Division of Pulmonary, Allergy
and Critical Care Medicine
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Mailing Address: 622 PH 8-101 Phone: 212-305-7759 Fax: 212-305-2277 Laboratory Address: 650 P&S
10-502 Clinical Practice Address: Irving Pavilion 6th Floor Phone:
212-305-0631 Office: 601
Affiliations: § Columbia
Center for Childrens' Environmental Health
(CCCEH.org) § John
Edsall John Wood Asthma Center |
Rachel L. Miller, M.D., FAAAAI Associate Professor of Medicine and Environmental
Health Sciences Division of Pulmonary, Allergy and Critical Care
Medicine Director,
Allergy and Immunology Fellowship Program Director,
Allergy, Director,
Asthma Project, CCCEH Associate
Director and Lead Physician Scientist, Disease Investigation through
Specialized Clinically-Oriented Ventures in Environment Research Research Interests Our work concentrates on
the mechanisms for the onset of asthma. One large research focus involves
establishing and studying a birth cohort from Clinical Interests The clinical office
specializes in the treatment of asthma and allergies. Clinical trials also
are conducted at the Biography Residency, Internal
Medicine, Fellowship, Pulmonary and
Critical Care Medicine: Fellowship, Allergy and
Immunology: College of Physicians and
Surgeons, 1997-1999 Positions and Appointments Assistant in Clinical Medicine, Department of Medicine, Instructor in Clinical Medicine, Department of Medicine, Assistant Professor of Clinical Medicine, Irving Assistant
Professor of Clinical Medicine, Co-Director, Asthma Project, Director, Asthma Project, Program Director,
Allergy and Immunology Fellowship, Columbia University College of Physicians
and Surgeons, 8/1/04-present Assistant Professor of
Clinical Medicine and Public Health (Environmental Health Sciences) at Fellow, Vice-Chair, Allergy
and Immunology Program Directors Residency Review Subcommittee, 1/06-present Director of Allergy, Associate Director,
Lead Physician Scientist, Disease Investigation through Specialized
Clinically-Oriented Ventures in Environment Research, 7/1/07 –present Associate Professor of
Medicine and Environmental Health Sciences at Chair, Allergy and Immunology Program Directors Residency Review
Subcommittee, 1/08-present Honors Harvard College Dean’s
List Collegiate National
Rowing Championship, second place, 1985 Thomas T. Hoopes Prize for excellent senior honors thesis, 1986 Faculty Prize for
distinguished senior honors thesis in psychobiology, 1986 President of NYU Chapter
of American Medical Student Association, 1987-1988 Eve Flechner
Award in Internal Medicine, 1990 2007
AAAAI Clinical Fellowship Award to Allergy and Immunology Training Program at
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Publications: Miller, R. L.
and M.J. Baum. Naloxone inhibits mating and
conditioned place preference for an estrous female in male rats soon after
castration. Pharmacology Biochemistry and Behavior 26:781-189, 1987. Miller, R. L.
and R. P. Cole. Association between reduced cuff leak volume and postextubation stridor, Chest
110:1035-40, 1996. Miller, R. L.,
S. Das, T. Anandarangam, D. W. Leibowitz,
B. Thomashow, P.O. Alderson, S. Homma. Relation between patent foramen ovale and perfusion abnormalities in acute pulmonary
embolism, The American Journal of Cardiology, 70:377-388, 1997. Miller, R. L.,
S. Das, T. Anandarangam, D. W. Leibowitz,
B. Thomashow, P.O. Alderson, S. Homma. Association between right ventricular
function and perfusion abnormalities in hemodynamically
stable patients with acute pulmonary embolism, Chest, 113:665-70, 1998. Miller, R. L.,
T. M. Eppinger, D. McConnell, C.
Cunningham-Rundles, P. B. Rothman. Analysis of cytokine signaling in patients
with extrinsic asthma and hyperimmunoglobulin E.
Journal of Allergy and Clinical Immunology, 102:503-11, 1998. Neugut, A.I., A. Ghatak, R. Miller. Anaphylaxis in the Miller,
R.L., G. Chew, C.A. Bell, S.A. Biedermann, M. Aggarwal, P.L.
Kinney, W.Y. Tsai, R.M. Whyatt, F. P. Perera, J.G.
Ford. Prenatal antigen exposure, maternal sensitization, and sensitization in
utero to indoor allergens in an inner-city cohort,
American Journal of Respiratory and Critical Care Medicine, 164:995-1001,
2001. Perera, F.P., S.M. Illman, P.L.
Kinney, R. M. Whyatt, E. A. Kelvin, P. Shepard, D.
Evans, M. Fullilove, J. G. Ford, R.L. Miller, I. Meyer, V. Rauh. The challenge of preventing environmentally-related
disease in young children: Community-based research in Chew, G.L., M.S. Perzanowski, R.L.
Miller, J.C. Correa, L. A. Hoepner, F.P. Perera,
P. L. Kinney. Distribution and determinants of mouse
allergen exposure in low-income Miller,
R.L., Cheng, M., DiMango, E.A., Geromanos, K., Rothman P.B. T cell priming and
hypersensitivity to influenza and egg antigens among asthmatic adults
immunized with the influenza vaccine, Journal of Allergy and Clinical
Immunology, 112:606-08, 2003. Miller,
R.L., J.C. Correa, P.L. Kinney. Rat
sensitization among inner-city asthmatic children, Journal of Children’s
Health, 1 (4), 489-98, 2003. Miller,
R.L., R. Garfinkel,
M. Horton, D. Camann, F. P. Perera, R. Whyatt, P.L.
Kinney. Prenatal exposure to polycyclic aromatic hydrocarbons, postnatal
environmental tobacco smoke, and pulmonary symptoms in a birth cohort, Chest,
126: 1071-78, 2004. Goldstein, I.F., Matthew S. Perzanowski,
Cynthia Lendor, Robin S. Garfinkel,
Eggleston, P.A, G. Diette, M. Lipsett, T. Lewis,
I. Tager, R. McConnell, E. Chrischilles,
B. Lanphear, R.
Miller, and J. Krishnan. Lessons learned for the study of childhood
asthma from the Centers for Children’s Environmental Health and Disease
Prevention Research, Environmental Health Perspectives, 113 (10): 1430-1436,
2005. Perzanowski MS, RL
Miller, PS Thorne, RG Barr, A Divjan, BJ Sheares, RS Garfinkel, IF
Goldstein, FP Perera, GL Chew. Endotoxin
inner-city homes and the association with atopy and
wheeze in the first two years of life. J Allergy Clin
Immunology, 117:1082-9, 2006. Rafael Narvaez, Kathleen
Moors, Mayra
Ramirez, Rachel
L. Miller Risks in using non-rigorous Spanish
translations of asthma questionnaires. Chest, 131(4): 1271-2, 2007, letter. Rastogi,
D., Chaodong Wang, Xia Mao, Cynthia Lendor, Paul B. Rothman, Rachel L. Miller. Antigen-specific immune responses to influenza
vaccine in utero,
Journal of Clinical Investigation, 117 (6):1637-46, 2007. Liu,
Jinming, Manisha Ballaney, Umaima Al-alem, Chunli Quan, Ximei Jin, Frederica Perera,
Lung-Chi Chen, Rachel L. Miller.
Combined inhaled diesel exhaust particles and allergen exposure alter methylation of T helper genes and IgE production in
vivo, Toxicological Sciences, 2008, 102 (1), 76-81, 2008. Perzanowski, M.S., GL Chew, A Divjan, K Panjwani, A Johnson, BJ Sheares,
IF Goldstein,
TA Platts-Mills, FP Perera, RL Miller. Cat ownership is a risk
factor for developing anti-cat IgE but not current
wheeze at age 5 in a low income urban NYC cohort, Journal of Allergy and
Clinical Immunology, 121:1047-52, 2008. Lendor, Cynthia, Alina Johnson, Matthew Perzanowski,
Ginger L. Chew, Inge F. Goldstein, Elizabeth
Kelvin, Frederica Perera, Rachel L. Miller. Effects of winter birth season and prenatal
indoor allergen exposure on indoor allergen- specific cord blood cell
proliferation and cytokine production, Annals of Allergy, Asthma and
Immunology, 2008, in press, 101(2):193-9, 2008 Perzanowski, M.S, Maria Jose Rosa, Adnan Divjan, Alina Johnson, Judith S. Jacobson, Rachel L. Miller. Modifications improve an offline exhaled NO
collection device for use with young children, Journal of Allergy and
Clinical Immunology, 122:213, 2008, letter. Miller, R. L., Ho, S.-m. Epigenetic studies should
focus on specific cell types. Am J Respir Crit
Care Med. 178:883-883, 2008,
letter. Narvaez,
Rafael F., Lori Hoepner, Steven N. Chillrud, Beizhan Yan, Robin Garfinkel,
Robin Whyatt, David Camann, Frederica P. Perera,
Patrick L. Kinney, Rachel L. Miller.
Spatial and temporal trends of polycyclic aromatic hydrocarbons and other
traffic-related airborne pollutants in Donohue, Kathleen M., Umaima Al-alem, Matthew S. Perzanowski, Ginger L. Chew, Alina
Johnson, Adnan Divjan,
Elizabeth A. Kelvin, Chapters, invited editorials: Miller, R. L.
and P. B. Rothman. Molecular mechanisms controlling IgE
responses In:T.F. Kresina, ed., Immune modulating agents, Marcel Dekker
Inc, Chapt. 2, 21-33, 1998. Miller, R. L.
Breathing freely: The need for asthma research on gene-environment
interactions. American Journal of Public Health, 89:819-822, 1999. Epidemiology
of Anaphylaxis: Findings of the ACAAI Epidemiology of Anaphylaxis Working
Group (Phil Lieberman, MD; Carlos Camargo, Jr., MD;
Kari Bohlke, ScD; Hershel Jick,
MD; Rachel L. Miller, MD; Aziz
Sheikh, MD; Estelle Simons, MD). Annals of Allergy, Asthma &
Immunology, 97: 596-602, 2006
Miller, Rachel L and Shuk-mei
Ho Environmental epigenetics and asthma: Current concepts and call for studies, American
Journal of Respiratory and Critical Care Medicine, 177:567-573, 2008. Donohue, Kathleen, Alissa Hersh, Rachel Miller. Continuing Medical
Education Examination. Asthma and
Obesity: Common Early-Life Influences.
Journal of Allergy and Clinical Immunology, 121(5): 1085-86,
2008. Miller, Rachel L. Prenatal maternal diet and asthma risk. The Journal of Clinical Investigation,
118(10):3265-3268, 2008. Rachel L. Miller and Julie
Herbstman. Epigenetic
mechanisms in asthma, In: Epigenetics Nutrition and
Environmental Health. Wiley
Publishers, 2008, in press. Abstracts: Miller, R. L.,
A. Chachoua, J. Le, R. H. Blum, J. Vilcek. Lack of stimulation of human monocyte-mediated
cytotoxicity by recombinant M-CSF. Proceedings of
the American Association for Cancer Research 31:242, 1990. Miller, R. L.,
S. Das, T. Anandarangam, D. Leibowitz,
B. Thomashow, M. T. Savoia, P.O. Alderson, S.
Homma. Extent of perfusion abnormality on V/Q scan in acute pulmonary emboli
determines presence of patent foramen ovale.
American Journal of Respiratory and Critical Care Medicine 153:A95, 1996. Miller, R. L.
T. Anandarangam, S. Das, D. Leibowitz,
B. Thomashow, M. T. Savoia, P. O. Alderson, S.
Homma. Right ventricular enlargement persists in acute pulmonary emboli
despite clinical improvement. American Journal of Respiratory and Critical
Care Medicine 153:A96, 1996. Miller, R. L.
and R. P. Cole. Reduced cuff leak volume predicts postextubation
stridor. American Journal of Respiratory and
Critical Care Medicine 153:A606, 1996. Miller, R. L.
and P. B. Rothman. Analysis of interleukin-4 mediated IgE
pathway in asthma and Hyperimmunoglobulin E
Syndrome, American Journal of Respiratory and Critical Care Medicine,
155:A883, 1997. Miller, R. L. , Y. Kuang, X. Bai,
P.B. Rothman, L. Mayer. 446-B Cell Differentiation Factor stimulates Stat1.
American Journal of Respiratory and Critical Care Medicine, 157:A423, 1998. Miller, R. L.,
L. Acosta, C. Bell, G. Chew, D. Evans, M. Northridge, I. Goldstein, P. Shepard, S. Frantz, P. Rothman, P. Kinney. Asthmatic
children in northern Chew, G., R.L. Miller, Miller, Rachel, Anita Ghatak, Paul Rothman, Alfred
Neugut. Anaphylaxis in the Miller, R. L.,
C.A. Bell, S.A. Biedermann, R.M. Whyatt, F.P. Perera, P.B. Rothman, J.Ford.
In utero sensitization to indoor allergens occurs
even in the absence of maternal allergy. American Journal of Respiratory and
Critical Care Medicine, 161(3):A203, 2000. Perera, F.P., V.A. Rauh, J.G.
Ford, I. Meyer, R.L. Miller, P.L.
Kinney, H.F. Andrews, D. Evans R. Wallace, D. Wallace, M. Fullilove,
P. Shepard. Recent study findings from the Perera, F.P, M. Aggarwal, H.
Andrews, G. Chew, D. Evans, J.G. Ford, M. Fullilove,
R. Fullilove, P.L. Kinney, I. Meyer, R.L. Miller, M. Orhuela,
V. Rauh, R. M. Santella, P. Shepard,
W.Y. Tsai, D. Wallace, R. Wallace, R. M. Whyatt. Recent study findings from
the Miller, R. L.
S.A. Biedermann, G.C. Chew, M. Aggarwal,
P.L. Kinney, R.M. Whyatt, F.P. Perera, J.G. Ford.
Increased cockroach and mouse-IgE level at age 2
years in a highly exposed inner-city cohort. American Journal of Respiratory
and Critical Care Medicine, 163(5): A603, 2001. Miller, R. L.,
S.A. Biedermann, C.A. Bell, G. Halasz,
J. Jerzynska, R.M. Whyatt, F.P. Perera,
J.F. Ford. Cord blood proliferation and cytokine production in response to
indoor allergens in an inner-city cohort. American Journal of Respiratory and
Critical Care Medicine, 163(5): A868, 2001. Perera, F.P. V.A. Rauh, R.M.
Whyatt, J.G. Ford, R.L. Miller,
G.L. Chew, P.L. Kinney. Miller R.L.
Biedermann, S.A., Chew, G.L., Kinney, P.K., Meyer,
I., Whyatt, R.M., Perera, F.P., Ford, J.F. Asthma
related phenotypes and IgE levels at age 2 years in
a high risk inner-city cohort, American Journal of Respiratory and Critical
Care Medicine, 165 (8):A244, 2002. Perera F.P., Rauh V.A., Whyatt
R.M., Ford J.G., Miller R.L., Chew
G.L., Kinney P.L. .A molecular epidemiologic
prospective cohort study of African American and Miller, R. L.,
M. Smith, R.S. Garfinkel, J. Ford, F.P. Perera, R.M. Whyatt, P.L. Kinney. Prenatal exposure to
polycyclic aromatic hydrocarbons and antigen-specific cytokine production, IgE production in a Northern Manhattan birth cohort,
American Journal of Respiratory and Critical Care Medicine, 167 (7): A942 ,
2003. Miller, R. L.,
J. Correa, P.L. Kinney, Rat sensitization among inner-city asthmatic
children. American Journal of Respiratory and Critical Care Medicine, 167
(7): A470, 2003. Rastogi, D., Y. Ogawa, C. Lendor,
D. Blythe, R.L. Miller. B cell
priming in utero
to influenza vaccine antigens, Journal of Allergy and Clinical Immunology,
113 (2):S51, 2004. Perzanowski, M.S., R.L.
Miller, P.S. Thorne, B.J. Sheares, J.C. Correa,
F.P. Perera, I.F. Goldstein, G.L. Chew. Endotoxin in inner-city homes and atopy
and wheeze in the first two years of life. Journal of Allergy and Clinical
Immunology, 113 (2): S98, 2004. Rastogi, D., C. Lendor, M. Horton, D.
Blythe, and R.L. Miller. Systemic Th2 polarization among pregnant
asthmatics, American Journal of Respiratory and Critical Care Medicine, 169
(7), A501, 2004. Goldstein, I.F., M.S. Perzanowski, R. S Garfinkel, C.
Lendor, L. A. Hoepner, F. P. Perera,
and R. L. Miller. Total IgE and
asthma symptoms and their association with birth order during the first three
years of life in an inner-city New York City cohort, American Journal of
Respiratory and Critical Care Medicine, 169 (7), A144, 2004. Mostecki J.W., W.J. Klimecki, P.E.
Graves, R.L. Miller et al. Single nucleotide polymorphism in the
SOCS-1 promoter is associated with lower IgE levels
in asthma patients Federation of Clinical Immunology Societies, 2004. Perzanowski, M.S., G.L. Chew, J.Y. Kong, C. Lendor,
F.P. Perera, RL
Miller. Pet Protective Effect in Perzanowski MS, GL. Chew, JY Kong, C. Lendor, FP. Perera, R.L.
Miller. Relevance of cat allergen to allergic asthma and rhinitis
symptoms among 5 year old children in a Perzanowski, M.S., I.F. Goldstein, R.G. Barr, B.J. Sheares,
G.L. Chew, R.S. Garfinkel, F.P. Perera,
R.L Miller. Elevated BMI at age 3
years predicts wheeze at age 5, independent of wheeze earlier in life.
Journal of Allergy and Clinical Immunology, 117 (2): S346, 2006. Perera,
F. Virginia Rauh, Robin Whyatt, Sally Lederman,
Rachel Miller, Wieslaw Jedrychowski,
Pat Kinney, David Camann, Howard Andrews, Manuela Orjuela,
Deliang Tang. International research on the effects
of in utero
exposure to air pollutants on child growth and development, asthma and cancer
risk, ISEA, 2006. McConnell,
R., F. Gilliland, N. Kuenzli, Panjwani,
K., G.L. Chew, A. Divjan, AM Reardon, F.P. Perera, RL Miller, M.S. Perzanowski.
Fel d 1 in the bed dust of cat non-owners differs
among ethnicities but not beighborhood in two NYC
cohorts. J Allergy Clin Immunol 119
(1): S186, 2007. Perzanowski, M.S., G.L. Chew, A. Divjan, A. Johnson,
K. Panjwani, B.J. Sheares,
T.A. Platts-Mills, F.P. Perera,
R.L Miller. Cat ownership is a risk factor for developing
sensitization to cat but not wheeze by age 5 in a low income New York City
birth Cohort. J Allergy Clin Immunol 119 (1): S310, 2007. Narvaez R., K. Moors, A. Reyes, M. Borjas, M. Ramirez, J. Tapia-Mendoza, R. Miller Spanish
translations of 'wheeze' on asthma questionnaires American Journal of
Respiratory and Critical Care Medicine, 175:A84, 2007. Sheares,, B.J., R.L.
Miller, A. Reyes, R.
Whyatt and P. Fani. Airway obstruction among a
cohort of urban African American and Dominican children American Journal
of Respiratory and Critical Care Medicine, 175:A86, 2007. Callaghan, K., K. Moors, J. Ross, R. Narvaez, M. Borjas, P. Kinney, F. Pererra, R.
Miller, and Steven Chillrud. Pilot survey of street-side summer ozone in
northern Rastogi, D, C. Wang, X. Mao, C. Lendor,
A. Johnson, M. Daswani, S. Kadura,
P.B. Rothman, and R.L. Miller Antigen-specific immune responses to
influenza vaccine In utero American Journal of Respiratory and
Critical Care Medicine, 175:A324, 2007. Donohue KM, F Perera, S Chanock, D Tang, H Andrews, L Hoepner, S Wang, R Liu, R
Chen, S Yadavalli, B Welch, RL Miller GST
polymorphisms and asthma outcomes in an inner city cohort American Journal
of Respiratory and Critical Care Medicine, 175:A462, 2007. Mao, X, A. Johnson, C. Lendor,
E. Kelvin, R. Garfinkel, R.L. Miller Season
of birth and biomarkers for allergic sensitization in young children American
Journal of Respiratory and Critical Care Medicine, 175:A476, 2007. Lendor, C., D.Diaz ,
M.B. Plaza, C.Pulgarin,
A. Sjodin,L.Romanoff,
Z. Li , D.G. Patterson, Jr., L. Needham. R.L. Miller Polycyclic aromatic
hydrocarbon metabolites and wheeze in an inner city cohort American
Journal of Respiratory and Critical Care Medicine, 175:A543, 2007. Mao, X, Manisha Daswani, Sullafa Kadura, Rachel L. Miller. Immune responses of dendritic cells to diesel exposure in vitro American
Journal of Respiratory and Critical Care Medicine, 175: A925, 2007. Donohue
KM, U. Al-alem, M.S. Perzanowski,
G.L. Chew, A. Johnson, E.A. Kelvin, L.A. Hoepner , F.P. Perera,
R.L. Miller. Anti-Cockroach, Mouse
IgE Associations with Early Wheeze and Atopy in an Inner-city Birth Cohort. J Allergy Clin Immunol, 121(2):S135,
2008. Adnan Divjan, Kiran Ghouri, Ginger L. Chew, Rachel L. Miller, Matthew S. Perzanowski. Morning and afternoon repeated measurements
of offline exhaled nitric oxide and exhaled Breath condensate pH. J
Allergy Clin Immunol,
121(2):S160, 2008. Narvaez,
R, L Hoepner, R Garfinkel, D Camman,
FP. Perera, PL. Kinney, Perzanowski, M.P., Rachel L. Miller, Robin S. Garfinkel, Ginger L. Chew, Inge
F. Goldstein, Frederica P. Perera, Robert
M. Zemble, Rachel
L. Miller. Response of peripheral blood invariant natural killer T
cells to diesel exhaust particles in mild atopic asthmatics. J Allergy Clin Immunol, 121(2):S261, 2008. Molini M. Patel, Steve Chillrud, Lori Hoepner, Andria Reyes, Robin Garfinkel, Robin Whyatt, Patrick Kinney, Frederica Perera, Rachel L. Miller. Effects of ambient
elemental carbon and metals on wheeze and cough during early childhood. ISEA,
2008. Shah, A. Miller.
R. L. Toxic epidermal necrolysis, probably
following administration of the experimental cancer vaccine CDX-110, ACAI
annual meeting, 2008. |
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Updated:
October 2008
© Columbia University,