Division of Pulmonary, Allergy and Critical Care Medicine

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Charles A. Powell, M.D.

Florence Irving Assistant Professor of Clinical Medicine, Division of Pulmonary, Allergy and Critical Care Medicine

Director, Pulmonary & Critical Care Fellowship

	Laboratory Address Columbia University, College of Physicians & Surgeons 630 W. 168th Street, P&S 8-503, New York, NY, 10032 Phone 212-305-3584, Lab: 212-305-0422 Fax 212-305-0089 Email cap6@columbia.edu
Our laboratory is focused on translational lung cancer research and functional genomics. Lung cancer is the leading cause of cancer death in both men and women in the United States. Despite advances in imaging, surgical techniques, and anti-neoplastic pharmacology, the five year survival rate of lung cancer has remained relatively fixed at 13-15% during the past 30 years. Recent research has identified novel therapeutic targets and specific molecular features of tumors that promise to enhance the individualization of cancer therapy and to improve lung cancer survival. Our laboratory investigations are directed to understanding the molecular events that are important in the early stages of lung cancer development and progression as well as to understanding genetic and environmental susceptibility factors.
Selected Publications Powell CA, Klares S, O’Connor G, Brody JS. Loss of Heterozygosity in Epithelial Cells Obtained by Bronchial Brushings: Clinical Utility in Lung Cancer. Clinical Cancer Research 1999; 5:2025-34. Li C, Guo M, Borczuk A, Powell CA, Wei M, Thaker HM, Friedman R, Klein U, and Tycko B. Gene Expression in Wilms Tumors Mimics the Earliest Committed Stage in the Metanephric Mesenchymal-Epithelial Transition. American Journal of Pathology 2002; 160:2181-90. Powell CA, Caracta C, Bueno R, Richards WG, Sugarbaker DJ, Brody JS Distinct Patterns of Allelic Loss in Lung Adenocarcinoma of Non-Smokers. Lung Cancer 2003; 39: 23-29 Powell CA, Spira A, Derte A, DeLisi C, Sugarbaker DJ, Bueno R, Richards W, Brody JS. Gene expression in lung adenocarcinomas of smokers and nonsmokers. American Journal of Respiratory Cell and Molecular Biology 2003; 29: 157-62. Kim H, Xu G, Borczuk A, Busch S, Filmus J, Capurro M, Brody JS, Lange J, D’Armiento JM, Rothman PB, Powell CA. The heparan sulfate proteoglycan GPC3 is a potential lung tumor suppressor. American Journal of Respiratory Cell and Molecular Biology 2003; 29: 694-701. Borczuk AC, Gorenstein L, Walter KL, Assaad AA, Wang L, Powell CA. Non-small cell lung cancer molecular signatures recapitulate lung developmental pathways. American Journal of Pathology 2003, 163: 1949-1960. Supplemental Data (external site) Borczuk AC, Shah L, Pearson GD, Walter KL, Wang L, Austin JH, Friedman RA, Powell CA. Molecular signatures in biopsy specimens of lung cancer. American Journal of Respiratory and Critical Care Medicine 2004, 170: 167-174. Supplemental Data and Files. Shah L, Walter KL, Borczuk AC, Kawut SM,Sonett JR, Gorenstein LA, Ginsburg ME, Steinglass KM, Powell CA. Expression of Syndecan-1 and Epidermal growth factor receptor is associated with survival in non-small cell lung cancer. Cancer 2004; 101: 1632-1638. Borczuk AC, Taub RN, Hesdorffer M, Hibshoosh H, Chabot JA, Keohan ML, Alsberry R, Alexis D, Powell CA. P16 loss and mitotic activity predict poor survival in patients with peritoneal malignant mesothelioma. Clinical Cancer Research 2005; 11:3303-8. Borczuk AC, Kim HK, Yegen HA, Friedman RA, Powell CA. Lung adenocarcinoma global profiling identifies Type II TGF-ß receptor as a repressor of invasiveness. American Journal of Respiratory and Critical Care Medicine 2005; 172: 729 – 737. Shao G, Berenguer J, Borczuk AC, Powell CA, Hei TK, Zhao Y. Epigenetic inactivation of Betaig-h3 in human cancer cells. Cancer Research 2006; 66:4566-4573. Borczuk AC, Cappellini GCA, Kim HK, Hesdorffer M, Taub RN, Powell CA. Molecular Profiling of Malignant Peritoneal Mesothelioma Identifies the Ubiquitin- Proteasome Pathway as a Therapeutic Target in Poor Prognosis Tumors, Oncogene 2007; 26:610-617. Borczuk AC, Powell CA. Expression Profiling and Lung Cancer Development. Proceedings of the American Thoracic Society 2007; 4:127-132. Bruce B, Khanna G, Ren L, Landberg G, Jurstrom K, Powell C, Borczuk A, Keller ET, Wojno KJ, Meltzer P, Baird K, McClatchey A, Bretscher A, Hewitt SM. Expression of the Cytoskeleton Linker Protein Ezrin in Human Cancers. Clinical Experimental Metastasis 2007; 24: 69-78. Vachani A, Nebozhyn M, Singhal S, Alila L, Wakeam E, Muschel R, Powell CA, Gaffney P, Singh B, Brose MS, Litzky LA, Kucharczuk J, Kaiser LR, Marron JS, Showe MK, Albelda SM, Showe LC. A 10-gene classifier for distinguishing head and neck squamous cell carcinoma and lung squamous cell carcinoma. Clinical Cancer Research 2007; 10: 2905 – 2915. Dubey S, Powell CA. Update in Lung Cancer 2006. American Journal of Respiratory and Critical Care Medicine 2007; 175: 868-874. Borczuk AC, Papankikolaou N, Toonkel RL, Sole M, Gorenstein LA, Ginsburg ME, Sonett JS, Friedman RA, Powell CA. Lung Adenocarcinoma Invasion in TGFβRII Deficient Cells is Mediated by CCL5/RANTES. Oncogene 2007:In Press. Present and Past Support American Thoracic Society / Lungevity Foundation National Institutes of Health/NCI American Cancer Society Joan’s Legacy NYCO Inc. Memorial Lung Cancer Research Fund Herbert and Florence Irving Clinical Scholar Award

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