatid Aberrations and Mutagenesis in Mammalian Cells: Studies Using Double-Mylar Dishes
Masao Suzuki, Hongning Zhou, Charles R. Geard, and Tom K. Hei

Mutagenicity of Cadmium in Mammalian Cells
Fei Sung, Stephanie Stern (Intern), and Tom K. Hei

Quantitative Measurement of Superoxides and Hydroxyl Radicals Generated in Arsenite-Treated Cells Using ESR Spectroscopy
Su-Xian Liu, Istvan Lippai, Mohammed Athar , and Tom K. Hei

Extension of Lifespan in Primary Human Bronchial Epithelial Cells by Expressing Telomerase
Chang Q. Piao, Yong L. Zhao, and Tom K. Hei

Markers in Progression of Human Breast Epithelial Cells Transformed by Estrogens and High-LET Radiation
Gloria M. Calaf and Tom K. Hei

Neoplastic Progression of Benzo(a)pyrene-Treated Breast Epithelial Cells
Gloria M. Calaf and Tom K. Hei

Karyotype Analysis in Tumorigenic Human Bronchial Epithelial Cells Transformed by Crysolite Asbestos Using Chemically Induced PCC Technique
Masao Suzuki, Chang Q. Piao, and Tom K. Hei

High-Energy Ions and Genomic Instability
Chang Q. Piao, Tom K. Hei, and Eric J. Hall

Cytogenetic Studies [PDF]

Induction and Recovery of Cytotoxic and Chromatic Damage in Primary Human Bronchial Epithelial Cells Irradiated with 56Fe Ions
Masao Suzuki, Chang-Qing Piao, and Tom K. Hei

Conservation of Chromosome-Specific Telomere Length in Mammalian Cells
Andrei Tchirkov and Elizabeth Chavez, M. Prakash Hanke, and Peter Lansdorp (TFL)

Chromosome Aberrations Induced by a Particles and Soft X-Rays in Human Primary Fibroblasts
M. Prakash Hande, Satin G. Sawant, Brian Ponnaiya, Sonu Dhar, Stephen A. Marino, Adayabalam S. Balajee, Charles R. Geard, and David J. Brenner

Use of Chromosome-Arm-Specific Probes in the Detection of Radiation-Induced Inter-Arm Exchanges
M. Prakash Hande, Sonu Dhar, Adayabalam S. Balajee, Charles R. Geard, and David J. Brenner

Molecular Studies [PDF]

S. pombe rad9 and its Human Homologue Have a BH3-Like Domain and Can Promote Apoptosis in Human
Howard B. Lieberman, Kevin M. Hopkins, and Haiying Hang, in collaboration with Hong-Gang Wang and Kiyoshi Komatsu

Construction and Analyses of Mrad9 Knockout Cells and Mice
Howard B. Lieberman, Kevin M. Hopkins, and Haiying Hang, in collaboration with Wojtek Auerbach and Alexandra L. Joyner

Effect of Human HRAD9 Overexpression on Cell Survival, Growth, and Checkpoint Control
Haiying Hang and Howard B. Lieberman

ATM Gene Proeuct is Not Required for DNA-Damage-Dependent Redistribution of PCNA Complex in Human Cells
Adayabalam S. Balajee, M. Prakash Hande, and Charles R. Geard

A Common Target Gene for p53 and Rb Functions in Apoptosis
Yuxin Yin, Yan Jin, and Eric J. Hall

The Catalytic Subunit of Telomerase is Expressed in Developing Brain Neurons and Serves a Cell-Survival-Promoting Function
Weiming Fu, Michael Killen, and Carten Culmsee, Sonu Dhar, Tej K. Pandita, and Mark P. Mattson

Regulation of the hTERT Telomerase Catalytic Subunit by the c-Abl tyrosine
Kinasem S. Kharbanda and V. Kumar, Sonu Dhar, P. Pandy, C. Chen, P. Majumder, and Z-M. Yuan, Y. Whang, W. Strauss, Tej K. Pandita, and D. Weaver and D. Kufe

Chronic Activation of Damage-Responsive Functions is Reduced by a-Lipoic Acid in Ataxia Telangiectasia Cells
Magtouf Gatei, Dganit Shkedy, Tej K. Pandita, Martin F. Lavin, and Galit Rotman

Meiotic Telomere Distribution and Sertoli-Cell Nuclear Architecture is Altered in Atm- and Atm/p53-Deficient Mice
Harry Scherthan and Martin Jerratsch, Sonu Dhar, Y. Alan Wang, Stephen P. Goff, and Tej K. Pandita

Characterization of Ataxia Telangiectasia Fibroblasts with Extended Lifespan through Telomerase Expression
Lauren D. Wood and Tanya L. Halvorsen , Sonu Dhar, Joseph A. Baur, Raj K. Pandita, Woodring E. Wright, M. Prakash Hande, Gloria M. Calaf, Tom K. Hei, Fred Levine, Jerry W. Shay, Jean J.Y. Wang, and Tej K. Pandita

Adenovirus-Mediated Antisense ATM Gene Transfer Sensitizes Prostate Cancer Cells to Ionizing Radiation
Zuoheng Fan and Prabir Chakravarty, Alan Alfieri, Tej K. Pandita, and Bhadrasain Vikram and Chandan Guha

Regulation of DNA-Dependent Protein Kinase Activity by Ionizing-Radiation-Activated Abl Kinase is an ATM-dependent Process
Sanjeev Shangary, Kevin D. Brown and Aaron W. Adamson, Scott Edmonson, Bobby Ng, Tej K. Pandita, Jack Yalowich, Guillermo E. Taccioli, and R. Baskaran

High Frequency of Hypermethylation at the 14-3-3sLocus to Gene Silencing in Breast Cancer
Anne T. Ferguson, Ella Evron, Christopher Umbricht , Tej K. Pandita, Timothy A. Chan and Heiko Hermeking (JHOC), Jeffrey Marks, Aouk R. Lambers and P. Andrew Futreal , Martha R. Stampfer , and Saraswati Sukumar (JHOC)

Inactivation of 14-3-3s Influences Telomere Behavior and Ionizing-Radiation-Induced Chromosomal Instability
Sonu Dhar, Jeremy A. Squire, M. Prakash Hande, Raymund J. Wellinger, and Tej K. Pandita

Telomerase-Associated Protein TEP1 is Not Essential for Telomerase Activity or Telomere-Length Maintenance In Vivo
Yie Liu and Bryan E. Snow, M. Prakash Hande, Gabriela Baerlocher, Valerie Kickhoefer, David Yeung, Drew Wakeham and Annick Itie, David Siderovski, Peter Lansdorp, Murray O. Robinson, and Lea Harrington

A Few Percent of the Population May Be Genetically Predisposed to Radiation-Induced Cancer
Lubomir B. Smilenov, Eric J. Hall, and David J. Brenner

Differentially Expressed Genes in Asbestos-Induced Tumorigenic Human Bronchial Epithelial Cells
Yong L. Zhao, Chang Q. Piao, and Tom K. Hei

Antisense ATM Gene Therapy: A Strategy to Increase the Radiosensitivity of Human Tumors
C. Guha, U. Guha, and S. Tribius, A. Alfieri, D. Casper and P. Chakravarty (AECOM), W. Mellado, Tej K. Pandita, and B. Vikram (AECOM)

Identification of a Defined Region with Allelic Loss in Chromosome 11 During Radiation
Debasish Roy, Gloria M. Calaf, and Tom K. Hei

Vitamin D Receptor Gene in a High-LET-Radiation- and Estrogen-Treated Breast Cancer Model
Debasish Roy, Gloria M. Calaf, and Tom K. Hei

Studies Related to Radiation Therapy [PDF]

Towards Optimal External-Beam Fractionation for Prostate Cancer
David J. Brenner

Adjuvant Radiotherapy for DCIS Pyrrhic or Low Risk?
David J. Brenner, with Peter B. Schiff and Lydia B. Zablotska

The Radiological Research Accelerator Facility an NIH-Supported Resource Center [PDF]
Dir, David J Brenner, PhD, DSc; Chief Physicist, Randers-Pehrson, PhD; Mnger, Stephen A Marino, MS

The Radiation Safety Office [PDF]


Updated 10/06/2010


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