Division of Pulmonary, Allergy and Critical Care Medicine

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Address:

Columbia University,

College of Physicians & Surgeons
630 West 168th Street
P&S 8-425
New York, NY 10032

Phone: (212) 342-6853

phf2103@columbia.edu

Phillip Factor, D.O.

Associate Professor of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine

Director of Medical Critical Care Services

Research Interests

Dr. Factor's work centers on the molecular mechanisms responsible for pulmonary edema clearance. These studies are focused on understanding the how ion transport proteins in the alveolar epithelium are regulated and how they are affected by acute lung injury. In particular Dr. Factor is interested in how the ß2-adrenergic receptor interacts with key epithelial solute transport proteins and how this membrane bound receptor is regulated in lung epithelial cells.

Dr. Factor is also pursuing studies into how ß2-adrenergic receptors in bronchial epithelial cells interact with airway smooth muscle cells to cause bronchodilation. Included in Dr. Factor’s studies is the development of novel gene transfer strategies to increase the lung’s ability to clear pulmonary edema in the setting of acute lung injury and to attenuate airway reactivity. The goals are being approached through the use of adenoviral gene transfer for purposes of augmenting the function of ß2-adrenergic receptors and Na,K-ATPases in lung epithelial cells.

Clinical Interests

Dr. Factor’s clinical research interests include the treatment of acute lung injury and prevention of complications of mechanical ventilation.

Education

A.B., Indiana University, Chemistry, 1980
D.O., Chicago College of Osteopathic Medicine, 1985
Residency, Michael Reese Hospital and Medical Center, 1985-1988
Chief Residency, Michael Reese Hospital and Medical Center, 1988-1989
Fellowship, Pulmonary and Critical Care Medicine, University of Chicago, 1989-1992
Fellowship, Pulmonary, Pulmonary Branch, National Heart Lung and Blood Institute, National Institutes of Health, 1992-1993

Honors

American Heart Association Established Investigator Award (1999)
American Thoracic Society J. Livingston Trudeau Research Scholar Award (2000)

Publications

1. Sznajder, J.I., A. Fraiman, J.B. Hall, W. Sanders, G. Schmidt, G. Crawford, A. Nahum, P. Factor, and L.D.H. Wood. Increased hydrogen peroxide in the expiratory breath of patients with acute hypoxemic respiratory failure. Chest 96:606-12 1989.
2. Factor, P. and J.I. Sznajder. Intravascular cannulation. In: Wood, L.D.H., Hall, J.B., Schmidt, G. eds. Principles of Critical Care Medicine, J.B. Lipincott, Phildelphia, Pa. 1991.
3. Factor, P. Cardiovascular surgery. In: Wood, L.D.H., Hall, J.B., Schmidt, G. eds. Principles of Critical Care Medicine: Companion text, J.B. Lipincott, Phildelphia, Pa. 1993.
4. Factor, P. Intravascular cannulation. In: Wood, L.D.H., Hall, J.B., Schmidt, G. eds. Principles of Critical Care Medicine: Companion text, J.B. Lipincott, Phildelphia, Pa. 1993.
5. Factor, P. Oncologic emergencies. In: Wood, L.D.H., Hall, J.B., Schmidt, G. eds. Principles of Critical Care Medicine: Companion text, J.B. Lipincott, Phildelphia, Pa. 1993.
6. Naureckas, T., P. Factor, O. Benjaminov, E. Hoffer, V. Sriram, and J.I. Sznajder. Pentoxyfilline does not protect against hyperoxic lung injury in rats. Eur Respir J. 7:1397-1402, 1994.
7. Factor, P., D. Ciccolella, and J.I. Sznajder. Fluid balance and renal function in ARDS. In: Haslett, C., Evans, T. Eds. Adult Respiratory Distress Syndrome, Chapman and Hall, London, England, 1996.
8. Christan, J., and P. Factor. Respiratory physiology and pathophysiology. In: Weinberg, G., ed. Anesthesiology, A Scientific Approach. New York, 1996.
9. Ridge, K., D. Rutschman, P. Factor, A.I. Katz, A.M. Berterello, and J.I. Sznajder. Differential expression of Na,K-ATPase isoforms in cultured rat alveolar epithelial cells. Am J Physiol 273:L246-255, 1997.
10. Ridge, K., W. Olivera, D.H. Rutschman, R.W. Mercer, B. Uhal, S. Horowitz, F. Hughes, P. Factor, M.L. Barnard, and J.I. Sznajder. Alpha-2 Na,K-ATPase contributes to lung liquid clearance. Ann NY Acad Sci. 834:651-652, 1997.
11. Factor, P., C. Senne, K. Ridge, H.A. Jaffe, G. Blanco, R.W. Mercer, and J.I. Sznajder. Effects of adenoviral mediated transfer of Na,K-ATPase subunit genes to alveolar epithelial cells. Ann NY Acad Sci. 834:104-107, 1997.
12. Factor, P., C. Senne, K. Ridge, H.A. Jaffe, and J.I. Sznajder. Differential effects of adenoviral mediated transfer of Na,K-ATPase subunit genes in lung epithelial cells. Chest 111:110S-111S, 1997.
13. Sznajder, J.I., P. Factor, and A. Zucker. Acute lung injury. In: Garrard, C., Foex, P., Westaby, S., eds. Principles and Practice of Critical Care. Blackwell Scientific, London, 1997.
14. Ridge, K., W. Olivera, S. Horowitz, D. Rutschman, P. Factor, and J.I. Sznajder. Role of the Na,K-ATPase ß2 subunit in lung liquid clearance. In: Matalon, S., and Sznajder. J.I., eds. Acute Respiratory Distress Syndrome: Cellular and Molecular Mechanisms and Clinical Management. Plenum, NY. 1998.
15. Factor, P. Gene therapy for the acute respiratory distress syndrome. In: Matalon, S., and Sznajder. J.I., eds. Acute Respiratory Distress Syndrome: Cellular and Molecular Mechanisms and Clinical Management. Plenum, NY, pp. 69-72, 1998.
16. Factor, P., C. Senne, K. Ridge, H.A. Jaffe, B. Uhal, Z. Gao, and J.I. Sznajder. Overexpression of the Na,K-ATPase a1 subunit increases Na,K-ATPase function in A549 cells. Am. J. Resp. Cell Mol. Biol. 18:741-749, 1998.
17. Factor, P., K. Ridge, H.A. Jaffe, C. Senne, M. Barnard, R. Mercer, R. Perrin, G. Blanco, and J.I. Sznajder. Augmentation of lung liquid clearance via adenovirus-mediated gene transfer of the Na,K-ATPase ß1 subunit. J. Clin. Invest. 102:1421-1430, 1998.
18. Brochard, L., F. Roudot-Thoraval, E. Roupie, C. Delclaux, J. Chastre, E. Fernandez-Mondejar, E. Clementi, J. Mancebo, P. Factor, D. Matamis, M. Ranieri, L. Blanch, G. Rodi, H. Mentec, D. Dreyfus, A. Torres, C. Brun-Buisson, M. Tobin, F. Lemaire, and the multicenter trial group on tidal volume reduction. Tidal volume reduction for the prevention of ventilator-induced lung injury in the adult respiratory distress syndrome. Am. J. Resp. Crit. Care Med. 158:1831-8, 1998.
19. Factor, P., V. Dumasius, F. Saldias and J.I. Sznajder. Adenoviral-mediated overexpression of the Na,K-ATPase ß1 subunit gene increases lung edema clearance and improves survival from acute hyperoxic lung injury. Chest 116:S24-25, 1999.
20. Factor, P. Vascular Cannulation. In: Wood, L.D.H., Hall, J.B., Schmidt, G. eds. Principles of Critical Care Medicine: Companion text, 2e, J.B. Lipincott, Philadelphia, pp. 21-37. 1999.
21. Factor, P. Overexpression of transport genes: Methods for studying and modulating alveolar solute movement. In: P. Byron, ed. Respiratory drug delivery 7. Serentec Press. Raleigh, pp. 25-32, 2000.
22. Factor, P. In consultation: mechanical ventilation of patients with ARDS and obstructive lung disease. J. Crit. Ill. 14:422, 1999.
23. Mutlu, G. and P. Factor. Complications of mechanical ventilation. Resp Care Clin North Amer. 6:213-252, 2000.
24. Factor, P., V. Dumasius, F. Saldias, L.S. Brown, and J.I. Sznajder. Adenoviral-mediated transfer of a Na,K-ATPase ß1 subunit gene improves alveolar fluid clearance and survival in hyperoxic rats. Hum Gene Ther. 26:2231-2242, 2000.
25. Factor, P., K. Ridge, J. Alverdy, and J.I. Sznajder. Continuous enteral nutrition attenuates pulmonary edema in hyperoxic rats. J Appl Phys. 89:1759-65, 2000.
26. Factor, P. The role and regulation of Na,K-ATPase in the lung. Cell Mol Biol. 47:348-361, 2001.
27. Mutlu, G., E.A. Mutlu, and P. Factor. Gastrointestinal complications of mechanical ventilation. Chest. 119:1222-41, 2001.
28. Factor, P. Gene therapy for acute diseases. Mol Ther. 4:515-524, 2001.
29. Thome, U., L. Chen, P. Factor, J.I. Sznajder, V. Dumasius, B. Freeman and S. Matalon. Mitigation of oxidant injury to active sodium transport in rat fetal ATII cells by Na,K-ATPase gene transfer. Am J Resp Cell Mol Biol. 24:245-252, 2001.
30. Factor, P., and J.I. Sznajder. Gene therapy for acute lung injury. In: Matalon, S., and Sznajder. J.I., eds. Etiology and Treatment of Acute Lung Injury: From Bench to Bedside. IOS Press BV, Amsterdam, pp. 93-102, 2001.
31. Dumasius, V., J.I. Sznajder, Z. Azzam, J. Boja, G. Mutlu, M. Maron, and Factor, P. ß2-adrenergic receptor overexpression increases alveolar fluid clearance and responsiveness to endogenous catecholamines in rats. Circ Res. 89:907-914, 2001.
32. Factor, P. and H. Lum. Maintenance of alveolar epithelial and endothelial function via gene transfer. In: Factor, P. ed. Gene Therapy for Acute and Acquired Conditions. Kluwer Academic Publishers. Norwell, MA. 2001.
33. Mutlu, G.M., and P. Factor. Acute onset quadriplegia, respiratory failure and ventricular tachycardia in a 21 year-old man following a soccer match. Chest. 121:2036-2039, 2002.
34. Mutlu, G.M., E.A. Mutlu, and P. Factor. Mechanical ventilation induced complications of the gastrointestinal system. NVIC Mon, 6:9-17, 2002.
35. Factor, P., Z. Azzam, J.I. Sznajder, and V. Dumasius. Enhancement of alveolar epithelial ß2-adrenergic receptor function via gene transfer. Chest. 121:45S-46S, 2002.
36. Dumasius, V., M. Mendez, G. Mutlu, and P. Factor. Acute lung injury does not impair adenoviral-mediated gene transfer to the alveolar epithelium. Chest. 121:33S-34S, 2002.
37. Sznajder, J.I., Factor, P., and D. Ingbar. Lung edema clearance: Role of Na,K-ATPase. J. Appl Physiol. 93:1860-6, 2002.
38. Mutlu, G.M. and P. Factor. In consultation: Gastrointestinal complications associated with mechanical ventilation. J. Crit. Ill., In press 2002.
39. Mutlu, G.M., E.A. Mutlu, and P. Factor. Prevention and Treatment of Gastrointestinal Complications in Patients on Mechanical Ventilation. Am J Resp Med., In press 2002.
40. Factor, P., Y. Adir, G.M. Mutlu, J. Burhop, and V. Dumasius. Effects of ß2-adrenergic receptor overexpression on alveolar epithelial active transport. J Allergy Clin Immunol. 110:S242-6, 2002.
41. Factor, P., M. Mendez, and V. Dumasius. Acute hyperoxic lung injury does not impede adenoviral-mediated alveolar gene transfer. Am J Resp Crit Care Med. 165:521-526, 2002.
42. Azzam, Z., V. Dumasius, F. Saldias, Y. Adir, J.I. Sznajder, and P. Factor. Na,K-ATPase overexpression improves alveolar fluid clearance in a rat model of elevated left atrial pressure. Circulation. 105:497-501, 2002.
43. Mutlu, G.M., P. Factor, D.E. Schwartz, and J.I. Sznajder. Severe status asthmaticus: Management with permissive hypercapnia and inhalation anesthesia. Crit Care Med. 30:477-480, 2002.
44. Mutlu, G.M., Oh, K., and P. Factor. An unresponsive biochemistry professor in the bathtub. Chest, 122:1073-6, 2002.
45. Weiss, D.J., G. Multu, L. Bonneau, M. Mendez, Y. Wang, V. Dumasius, and P. Factor. Comparison of surfactant and perflurocarbon liquid enhanced adenovirus mediated gene transfer in normal rat lung. Mol Ther, 6:43-49, 2002.
46. Dumasius, V., M. Jameel, J. Burhop, F.J. Meng, L.C. Welch, G.M. Mutlu, and P. Factor. In vivo timing of onset of transgene expression following adenoviral-mediated gene transfer. Virology, 308:243-249, 2003.
47. Ridge K.M., W. Olivera, F. Saldias, Z. Azzam, S. Horowitz, D.H. Rutschman, P. Factor, and J.I. Sznajder. Localization and role of Na,K-ATPase ß2 isoform in rat alveolar epithelium. Circ. Res., 92:453-60, 2003.
48. Richard, J.C., Z. Zhou, D.E. Pond, C.S. Dence, P. Factor, P.N. Reynolds, G. D. Luker, V. Sharma, T. Ferkol, D. Piwnica-Worms, and D.P. Schuster. Imaging pulmonary gene expression with positron emission tomography (PET). Am J Resp Crit Care Med., 167:1257-63, 2003.
49. Mutlu GM, Factor P, Schwartz D, Sznajder JI. Ventilating asthmatics using intensive care ventilators. Crit Care Med. 31:665-6, 2003.
50. Factor, P. Gene therapy for asthma. Mol Ther., 7:148-52, 2003.

51. Richard, J.C, P. Factor, L. Welch, and D.P. Schuster. Imaging the spatial distribution of transgene expression in the lungs with positron emission tomography. Gene Ther., 10:2074-80, 2003.

52. Adir, Y., Z.S. Azzam, E. Lecuona, S. Leal, L. Pesce, V. Dumasius, A.M. Bertorello, P. Factor, J.B. Young, K.M. Ridge and J.I. Sznajder. Augmentation of endogenous dopamine production increases Na,K-ATPase and lung liquid clearance. Am J Resp Crit Care Med, 169:757-63 2004.

53. Richard JC, Z. Zhou, D.L. Chen, M.A. Mintun, D. Piwnica-Worms, P. Factor, D.E. Ponde, and D.P. Schuster. Quantitation of pulmonary gene expression with PET imaging. J Nucl Med. 45:644-54, 2004.

54. Mutlu, G.M., V. Dumasius, J. Burhop, P.J. McShane, F.J. Meng, L. Welch, A. Dumasius, N. Mohebahmadi, K. Hardiman, S. Matalon, S. Hollenberg, and P. Factor. Upregulation of alveolar epithelial active Na⁺ transport is dependent on ß₂-adrenergic receptor signaling. Circ Res., 94:1091-1100, 2004.

55. Mutlu, G.M., T. Kuzniar, and P. Factor. A 41-year-old man with altered mental status and acute flaccid paralysis. Chest, In press 2005.

56. Swystun, V., L. Chen, P. Factor, B. Siroky, P.D. Bell, and S. Matalon. Apical trypsin increases ion transport and resistance by a phospholipase C dependent rise of Ca²⁺. Am J Phys Lung Cell Mol Physio. In press, 2005.

57. Mutlu, M. and P. Factor. Pulmonary Tumor Embolism of Unknown Origin. Mayo Clin Proceed. In press, 2005.

58. Mutlu, G.M. and P. Factor. Vasopressin for the management of septic shock. Int Care Med., 30:1276-91, 2004.

59. Factor, P., A. Akhmedov, and G.M. Mutlu. Potential genetic therapies for acute lung injury. Cur Gene Ther. 4:487-95, 2004.

60. Mutlu, G.M, W.J. Koch, and P. Factor. Alveolar epithelial ß₂-adrenergic receptors: Their role in regulation of alveolar active Na⁺ transport. Am J Resp Crit Care Med. 170:1270-5, 2004.

Books Edited
Gene Therapy for Acute and Acquired Diseases. Factor, P. ed. Kluwer Academic Publishers. Boston, MA. 2001.