PET Publications
Milak MS, Parsey RV, Keilp J, Oquendo MA, Malone KM, and Mann JJ. "Neuroanatomic correlates of psychopathologic components of major depressive disorder." Arch. Gen. Psychiatry, in press.
Parsey RV, Bélanger M-J, Sullivan GM, Simpson NR, Stabin MG, Van Heertum R, and Mann JJ. "Biodistribution and radiation dosimetry of [11C]WAY 100635 in human subjects." J. Nuclear Med., in press.
Parsey RV, Arango V, Olvet DM, Oquendo MA, Van Heertum RL, and Mann JJ. "Regional heterogeneity of 5-HT1A receptors in human cerebellum as assessed by positron emission tomography." J. Cereb. Blood Flow Metab., in press.
Feldman F, Van Heertum RL, Manoj C, Lee F, Parisien M. "18FDG PET: Efficacy in Cartilage Lesions." Skeletal Radiology (Accepted for publication).
Oquendo MA, Krunic A, Parsey RV, Milak M, Malone KM., Anderson A, Van Heertum RL, and Mann JJ. "Positron emission tomography of regional brain metabolic responses to a serotonergic challenge in major depressive disorder with and without borderline personality disorder." Neuropsychopharmacology, advance online publication, 16 March 2005 doi:10.1038/sj.npp.1300689.
Stern Y, Habeck C, Moeller J, Scarmeas N, Anderson KE, Hilto HJ, Flynn J, Sackeim H, Van Heertum R. "Brain Networks Associated with cognitive reserve in Healthy Young and Old Adults." Cerebral Cortex 15(4): 394-402, 2005.
Parsey RV, Arango V, Olivet DM, Oquendo MA, Van Heertum RL and Mann JJ. "Regional Heterogeneity of 5-HT1A Receptors in Human Cerebellum as Assessed by Positron Emission Tomography." J Cerebral Blood Flow & Metabolism (epub 2005).
Milak M S.; Ogden T, Vincour DN, Van Heertum RL, Cooper TB, Mann JJ, Parsey RV. "Effects of Tryptophan Depletion on the Binding of [11C] DASB to the Serotonin Transporter in Baboons: a response to an acute serotonin deficiency." Biological Psychiatry 57:102-106, 2005.
Bélanger M-J, Simpson NR, Wang T, VanHeertum RL, Mann JJ, Parsey RV. "Biodistribution and Radiation Dosimetry of [11C]DASB in Non-Human Primates." Nuclear Medicine and Biology. 31:1097-1102, 2004.
Suehiro M, Simpson N and Van Heertum RL. "Radiolabeling of Ginkgolide B with 18F." Journal Labeled Compounds & Radiopharmaceuticals 47:485-491, 2004.
Van Heertum RL, Greenstein EA, and Tikofsky RS. "FDG-Positron Emission Tomography Imaging of the Brain: Current Clinical Applications with Emphasis on the Dementias." Seminars in Nuclear Medicine 34(4):300-12, 2004.
Frankle G, Huang H, Hwang D-R, Talbot P, Slifstein M, Van Heertum RL, Abi-Dargham A, Laruelle M. "Comparative evaluation of serotonin transporter radioligands [11C]DASB and [11C]McN 5652 in healthy human." Journal of Nuclear Medicine 45:682-694, 2004.
Bélanger M-J, Parsey RV, and Mann JJ. "OS-EM and FBP reconstructions at low count rates: Effect on 3D PET studies of [11C-carbonyl] WAY-100635." NeuroImage 21:244-250, 2004.
Kumar JS, Prabhakaran J, Arango V, Parsey RV, Underwood MD, Simpson NR, Kassir SA, Majo VJ, Van Heertum RL, Mann JJ. "Synthesis of [O-methyl-(11)C]1 -(2-chlorophenyl)-5-(4-methoxyphenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide: a potential PET ligand for CB(1) receptors." Bioorganic Medicinal Chemistry Letters 14:23932396, 2004.
Kumar JSD, Majo VJ, Simpson NR, Prabhakaran J., Van Heertum RL, and Mann JJ. "Synthesis of [O-methyl-11C]-4-(1,3-dimethoxy-2-propylamino)-2,7-dimethyl-8- (2,4-dichlorophenyl)[1,5-a]pyrazolo-1,3,5-triazine ([11C]DMP696: A potential PET ligand for CRF1 receptors." J. Labelled Compounds and Radiopharmaceuticals 47:971-976, 2004.
Akinboboye OO, Chou RL, Bergmann SR. „Myocardial blood flow and efficiency in concentric and eccentric left ventricular hypertrophy.” Am J Hypertens 17(5 Pt 1):433-8, 2004
Hickey KT, Sciacca RR, Bokhari S, Rodriguez O, Chou RL, Faber TL, Cooke CD, Garcia EV, Nichols K, Bergmann SR. “Assessment of cardiac wall motion and ejection fraction with gated PET using N-13 ammonia.” Clin Nucl Med 29(4):243-8, 2004
Parsey RV, and Mann JJ. "Applications of positron emission tomography in psychiatry." Seminars in Nuclear Medicine XXXIII:129-135, 2003.
Kumar JSD, Majo VJ, Prabhtakaram J, Simpson NR, Van Heertum RL, Mann JJ. "Synthesis of [N-methyl-11C](-3-[6-dimethylamino)pyridin-3-yl]-2,5-dimethyl- N,N- dipropylpyrazolo(1,5-alpyrimidine-7-amine:A potential PET ligand for in vivo imaging ofCRF1 receptors." Journal of Labelled Componds and Radiopharmaceuticals 46:1055-1065, 2003.
Henry TR and Van Heertum RL. "Positron emission tomography and single photon emission computed tomography in epilepsy care." Seminars in Nuclear Medicine 33:88-104, 2003.
Feldman F and Van Heertum RL. "18F-FDG PET scanning in benign and malignant musculoskeletal lesions." Skeletal Radiology 32:201-208, 2003.
Scarmeas N, Zarahn E, Anderson KE, Habeck CG, Hilton J, Flynn J, Marder KS, Bell Kl, Sackeim HA, Van Heertum RL, Moeller JR, Stern Y. "Association of Life activities with Cerebral Blood Flow in Alzheimer’s disease: Implications for the Cognitive Reserve Hypothesis." Arch Neurol 60:359-365; 2003.
Scarmeas N, Zarahn E, Anderson KE, Hilton J, Flynn J, Van Heertum RL, Sackeim HA, Stern Y. "Cognitive reserve modulates functional brain responses during memory tasks: a PET study in healthy young and elderly subjects." NeuroImage 19:1215-1227, 2003.
Van Heertum RL and Tikofsky RS. "PET and SPECT brain imaging in Dementia." Seminars in Nuclear Medicine 33: 77-86, 2003.
Kegeles LS, Malone KM, Slifstein M, Ellis SP, Xanthopoulos E, Keilp JG, Campbell C, Oquendo M, Van Heertum RL, Mann JJ. "Response of cortical metabolic deficits to serotonergic challenge in familial mood disorders." Am J Psychiatry 160:76-82, 2003.
Oquendo MA, Placidi GPA, Malone KM, Campbell C, Kelip J, Brodsky B, Kegeles LS, Cooper TB, Parsey RV, Van Heertum RL, Mann JJ. "Positron Emission Tomography of regional brain Metabolism response to a serotonergic challenge and lethality of suicide attempts in major depression." Archives of General Psychiatry 60:14-22, 2003.
Akinboboye OO, Reichek N, Bergmann SR, Chou RL. “Correlates of myocardial oxygen demand measured by positron emission tomography in the hypertrophied left ventricle.” Am J Hypertens 16(3):240-3, 2003
Parsey RV, Oquendo MA, Simpson N, Van Heertum R, Arango V, Mann JJ. "Effects of sex, age and aggressive traits in man on serotonin 5-HT1A receptor binding potential using PET and [11C]WAY-100635." Brain Research 954:173182, 2002.
Abi-Dargham A, Mawlawi O, Lombardo I, Gil R, Martinez D, Huang Y, Hwang D-R, Keilp J, Kochan L, Van Heertum R, Gorman, JM, Laruelle M. "Prefrontal D1 receptor and working memory in schizophrenia." Journal of Neuroscience 22:3708-19, 2002.
Pascual, JM, Van Heertum RL, Wang D, Engelstad K, De VivoDC. „Imaging the footprint of GLUT! Deficiency on the brain." Annals of Neurology 52:458-464, 2002.
Kegeles LS, Martinez D, Kochan LD, Hwang DR, Huang Y, Mawlawi O, Suckow RF, Van Heertum RL, Laruelle M. "NMDA antagonist effects on striatal dopamine release: positron emission tomography studies in humans." Synapse 43:19-29, 2002.
Collier TL, Hwang Y, Ramasamy R, Sciacca RR, Hickey KT, Simpson NR, Bergmann SR. “Synthesis and initial evaluation of 17-(11)C-heptadecanoic acid for measurement of myocardial fatty acid metabolism.” J Nucl Med 43(12):1707-14, 2002
Hwang YC, Bakr S, Ramasamy R, Bergmann SR. “Relative importance of enhanced glucose uptake versus attenuation of long-chain acyl carnitines in protecting ischemic myocardium.” Coron Artery Dis. 13(6):313-8, 2002
Parsey RV, Oquendo M, Zea-Ponce Y, Rodenhiser J, Kegeles LS, Pratap M, Van Heertum R, Mann JJ, Laruelle M. "Dopamine D2 receptor availability and amphetamine-induced dopamine release in unipolar depression." Biological Psychiatry 50:313-322, 2001.
Mawlawi O, Martinez D, Slifstein M, Broft A, Chatterjee R, Hwang D-R, Huang Y, Simpson N, Ngo K, Van Heertum R, and Laruelle M. "Imaging Human Mesolimbic Dopamine Transmission with Positron Emission Tomography: I. Accuracy and Precision of D2 Receptor Parameter Measurements in Ventral Striatum." Journal of Cerebral Blood Flow and Metabolism 21:1034-1057, 2001.
Van Heertum RL, Ichise M, Drocea C, Lobotes K, Fawwaz RA. "PET and SPECT Brain Imaging in the Evaluation of Neurologic Disease." Radiologic Clinics of North America 39:1007-1033, 2001.
*Van Heertum RL and Fawwaz RA. "The Role of Nuclear Medicine in the Evaluation of Pancreatic Disease." Surgical Clinics of North America 81:345-358, 2001.
Jaust W, Thisted R, Devous MD Sr, Van Heertum R, Mayberg H, Jobst K, Smith D, Borys N: "SPECT Perfusion Imaging in the Diagnosis of Alzheimer’s Disease: A Clinical-Pathological study" Neurology 56:950-956, 2001.
Martinez D, Huang D-R, Mawlavi O, Slifstein M, Kent J, Simpson N, Parsey RV, Hasbimoto T, Huang Y, Shinn A, Van Heertum R, Abi-Dargham A, Caliabiano S, Malizia A, Cowley H, Mann JJ, Laruelle M. "Differential Occupancy of Somatodendritic and Postsynaptic 5HT1A Receptors by Pindolol: A Dose-Occupancy Study with [11C]WAY 100635 and Positron Emission Tomography in Humans." Neuropsychopharmacology 24:209-229, 2001.
Bergmann SR, Herrero P, Sciacca R, Hartman JJ, Rubin PJ, Hickey KT, Epstein S, Kelly DP. "Characterization of altered myocardial fatty acid metabolism in patients with inherited cardiomyopathy." J Inherit Metab Dis. 24(6):657-74, 2001.
Parsey RV, Kegeles LS, Hwang D-R, Simpson N, Abi-Dargham A, Mawlawi O, Slifstein M, Van Heertum RL, Mann JJ, and Laruelle. "In vivo quantification of brain serotonin transporters in humans using [11C]McN 5652." Journal of Nuclear Medicine 41:1465-1477, 2000.
Stern Y, Moeller JR, Anderson KE, Luber B, Zubin NR, DiMauro AA, Park A, Campbell CE, Marder K, Bell K, Van Heertum R, Sackeim HA. "Different Brain Networks Mediate Task Performance in Normal Aging and AD: Defining Compensation." Neurology 55:1291-1297, 2000.
Malaspina D, Bruder G, Furman V, Gorman JM, Berman A, Van Heertum R. "Schizophrenics Subgroups Differing in Dichotic Listening Laterality also Differ in Neurometabolism and Symptomatology." Journal of Neuropsychiatry and Clinical Neurosciences12:485-492, 2000.
Martinez D, Mawlawi O, Hwang DR, Kent J, Simpson N, Parsey RV, Hashimoto T, Slifstein M, Huang Y, Van Heertum R, Abi-Dargham A, Caltabiano S, Malizia A, Cowley H, Mann JJ, Laruelle M. "Positron emission tomography study of pindolol occupancy of 5-HT(1A) receptors in humans: preliminary analyses." Nuclear Medicine and Biology 27:523-527, 2000.
Nobler MS, Roose SP, Prohovnik, I, Moeller JR, Louie J, Van Heertum RL, Sackeim HA. "Regional Cerebral Blood Flow in Mood Disorders: V. Effect of Antidepressant Medication in Late-Life Depression." American Journal of Geriatric Psychiatry 8:289-296, 2000.
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