Division of Pulmonary, Allergy and Critical Care Medicine

Address:

Columbia University, College of Physicians & Surgeons
622 West 168th Street
PH 8 Center, Room 840
New York, NY 10032

Phone: 212-305-1586

Steven Greenberg, M.D.

Associate Professor of Medicine (in Pharmacology), Division of Pulmonary, Allergy and Critical Care Medicine

Research Interests

Dr. Greenberg investigates the molecular mechanisms innate immunity and phagocytosis. He also studies the pathogenesis and treatment of pulmonary fibrosis.

Education and Training

B.A., Harvard University, 1978
M.D., Columbia University College of Physicians and Surgeons, 1982
Residency, The Presbyterian Hospital
Fellowship, Pulmonary Disease, Columbia-Presbyterian Medical Center

Honors

Harvard College Scholarship, 1974-1978
Bachelor of Arts, magna cum laude, Biology, 1978
Britenstool Scholarship, 1981
Parker B. Francis Foundation Fellowship, 1988-1991
NIH Clinical Investigator Award, 1991-1996
Edward Livingston Trudeau Scholar, American Lung Association, 1993 (declined)
Henry Christian Award for Excellence in Research, AFCR, 1993
George A. Carden, Jr. Scholar, 1993-1995
American Heart Association, Established Investigator Award, 1996-present
American Society for Clinical Investigation, 1999

Institutional representative, American Society for Clinical Investigation, 2004-

Association of American Physicians, 2004

Selected Publications

1. Bhattacharya, S., C. Fu, J. Bhattacharya and S. Greenberg. (1995). Soluble ligands of the alphavß3 integrin mediate enhanced tyrosine phosphorylation of multiple proteins in adherent bovine pulmonary artery endothelial cells. J. Biol. Chem. 270:16781-16787.

2. Greenberg, S. (1995). Signal transduction of phagocytosis. Trends Cell Biol. 5:93-99.

3. Cox, D., P. Chang, T. Kurosaki, and S. Greenberg. (1996). Syk tyrosine kinase is required for immunoreceptor tyrosine activation motif-dependent actin assembly. J. Biol. Chem. 271:16597-16602.

4. Greenberg, S., P. Chang, D-C. Wang, R. Xavier, and B. Seed. (1996). Phagocytosis mediated by clustered Syk tyrosine kinase domains. Proc. Natl. Acad. Sci. USA. 93:1103-1107.

5. Cox, D., Chang, P., Zhang, Q., Reddy, P.G., Bokotch, G.M., Greenberg, S. (1997). Requirements for Rac and Cdc42 in membrane ruffling and phagocytosis in leukocytes. J. Exp. Med. 186:1487-1494.

6. Thomas, C.A., Weinberger, O.K., Ziegler, B.L., Greenberg, S., Schieren, I., Silverstein, S.C., El Khoury, J. (1997). HIV-1 impairs Fcgamma receptor-mediated phagocytosis via a cAMP-dependent mechanism. Blood. 90:3760-3765.

7. Zhang, Q., Cox, D., Tseng, C.-C., Donaldson, J.G., Greenberg, S. (1998). A requirement for ARF6 in Fcgamma receptor-mediated phagocytosis in macrophages. J. Biol. Chem. 273:19977-19981.

8. Hashimoto, A., Okada, H., Aimin, J., Kurosaki, M., Bokoch, G.M., Greenberg, S., Clark, E.A., Kurosaki, T. (1998). Involvement of guanosine triphosphstases and phospholipase C-gamma2 in extracellular signal-regulated kinase, c-Jun NH2-terminal kinase, and p38 mitogen-activated protein kinase activation by the B cell antigen receptor. J. Exp. Med. 188:1287-1295.

9. Cox, D., Tseng, C.-C., Bjekic, G., Greenberg, S. (1999). A requirement for phosphatidylinositol 3-kinase in pseudopod extension. J. Biol. Chem. 274:1240-1247.

10. Palmer, L.E., Pancetti, A.R., Greenberg, S., Bliska, J. (1999). YopJ of Yersinia spp. is sufficient to cause downregulation of multiple mitogen-activated protein kinases in eukaryotic cells. Infect. Immun. 67:708-716.

11. Zhang, Q., Jansen, H., Calafat, J., and Greenberg, S. (1999). ARF6 is required for growth factor and Rac-mediated membrane ruffling in macrophages at a stage distal to Rac membrane targeting. Mol. Cell. Biol.. 19:8158-8168.

12. Greenberg, S. (1999). Phagocytosis. In Inflammation: Basic Principles and Clinical Correlates, 3rd Ed. John I. Gallin and Ralph Snyderman, editors (Lippincott-Raven: Philadelphia). pp. 681-701.

13. Greenberg, S. (1999). Modular components of phagocytosis. J. Leuk. Biol. 66:712-717.

14. Greenberg, S. (1999). Fc receptors and phagocytosis. In Advances In Cell and Molecular Biology of Membranes And Organelles--Phagocytosis and Pathogens. Alan Tartakoff, editor (JAI Press:Greenwich). pp. 149-191.

15. Lee, D.J., Li, J., Cox, D., and Greenberg, S. (2000). Rac1 and Cdc42 are required for phagocytosis, but not NF-kB-dependent gene expression, in macrophages challenged with Pseudomonas aeruginosa. J. Biol. Chem. 275:141-146.

16. Bhattacharya, S., Ying, X., Fu, C-Z., Patel, R., Kuebler, W., Greenberg, S., and Bhattacharya, J. (2000) The alphavß3 integrin induces tyrosine phosphorylation-dependent Ca2+ influx in pulmonary endothelial cells. Circ. Res. 86:456-462.

17. Cox, D., Lee, D.J., Dale, B.M., Calafat, J., and Greenberg, S. (2000). A Rab 11-containing rapidly recycling compartment in macrophages that promotes phagocytosis. Proc. Natl. Acad. Sci., U.S.A. 97:680-685.

18. Cox, D., Dale, B.M., Kashiwada, M., Helgason, C.D., and Greenberg, S. (2001). A Regulatory Role for SH2 Domain-containing Inositol 5' Phosphatase (SHIP) in Phagocytosis Mediated by Fcg Receptors and Complement Receptor 3 (_M₂; CD11b/CD18). J. Exp. Med. 193:61-71.

19. Sakr, S.W., Eddy, R.J., Barth, H., Greenberg, S., Maxfield, F.R., and Tabas, I. (2001). The uptake and degradation of matrix-bound lipoproteins by macrophages requires an intact actin cytoskeleton,
Rho family GTPases, and myosin ATPase activity. J. Biol. Chem. 276:37649-37658.

20. Cox, D. and Greenberg, S. (2001). Phagocytic signaling strategies: Fcgreceptor-mediated phagocytosis as a model system. Sem. Immunol. 13:339-345.

21. Cox, D., Berg, J.S., Cammer, M., Chinegwundoh, J.O., Dale, B.M., Cheney, R.E., and Greenberg, S. (2002). Myosin-X is a downstream effector of PI 3-kinase during phagocytosis. Nature Cell Biol. 4:469-477. [see News and Views]

22. Greenberg, S. and Grinstein, S. (2002). Phagocytosis and innate immunity. Curr. Opin. Immunol. 14:136-145.

23. Saba, S., Soong, G., Rush, W., Rastogi, D., Greenberg, S., and Prince, A. (2002). Bacterial stimulation of epithelial G-CSF and GM-CSF expression promotes polymorphonuclear leukocyte survival in cystic fibrosis airways. Am. J. Respir. Cell Mol. Biol. 27:561-567.

24. Patel, M. Morrow, J. Maxfield, F.R., Strickland, D.K., Greenberg, S., and Tabas, I. (2003). The cytoplasmic domain of LDL receptor-related protein, but not that of the LDL receptor, triggers phagocytosis. J. Biol. Chem. 278:44799-44807.

25. Vakevainen, M., Greenberg, S., and Hansen, E.J. (2003). Inhibition of phagocytosis by Haemophilus ducreyi requires expression of the LspA1 and LspA2 proteins. Infect. Immun. 71:5994-6000.

26. Greenberg, S. (2004) Phagocytosis and Immunity. In Molecular Mechanisms of Phagocytosis. Carlos Rosales, editor. (Landes Bioscience: Georgetown). Invited review.