Division of Pulmonary, Allergy and Critical Care Medicine

Division of Pulmonary, Allergy and Critical Care Medicine

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Rachel L. Miller, M.D., FAAAAI

Associate Professor of Medicine and Environmental Health Sciences at the New York Presbyterian Hospital/Columbia University Medical Center, Division of Pulmonary, Allergy and Critical Care Medicine

Director, Allergy and Immunology Fellowship Program

Director, Asthma Project, CCCEH; Associate Director and Lead Physician Scientist, Disease Investigation through Specialized Clinically-Oriented Ventures in Environment Research

Director, Allergy, New York Presbyterian Hospital

Laboratory/Academic Address

Columbia University, College of Physicians & Surgeons

630 W. 168th Street, P&S 10-502

New York, NY, 10032

601 w. 168^th st, apt 56

NY, NY, 10032

Phone 212-305-7759

Fax 212-342-0072

rlm14@columbia.edu

Mailing Address

Columbia University, College of Physicians & Surgeons

622 W. 168th Street, PH 8 Center,

New York, NY, 10032

Our work concentrates on the mechanisms for the onset of asthma. One large research focus involves establishing and studying a birth cohort from Northern Manhattan (CCCEH.org), determining the importance of environmental allergens, traffic-related pollutants, and phthalate exposure to the onset of allergies, asthma, and Th2 immune responses. A major emphasis is on the role of prenatal and early postnatal exposure on later pediatric and adolescent asthma risk. Additional areas of research include identifying novel genetic by environment interactions and epigenetic by environment interactions important to the onset of asthma. We also have established several mouse models examining the importance of prenatal and postnatal environmental exposures on asthma risk. Recent work on antigen-specific immune responses to influenza vaccine in utero was cited by the journals Nature and Science on their websites.

Publications

Miller, R. L. and M.J. Baum. Naloxone inhibits mating and conditioned place preference for an estrous female in male rats soon after castration. Pharmacology Biochemistry and Behavior 26:781-189, 1987.

Miller, R. L. and R. P. Cole. Association between reduced cuff leak volume and postextubation stridor, Chest 110:1035-40, 1996.

Miller, R. L., S. Das, T. Anandarangam, D. W. Leibowitz, B. Thomashow, P.O. Alderson, S. Homma. Relation between patent foramen ovale and perfusion abnormalities in acute pulmonary embolism, The American Journal of Cardiology, 70:377-388, 1997.

Miller, R. L., S. Das, T. Anandarangam, D. W. Leibowitz, B. Thomashow, P.O. Alderson, S. Homma. Association between right ventricular function and perfusion abnormalities in hemodynamically stable patients with acute pulmonary embolism, Chest, 113:665-70, 1998.

Miller, R. L., T. M. Eppinger, D. McConnell, C. Cunningham-Rundles, P. B. Rothman. Analysis of cytokine signaling in patients with extrinsic asthma and hyperimmunoglobulin E. Journal of Allergy and Clinical Immunology, 102:503-11, 1998.

Neugut, A.I., A. Ghatak, R. Miller. Anaphylaxis in the United States: An investigation into its epidemiology. Archives of Internal Medicine, 161:15-21, 2001.

Miller, R.L., G. Chew, C.A. Bell, S.A. Biedermann, M. Aggarwal, P.L. Kinney, W.Y. Tsai, R.M. Whyatt, F. P. Perera, J.G. Ford. Prenatal antigen exposure, maternal sensitization, and sensitization in utero to indoor allergens in an inner-city cohort, American Journal of Respiratory and Critical Care Medicine, 164:995-1001, 2001.

Perera, F.P., S.M. Illman, P.L. Kinney, R. M. Whyatt, E. A. Kelvin, P. Shepard, D. Evans, M. Fullilove, J. G. Ford, R.L. Miller, I. Meyer, V. Rauh. The challenge of preventing environmentally-related disease in young children: Community-based research in New York City, Environmental Health Perspectives, 110(2):197-204, 2002.

Chew, G.L., M.S. Perzanowski, R.L. Miller, J.C. Correa, L. A. Hoepner, F.P. Perera, P. L. Kinney. Distribution and determinants of mouse allergen exposure in low-income New York City apartments, Environmental Health Perspectives, 111 (10):1348-1351, 2003.

Miller, R.L., Cheng, M., DiMango, E.A., Geromanos, K., Rothman P.B. T cell priming and hypersensitivity to influenza and egg antigens among asthmatic adults immunized with the influenza vaccine, Journal of Allergy and Clinical Immunology, 112:606-08, 2003.

Miller, R.L., J.C. Correa, P.L. Kinney. Rat sensitization among inner-city asthmatic children, Journal of Children’s Health, 1 (4), 489-98, 2003.

Miller, R.L., R. Garfinkel, M. Horton, D. Camann, F. P. Perera, R. Whyatt, P.L. Kinney. Prenatal exposure to polycyclic aromatic hydrocarbons, postnatal environmental tobacco smoke, and pulmonary symptoms in a birth cohort, Chest, 126: 1071-78, 2004.

Goldstein, I.F., Matthew S. Perzanowski, Cynthia Lendor, Robin S. Garfinkel, Lori A. Hoepner, Frederica P. Perera, Rachel L. Miller. Prevalence of allergy symptoms and total IgE in a New York City cohort and their association with birth order, International Archives of Allergy and Immunology, 137 (3), 249-257, 2005.

Eggleston, P.A, G. Diette, M. Lipsett, T. Lewis, I. Tager, R. McConnell, E. Chrischilles, B. Lanphear, R. Miller, and J. Krishnan. Lessons learned for the study of childhood asthma from the Centers for Children’s Environmental Health and Disease Prevention Research, Environmental Health Perspectives, 113 (10): 1430-1436, 2005.

Perzanowski MS, RL Miller, PS Thorne, RG Barr, A Divjan, BJ Sheares, RS Garfinkel, IF Goldstein, FP Perera, GL Chew. Endotoxin inner-city homes and the association with atopy and wheeze in the first two years of life. J Allergy Clin Immunology, 117:1082-9, 2006.

Rastogi, D. Chaodong Wang, Cynthia Lendor, Paul B. Rothman, Rachel L. Miller. T helper 2 polarization among asthmatics during and following pregnancy and its effect on newborns, Clinical and Experimental Allergy, 36:892-898, 2006.

Chung, E.K., Rachel L. Miller, Michael T. Wilson, Stephen J. McGeady, Jennifer F. Culhane. Antenatal risk factors, cytokines and he development of atopic disease in early childhood, Archives of Disease in Childhood, 92: 68-73, 2007

Rafael Narvaez,Kathleen Moors, Mayra Ramirez, Rachel L. Miller Risks in using non-rigorous Spanish translations of asthma questionnaires. Chest, 131(4): 1271-2, 2007, letter.

Rastogi,D., Chaodong Wang, Xia Mao, Cynthia Lendor,Paul B. Rothman, Rachel L. Miller. Antigen-specific immune responses to influenza vaccine in utero, Journal of Clinical Investigation, 117 (6):1637-46, 2007.

Liu, Jinming, Manisha Ballaney, Umaima Al-alem, Chunli Quan, Ximei Jin, Frederica Perera, Lung-Chi Chen, Rachel L. Miller. Combined inhaled diesel exhaust particles and allergen exposure alter methylation of T helper genes and IgE production in vivo, Toxicological Sciences, 2008, 102 (1), 76-81, 2008.

Perzanowski, M.S., GL Chew, A Divjan, K Panjwani, A Johnson, BJ Sheares, IF Goldstein, TA Platts-Mills, FP Perera, RL Miller. Cat ownership is a risk factor for developing anti-cat IgE but not current wheeze at age 5 in a low income urban NYC cohort, Journal of Allergy and Clinical Immunology, 121:1047-52, 2008.

Lendor, Cynthia, Alina Johnson, Matthew Perzanowski, Ginger L. Chew, Inge F. Goldstein, Elizabeth Kelvin, Frederica Perera, Rachel L. Miller. Effects of winter birth season and prenatal indoor allergen exposure on indoor allergen- specific cord blood cell proliferation and cytokine production, Annals of Allergy, Asthma and Immunology, 2008, in press, 101(2):193-9, 2008

Perzanowski, M.S, Maria Jose Rosa, Adnan Divjan, Alina Johnson, Judith S. Jacobson, Rachel L. Miller. Modifications improve an offline exhaled NO collection device for use with young children, Journal of Allergy and Clinical Immunology, 122:213, 2008, letter.

Miller, R. L., Ho, S.-m. Epigenetic studies should focus on specific cell types. Am J Respir Crit Care Med. 178:883-883, 2008, letter.

Narvaez, Rafael F., Lori Hoepner, Steven N. Chillrud, Beizhan Yan, Robin Garfinkel, Robin Whyatt, David Camann^,Frederica P. Perera, Patrick L. Kinney, Rachel L. Miller. Spatial and temporal trends of polycyclic aromatic hydrocarbons and other traffic-related airborne pollutants in New York City, Environmental Science and Technology, 42:7330-35, 2008.

Donohue, Kathleen M., Umaima Al-alem, Matthew S. Perzanowski, Ginger L. Chew, Alina Johnson, Adnan Divjan, Elizabeth A. Kelvin, Lori A. Hoepner, Frederica P. Perera, Rachel L. Miller, Anti-cockroach, mouse IgE is associated with early wheeze and atopy in an inner-city birth cohort, Journal of Allergy and Clinical Immunology, in press, 2008.

Original, peer reviewed:

Miller, R. L. and R. P. Cole. Association between reduced cuff leak volume and postextubation stridor, Chest 110:1035-40, 1996.

Neugut, A.I., A. Ghatak, R. Miller. Anaphylaxis in the United States: An investigation into its epidemiology. Archives of Internal Medicine, 161:15-21, 2001.

Miller, R.L., J.C. Correa, P.L. Kinney. Rat sensitization among inner-city asthmatic children, Journal of Children’s Health, 1 (4), 489-98, 2003.

Goldstein, I.F., Matthew S. Perzanowski, Cynthia Lendor, Robin S. Garfinkel, Lori A. Hoepner, Frederica P. Perera, Rachel L. Miller. IgE, allergy symptoms and their association with birth order in a New York City cohort, International Archives of Allergy and Immunology, 137 (3), 249-257, 2005

Rastogi, D. Chaodong Wang, Cynthia Lendor, Paul B. Rothman, Rachel L. Miller.T helper 2 polarization among asthmatics during and following pregnancy and its effect on newborns, Clinical and Experimental Allergy, 36:892-898, 2006.

Chung, E.K., R. L. Miller, M. T. Wilson, S. J. McGeady, J. F. Culhane. Antenatal risk factors, cytokines and the development of atopic disease in early childhood, Arch. Dis. in Child. Fetal Neontal Ed. 92: 68-73, 2007.

Rafael Narvaez,Kathleen Moors, Mayra Ramirez, Rachel L. Miller Risks in using non-rigorous Spanish translations of asthma questionnaires. Chest, 131(4): 1271-2, 2007, letter.

Rastogi,D., Chaodong Wang, Xia Mao, Cynthia Lendor,Paul B. Rothman, Rachel L. Miller. Antigen-specific immune responses to influenza vaccine in utero, Journal of Clinical Investigation, 117 (6):1637-46, 2007.

Perzanowski, M.S, Maria Jose Rosa, Adnan Divjan, Alina Johnson, Judith S. Jacobson, Rachel L. Miller. Modifications improve an offline exhaled NO collection device for use with young children, Journal of Allergy and Clinical Immunology, 122:213, 2008, letter.

Lendor, Cynthia, Alina Johnson, Matthew Perzanowski, Ginger L. Chew, Inge F. Goldstein, Elizabeth Kelvin, Frederica Perera, Rachel L. Miller^. Effects of winter birth season and prenatal indoor allergen exposure on indoor allergen- specific cord blood cell proliferation and cytokine production, Annals of Allergy, Asthma and Immunology, 101(2):193-9, 2008.

Miller, R. L., Ho, S.-m. Epigenetic studies should focus on specific cell types. Am J Respir Crit Care Med. 178:883-883, 2008, letter.

Chapters, invited editorials:

Miller, R. L. and P. B. Rothman. Molecular mechanisms controlling IgE responses In:T.F. Kresina, ed., Immune modulating agents, Marcel Dekker Inc, Chapt. 2, 21-33, 1998.

Miller, R. L. Breathing freely: The need for asthma research on gene-environment interactions. American Journal of Public Health, 89:819-822, 1999.

Children’s Environmental Health Research – Highlights from the Columbia Center for Children’s Environmental Health. Frederica Perera, Sheila Viswanathan, Robin Whyatt, Deliang Tang, Rachel L. Miller, Virginia Rauh, Ann. New York Academy of Sciences, 1076:15-28, 2006.

Epidemiology of Anaphylaxis: Findings of the ACAAI Epidemiology of Anaphylaxis Working Group (Phil Lieberman, MD; Carlos Camargo, Jr., MD; Kari Bohlke, ScD; Hershel Jick, MD; Rachel L. Miller, MD; Aziz Sheikh, MD; Estelle Simons, MD). Annals of Allergy, Asthma & Immunology, 97: 596-602, 2006.

Rachel L. Miller, Manisha Daswani, and Cynthia Lendor. Prenatal exposure to air pollution and respiratory outcomes in children. In: Passive Smoking and Health Research, Editor: N.A. Jeorgenson, Nova Science Publishers, Inc., Chapt 12, 283-296, 2007.

Miller, Rachel L and Shuk-mei Ho Environmental epigenetics and asthma: Current concepts and call for studies, American Journal of Respiratory and Critical Care Medicine, 177:567-573, 2008.

Donohue, Kathleen, Alissa Hersh, Rachel Miller. Continuing Medical Education examination. Asthma and obesity: Common early-life influences. Journal of Allergy and Clinical Immunology121(5): 1085-86, 2008.

Miller, Rachel L. Prenatal maternal diet and asthma risk. The Journal of Clinical Investigation, 118(10):3265-3268, 2008.

Rachel L. Miller and Julie Herbstman. Epigenetic mechanisms in asthma, In: Epigenetics Nutrition and Environmental Health. Wiley Publishers, 2008, in press.