Genetics: Unlocking Medicine’s Potential ANNUAL REPORT | 2006
Columbia University College of Physicans & Surgeons

The potential of genetic medicine is far-reaching, but much work lies ahead to use the human genome as a base for personalized medicine. Work at Columbia is illustrated in this report by three compelling pursuits: seeking the unknown, unlocking the potential, and translating the knowledge. The image on the cover is a fluorescent sequencing chip image from innovative DNA sequencing technology invented by Professor Jingyue Ju, Ph.D., Head of DNA Sequencing and Chemical Biology at the Judith P. Sulzberger, M.D., Columbia Genome Center. This new technology will have the potential of deciphering an entire human genome for just $1,000.

Human DNA has about 22,000 genes.
These genes code for about 400,000 proteins.
3 billion chemical base pairs make up human DNA.
Columbia received nearly $50 million of the $235 million in grants awarded by the
NIH for Roadmap projects in 2005.
The Irving Cancer Research Center has 120,000 square feet of research space
on nine floors.
The FASTER Trial (First and Second Trimester Evaluation of Risk) involved some
38,000 women at 15 centers nationwide and found that a new prenatal
screening method is 87% accurate in detecting Down syndrome in the first trimester.

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Clyde Y.C. Wu, M.D., Chairman
Stephen H. Case
Patricia M. Cloherty
Kenneth Forde, M.D.
Marilyn Laurie
Michael B. Rothfeld
Savio Tung
Faye Wattleton

Eugene Braunwald, M.D.
Paul Brown, M.D.
Gail Cassell, Ph.D.
Thomas J. Connolly, D.D.S.
Richard Elias, M.D.
Loren Eng
Daniel Federman, M.D.
Michael Jaharis
Paul Marks, M.D.
Allen Mebane
Philip Milstein
Joseph M. Murphy
William Peck, M.D.
Cecil B. Pickett, Ph.D.
John W. Rowe, M.D.
G. Lynn Shostack
Richard Silverman
Dinakar Singh
Judith P. Sulzberger, M.D.
Miranda Tang
Leonard C. Tow, Ph.D.
Savio Tung
P. Roy Vagelos, M.D.
Torsten Wiesel, M.D.
Clyde Wu, M.D.

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Roger Barnett
Jeremiah A. Barondess, M.D.
Page Morton Black
Charles Brunie
Joan O. Camins
Bryan J. Carey
John K. Castle, Chairman
Thomas L. Chrystie
Maureen A. Cogan
Rhoda Cohen
Ron Cohen, M.D.
Stephen Cohen, M.D.
Sue Dalsemer
James J. Daly
Robert K. Dresing
Abigail Black Elbaum
Richard Elias, M.D.
Loren Eng
Gloria Farber, Ed.D.
Phyllis R. Farley
Mark Fisch
Susan Fuirst
Oscar Garfein, M.D.
Louis Gary
Philip Goelet, Ph.D.
Sandra O. Gold, Ed.D.
Ernest Haas
Daniel Hauser, Ph.D.
Helen S. Hintz
Abi Aboodi Hoffman
Herbert Irving
Ellen Jewett
Barbara Jonas
Vera Joseph, M.D.
Pasty Kahn
Cindie Kastenbaum
Henry L. King
E. Peter Krulewitch
Eugene M. Lang
Burton J. Lee III, M.D.
Deanna Levine
Constance Lieber
Ethel Lipsitz
Hildegarde Mahoney
Phyllis Mailman
John H. Manice
Paul A. Marks, M.D.
Ariane M.H. Matschullat
William F. May
Guri McKinnell
Allen Mebane
Constance Milstein
Shelby Modell
JoAnn M. Murphy
Joseph M. Murphy
Fred F. Nazem
Patricia Papper
Gordon Pattee
Ponchitta Pierce
John Pinto
Irene Pollin
Stuart Rabin
Richard S. Rivlin, M.D.
Elaine Samson
Joan Schneeweiss
Mark Schwartz
Steven Segal
G. Lynn Shostack
Ruth Siegel
Wilma Bulkin Siegel, M.D.
John Stafford
Judith Sulzberger, M.D.
Suzanne Sunshine
Doris Tananbaum
Jeff C. Tarr
Vincent Tese
John Tognino
Doris F. Tulcin
Gerard Turino, M.D.
Kathleen Walas
Audrey Weiderlight, Ph.D.
Dayna J. Wilkinson
Joseph Williams
Ruth Wooden
Clyde Y. Wu, M.D.

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Lee C. Bollinger, J.D.
President of the University

Alan Brinkley, Ph.D.
Provost of the University and Dean of the Faculties

Lee Goldman, M.D.
Executive Vice President for Health and Biomedical Sciences and Dean of the Faculties of Health Sciences and Medicine

David Hirsh, Ph.D.
Executive Vice President for Research

Ira B. Lamster, D.D.S., M.M.Sc.
Dean, College of Dental Medicine

Allan Rosenfield, M.D.
Dean, Mailman School of Public Health

Mary O’Neil Mundinger, Dr.P.H., R.N.
Dean, School of Nursing

Thomas Jackiewicz, M.P.H.
Chief Operating Officer

Joanne Quan, M.A.
Chief Financial Officer

Susan S. Stalcup, B.A., CFP
Vice President for Development

Marilyn L. Castaldi, M.B.A.
Chief Communications Officer

Ross Frommer, J.D.
Deputy Vice President for Government and Community Affairs

Robert Lemieux, B.A., M.S.
Deputy Vice President for Facilities Management

Patricia Sachs Catapano, J.D.
Associate General Counsel

Allan Formicola, D.D.S.
Vice Dean of the Center for Community Health Partnerships

P. Paul Alexander, M.P.A.
Associate Vice President for Human Resources

Kathleen Crowley, M.P.H.
Associate Vice President, Environmental Health and Safety/Environmental Health and Radiation Safety

Jeffrey Davis, J.D.
Associate Vice President for HIPAA Compliance/Privacy Officer

Patricia Molholt, Ph.D.
Associate Vice President and Associate Dean for Scholarly Resources

Frank Moore, Ph.D.
Associate Vice President for Information Resources

Renee Riley, M.S.
Associate Vice President for Residence Halls, University Housing

Jeffrey A. Szmulewicz, M.A.
Associate Vice President for Biomedical Communications

Diane Lloyd Yaeger, J.D.
Associate Vice President and Chief Compliance Officer

Bonita Eaton Enochs, M.A.
Assistant Vice President for External Relations & Director of Publications

Michelle Gelber, B.A.
Assistant Vice President, Development

Jeannine Jennette, M.P.A.
Associate Director for Public Safety

Anne Jacobs McWilliams, M.A.
Assistant Vice President, Biomedical Communications

Jean Ford Keane, B.A.
Assistant Vice President, Development

William D. Marchand
Assistant Vice President for Facilities Management

Robin Rosenbluth, B.A.
Assistant Vice President, Development

Ann Viney, B.A.
Assistant Vice President, Development

George Gasparis, B.S.
Executive Director, Institutional Review Board

College of Physicians & Surgeons
Lee Goldman, M.D., Dean

Steven Shea, M.D.
Vice Dean of the Faculty of Medicine and Senior Associate Dean for Clinical Affairs

Marian Carlson, Ph.D.
Vice Dean for Research

Ronald E. Drusin, M.D.
Senior Associate Dean for Education (Interim)

Richard U. Levine, M.D.
President, Faculty Practice Organization

Michael Duncan, B.S.
Executive Director, Faculty Practice Organization

John T. Herbert, M.D., M.B.A.
Senior Associate Dean, Harlem Hospital Center

Robert Lewy, M.D.
Senior Associate Dean for Faculty Affairs and Health and Safety

Lisa Mellman, M.D.
Senior Associate Dean for Student Affairs

Jeanine D’Armiento, M.D., Ph.D.
Associate Dean for Gender Equity and Career Development

Walter Franck, M.D.
Associate Dean, Bassett Healthcare

Andrew Frantz, M.D.
Associate Dean for Admissions

Ernest Hart, J.D.
Chief Administrative Officer, Harlem Hospital Center

Michael Herman, M.D.
Associate Dean, St. Vincent’s Hospital in Bridgeport

Hilda Y. Hutcherson, M.D.
Associate Dean for Diversity and Minority Affairs

Anke Nolting, Ph.D.
Associate Dean for Alumni Relations and Development

Noel Robin, M.D.
Associate Dean, Stamford Health System

Richard B. Robinson, Ph.D.
Associate Dean for Graduate Affairs

William Rosner, M.D.
Associate Dean, St. Luke’s-Roosevelt Hospital Center

Fred Loweff, M.P.A.
Assistant Dean for Graduate Affairs

Thomas Garrett, M.D.
Director, Glenda Garvey Teaching Academy

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Asa Abeliovich, M.D., Ph.D.
Assistant Professor of Pathology and Neurology

Barbara Barlow, M.D.
Professor of Surgery

Julia Glade Bender, M.D.
Assistant Professor of Clinical Pediatrics

Timothy Bestor, Ph.D.
Professor of Genetics and Development

Gary Brittenham, M.D.
Professor of Pediatrics and Medicine

Lucian Del Priore, M.D., Ph.D.
Associate Professor of Ophthalmology

George Hripcsak, M.D.
Professor and Vice Chairman of Biomedical Informatics

James McKiernan, M.D.
Assistant Professor of Urology

Richard Polin, M.D.
Professor of Pediatrics

Michael Shelanski, M.D., Ph.D.
Frances E. Delafield Professor and Chairman of Pathology

B. Timothy Walsh, M.D.
Ruane Professor of Psychiatry

Anesthesiology
Margaret Wood, M.D.

Biochemistry & Molecular Biophysics
Arthur G. Palmer, Ph.D. (interim)

Biomedical Informatics
Edward Shortliffe, M.D., Ph.D.

Dermatology
David R. Bickers, M.D.

Genetics & Development
Gerard Karsenty, M.D., Ph.D.

Medicine
David Brenner, M.D.

Microbiology
Aaron Mitchell, Ph.D. (interim)

Neurological Surgery
Robert A. Solomon, M.D.

Neurology
Timothy Pedley, M.D.

Neuroscience
John Koester, Ph.D. (interim)

Obstetrics & Gynecology
Mary E. D’Alton, M.D.

Ophthalmology
Stanley Chang, M.D.

Orthopedic Surgery
Louis U. Bigliani, M.D.

Otolaryngology/Head & Neck Surgery
Lanny Garth Close, M.D.

Pathology
Michael Shelanski, M.D., Ph.D.

Pediatrics
John M. Driscoll, M.D.

Pharmacology
Robert S. Kass, Ph.D.

Physiology & Cellular Biophysics
Andrew Marks, M.D.

Psychiatry
Jeffrey Lieberman, M.D.

Radiation Oncology
Philip O. Alderson, M.D. (interim)

Radiology
Philip O. Alderson, M.D.

Rehabilitation Medicine
Nancy E. Strauss, M.D. (interim)

Surgery
Eric Rose, M.D.

Urology
Mitchell Benson, M.D.

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Arteriosclerosis Research Center
Alan Tall, M.D.

Naomi Berrie Diabetes Center
Robin S. Goland, M.D.
Rudolph L. Leibel, M.D.

Center for Bioethics
Ruth L. Fischbach, Ph.D., M.P.E.

Center for Computational Biology and Bioinformatics (C2B2)
Andrea Califano, Ph.D.
Barry Honig, Ph.D.

Center for Emergency Medicine
James Giglio, M.D.

Center for Family Medicine
Kathleen Klink, M.D.

Center for Human Genetics
Angela Christiano, Ph.D.

Center for Molecular Recognition
Arthur Karlin, Ph.D.

Center for Neuroscience Initiatives
Sarah Caddick, Ph.D.

Center for Radiological Research
Eric J. Hall, D.Phil., D.Sc.

Center for the Study of Society and Medicine
David J. Rothman, Ph.D.

Center for Theoretical Neuroscience
Laurence Abbott, Ph.D.
Kenneth Miller, Ph.D.

Center on Medicine as a Profession
David J. Rothman, Ph.D.

Columbia-Rockefeller Center for AIDS Research
Scott Hammer, M.D.

Columbia University Immunology Center
Kathryn Calame, Ph.D.

Diabetes and Endocrinology Research Center
Domenico Accili, M.D.
Rudolph L. Leibel, M.D.

Institute for Cancer Genetics
Riccardo Dalla-Favera, M.D.

Institute for Gene Research
Maxwell Gottesman, M.D., Ph.D.

Institute of Comparative Medicine
Thomas Martin, DVM, Ph.D.

Institute of Human Nutrition
Richard J. Deckelbaum, M.D.

International Center for Health Outcomes and Innovation Research (InCHOIR)
Annetine Gelijns, Ph.D.
Alan J. Moskowitz, M.D.

Herbert Irving Comprehensive Cancer Center
Riccardo Dalla-Favera, M.D.

Irving Center for Clinical Research
Henry N. Ginsberg, M.D.

Kavli Institute for Brain Science
Eric Kandel, M.D.

W.M. Keck Center for Cognition and Plasticity
Michael Goldberg, M.D.

Morton A. Kreitchman PET Center
Ronald Van Heertum, M.D.

New York Obesity Research Center (St. Luke’s-Roosevelt)
F. Xavier Pi-Sunyer, M.D., M.P.H.
Rudolph L. Leibel, M.D.

Sackler Institute for Developmental Psychobiology
Myron Hofer, M.D.

Gertrude H. Sergievsky Center
Richard Mayeux, M.D., M.Sc.

Morris W. Stroud III Center for Study of Quality of Life
Barry Gurland, FRC Physicians (London) and FRC Psychiatry

Judith P. Sulzberger, M.D. Columbia Genome Center
James E. Rothman, Ph.D.

Taub Institute for Research on Alzheimer’s Disease and the Aging Brain
Richard Mayeux, M.D., M.Sc.
Michael Shelanski, M.D., Ph.D.

Clyde and Helen Wu Center for Molecular Cardiology
Andrew Marks, M.D.

Center for Motor Neuron Biology and Disease
Darryl De Vivo, M.D.
Christopher Henderson, Ph.D.
Serge Przedborski, M.D., Ph.D.
Lewis Rowland, M.D., Honorary Director

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Anesthesiology
Pain Medicine Center
Michael Weinberger, M.D.

Biomedical Informatics
New York State Center for Advanced Information Management
Edward H. Shortliffe, M.D., Ph.D.

Dermatology
Skin Diseases Research Center
David R. Bickers, M.D.

Medicine
Center for Advanced Cardiac Care
Donna Mancini, M.D.

Center for Women’s Health Research and Education
Elsa-Grace V. Giardina, M.D.

Columbia Center for the Active Life of Minority Elders
Rafael A. Lantigua, M.D.

Toni Stabile Osteoporosis Center
Ethel S. Siris, M.D.

Neurological Surgery
Brain Tumor Center
Steven S. Rosenfeld, M.D., Ph.D.

Center for Movement Disorder Surgery
Blair Ford, M.D.
Robert R. Goodman, M.D., Ph.D.

Neuro-oncology Center
Jeffrey N. Bruce, M.D.

Pediatric Neurosurgery Center
Neil A. Feldstein, M.D.

Spine Center
Paul C. McCormick, M.D.

Neurology
Brain Tumor Center
Steven S. Rosenfeld, M.D., Ph.D.

Center for Movement Disorder Surgery
Blair Ford, M.D.
Robert R. Goodman, M.D., Ph.D.

Center for Parkinson’s Disease and Related Disorders
Stanley Fahn, M.D.

Comprehensive Epilepsy Center
Frank G. Gilliam, M.D., M.P.H.

Doris & Stanley Tananbaum Center for Cerebrovascular Diseases
J.P. Mohr, M.D.

Dystonia Research Center
Stanley Fahn, M.D.

Eleanor and Lou Gehrig MDA/ALS Research Center
Hiroshi Mitsumoto, M.D.
Serge Przedborski, M.D., Ph.D.

Huntington’s Disease Center
Karen S. Marder, M.D.

H. Houston Merritt Center for Neuromuscular Disorders
Salvatore DiMauro, M.D.

Lucy G. Moses Center for Memory and Behavior
Karen S. Marder, M.D.

Spinal Muscular Atrophy Clinical Research Center
Darryl C. De Vivo, M.D.

Obstetrics & Gynecology
Center for Ovarian Cancer Screening
Carmel Cohen, M.D.

Center for Perinatal Research
Ronald Wapner, M.D.

Center for Prenatal Pediatrics
Lynn Simpson, M.D.

Center for Reproductive Sciences
Mary E. D’Alton, M.D.

Multiple Birth Center
Mary E. D’Alton, M.D.

Center for Women’s Reproductive Care
Mark Sauer, M.D.

Center for Pelvic Reconstruction
Jody Blanco, M.D.

Ophthalmology
Louis V. Gerstner Jr. Clinical Research Center in Vision
Stanley Chang, M.D. (Acting)

Orthopedic Surgery
Anne Youle Stein Center for Orthopedic Education and Research
Louis U. Bigliani, M.D.

Center for Hip and Knee Replacement
William B. Macaulay Jr., M.D.

Center for Orthopaedic Research
Francis Y. Lee, M.D., Ph.D.
Theodore A. Blaine, M.D.

Center for Shoulder, Elbow, and Sports Medicine
Louis U. Bigliani, M.D.

Trauma Training Center
Melvin P. Rosenwasser, M.D.

Otolaryngology/Head & Neck Surgery
Voice and Swallowing Center
Jonathan Aviv, M.D.
Thomas Murry, Ph.D.

Pathology
Center for Advanced Laboratory Medicine
Daniel Fink, M.D.

Pediatrics
Center for Prenatal Pediatrics
Richard Polin, M.D.

Child Advocacy Center
Jocelyn Brown, M.D.

Children’s Cardiovascular Health Center
Allan Hordof, M.D.
Thomas Starc, M.D.
Christine Williams, M.D.

Children’s Digestive Health Center
Joseph Levy, M.D.

Children’s Lung Center
Michael Bye, M.D.

Cystic Fibrosis Center
Lynne Quittell, M.D.

Cystic Fibrosis Referral Center for Susceptibility & Synergy Studies
Lisa Saiman, M.D.

Herbert Irving Child & Adolescent Oncology Center
Michael Weiner, M.D.

Pediatric Pulmonary Hypertension Center
Robyn Barst, M.D.

Perinatal Emphasis Research Center
Raymond Stark, M.D.

Pharmacology
Center for Molecular Therapeutics
Michael R. Rosen, M.D.

Psychiatry
Carmel Hill Center
Laurie Flynn

Center for the Advancement of Children’s Mental Health
Peter Jensen, M.D.

Center for the Promotion of Mental Health in Juvenile Justice
Gail A. Wasserman, Ph.D.

Center for Psychoanalytic Training and Research
Robert A. Glick, M.D.

David Mahoney Center for Brain & Behavior Research
Michael Goldberg, M.D.

Lieber Schizophrenia Research Center
Jeffrey Lieberman, M.D.

Ruane Center for Early Identification of Mood Disorders
David Shaffer, M.D.

Stanley Medical Research Institute Center for Applied Neuroscience of Bipolar Disorders
John Mann, M.D.

Moody Foundation Family Center for Early Detection and Prevention in Offspring of Individuals with Bipolar Disorder
Maria A. Oquendo, M.D.

Substance Abuse Medications Development Center
Herbert D. Kleber, M.D.

Substance Use Research Center
Richard W. Foltin, Ph.D.

Women’s Research Center
Suzette M. Evans, Ph.D.

HIV Center for Clinical and Behavioral Studies
Anke A. Ehrhardt, Ph.D.

Radiation Oncology
Center for Radiosurgery
Steven R. Isaacson, M.D.
Michael Sisti, M.D.

Radiology
Hatch Research Center
Truman Brown, Ph.D. (director of mag­netic resonance research)
Robert DeLaPaz, M.D. (medical director)

Functional MRI Research Center
Joy Hirsch, Ph.D.

Biomedical Engineering Imaging Center
Andrew Laine, D.Sc.

Rehabilitation Medicine
Programs in Occupational Therapy
Janet Falk-Kessler, Ed.D.

Programs in Physical Therapy
Risa Granick, Ed.D., MPA, PT

Richard and Hinda Rosenthal Center for Complementary & Alternative Medicine
Fredi Kronenberg, Ph.D.

Surgery
Aortic Surgery Program
Allan S. Stewart, M.D.

Center for Chest Disease & Respiratory Failure
Mark E. Ginsburg, M.D.

Center for Extracorporeal Membrane Oxygenation
Charles J.H. Stolar, M.D.

Center for Lung Disease and Transplantation
Joshua R. Sonett, M.D.
Selim M. Arcasoy, M.D.

Chronic Wound Care Center
Harold Brem, M.D.

Colorectal Care Center
R. Lawrence Whelan, M.D.

Columbia Hyperhidrosis Center
Lyall A. Gorenstein, M.D.

Comprehensive Adolescent Bariatric Surgery Program
Jeffrey Zitsman, M.D.

Comprehensive Breast Center
Freya R. Schnabel, M.D.

Craniofacial Reconstruction Program
Jeffrey A. Ascherman, M.D.

Endocrine Surgery Program
William B. Inabnet, M.D.

Esophageal and Gastric Cancer Program
Marc Bessler, M.D.

Heart Transplantation Program
Yoshifumi Naka, M.D., Ph.D.

Integrative Medicine Program
Mehmet C. Oz, M.D.

Interventional Bronchoscopy and Endobronchial Therapy Program
Roger A. Maxfield, M.D.
Joshua R. Sonett, M.D.
Mark E. Ginsberg, M.D.

Mechanical Circulatory Support Program
Yoshifumi Naka, M.D., Ph.D.

Melanoma Center
Howard L. Kaufman, M.D.

Paul Milstein Institute for Surgical Science
Ann Marie Schmidt, M.D.

Minimal Access Surgery Program
Dennis Fowler, M.D.

Minimally Invasive and Robotic Cardiac Surgery Program
Michael Argenziano, M.D.

New York Thyroid Center
William B. Inabnet, M.D.

Obesity Management and Surgery Center
Marc Bessler, M.D.

Pancreas Center
John A. Chabot, M.D.

Pancreatic Islet Cell Transplantation Program
Mark A. Hardy, M.D.

Pediatric Intestinal Rehabilitation Program
Dominique Jan, M.D.

Pediatric Minimal Access Surgery Program
Jeffrey Zitsman, M.D.

Pediatric Trauma Program
William Middlesworth, M.D.

Robotically Assisted Cardiac Surgery Program
Michael Argenziano, M.D.

Surgical Atrial Fibrillation Program
Michael Argenziano, M.D.

Transplant Center (liver, lung, heart)
Jean C. Emond, M.D.

Tumor Immunotherapy Program
Howard L. Kaufman, M.D.

Ulcer and Wound Healing Center
Nicholas Morrissey, M.D.

Vascular Institute
K. Craig Kent, M.D.

Vein Disorder Treatment Center
Roman Nowygrod, M.D.

Women at Risk
Freya R. Schnabel, M.D.

Urology
Center for Holistic Urology
Aaron Katz, M.D.

Center for Minimally Invasive Surgery
Jaime Landman, M.D.

Center for Robotic Surgery
David Samadi, M.D.

Center for Urologic Oncology
James McKiernan, M.D.

Male Reproductive Center
Harry Fisch, M.D.

New York Center for Human Sexuality
Jason Greenfield, M.D.

Center for Bladder & Prostate Health
Matthew Rutman, M.D.

Stone Center
Mantu Gupta, M.D.

Men’s Health Initiative
Brian Stone, M.D.

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P&S affiliated hospitals:
NewYork-Presbyterian Hospital, New York, NY
Arnot Ogden Medical Center, Elmira, NY
Isabella Geriatric Center, New York, NY
Harlem Hospital, New York, NY
Mary Imogene Bassett Hospital, Cooperstown, NY
New York State Psychiatric Institute, New York, NY
St. Luke’s-Roosevelt Hospital Center, New York, NY

P&S/NewYork-Presbyterian Hospital
affiliated hospitals:
Helen Hayes Hospital, West Haverstraw, NY
Holy Name Hospital, Teaneck, NJ
Lawrence Hospital, Bronxville, NY
New Milford Hospital, New Milford, CT
New York College of Podiatric Medicine and the Foot Clinics, New York, NY
Nyack Hospital, Nyack, NY
Orange Regional Medical Center, Middletown, NY
Palisades Hospital, Palisades, NJ
St. Mary’s Hospital for Children, Bayside, NY
St. Vincent’s Hospital, Bridgeport, CT
Stamford Hospital, Stamford, CT
Valley Hospital, Ridgewood, NJ
White Plains Hospital Center, White Plains, NY

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