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Jonathan A. Javitch, M.D., Ph.D.
Professor of Psychiatry & Pharmacology in the
Center for Molecular Recognition and in Physiology & Cellular Biophysics
Email: jaj2@columbia.edu
Fax: (212) 305-5594
Electronic Fax: (775) 898-5133


CURRENT RESEARCH

STRUCTURE, FUNCTION AND REGULATION OF G-PROTEIN-COUPLED RECEPTORS AND NEUROTRANSMITTER TRANSPORTERS

Jonathan A. Javitch attended Stanford University where he obtained a B.S. and M.S. in Biological Sciences in 1980. In 1986 he completed the joint M.D.-Ph.D. program at the Johns Hopkins University School of Medicine, where as a graduate student with Dr. Solomon Snyder he demonstrated that a key step in the ParkinsonŒs-like neurotoxicity of MPTP is the uptake of its metabolite MPP+ by the dopamine transporter. After graduating from Hopkins, Dr. Javitch completed a medical internship and psychiatric residency at the Columbia Presbyterian Hospital and the New York State Psychiatric Institute. He did postdoctoral work on the structure of dopamine receptors with Dr. Arthur Karlin at Columbia University. Dr. Javitch currently is a tenured Associate Professor of Psychiatry and Pharmacology in the Center for Molecular Recognition at Columbia University. His laboratory focuses on understanding the structure and function of G-protein coupled receptors and neurotransmitter transporters, with a particular focus on dopamine receptors and transporter, the targets for antipsychotic drugs and cocaine, respectively.


SELECTED PUBLICATIONS

Erreger, K. Grewer, C., Javitch, J.A., Galli, A. 2008. Currents in response to rapid concentration jumps of amphetamine uncover novel aspects of human dopamine transporter function, J Neurosci, 27:976-89
.
Skrabanek, L., Murcia, M., Bouvier, M., Devi, L., George, S.R., Lohse, M.J., Milligan, G., Neubig, R., Palczewski, K., Parmentier, M., Pin, J.P., Vriend, G., Javitch, J.A., Campagne, F., Filizola, M. 2007. Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base. BMC Bioinformatics. 8:177.

Zomot, E., Bendahan, A., Quick, M., Zhao, Y., Javitch, J.A., Kanner, B.I. 2007. Mechanism of chloride interaction with neurotransmitter:sodium symporters, Nature, 449:726-730.

Zapata, A., Kivell, B., Han, Y., Javitch, J.A., Bolan, E.A., Kuraguntla, D., Jaligam, V., Oz, M., Jayanthi, L.D., Samuvel, D.J., Ramamoorthy, S., Shippenberg, T.S. 2007. Regulation of dopamine transporter function and cell surface expression by D3 dopamine receptors. J Biol Chem, 282:35842-54.

Wei, Y., Williams, J., Javitch, J.A., Galli, A., Saunders, C. 2007. Dopamine transporter activity mediates amphetamine-induced inhibition of Akt through a CamKII dependent mechanism, Mol Pharmacol. 71:835-42.

Bolan, E.A., Kivell, B., Jaligam, V., Oz, M., Jayanthi, L.D., Han, Y., Sen, N., Urizar, E., Gomes, I., Devi, L.A., Ramamoorthy, S., Javitch, J.A., Zapata, A., and Shippenberg, T.S. 2007. D2 Receptors Regulate Dopamine Transporter Function Via an ERK 1/2-Dependent and PI3 Kinase-Independent Mechanism, Mol Pharmacol. Jan. 31 e-pub.

Pin, J.P., Neubig, R., Bouvier, M., Devi, L., Filizola, M., Javitch, J.A., Lohse, M.J., Milligan, G., Palczewski, K., Parmentier, M., and Spedding, M. 2007.  International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the Recognition and Nomenclature of G Protein-Coupled Receptor Heteromultimers. Pharmacol Rev. 59:5-13.

Quick, M. and Javitch, J.A. 2007. Monitoring the activity of membrane transport proteins in detergent-solubilized form, Proc. Natl. Acad. Sci. USA. 104: 3603-3608.

Kahlig, K.M., Lute, B.J., Wei, Y., Loland, C.J., Gether, U., Javitch, J.A., and Galli, A. 2006. Regulation of Dopamine Transporter Trafficking by Intracellular Amphetamine. Mol Pharmacol., 70:542-548.

Shi, L., and Javitch, J.A. 2006. A role for information collection, management, and integration in structure-function studies of G-protein coupled receptors. Curr Pharm Des. 12:1771-83.

Urban, J.D., Clarke, W.P., von Zastrow, M., Nichols, D.E., Kobilka, B.K., Weinstein, H., Javitch, J.A., Roth, B.L., Christopoulos, A., Sexton, P., Miller, K., Spedding, M., and Mailman, R.B. 2006. Functional selectivity and classical concepts of quantitative pharmacology, J Pharmacol Exp Ther. 320:1-13.

Fog, J.U., Khoshbouei, H., Holy, M., Owen, W.A., Bjerggaard, C., Sen, N., Nikandrova, Y., Bowton, E., McMahon, D.G., Colbran, R.J., Daws, L.C., Sitte, H.H., Javitch, J.A., Galli, A., and Gether, U. 2006. Calmodulin kinase II interacts with the dopamine transporter C-terminus to regulate amphetamine-induced reverse transport, 51:417-29. Neuron.

Quick, M., Yano, H., Goldberg, N., Duan, L., Beuming. T., Shi, L., Weinstein, H., and Javitch, J.A. 2006. State-dependent conformations of the translocation pathway in the tyrosine transporter Tyt1, a novel neurotransmitter: sodium symporter, J. Biol. Chem., 281:26444-26454.

Beuming, T., Shi, L., Javitch, J.A., and Weinstein, H.  2006. A comprehensive structure-based alignment of prokaryotic and eukaryotic neurotransmitter/Na+ symporters (NSS) aids in the use of the LeuT structure to probe NSS structure and function, Mol Pharmacol., 70:1630-42.

Guo, W., Shi, L., Filizola, M., Weinstein, H., and Javitch, J.A. 2005. Crosstalk in G protein-coupled receptors: Changes at the transmembrane homodimer interface determine activation., Proc. Natl. Acad. Sci. USA, 102:17495-500.

Kahlig, K.M., Binda, F., Khoshbouei, H., Blakely, R.D., McMahon, D.G., Javitch, J.A., and Galli, A. 2005. Amphetamine induces dopamine efflux through a dopamine transporter channel. Proc Natl Acad Sci 102:3495-500.

Garcia, B.G., Wei, Y., Moron, J.A., Lin, R.Z., Javitch, J.A., and Galli, A. 2005. Akt is essential for insulin modulation of amphetamine-induced human dopamine transporter cell-surface redistribution. Mol Pharmacol.68:102-9.

Sonders, M.S., Quick, M., and Javitch, J.A. 2005. How did the neurotransmitter cross the bilayer? A closer view. Curr Opin Neurobiol. 15:296-304. Review.

Kniazeff, J., Loland, C.J., Goldberg, N., Quick, M., Das, S., Sitte, H.H., Javitch, J.A., and Gether, U. 2005. Intramolecular cross-linking in a bacterial homolog of mammalian SLC6 neurotransmitter transporters suggests an evolutionary conserved role of transmembrane segments 7 and 8. Neuropharmacology. 49:715-23.


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