Division of Pulmonary, Allergy
and Critical Care Medicine
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Mailing Address: 622 PH 8-101 Phone: 212-305-7759 Fax: 212-305-2277 Laboratory Address: 650 P&S
10-502 Clinical Practice Address: Irving Pavilion 6th Floor Phone:
212-305-0631 Office: 601
Affiliations: § Columbia
Center for Childrens' Environmental Health (CCCEH.org) § John
Edsall John Wood Asthma Center |
Rachel L. Miller, M.D., FAAAAI Associate Professor of Clinical Medicine and
Environmental Health Sciences Division of Pulmonary, Allergy and Critical Care
Medicine Director,
Allergy and Immunology Fellowship Program Director,
Allergy, Director,
Asthma Project, CCCEH Associate
Director and Lead Physician Scientist, Disease Investigation through
Specialized Clinically-Oriented Ventures in Environment Research Research Interests Our work concentrates on
the mechanisms for the onset of asthma. One large research focus involves
establishing and studying a birth cohort from Clinical Interests The clinical office
specializes in the treatment of asthma and allergies. Clinical trials also
are conducted at the Biography Residency, Internal
Medicine, Fellowship, Pulmonary and
Critical Care Medicine: Fellowship, Allergy and
Immunology: College of Physicians and
Surgeons, 1997-1999 Positions and Appointments Assistant in Clinical Medicine, Department of Medicine, Instructor in Clinical Medicine, Department of Medicine, Assistant Professor of Clinical Medicine, Irving Assistant
Professor of Clinical Medicine, Co-Director, Asthma Project, Director, Asthma Project, Program Director,
Allergy and Immunology Fellowship, Columbia University College of Physicians
and Surgeons, 8/1/04-present Assistant Professor of
Clinical Medicine and Public Health (Environmental Health Sciences) at Fellow, Vice-Chair, Allergy
and Immunology Program Directors Residency Review Subcommittee, 1/06-present Director of Allergy, Associate Director,
Lead Physician Scientist, Disease Investigation through Specialized
Clinically-Oriented Ventures in Environment Research, 7/1/07 –present Associate Professor of Clinical
Medicine and Environmental Health Sciences at Chair, Allergy and Immunology Program Directors Residency Review
Subcommittee, 1/08-present Honors Harvard College Dean’s
List Collegiate National
Rowing Championship, second place, 1985 Thomas T. Hoopes Prize
for excellent senior honors thesis, 1986 Faculty Prize for
distinguished senior honors thesis in psychobiology, 1986 President of NYU Chapter
of American Medical Student Association, 1987-1988 Eve Flechner Award in
Internal Medicine, 1990 2007
AAAAI Clinical Fellowship Award to Allergy and Immunology Training Program at
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Publications: Miller, R. L.
and M.J. Baum. Naloxone inhibits mating and conditioned place preference for
an estrous female in male rats soon after castration. Pharmacology
Biochemistry and Behavior 26:781-189, 1987. Miller, R. L.
and R. P. Cole. Association between reduced cuff leak volume and
postextubation stridor, Chest 110:1035-40, 1996. Miller, R. L.,
S. Das, T. Anandarangam, D. W. Leibowitz, B. Thomashow, P.O. Alderson, S.
Homma. Relation between patent foramen ovale and perfusion abnormalities in
acute pulmonary embolism, The American Journal of Cardiology, 70:377-388,
1997. Miller, R. L.,
S. Das, T. Anandarangam, D. W. Leibowitz, B. Thomashow, P.O. Alderson, S.
Homma. Association between right ventricular function and perfusion
abnormalities in hemodynamically stable patients with acute pulmonary
embolism, Chest, 113:665-70, 1998. Miller, R. L.,
T. M. Eppinger, D. McConnell, C. Cunningham-Rundles, P. B. Rothman. Analysis
of cytokine signaling in patients with extrinsic asthma and
hyperimmunoglobulin E. Journal of Allergy and Clinical Immunology,
102:503-11, 1998. Neugut, A.I., A. Ghatak, R. Miller. Anaphylaxis in the Miller,
R.L., G. Chew, C.A. Bell, S.A.
Biedermann, M. Aggarwal, P.L. Kinney, W.Y. Tsai, R.M. Whyatt, F. P. Perera,
J.G. Ford. Prenatal antigen exposure, maternal sensitization, and
sensitization in utero to indoor allergens in an inner-city cohort, American
Journal of Respiratory and Critical Care Medicine, 164:995-1001, 2001. Perera, F.P., S.M. Illman,
P.L. Kinney, R. M. Whyatt, E. A. Kelvin, P. Shepard, D. Evans, M. Fullilove,
J. G. Ford, R.L. Miller, I. Meyer,
V. Rauh. The challenge of preventing environmentally-related disease in young
children: Community-based research in Chew, G.L., M.S.
Perzanowski, R.L. Miller, J.C.
Correa, L. A. Hoepner, F.P. Perera, P. L. Kinney. Distribution and
determinants of mouse allergen exposure in low-income Miller,
R.L., Cheng, M., DiMango, E.A.,
Geromanos, K., Rothman P.B. T cell priming and hypersensitivity to influenza
and egg antigens among asthmatic adults immunized with the influenza vaccine,
Journal of Allergy and Clinical Immunology, 112:606-08, 2003. Miller,
R.L., J.C. Correa, P.L. Kinney. Rat
sensitization among inner-city asthmatic children, Journal of Children’s
Health, 1 (4), 489-98, 2003. Miller,
R.L., R. Garfinkel, M. Horton, D.
Camann, F. P. Perera, R. Whyatt, P.L. Kinney. Prenatal exposure to polycyclic
aromatic hydrocarbons, postnatal environmental tobacco smoke, and pulmonary
symptoms in a birth cohort, Chest, 126: 1071-78, 2004. Goldstein, I.F., Matthew S. Perzanowski, Cynthia
Lendor, Robin S. Garfinkel, Lori A. Hoepner, Frederica P. Perera, Rachel L. Miller. Prevalence of
allergy symptoms and total IgE in a New York City cohort and their
association with birth order, International Archives of Allergy and
Immunology, 137 (3), 249-257, 2005. Eggleston, P.A, G.
Diette, M. Lipsett, T. Lewis, I. Tager, R. McConnell, E. Chrischilles, B.
Lanphear, R. Miller, and J.
Krishnan. Lessons learned for the study of childhood asthma from the Centers
for Children’s Environmental Health and Disease Prevention Research,
Environmental Health Perspectives, 113 (10): 1430-1436, 2005. Perzanowski MS, RL Miller, PS Thorne, RG Barr, A
Divjan, BJ Sheares, RS Garfinkel, IF Goldstein, FP Perera, GL Chew. Endotoxin
inner-city homes and the association with atopy and wheeze in the first two
years of life. J Allergy Clin Immunology, 117:1082-9, 2006. Rafael Narvaez, Kathleen
Moors, Mayra
Ramirez, Rachel L. Miller Risks in
using non-rigorous Spanish translations of asthma questionnaires. Chest,
131(4): 1271-2, 2007, letter. Rastogi,
D., Chaodong Wang, Xia Mao, Cynthia Lendor, Paul B. Rothman,
Rachel L. Miller. Antigen-specific
immune responses to influenza vaccine in
utero, Journal of Clinical Investigation, 117 (6):1637-46, 2007. Liu,
Jinming, Manisha Ballaney, Umaima Al-alem, Chunli Quan, Ximei Jin, Frederica Perera, Lung-Chi Chen, Rachel L. Miller. Combined
inhaled diesel exhaust particles and allergen exposure alter methylation of T helper genes and IgE production in vivo, Toxicological Sciences,
2008, in press. Perzanowski, M.S., GL Chew, A Divjan, K Panjwani,
A Johnson, BJ Sheares, IF Goldstein, TA Platts-Mills, FP Perera, RL Miller. Cat ownership is a risk
factor for developing anti-cat IgE but not current wheeze at age 5 in a low
income urban NYC cohort, Journal of Allergy and Clinical Immunology,
2008, in press. Chapters, invited editorials: Miller, R. L.
and P. B. Rothman. Molecular mechanisms controlling IgE responses In:T.F.
Kresina, ed., Immune modulating agents, Marcel Dekker Inc, Chapt. 2, 21-33,
1998. Miller, R. L.
Breathing freely: The need for asthma research on gene-environment
interactions. American Journal of Public Health, 89:819-822, 1999. Epidemiology
of Anaphylaxis: Findings of the ACAAI Epidemiology of Anaphylaxis Working
Group (Phil Lieberman, MD; Carlos Camargo, Jr., MD; Kari Bohlke, ScD; Hershel
Jick, MD; Rachel L. Miller, MD;
Aziz Sheikh, MD; Estelle Simons, MD). Annals of Allergy, Asthma &
Immunology, 97: 596-602, 2006
Miller, Rachel L
and Shuk-mei Ho Environmental epigenetics and asthma: Current concepts and call for studies, American
Journal of Respiratory and Critical Care Medicine, in press, 2008. Abstracts: Miller, R. L.,
A. Chachoua, J. Le, R. H. Blum, J. Vilcek. Lack of stimulation of human
monocyte-mediated cytotoxicity by recombinant M-CSF. Proceedings of the
American Association for Cancer Research 31:242, 1990. Miller, R. L.,
S. Das, T. Anandarangam, D. Leibowitz, B. Thomashow, M. T. Savoia, P.O.
Alderson, S. Homma. Extent of perfusion abnormality on V/Q scan in acute
pulmonary emboli determines presence of patent foramen ovale. American
Journal of Respiratory and Critical Care Medicine 153:A95, 1996. Miller, R. L.
T. Anandarangam, S. Das, D. Leibowitz, B. Thomashow, M. T. Savoia, P. O.
Alderson, S. Homma. Right ventricular enlargement persists in acute pulmonary
emboli despite clinical improvement. American Journal of Respiratory and
Critical Care Medicine 153:A96, 1996. Miller, R. L.
and R. P. Cole. Reduced cuff leak volume predicts postextubation stridor.
American Journal of Respiratory and Critical Care Medicine 153:A606, 1996. Miller, R. L.
and P. B. Rothman. Analysis of interleukin-4 mediated IgE pathway in asthma
and Hyperimmunoglobulin E Syndrome, American Journal of Respiratory and
Critical Care Medicine, 155:A883, 1997. Miller, R. L.
, Y. Kuang, X. Bai, P.B. Rothman, L. Mayer. 446-B Cell Differentiation Factor
stimulates Stat1. American Journal of Respiratory and Critical Care Medicine,
157:A423, 1998. Miller, R. L.,
L. Acosta, C. Bell, G. Chew, D. Evans, M. Northridge, I. Goldstein, P.
Shepard, S. Frantz, P. Rothman, P. Kinney. Asthmatic children in northern Chew, G., R.L. Miller, Miller, Rachel, Anita Ghatak, Paul Rothman, Alfred Neugut. Anaphylaxis in the Miller, R. L.,
C.A. Bell, S.A. Biedermann, R.M. Whyatt, F.P. Perera, P.B. Rothman, J.Ford.
In utero sensitization to indoor allergens occurs even in the absence of
maternal allergy. American Journal of Respiratory and Critical Care Medicine,
161(3):A203, 2000. Perera, F.P., V.A. Rauh,
J.G. Ford, I. Meyer, R.L. Miller,
P.L. Kinney, H.F. Andrews, D. Evans R. Wallace, D. Wallace, M. Fullilove, P.
Shepard. Recent study findings from the Perera, F.P, M. Aggarwal,
H. Andrews, G. Chew, D. Evans, J.G. Ford, M. Fullilove, R. Fullilove, P.L.
Kinney, I. Meyer, R.L. Miller, M.
Orhuela, V. Rauh, R. M. Santella, P. Shepard, W.Y. Tsai, D. Wallace, R.
Wallace, R. M. Whyatt. Recent study findings from the Miller, R. L.
S.A. Biedermann, G.C. Chew, M. Aggarwal, P.L. Kinney, R.M. Whyatt, F.P.
Perera, J.G. Ford. Increased cockroach and mouse-IgE level at age 2 years in
a highly exposed inner-city cohort. American Journal of Respiratory and
Critical Care Medicine, 163(5): A603, 2001. Miller, R. L.,
S.A. Biedermann, C.A. Bell, G. Halasz, J. Jerzynska, R.M. Whyatt, F.P.
Perera, J.F. Ford. Cord blood proliferation and cytokine production in response
to indoor allergens in an inner-city cohort. American Journal of Respiratory
and Critical Care Medicine, 163(5): A868, 2001. Perera, F.P. V.A. Rauh,
R.M. Whyatt, J.G. Ford, R.L. Miller,
G.L. Chew, P.L. Kinney. Miller R.L.
Biedermann, S.A., Chew, G.L., Kinney, P.K., Meyer, I., Whyatt, R.M., Perera,
F.P., Ford, J.F. Asthma related phenotypes and IgE levels at age 2 years in a
high risk inner-city cohort, American Journal of Respiratory and Critical
Care Medicine, 165 (8):A244, 2002. Perera F.P., Rauh V.A.,
Whyatt R.M., Ford J.G., Miller R.L.,
Chew G.L., Kinney P.L. .A molecular epidemiologic prospective cohort study of
African American and Miller, R. L.,
M. Smith, R.S. Garfinkel, J. Ford, F.P. Perera, R.M. Whyatt, P.L. Kinney.
Prenatal exposure to polycyclic aromatic hydrocarbons and antigen-specific
cytokine production, IgE production in a Northern Manhattan birth cohort,
American Journal of Respiratory and Critical Care Medicine, 167 (7): A942 ,
2003. Miller, R. L.,
J. Correa, P.L. Kinney, Rat sensitization among inner-city asthmatic
children. American Journal of Respiratory and Critical Care Medicine, 167
(7): A470, 2003. Rastogi, D., Y. Ogawa, C.
Lendor, D. Blythe, R.L. Miller. B
cell priming in utero to influenza
vaccine antigens, Journal of Allergy and Clinical Immunology, 113 (2):S51,
2004. Perzanowski, M.S., R.L. Miller, P.S. Thorne, B.J.
Sheares, J.C. Correa, F.P. Perera, I.F. Goldstein, G.L. Chew. Endotoxin in
inner-city homes and atopy and wheeze in the first two years of life. Journal
of Allergy and Clinical Immunology, 113 (2): S98, 2004. Rastogi, D., C.
Lendor, M. Horton, D. Blythe, and R.L. Miller. Systemic Th2 polarization among pregnant
asthmatics, American Journal of Respiratory and Critical Care Medicine, 169
(7), A501, 2004. Goldstein, I.F., M.S.
Perzanowski, R. S Garfinkel, C. Lendor, L. A. Hoepner, F. P. Perera, and R. L. Miller. Total IgE and asthma symptoms and their
association with birth order during the first three years of life in an
inner-city New York City cohort, American Journal of Respiratory and Critical
Care Medicine, 169 (7), A144, 2004. Mostecki J.W., W.J.
Klimecki, P.E. Graves, R.L. Miller
et al. Single nucleotide polymorphism
in the SOCS-1 promoter is associated with lower IgE levels in asthma patients
Federation of Clinical Immunology Societies, 2004. Perzanowski, M.S., G.L.
Chew, J.Y. Kong, C. Lendor, F.P. Perera, RL
Miller. Pet Protective Effect in Perzanowski
MS, GL. Chew, JY Kong, C. Lendor, FP. Perera, R.L. Miller. Relevance of cat allergen to allergic asthma and
rhinitis symptoms among 5 year old children in a Perzanowski,
M.S., I.F. Goldstein, R.G. Barr, B.J. Sheares, G.L. Chew, R.S. Garfinkel,
F.P. Perera, R.L Miller. Elevated
BMI at age 3 years predicts wheeze at age 5, independent of wheeze earlier in
life. Journal of Allergy and Clinical Immunology, 117 (2): S346, 2006. Perera,
F. Virginia Rauh, Robin Whyatt, Sally Lederman, Rachel Miller,
Wieslaw Jedrychowski, Pat Kinney, David Camann, Howard Andrews, Manuela
Orjuela, Deliang Tang. International research on the effects of in utero exposure to air pollutants on
child growth and development, asthma and cancer risk, ISEA, 2006. McConnell,
R., F. Gilliland, N. Kuenzli, Panjwani,
K., G.L. Chew, A. Divjan, AM Reardon, F.P. Perera, RL Miller, M.S.
Perzanowski. Fel d 1 in the bed dust of cat non-owners differs among
ethnicities but not beighborhood in two NYC cohorts. J Allergy Clin
Immunol 119 (1): S186, 2007. Perzanowski,
M.S., G.L. Chew, A. Divjan, A. Johnson, K. Panjwani, B.J. Sheares, T.A.
Platts-Mills, F.P. Perera, R.L Miller. Cat ownership is a risk factor
for developing sensitization to cat but not wheeze by age 5 in a low income
New York City birth Cohort. J Allergy Clin Immunol 119 (1): S310, 2007. Narvaez R., K. Moors, A. Reyes, M. Borjas, M.
Ramirez, J. Tapia-Mendoza, R. Miller Spanish translations of 'wheeze'
on asthma questionnaires American Journal of Respiratory and Critical Care
Medicine, 175:A84, 2007. Sheares,, B.J.,
R.L. Miller, A. Reyes,
R. Whyatt and P. Fani. Airway obstruction among a cohort of urban African
American and Dominican children American Journal of Respiratory and
Critical Care Medicine, 175:A86, 2007. Callaghan, K., K. Moors, J. Ross, R. Narvaez, M.
Borjas, P. Kinney, F. Pererra, R. Miller, and Steven Chillrud. Pilot survey of street-side summer ozone in
northern Rastogi, D, C. Wang, X. Mao, C. Lendor, A. Johnson,
M. Daswani, S. Kadura, P.B. Rothman, and R.L. Miller Antigen-specific
immune responses to influenza vaccine In utero American Journal of Respiratory and
Critical Care Medicine, 175:A324, 2007. Donohue KM, F Perera, S Chanock, D Tang, H Andrews,
L Hoepner, S Wang, R Liu, R Chen, S Yadavalli, B Welch, RL Miller GST
polymorphisms and asthma outcomes in an inner city cohort American Journal
of Respiratory and Critical Care Medicine, 175:A462, 2007. Mao, X, A. Johnson, C. Lendor, E. Kelvin, R.
Garfinkel, R.L. Miller Season of birth and biomarkers for allergic
sensitization in young children American Journal of Respiratory and
Critical Care Medicine, 175:A476, 2007. Lendor, C., D.Diaz , M.B.
Plaza, C.Pulgarin, A. Sjodin,L.Romanoff, Z. Li , D.G.
Patterson, Jr., L. Needham. R.L. Miller Polycyclic aromatic
hydrocarbon metabolites and wheeze in an inner city cohort American
Journal of Respiratory and Critical Care Medicine, 175:A543, 2007. Mao, X, Manisha Daswani, Sullafa Kadura, Rachel
L. Miller. Immune responses of dendritic cells to diesel exposure in
vitro American Journal of Respiratory and Critical Care Medicine, 175: A925, 2007. Donohue KM, U. Al-alem, M.S. Perzanowski, G.L.
Chew, A. Johnson, E.A. Kelvin, L.A. Hoepner , F.P. Perera, R.L. Miller.
Anti-Cockroach, Mouse IgE Associations with Early Wheeze and Atopy in an
Inner-city Birth Cohort. J Allergy Clin Immunol,
2008, in press. Adnan Divjan, Kiran
Ghouri, Ginger L. Chew, Rachel L. Miller, Matthew S. Perzanowski. Morning and
afternoon repeated measurements of offline exhaled nitric oxide and exhaled
Breath condensate pH. J Allergy Clin Immunol,
2008, in press. Narvaez, R, L Hoepner, R Garfinkel, D Camman, FP.
Perera, PL. Kinney, Perzanowski, M.P., Rachel L. Miller, Robin
S. Garfinkel, Ginger L. Chew, Inge F.
Goldstein, Frederica P. Perera, R. Graham Barr. Prenatal acetaminophen use is
a risk for wheeze at age 5 years in a low income urban population with a high
risk for asthma. J Allergy Clin Immunol,
2008, in press. Robert M. Zemble, Rachel L. Miller. Response
of peripheral blood invariant natural killer T cells to diesel exhaust
particles in mild atopic asthmatics. J Allergy Clin Immunol,
2008, in press. |
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