Elizabeth M.C. Hillman, Ph.D.

Name, Title
Contact Information
Elizabeth M.C. Hillman, Ph.D.
Assistant Professor of Biomedical Engineering and Radiology

1210 Amsterdam Avenue
351L Engineering Terrace, Mail Code: 8904
New York, NY 10027
Tel: +1 212 854 2788
Email: eh2245@columbia.edu

 
Biography                                 Specialty                             Publications
 

Biography
Elizabeth M.C. Hillman, PhD, is Assistant Professor of Biomedical Engineering and Radiology.  Dr. Hillman received her PhD in medical physics and bioengineering at University College London, London, UK, and did her post-doctoral research in the Martinos Center for Biomedical Imaging at Massachusetts General Hospital in Boston, MA .  Dr. Hillman has received grant support from the National Institute of Neurological Disorders and Stroke (NINDS), National Heart, Blood and Lung Institute (NHLBI), and National Cancer Institute (NCI), as well as the Wallace H. Coulter Foundation and the Human Frontier Science Program (HFSP).  Her research focuses on the development of novel optical imaging tools for in-vivo measurement of tissue function. These techniques include high-resolution, depth resolved spectroscopic imaging of superficial tissues, with extensions to endoscopic, laparoscopic or intrasurgical imaging of internal tissues. She is also developing novel microscopy tools such as in-vivo two-photon microscopy for in-vivo imaging of function at a cellular level. Dr Hillman is pursuing clinical translation of these techniques, and is currently developing a system for dermal imaging (mapping and staging skin cancer margins). She is also actively applying these tools for preclinical research in the areas of neuroscience (imaging exposed brain in-vivo to explore the relationship between blood flow and neuronal activity), cardiac imaging (studying the effects of ischemia on normal electrical propagation) and is also developing advanced methods for small animal molecular imaging (to assist in the development of clinical molecular probes, and for basic disease research).

Specialty

Imaging Research

Publications
  1. Hillman E. M. C and Moore A, "All-optical anatomical co-registration for molecular imaging of small animals using dynamic contrast", Nature Photonics, 1 (9), 526 - 530, (2007).
  2. Hillman E. M. C, "Optical Brain Imaging In-vivo: Techniques and Applications from Animal to Man" [Invited Review], J Biomed Opt, 12 (5): (2007).
  3. Hillman E. M. C, Devor A, Bouchard M. B, Dunn A. K, Krauss G. W, Skoch J, Bacskai B. J, Dale A. M, Boas D. A, “Depth-resolved Optical Imaging and Microscopy of Vascular Compartment Dynamics During Somatosensory Stimulation”, NeuroImage, 35(1): 89-104 (2007).
  4. Devor A, Tian P, Nishimura N, Teng IC, Hillman E. M. C, Narayanan S. N, Ulbert I, Boas D. A, Kleinfeld D, Dale A. M.“Suppressed neuronal activity and concurrent arteriolar vasoconstriction may explain negative BOLD”, J Neurosci, 27(16): 4452-4459. (2007).
  5. Custo A, Wells W. M, Barnett A. H, Hillman E. M. C, Boas D. A. "Effective Scattering Coefficient of the Cerebral Spinal Fluid in Adult Head Models for Diffuse Optical Imaging", Appl Opt. 45(19): 4747-4755 (2006).
  6. Zhang Q, Brukilacchio T. J, Li A, Stott J. J, Chaves T, Hillman E. M. C, Wu T, Chorlton M. A, Rafferty E, Moore R. H, Kopans D. B, Boas D. A., "Co-registered Tomographic X-ray and Optical Breast Imaging: Initial Results." J Biomed Opt, 10(2), 024033-1-9 (2005).
  7. Corlu A, Choe R, Durduran T, Lee K, Schweiger M, Arridge S. R, Hillman E. M. C, Yodh A. G., "Diffuse optical tomography with spectral constraints and wavelength opt imization." Appl Opt, 44(11), 2082-2093 (2005)
  8. Li A, Boverman G, Zhang Y, Brooks D, Miller E. L, Kilmer M. E, Zhang Q, Hillman E. M. C, Boas D. A., "An optimal linear inverse solution given multiple priors in diffuse optical tomography." Appl Opt, 44(10), 1948-1956 (2005)
  9. Hillman, E. M. C, Boas, D. A, Dale, A. M, Dunn, A. K, "Laminar Optical Tomography: demonstration of millimeter-scale depth-resolved imaging in turbid media" Optics Letters, 29, (14), 1650-1652 (2004).
  10. Hillman, E. M. C, "Optical tomography", Book chapter in 'Optics Encyclopedia', Wiley-VCH. (Released December 2003).
  11. Corlu, A, Durduran, T, Choe, R, Schweiger, M, Hillman, E. M. C, Arridge, S. R. Yodh, A. G. "Uniqueness and wavelength optimization in continuous-wave multispectral diffuse optical tomography” Optics Letters, 28, 23, 2339-2341 (2003).
  12. Hebden, J. C, Gonzalez, F. M, Gibson, A, Hillman, E. M. C, Yusof, R, Everdell, N, Delpy, D. T, Zaccanti, G, and Martelli, F, “Assessment of an in situ temporal calibration method for time-resolved optical tomography” Journal of Biomedical Optics 8, 87-92 (2003).
  13. Hebden,J. C, Gibson, A, Yusof, R, Everdell, N, Hillman, E. M. C, Delpy, D. T, Arridge, S. R, Austin, T, Meek, J. H, Wyatt, J. S, "Three-dimensional optical tomography of the premature infant brain” Phys. Med. Biol , 47, 23, 4155-4166 (2002).
  14. Hebden, J. C, Veenstra, H, Dehghani, H, Hillman, E. M. C, Schweiger, M, Arridge, S. R, nd Delpy, D. T. "Three dimensional time-resolved optical tomography of a conical breast phantom" Applied Optics 40 19, 3278-3287 (2001).
  15. Hillman, E. M. C, Hebden, J. C, Schweiger, M, Dehghani, H, Schmidt, F. E. W, Delpy, D. T, Arridge, S. R "Time Resolved Optical Tomography of the Human Forearm"; Phys. Med. Biol, 46, 4, 1117-1130 (2001)
  16. Hillman,E.M.C, Hebden,J.C, Schmidt,F.E.W, Arridge,S.R, Schweiger,M, Dehghani,H, Delpy, D.T. "Calibration techniques and datatype extraction for time-resolved optical tomography" Rev Sci Instrum, 71, 9, 3415-3427 (2000).
  17. Schmidt, F. E. W, Hebden, J. C, Hillman, E. M. C, Fry ,M. E, Schweiger,M, Delpy,D. T. "Multiple slice imaging of a tissue-equivalent phantom using time-resolved optical tomography" Applied Optics 39, 19 3380-3387 (2000).
  18. Arridge, S. R., Hebden, J. C, Schweiger, M, Schmidt, FEW, Fry, M. E. Hillman, E. M. C, Dehghani,H "A method for 3D time-resolved optical tomography”. Imaging. Syst. Technol, 11, 2-11 (2000).
  19. Schmidt, F.E.W, Fry, M.E, Hillman, E.M.C, Hebden, J.C, and Delpy, D.T "A 32-channel time-resolved instrument for medical optical tomography" Rev. Sci. Instrum 71, 1, 256 - 265 (2000).
  20. Hebden, J.C, Schmidt, F.E.W, Fry, M.E, Schweiger, M, Hillman, E.M.C, Delpy, D.T, and Arridge, S. R "Simultaneous reconstruction of absorption and scattering images using multi-channel measurement of purely temporal data" Optics Letters, 24, 8, 534-536. (1999)
  21. Elwell, C.E, Springett, R, Hillman, E.M.C, Delpy,D.T "Oscillations in Cerebral Haemodynamics - Implications for Functional Activation Studies". “Oscillations in Cerebral Haemodynamics - Implications for Functional Activation Studies" Adv. Exp Med & Biol 471, 57-65 (1999).