Division of Pulmonary, Allergy
and Critical Care Medicine
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Address: College of Physicians &
Surgeons
Affiliations: |
Jeannine D'Armiento,
M.D., Ph.D. Assistant Professor of Medicine, Division
of Pulmonary, Allergy and Critical Care Medicine Research Summary The research in our
laboratory centers on several projects directed at understanding the role of
matrix metalloproteinases in tissue destruction
during certain disease processes. Our laboratory has made use of transgenic
mice in which to express these enzymes at pathophysiological
levels in specific tissues so as to recreate the natural proteolytic
imbalance that occurs during a disease process. Through the generation of
these transgenic animals we have been able to develop several mouse models of
emphysema, atherosclerosis and heart failure and also gain insight into the
role these enzymes may be playing in the pathogenesis of these diseases. Education and Training BA, Rutgers University, 1995 Honors Henry Rutgers Honors, 1985 Publications 1. Berg, R.A., Capodici, C., and D’Armiento, J. (1989). Collagenase Activation. In Therapeutic Approaches to
Inflammatory Diseases, Lewis, A., Doherty, N. and Ackerman, N. Elsevier
Science Publishing Co. 2. Buttice,
G., Kaytes, P., D’Armiento, J., Bogeli, G., and Kurkinen, M.
(1990). Evolution of Collagen IV Genes From a 54-Base Pair Exon: A Role for Introns in
Gene Evolution. J. Mol. Evol., 30:479-488. 3. D’Armiento, J.,
Dalal, S., Okada, Y., Berg, R. A., and Chada, K.
(1992). Collagenase Expression in the Lungs of
Transgenic Mice Causes Pulmonary Emphysema. Cell, 71:955-961. 4. D'Armiento, J.
and Chada, K. (1995). Frontiers in Transgenics. Trends
in Pharmacology 19:26-28. 5. D'Armiento, J.,
DiColandrea, T., Dalal,
S., Okada, Y. and Chada, K. (1995). Transgenic Overexpression
of Collagenase in Mouse Skin Increases the
Susceptibility to Tumorigenesis. Mol. Cell. Biol.,
15:5732-5739. 6. Cherath,
L., Tkachenko, A., D'Armiento, J., Welsh,
J., McClelland, M., and Chada, K. (1996). RNA Fingerprinting by
Arbitrarily-Primed PCR. In: Laboratory Guide to RNA: Isolation, Analysis and
Synthesis. Ed. Paul Kreig. Wiley-Liss Inc., N.Y.; pp..251-271. 7. D'Armiento, J.,
Dalal, S., and Chada, K. (1997). Tissue Expression
of Haptoglobin. Gene 195:19-27 8. Jiang, X., D’Armiento, J.,
Mallampalli, R. K., Mar, J., Yan,
S-F., and Lin, M. (1998). Expression of plasma phospholipid
transfer protein mRNA in normal and emphysematous lungs and regulation by
hypoxia. J. Biol. Chem, 273:15714-15718. 9. DiColandrea,
T., Wang, L., Wille, J., D’Armiento, J.
and Chada, K. (1998) Epidermal expression of callgenase
delays wound-healing in transgenic mice. J. Invest. Dermatol.
111:1029-103. 10. Lemaitre, V., O’Byrne,
T.K., Dalal, S.S., Tall, A.R. and D’Armiento, J.
(1999) Macrophage-Specific Expression of Human Collagenase
(MMP-1) in Transgenic Mice. Annals 11. DiColandrea,
T., D’Armiento,
J., Kesari, K.V., and Chada, K.
(2000) Collagenase Induction Promotes Mouse Tumorigenesis via Two Independent Pathways. Molecular
Carcinogenesis 29:8-16. 12. Kim, H., Dalal., S.S., Young, E., Legado,M.,
Weisfeldt, M.L., and D’Armiento, J.
(2000) Disruption of the cardiac matrix leads to altered myocardial function
in transgenic mice expressing collagenase (MMP-1)
in the heart. J. Clin. Invest. 106:857-866. 13. Dalal,
S., Chen, E.S., 14. Lemaitre, V., O’Byrne,
T.K., Okada, Y., Borczuk, A. C., Tall, A.R. and D’Armiento, J
(2001) Apo E knock-out mice expressing human interstitial collagenase
(MMP-1) in macrophages have less advanced atherosclerosis. J. Clin. Invest. 107:1227-1234. 15. Foronjy,
B. and D’Armiento,
J. (2001) The role of collagenase
in emphysema. Respiratory Review. 2:348-352. 16. Schluger, N. W. and D’Armiento, J.
(2002) The Pathogenesis and Pathophysiology of
Emphysema. In:Lung Volume
Reduction Surgery Ed. M Argenziano and M. Ginsburg
Humana Press, Totowa, N.J; pp.3-15. 17. Arbiser,
J.L., Brat, D., Hunter, S., D’Armiento, J., Henske, E.P., Arbiser, Z.K., Bai, X., Goldberg, G., Cohen, C., and Weiss, S.W. (2002)
Tuberous Sclerosis-Associated Lesions of the Kidney, Brain, and Skin are Angiogenic Neoplasms J. Am.
Acad. Dermatol. 46:376-80. 18. D’Armiento, J.
(2002) Matrix Metalloproteinase Disruption of the Extracellular
Matrix and Cardiac Dysfunction. Trends in Cardiovascular Medicine 12:97-101. 19. Marx, S., Kurokawa, J., Reiken, S., Motoike, H., D’Armiento, J., Marks, A.R.,
Kass, R.S. (2002) Requirement of a Macromolecular Signaling Complex for b
Adrenergic Receptor Modulation of the KCNQ1-KCNE1 Potassium Channel Science
295:466-9. 20. Reiken,
S., Gaburjakova, M., Guatimosim,
S., Gomez, A.M., D'Armiento, J., Burkhoff,
D., Wang, J., Vassort, G., Lederer, W. J., and
Marks, A.. (2003) PKA phosphorylation
of the cardiac calcium release channel in normal and failing hearts: role of phosphatases and response to isoproterenol.
J. Biol. Chem. 278:444-53.. 21. Shiomi,
T., Okada, Y., Foronjy, B., Schiltz,
J., Jaenish, R., and D'Armiento, J.
(2003). Emphysematous changes are caused by degradation of type III collagen
in transgenic mice overexpressing tissue collagenase. Exp. Lung Res. 29:1-15. 22. Lemaitre, V., Soloway, P.D., and D’Amiento, J.
(2003) Increased medial Degradation with Pseudo-aneurysm Formation in ApoE Knockout Mice deficient in Tissue Inhibitor of
Metalloproteinases-1. Circulation.107:333-338. 23. Foronjy,
R. F., Okada, Y., Cole, R., and D’Armiento, J. (2003) Progressive
Adult-Onset Emphysema in Transgenic Mice Expressing Human MMP-1 in the Lung.
In Press Am. J. Physiology |
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