Division of Pulmonary, Allergy and Critical Care Medicine

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Address:

Columbia University, College of Physicians & Surgeons

161 Fort Washington Avenue
Herbert Irving Pavilion-323
New York, New York 10032

Phone: 212-305-1544

pfsl@columbia.edu

Paul Simonelli, MD, Ph.D., FCCP

Assistant Professor of Clinical Medicine, Division of Pulmonary, Allergy and Critical Care Medicine

Clinical and Research Interests

Dr. Simonelli’s principal interest is the diagnosis and treatment of interstitial lung disease, including pulmonary fibrosis. He is involved in the management of patients with this type of lung disease clinically, and in trials of new potential therapeutic agents for interstitial lung disease. His other areas of interest include the management of advanced lung disease such as emphysema and other forms of COPD, pulmonary hypertension, and pulmonary complications in the immunocompromised host: transplant and AIDS.

Education and Training

Boston University, Boston Mass. 1970-1974 AB, Chemistry
Fairleigh Dickinson University, N.J. 1976-1977 MS, Biology
The City University of New York 1979-1985 PhD, Biochemistry
The Mount Sinai School of Medicine, N.Y. 1983-1987 MD
Intern, Internal Medicine 1987-1988 The Presbyterian Hospital, NY
Resident, Internal Medicine 1988-1990 The Presbyterian Hospital, NY
Fellow, Pulmonary Medicine 1990-1992 The Presbyterian Hospital, NY
Postdoctoral Research Fellowship 1992-1994 Columbia University

Honors

Magna Cum Laude 1974 Boston University
Distinction in Biological Research 1974 Boston University
Morris Bender Award in Neurosciences 1985 The Mount Sinai Sch. Medicine
Medical Attendings Award in Medicine 1987 The Mount Sinai Sch. Medicine
Alpha Omega Alpha Honor Society 1987 The Mount Sinai Sch. Medicine
Housestaff Award for Clinical Teaching 1991 The Presbyterian Hospital
J. Burns Amberson Fellow of the
NY Lung Association 1991 Columbia University
Parker B. Francis Fellow In Pulmonary Research 1993 Columbia University
Fellow, American College of Chest Physicians 1994
Matheson Foundation Award 1995 Columbia University
Stony Wold-Herbert Fund Grant-in-aid of Research 1996 Columbia University

Publications

1. National Emphysema Treatment Trial Research Group (2001) Patients At High Risk of Death After Lung-Volume-Reduction Surgery. New Eng. J. Med. 345:1075-1083.

2. National Emphysema Treatment Trial Research Group. Rationale and design of the National Emphysema Treatment Trial (NETT): A prospective randomized trial of lung volume reduction. J Thorac Cardiovasc Surg 1999; 118: 518-528.

3. National Emphysema Treatment Trial Research Group. Rationale and design of the National Emphysema Treatment Trial (NETT): A prospective randomized trial of lung volume reduction. Chest 1999; 116: 1750-1761.

4. National Emphysema Treatment Trial Research Group. Rationale and design of the National Emphysema Treatment Trial (NETT): A prospective randomized trial of lung volume reduction. J Cardiopulm Rehabil 2000; 20:24-36.

5. Ramsey S, Sullivan S, Kaplan R, Wood D, Chiang Y, Wagber J, for the NETT Research Group. Economic analysis of lung volume reduction surgery as part of the National Emphysema Treatment Trial. Ann Thorac Surg 2001; 71:995-1002.

6. National Emphysema Treatment Trial Research Group. Patients at high risk of death after lung volume reduction surgery. N Engl J Med 2001; 345: 1075-83.

7. Scharf S, Iqbal M, Keller C, Criner G, Lee S, Fessler HE for the NETT Research Group. Hemodynamic characterization of patients with severe emphysema. Am J Respir Crit Care Med 2002; 166: 314-322.

8. R. Foronjy, N. Kolesnikova, J. Wilt, P. Simonelli, B. Thomashow, M. Ginsburg, L. Schulman, J. D. Darmiento, & K. Chada (2001) Benign Mesenchymal Tumor Gene, HMG1-C as a Diagnostic Marker in Lymphangioliomyomatosis (LAM). Am. J. Resp. Crit. Care Med. 163:A559.

9. Shi, L., Z. Liu, & P.F. Simonelli (1997) Reverse transcriptase inhibits the polymerase chain reaction. J Dental Research 76: 320.
AM DiMango, PF Simonelli, B Thomashaw, J Edsall, C Yip, KM Prager, M. Argenziano, LA Gorenstein, KM Steinglass, ME Ginsberg (1996) Spirometry and exercise tolerance are significantly improved in patients who undergo volume reduction pneumectomy (VRP) for the treatment of advanced emphysema Amer J Respir Crit Care Med. 153.

10. PF Simonelli, AM DiMango, ZL Liu, & A Shang (1996) Peptides modeled on an envelope V3 domain motif that is conserved in HIV-1 isolated from alveolar macrophages inhibit viral replication in vitro Amer J Respir Crit Care Med. 153.
AM DiMango, L Schulman, C McGregor, W Tester, & PF Simonelli (1996) Transforming growth factor (TGF)-b1 RNA expression by bronchoalveolar lavage cells obtained from lung transplant recipients is increased during episodes of acute rejection Amer J Respir Crit Care Med. 153.

11. Simonelli, P.F., Liu, Z.-L., Shi, L.-Z., & Itescu, S. (1996) HIV-1 Isolated from the Lungs and Peripheral Blood of the Same Individuals Have Biologically Distinct Characteristics Which Are Related to Differences in the env V3 Domain. Keystone Symposia.

12. LJ Branker, S Itescu, & PF Simonelli (1996) HIV-1 envelope protein gp120 alters the expression of surface antigenic determinants in cultured macrophages Amer J Respir Crit Care Med. 153.

13. PF Simonelli, AM DiMango, ZL Liu, & A Shang (1996) HIV-1 proviral gag DNA content of bronchoalveolar lavage cells, but not gag RNA expression, correlates with the occurrence of pulmonary infiltrates Amer J Respir Crit Care Med. 153.
DiMango, A.M., Rogers, L., & Simonelli, P.F. (1995) Determination of gag DNA and RNA Levels in Bronchoalveolar Lavage Cells Obtained from Healthy, Asymptomatic HIV-1 Infected Individuals. Chest 108:98S.
DiMango, A.M., Shulman, L., McGregor, C., & Simonelli, P.F. (1995) Expression of Transforming Growth Factor (TGF)-B1 RNA by Bronchoalveolar Cells Obtained from Lung Transplant Recipients. Chest 108:126S.

14. Branker, L., Shi, L.-Z., Liu, Z.L., & Simonelli, P.F. (1994) Quantification of DNA & RNA in Bronchoalveolar Lavage Mononuclear Cells. Chest 106:A72.

15. Simonelli, P.F., Liu, Z.-L., Shi, L.-Z., & Itescu, S. (1994) Biologically Distinct HIV-1 Strains Are Present in the Lungs and Peripheral Blood of the Same Individuals. Clinical Research 42:458A.

16. Itescu, S., Simonelli, P.F., Winchester, R., Ginsberg, H.S. (1994) Human immunodeficiency virus type-1 strains in the lungs of infected individuals evolve independently from those in peripheral blood and have a conserved C-terminal region of the envelope V3 loop. Proc. Natl. Acad. Sci. USA 91: 11378-11382.

17. Simonelli, P.F., Shi, L.-Z., & Ginsberg, H.S. (1994) Differential Expression of HIV-1 gag RNA in Bronchoalveolar Lavage and Peripheral Blood Mononuclear Cells Correlates with Viral Growth in Culture. Amer. J. Respir. Crit. Care Med. 149:A518.

18. Doctoral Thesis: Isolation and Characterization of Bovine Cerebellar Protein Phosphatases. The City University of New York, New York. Sponsor: H.-C. Li, Ph.D. (1984)