Andreas H. Hielscher, Ph.D.

Name, Title
Contact Information
Andreas H. Hielscher, Ph.D.
Associate Professor of Biomedical Engineering and Radiology

500 West 120th Street
ET 351 Mudd Bldg. Mail Code: 8904
New York, NY 10027
Tel: +1 212 854 5080
Email: ahh2004@columbia.edu

 
Biography                                 Specialty                             Publications
 

Biography

Andreas H. Hielscher, Ph.D., is the Director of the Biophotonics and Optical Radiology Laboratory at Columbia University. He holds joint appointments as Associate Professor in the Departments of Biomedical Engineering and Radiology.  Dr. Hielscher made pioneering contribution in the field of Biomedical Optics. His work currently focuses on the development of state-of-the-art imaging software and hardware for optical tomography. He applies this emerging technology to imaging of cancer and joint diseases and uses it in support of drug development. He has published over 120 articles in peer-reviewed scientific journals and conference proceedings. Dr. Hielscher’s work has been funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Heart, Lung, and Blood Institute (NHLB), the National Institute for Biomedical Imaging and Bioengineering (NIBIB), the National Cancer Institut, the Whitaker Foundation for Biomedical Engineering, and the New York State Office of Science, Technology and Academic Research.

Dr. Hielscher currently serves as Associate Editor of the IEEE Transactions of Medical Imaging and has reviewed papers for over 30 scientific journals, including the Journal of Biomedical Optics, Optics Letters, IEEE Transactions on Biomedical Engineering, Medical Physics, Physics Review Letters, and Review of Scientific Instrumentation.  He has been active in organizing conferences and meetings that promote the field of Biomedical Optics on more than 20 occasions.  Among others, he was Chair of the Biomedical Optical Spectroscopy Group at the Optical Society of America (OSA) from October 2001 – 2003, and chaired symposia and sessions on optical imaging at the IEEE –EMBS conferences in 1997, 1998, 1999, and 2005. His is currently a member of the SPIE Medical Imaging Conference Program Committee on "Physiology, Function, and Structure from Medical Images,” and the OSA Conference Program Committee for “Advances in Optical Imaging and Photon Migration.” In addition he frequently serves on review panels for the National Institutes of Health (NIH) and National Science Foundation (NSF) as well as several international funding agencies, such as the British Welcome Trust or Dutch Organization for Scientific Research. He is listed in Marquis Who’s is Who in America since 2005.

Specialty

Biomedical Optics

Publications

  1. K. Ren, G. Bal, A.H. Hielscher, “Transport- and diffusion-based optical tomography in small domains: A comparative study,” accepted for publication in Applied Optics.
  2. J.M. Lasker, Christopher J. Fong, Daniel T. Ginat, E. Dwyer, A.H. Hielscher, “Dynamic Optical Imaging of Vascular and Metabolic Reactivity in Rheumatoid Joints,” accepted for publication in the Journal of Biomedical Optics.
  3. A.K. Klose, A.H. Hielscher, “Diffuse Optical Tomography with the Equation of Radiative Transfer,” accepted for publication in the International Journal for Numerical Methods in Heat and Fluid Flow.
  4. J.M. Masciotti, J.L. Lasker, A.H. Hielscher, “Digital Lock-in Detection for Discriminating Multiple Modulation Frequencies with High Accuracy and Computational Efficiency,” accepted for publication in IEEE Transactions on Instrumentation and Measurement.
  5. J.M. Lasker, J. Masciotti, M. Schoenecker, C. Schmitz, A.H. Hielscher, ”Digital-Signal-Processor-Based Dynamic Optical Tomography Imaging System,” Review of Scientific Instruments 78(8) 083706 (2007).
  6. X. Gu, K. Ren, A.H. Hielscher, “Frequency-domain sensitivity analysis for small imaging domains using the equation of radiative transfer,” Applied Optics 46 (10), pp. 1624-1632 (2007).
  7. U.J. Netz, A.H. Hielscher. A.K. Scheel. J. Beuthan, “ Experimental results for propagation of diffuse photon-density waves up to 1 Ghz in a tissue-like medium containing an absorbing edge,” Laser Physics 16, pp. 765-773 (2006).
  8. K. Ren, G. Abdoulaev, G. Bal, A.H. Hielscher, "Frequency-domain optical tomography based on the equation of radiative transfer,” SIAM Journal on Scientific Computing 28(4), pp. 1463-1489 (2006).
  9. G. Abdoulaev, K. Ren, A.H. Hielscher, "Optical tomography as a constrained optimization problem,” Inverse Problems 21, pp. 1507–1530 (2005).
  10. A.H, Hielscher, “Optical tomographic imaging of small animals,” Current Opinion in Biotechnology 16(1), pp. 79-88 (2005).
  11. A.K. Scheel, M. Backhaus, A.D. Klose, B. Moa-Anderson, U. Netz, K. G. Hermann, J. Beuthan, G.A. Müller, G.R. Burmester, A.H. Hielscher, " First clinical evaluation of sagittal laser optical tomography for detection of synovitis in arthritic finger joints," Annals of the Rheumatic Diseases 64, pp. 239-245 (2005).
  12. A.K. Klose, V. Ntziachristos, A.H. Hielscher, "The inverse source problem based on the radiative transfer equation in molecular optical imaging," J. of Computational Physics 202, pp.  323-345 (2005).
  13. A.H. Hielscher, A. Klose, A. Scheel, B. Moa-Anderson, M. Backhaus, U. Netz, J. Beuthan, "Sagittal Laser Optical Tomography for Imaging of Rheumatoid Finger Joints," Physics in Medicine and Biology 49(7), pp. 1147 - 1163 (2004).
  14. A.Y. Bluestone, M. Stewart, B. Lei, I.S. Kass, J. Lasker, G.S. Abdoulaev, A.H. Hielscher, "Three-dimensional optical tomographic brain imaging in small animals, Part I: Hypercapnia," Journal of Biomedical Optics 9(5), pp. 1046-1062 (2004).
  15. A.Y. Bluestone, M. Stewart, J. Lasker, G.S. Abdoulaev, A.H. Hielscher, "Three-dimensional optical tomographic brain imaging in small animals, Part II: Unilateral Carotid Occlusion," Journal of Biomedical Optics 9(5), pp. 1063-1073 (2004).
  16. K. Ren, G. Abdoulaev, G. Bal, A.H. Hielscher, "Algorithm for solving the equation of radiative transfer in the frequency domain," Optics Letters 29(6), pp. 578-580 (2004).
  17. A.H. Hielscher and S. Bartel, "Parallelization of gradient-based iterative image reconstruction algorithms for optical tomography," Computer Methods and Programs in Biomedicine 73(2), pp 101-113 (2004).
  18. A.K. Scheel, U.J. Netz, K.-G.A. Hermann, A.H. Hielscher, A.D. Klose, V. Tresp, A. Schwaighofer, G.A. Müller, G.-R. Burmester, M. Backhaus, "Laser imaging techniques for follow-up analysis of joint inflammation in patients with rheumatoid arthritis," Medical Laser Applications 18, pp. 198-205 (2003). (invited)
  19. G. Abdoulaev and A.H. Hielscher, "Three-dimensional optical tomography with the equation of radiative transfer," Journal of Electronic Imaging 12(4), pp. 594-60 (2003).
  20. A.K. Klose, A.H. Hielscher, "Fluorescence tomography with the equation of radiative transfer for molecular imaging," Optics Letters 28(12), pp. 1019-1021 (2003).
  21. A.K. Klose, A.H. Hielscher, " Quasi-Newton methods in optical tomographic imaging," Inverse Problems 19, pp. 387-409 (2003).
  22. A.H. Hielscher, A.Y. Bluestone, G.S.Abdoulaev, A.D. Klose, J.  Lasker, M. Stewart, U. Netz, J. Beuthan, "Near-infrared diffuse optical tomography," Disease Markers 18(5-6), pp. 313-337 (2002).
  23. J. Beuthan, U. Netz, O. Minet, A.D. Klose, A.H. Hielscher, A. Scheel, J. Henniger, G. Müller, "Light scattering study of rheumatoid arthritis," Quantum Electronics 32(11), pp. 945-952 (2002).
  24. C.H. Schmitz, M. Löcker, J.M. Lasker, A.H. Hielscher, R.L. Barbour, "Instrumentation for fast functional optical tomography," Rev. of Scientific Instruments 73(2), pp. 429-439 (2002).
  25. A.D. Klose, U. Netz, J. Beuthan, A.H. Hielscher, "Optical tomography using the time-independent equation of radiative transfer. Part 1: Forward model," Journal of Quantitative Spectroscopy and Radiative Transfer, Vol 72/5, pp 691-713 (2002).
  26. A.D. Klose, A.H. Hielscher, "Optical tomography using the time-independent equation of radiative transfer. Part 2: Inverse model," Journal of Quantitative Spectroscopy and Radiative Transfer, Vol 72/5, pp 715-732 (2002).
  27. J. Beuthan, H.J. Cappius, A.H. Hielscher, M. Hopf, A.D. Klose, U. Netz, " Initial investigations of the applications of linear signal transfer theory to tissue optics, Biomedizinische Technik 46(11), pp. 298-303 (2001).
  28. U. Netz, J. Beuthan, H.J. Capius, H.C. Koch, A.D. Klose, A.H. Hielscher, "Imaging of rheumatoid arthritis in finger joints by sagittal optical tomography, Medical Laser Application 16, pp. 306-310 (2001).
  29. A.Y. Bluestone, G. Abdoulaev, C. Schmitz, R.L. Barbour, A.H. Hielscher, "Three-dimensional optical-tomography of hemodynamics in the human head", Optics Express 9(6), pp. 272-286 (2001).
  30. V. Ntziachristos, A.H. Hielscher, A.G. Yodh, B. Chance, "Diffuse optical tomography of highly heterogeneous media," IEEE Transactions on Medical Imaging 20(6), pp. 470-478 (2001).
  31. A.H. Hielscher and S. Bartel, "Use of penalty terms in gradient-based iterative reconstruction schemes for optical tomography," Journal of Biomedical Optics 6(2), pp. 183-192 (2001).
  32. A.H. Hielscher, A.D. Klose, J. Beuthan, "Evolution strategies for optical tomographic characterization of homogeneous media," Optics Express 7(13), pp. 507-518, 2000. (INVITED) (http://www.opticsexpress.org/abstract.cfm?URI=OPEX-7-13-507)
  33. N. Ramanujam, G. Vishnoi, A.H. Hielscher, M. Rode, I. Forouzan, and B. Chance, "Photon migration through the fetal head in utero using continuous wave, near infrared spectroscopy: Clinical and experimental model studies," Journal of Biomedical Optics 5, pp. 173-184 (2000).
  34. G. Vishnoi, A.H. Hielscher, N. Ramanujam, and B.Chance, "Photon migration through fetal head in utero using continuous wave, near infrared spectroscopy: Development and evaluation of experimental and numerical models," Journal of Biomedical Optics 5, pp. 163-172 (2000).
  35. S. Bartel and A.H. Hielscher, "Monte Carlo simulations of the diffuse backscattering Mueller matrix for highly scattering media," Applied Optics 39, pp. 1580 - 1588 (2000).
  36. A.D. Klose and A.H. Hielscher, "Iterative reconstruction scheme for optical tomography based on the equation of radiative transfer," Medical Physics, vol. 26, no. 8, pp. 1698-1707 (1999).
  37. A.H. Hielscher, A.D. Klose, K.M. Hanson, "Gradient-based iterative image reconstruction scheme for time-resolved optical tomography," IEEE Transactions on Medical Imaging 18, pp. 262-271 (1999).
  38. J.R. Mourant, A.H. Hielscher, A.A. Eick, D. Shen,  T.M. Johnson, J.P. Freyer, "Evidence for intrinsic differences in light-scattering properties of tumorigenic and nontumorigenic cells," Cancer 84, pp. 366-374 (1998).
  39. A.H. Hielscher, R.E. Alcouffe, R.L. Barbour, "Comparison of finite-difference transport and diffusion calculations for photon migration in homogeneous and heterogeneous tissues," Physics in Medicine and Biology 43, pp. 1285-1302 (1998).
  40. J.R. Mourant, A.H. Hielscher, J.P. Freyer, A.A. Eick, T.M. Johnson, "Mechanisms of light scattering from biological cells relevant to noninvasive optical tissue diagnostic," Applied Optics 37, pp. 3586 - 3593 (1998).
  41. A.H. Hielscher, A.A. Eick, J.R. Mourant, D. Shen, J.P. Freyer, I.J. Bigio, "Diffuse backscattering Mueller matrices for highly scattering media,"Optics Express 1, pp. 441-454 (1997). (http://www.opticsexpress.org/abstract.cfm?URI=OPEX-1-13-441)
  42. A.H. Hielscher, J.R. Mourant, I.J. Bigio, "Influence of particle size and concentration on the diffuse backscattering of polarized light from tissue phantoms and biological cell suspensions," Applied Optics 36, pp. 125-135 (1997).
  43. J.R. Mourant, James Boyer, A.H. Hielscher, I.J. Bigio, "Influence of the scattering phase function on light transport measurements in turbid media performed with small source-detector separations," Optics Letters 21, pp. 546-548 (1996).
  44. A.H. Hielscher, H. Liu, B. Chance, F.K. Tittel, S.L. Jacques, "Time-resolved photon emission from layered turbid media," Applied Optics 35, pp. 719-728 (1996).
  45. A.H. Hielscher, L.Wang , F.K. Tittel, S.L. Jacques, "Influence of boundary conditions on the accuracy of diffusion theory in time-resolved reflectance spectroscopy of biological tissues," Physics in Medicine and Biology 40, pp. 1957-1975 (1995).
  46. H. Liu, A.H. Hielscher, S.L. Jacques, F.K. Tittel, B. Chance, "Influence of blood vessels on the measurement of hemoglobin oxygenation as determined by time-resolved reflectance spectroscopy," Medical Physics 22, pp. 1209-1217 (1995).
  47. A. H. Hielscher, C.E. Miller, D.C. Bayard, K.P. Smolka, R.F. Curl, F.K. Tittel, "Optimization of a mid-infrared high resolution difference frequency laser spectrometer," J. Optical Society of America B 9, pp. 1962-1967 (1992).
  48. P. Canarelli, Z. Benko, A.H. Hielscher, R.F. Curl, F.K. Tittel, "Measurement of nonlinear coefficient and phase matching characteristics of AgGaS2," IEEE Quantum Electronics 28, pp. 52-55 (1992).