Columbia University

My research involves the mathematical modeling and analysis of neurons and neural networks. Analytic techniques and computer simulation are used to study how different conductances contribute to the electrical characteristics of a neuron, how neurons interact to produce functioning neural circuits, and how large populations of neurons represent, store, and process information.

SELECTED PUBLICATIONS

Brozovic, M., Abbott, L.F., and Andersen, R.A. 2007. Mechanisms of Gain Modulation at Single Neuron and Network Levels. J. Computational Neurosci. (in press).

Monaco, J.D., Abbott, L.F., and Kahana, M.J. 2007. Lexico-Semantic Structure and the Word Frequency Effect in Recognition Memory.
Learning and Memory 14:204-213.

Rajan, K., and Abbott, L.F. 2007. Temperature Compensation of Chemical Reactions. Phys. Rev. E 75:022902.

Fusi, S., and Abbott, L.F. 2007. Limits on the memory-storage capacity of bounded synapses. Nature Neurosci. 10:485-493.

Parga, N., and Abbott, L.F. 2007. Network Model of Spontaneous Activity Exhibiting Synchronous Transitions Between Up and Down
States. Frontiers in Neuroscience 1:57-66.

Abbott, L.F., and Luo, S.X. 2007. A Step Toward Optimal Coding in Olfaction (news and views). Nature Neurosci. 10:1342-1343.

Abbott, L.F, and Rohrkempter, R. 2007. A Simple Growth Model Constructs Critical Avalanche Networks. Prog. Brain Res. 165:13-19.

Rumsey, C., and Abbott, L.F. 2006. Synaptic Democracy in Active Dendrites. J. Neurophys. 96:2307-2318.

Rajan, K., and Abbott, L.F. 2006. Eigenvalue Spectra of Random Matrices for Neural Networks. Phys. Rev. Lett. 97:188104.

Swinehard, C., and Abbott, L.F. 2006. Dimensional Reduction in Reward-Based Learning. Network: Comp. Neural Sys. 17:235-252.

Billimoria, C.P., DiCaprio, R.A., Birmingham, J.T., Abbott, L.F. and Marder, E. 2006. Neuromodulation of spike timing precision in sensory neurons. J. Neurosci. 26:5910-5919.

Drew, P.J. and Abbott, L.F. 2006. Extending the Effects of STDP to Behavioral Timescales. Proc. Natl. Acad. Sci. USA 103:8876-8881.

Drew, P.J. and Abbott, L.F. 2006. Models and Properties of Power-Law Adaptation in Neural Systems. J. Neurophysiol. 96:826-833.

Rumsey, C. and Abbott, L.F. 2006. Synaptic Democracy in Active Dendrites. J. Neurophys. doi:10.1152/jn.00149.
Swinehard, C. and Abbott, L.F. 2006. Dimensional Reduction in Reward-Based Learning. Network: Comp. Neural Sys. (3):235-52.

Swinehart, C., and Abbott, L.F. 2005. Supervised Learning Through Neuronal Response Modulation. Neural Computation 17:609-631.

Fusi, S., Drew, P., and Abbott, L.F. 2005. Cascade Models of Synaptically Stored Memories. Neuron 45:599-611.

Vogels, T.P., Rajan, K., and Abbott, L.F. 2005. Neural Network Dynamics. Annu. Rev. Neurosci. 28:357-376.

Vogels, T.P. and Abbott, L.F. 2005. Signal Propagation in Networks of Integrate-and-Fire Neurons. J. Neurosci.
Rumsey, C., and Abbott, L.F. 2004. Equalization of Synaptic Efficacy by Activity - and Timing-Dependent Synaptic Plasticity. J. Neurophysiol. 91:2273-2280.

Prinz, A.A., Abbott, L.F., and Marder, E. 2004. The Dynamic Clamp Comes of Age. Trends in Neurosci 27:218-224.

	Laurence F. Abbott, Ph.D. Professor of Physiology and Cellular Biophysics E-mail: lfa2103@columbia.edu Tel: (212) 543-5070 Office: Kolb Research Annex, Room 759 Fax: (212) 543-5010
CURRENT RESEARCH MATHEMATICAL MODELING AND ANALYSIS OF NEURONS AND NEURAL NETWORKS. My research involves the mathematical modeling and analysis of neurons and neural networks. Analytic techniques and computer simulation are used to study how different conductances contribute to the electrical characteristics of a neuron, how neurons interact to produce functioning neural circuits, and how large populations of neurons represent, store, and process information. SELECTED PUBLICATIONS Brozovic, M., Abbott, L.F., and Andersen, R.A. 2007. Mechanisms of Gain Modulation at Single Neuron and Network Levels. J. Computational Neurosci. (in press). Monaco, J.D., Abbott, L.F., and Kahana, M.J. 2007. Lexico-Semantic Structure and the Word Frequency Effect in Recognition Memory. Learning and Memory 14:204-213. Rajan, K., and Abbott, L.F. 2007. Temperature Compensation of Chemical Reactions. Phys. Rev. E 75:022902. Fusi, S., and Abbott, L.F. 2007. Limits on the memory-storage capacity of bounded synapses. Nature Neurosci. 10:485-493. Parga, N., and Abbott, L.F. 2007. Network Model of Spontaneous Activity Exhibiting Synchronous Transitions Between Up and Down States. Frontiers in Neuroscience 1:57-66. Abbott, L.F., and Luo, S.X. 2007. A Step Toward Optimal Coding in Olfaction (news and views). Nature Neurosci. 10:1342-1343. Abbott, L.F, and Rohrkempter, R. 2007. A Simple Growth Model Constructs Critical Avalanche Networks. Prog. Brain Res. 165:13-19. Rumsey, C., and Abbott, L.F. 2006. Synaptic Democracy in Active Dendrites. J. Neurophys. 96:2307-2318. Rajan, K., and Abbott, L.F. 2006. Eigenvalue Spectra of Random Matrices for Neural Networks. Phys. Rev. Lett. 97:188104. Swinehard, C., and Abbott, L.F. 2006. Dimensional Reduction in Reward-Based Learning. Network: Comp. Neural Sys. 17:235-252. Billimoria, C.P., DiCaprio, R.A., Birmingham, J.T., Abbott, L.F. and Marder, E. 2006. Neuromodulation of spike timing precision in sensory neurons. J. Neurosci. 26:5910-5919. Drew, P.J. and Abbott, L.F. 2006. Extending the Effects of STDP to Behavioral Timescales. Proc. Natl. Acad. Sci. USA 103:8876-8881. Drew, P.J. and Abbott, L.F. 2006. Models and Properties of Power-Law Adaptation in Neural Systems. J. Neurophysiol. 96:826-833. Rumsey, C. and Abbott, L.F. 2006. Synaptic Democracy in Active Dendrites. J. Neurophys. doi:10.1152/jn.00149. Swinehard, C. and Abbott, L.F. 2006. Dimensional Reduction in Reward-Based Learning. Network: Comp. Neural Sys. (3):235-52. Swinehart, C., and Abbott, L.F. 2005. Supervised Learning Through Neuronal Response Modulation. Neural Computation 17:609-631. Fusi, S., Drew, P., and Abbott, L.F. 2005. Cascade Models of Synaptically Stored Memories. Neuron 45:599-611. Vogels, T.P., Rajan, K., and Abbott, L.F. 2005. Neural Network Dynamics. Annu. Rev. Neurosci. 28:357-376. Vogels, T.P. and Abbott, L.F. 2005. Signal Propagation in Networks of Integrate-and-Fire Neurons. J. Neurosci. Rumsey, C., and Abbott, L.F. 2004. Equalization of Synaptic Efficacy by Activity - and Timing-Dependent Synaptic Plasticity. J. Neurophysiol. 91:2273-2280. Prinz, A.A., Abbott, L.F., and Marder, E. 2004. The Dynamic Clamp Comes of Age. Trends in Neurosci 27:218-224. Abbott, L.F., and Regehr, W. 2004. Synaptic Computation. Nature 431:796-803.
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