Division of Pulmonary, Allergy
and Critical Care Medicine
Research Laboratories
Associate Professor of Medicine (in
Pharmacology), Division of Pulmonary, Allergy and Critical Care Medicine
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Laboratory Address 650 Phone 212-305-1586 Fax
212-305-1146 |
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Dr. Greenberg's laboratory is investigating the
molecular mechanisms of inflammation in macrophages. A major focus is to
understand Fcg receptor-mediated phagocytosis. The study of this process affords the
unique opportunity of investigating basic mechanisms of both transmembrane signaling and cell motility. In addition,
since phagocytosis is an essential arm in both humoral and cell-mediated immunity, and is impaired in a
variety of chronic diseases, such as AIDS, diabetes, uremia, cirrhosis, and
SLE, it's study should lead to novel therapeutic
interventions. Dr. Greenberg's laboratory has found that Fc receptor-mediated phagocytosis
requires the participation of several tyrosine kinases,
the foremost of which is Syk (p72syk). Using
several model systems of phagocytosis, including transfection of phagocytic
constructs in This laboratory is also addressing the signal
transduction events that underlie sepsis. These studies include exploring the
mechanisms that govern lipopolysaccharide
(LPS)-mediated inflammation in macrophages. They are exploiting in vitro
systems to understand how gram-negative bacteria, such as Pseudomonas aeruginosa and interact with host cells to trigger an
inflammatory response. A third project that is ongoing is the
investigation of pulmonary fibrosis. Using microarray
technology and gene targeting, our laboratory has identified key
intermediates in the pathways leading to pulmonary fibrosis. We are
exploiting this information and are currently testing potential drug targets
in animal models. |
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