Using behavioral, cognitive, and neurophysiological techniques, we investigate brain-behavior relationships and the neurobiological and cognitive mechanisms underlying neuropsychiatric disorders. Our work spans basic and preclinical studies, development and application of laboratory-based assessment, clinical trials and clinical care. Training and research opportunities are available in the following units:

Psychophysiology Laboratory (Gerard Bruder, PhD, director). Studies of quantitative electroencephalography, brain event-related potentials (ERPs), hemispheric asymmetry, and cognitive function in schizophrenia and depressive disorders.

Cognitive Electrophysiology Laboratory (David Friedman, director). A series of interlocking investigations concerned with cognitive function and brain ERPs in projects focusing on memory and attention in normal development, aging, Mild Cognitive Impairment and Alzheimer's disease.

Timing and Cognition Laboratory (Chariklia Malapani, MD, PhD, and Peter Balsam, PhD, directors).  Studies of how time is perceived, remembered and used flexibly to guide behavior, as well as underlying brain mechanisms, in patient populations (e.g., Parkinson's disease) and animal models.

Working Memory and Cognitive Function (Edward E. Smith, director). Behavioral and neuroimaging studies of working memory, attention and inhibition in healthy individuals and those with psychopathology.

Clinical Chronobiology Program (Michael Terman, PhD, director). Basic research on the circadian timing system, with a bridge to the chronotherapeutics (light and melatonin treatment) of depressive and sleep phase disorders.

Center for Prevention & Evaluation (COPE) (Cheryl M. Corcoran, MD, director).  An outpatient research program for teen ages and young adults who show early signs of cognitive deficits or clinical symptoms associated with risk for developing psychiatric disorders.

Sensory Measurement Laboratory (W. Crawford Clark, director).  Application of three mathematical models:  (1) statistical (or medical) decision making theory; (2) multidimensional scaling; and (3) cluster analysis to study of psychometrics of pain perception, memory and rating scale construction.