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Columbia University, College of Physicians & Surgeons

622 West 168th Street
PH 8 East, Room 101

New York, NY 10032


Phone: 212-305-9817

ns311@columbia.edu

 

 

 

Neil W. Schluger, M.D.

Professor of Medicine, Epidemiology & Environmental Health Sciences

Chief, Division of Pulmonary, Allergy, and Critical Care Medicine

 

 

Clinical and Research Interests

Dr. Schluger’s main area of academic interest has been in tuberculosis, including clinical trials, molecular epidemiology, development and evaluation of diagnostics, and human host immune responses. He is the principal investigator at Columbia University for the Tuberculosis Trials Consortium, a CDC-funded collaboration in clinical trials in which patients are enrolled in trials of treatment of latent tuberculosis infection and active tuberculosis disease. In addition, Dr. Schluger has led studies examining the transmission dynamics of tuberculosis in New York City, using tools of molecular epidemiology. He has a long standing interest in the development and evaluation of new tools for the diagnosis of tuberculosis.

 

More recently, in addition to his studies in tuberculosis, he has led clinical trials for the use of retinoids in the treatment of emphysema and for the use of interferon gamma in the treatment of idiopathic pulmonary fibrosis.

 

Education and Training

Harvard University, B.A., 1981
University of Pennsylvania, M.D., 1985
Residency, St. Luke’s Hospital, New York, Internal Medicine
Fellowship, The New York Hospital/Cornell Medical Center, Pulmonary and Critical Care Medicine

 

Honors

1979-1980 John Harvard Scholarship
1990-1992 Stony Wold-Herbert Fund Foundation Fellowship for Pulmonary
Research
1993-1994 National Research Service Award (individual), National Institute of Allergy and Infectious Diseases (NIH)
1994-1999 Tuberculosis Academic Award, National Heart, Lung, and Blood Institute, NIH
1994 Fellow, American College of Chest Physicians
1999-2004 Mid-Career Investigator Award in Patient-Oriented Research, National Heart, Lung, and Blood Institute, National Institutes of Health
2001-present listed in “New York’s Top Doctors” (Castle Connolly Medical)
2001-present listed in “America’s Top Doctors” (Castle Connolly Medical)
2002 elected, American Society of Clinical Investigation

 

Publications (partial list)

1.      Sandman L, Davidow A, Bonk S, Schluger NW. Risk factors for rifampin mono-resistant tuberculosis: a case control study. Am J Respir Crit Care Med, 1999; 159: 468-472.

2.      Schluger NW, Huberman R, Holzman R, Rom WN, Cohen DI. Screening for infection and disease as a tuberculosis control measure among indigents in New York City, 1994-1997, Int J Tuberc Lung Dis 1999; 3: 281-286

3.      Vernon A, Burman W, Benator D, Khan A, Bozeman L and the Tuberculosis Trials Consortium*. Acquired rifamycin mono-resistance among patients with HIV-related tuberculosis treated with supervised once weekly rifapentine and isoniazid. Lancet 1999; 353:1843-47

4.      Davidson H, Schluger NW, Feldman PH, Valentine DP, Telzak EE, Laufer FN. The effects of increasing incentives on adherence to tuberculosis directly observed therapy. Int J Tuberc Lung Dis 2000; 9: 860-865

5.      Raju B, Schluger NW. Significance of respiratory isolates of Mycobacterium avium complex in HIV-positive and HIV-negative patients. Int J Infect Dis. 2000; 4:134-139.

6.      Schluger NW. The impact of drug resistance on the global tuberculosis epidemic. Int J Tuberc Lung Dis 2000; 4: S71-5

7.      Schluger NW. Clearing up confusion in pulmonary embolism diagnosis. J Crit Illness 2000; 15: 592-598

8.      Johnson S, Brusasca P, Lyashchenko K, Spencer JS, Wiker HG, Bifani P, Shashkina E, Kreiswirth B, Harboe M, Schluger N, Gomez M, Gennaro ML. Characterization of the secreted MPT53 antigen of Mycobacterium tuberculosis. Infect Immun. 2001; 69: 5936-9.

9.      Schluger NW. Recent advances in our understanding of human host responses to tuberculosis. Respiratory Research 2001; 2: 157-163

10.  Schluger NW, Burzynski J. Tuberculosis in HIV-infected patients: epidemiology, pathogenesis, treatment. HIV Clinical Trials 2001; 2: 356-365

11.  Schluger NW. Changing Approaches to the Diagnosis of Tuberculosis. Am J Respir Crit Care Med.2001; 164: 2020-2024

12.  Chan ED, Chan J, Schluger NW. What is the role of nitric oxide in murine and human host-defense against tuberculosis? Current knowledge. Am J Respir Cell Mol Biol 2001; 25: 606-612.

13.  Tuberculosis Trials Consortium*. The Tuberculosis Trials Consortium: A Model for Clinical Trials Collaborations. Public Health Reports 2001; 116 (Supplement 1):41-49.

14.  N Bock, T Sterling, CD Hamilton, C Pachucki, YC Wang, DS Conwell, A Mosher, M Samuels, Vernon A, and the Tuberculosis Trials Consortium*. A prospective, randomized, double-blind study of the tolerability of rifapentine 600 mg, 900 mg and 1200 mg plus isoniazid in the continuation phase of tuberculosis treatment. Amer J Resp Crit Care Med 2002; 165: 1526-1530.

15.  Schluger NW. Challenges of Treating Latent Tuberculosis Infection. Chest, 2002;121:1733-1735

16.  Geng E, Kreiswirth B, Driver C, Li J, Burzynski J, LaPaz A, Della Latta P, Schluger NW. Changes in tuberculosis transmission in New York City from 1990-1999: implications for tuberculosis control and elimination practices. New Engl J Med, 2002; 346: 1453-1458

17.  Schluger NW, Perez D, Liu YM. Reconstitution of immune responses to tuberculosis in HIV-infected patients receiving anti-retroviral therapy. Chest 2002; 122:597-602

18.  Tuberculosis Trials Consortium*. Treatment of drug-susceptible tuberculosis with a once weekly regimen of isoniazid and rifapentine in the continuation phase. The Lancet 2002; 360: 528-534

 

 

 

 

 

 

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