Jahar Bhattacharya M.D., Ph.D.
Professor of Physiology & Cellular Biophysics,
Clinical Physiological Medicine, and Medicine
Email: jb39@columbia.edu
Tel: (212) 523-7310
Office: St. Luke's/Roosevelt Hospital, 1000 Tenth Avenue NYC 10019
Fax: (212) 523-8005


CURRENT RESEARCH

ENDOTHELIAL MECHANISMS OF LUNG INJURY USING CULTURED CELLS AND THE OPTICALLY IMAGED LUNG.

The Lung Biology Laboratory specializes in single and two-photon laser scanning microscopy of the intact lung. The overall direction is to apply real-time imaging in understanding molecular mechanisms underlying lung injury. Ongoing projects are:
  • Mitochondrial regulation of inflammatory exocytosis
  • 3-D alveolar geometry during lung inflation
  • Focal adhesion proteins in endothelial barrier enhancement
  • Second messengers in alveolo-capillary crosstalk



SELECTED PUBLICATIONS

Kiefmann, R., Rifkind, J.M., Nagababu, E., and Bhattacharya, J. 2008. RBC induce hypoxic lung inflammation. Blood. (In press)

Bhattacharya, J. 2008. Lung neovascularization: a tale of two circulations. Am J Physiol Lung Cell Mol Physiol. (Epub)

Quadri, S., and Bhattacharya, J. 2007. Resealing of endothelial junctions by focal adhesion kinase. Am. J. Physiol. Lung Cell. Mol. Physiol. 292:L334-42.

Lindert, J., Parthasarathi, K., and Bhattacharya, J. 2007. Chloride-dependent secretion of alveolar wall liquid determined by optical-sectioning microscopy. Am. J. Resp. Cell. Mol. Biol. 36:688-96.

Perlman, C.E., and Bhattacharya, J. 2007. Alveolar micromechanics determined by optical sectioning microscopy. J. Appl. Physiol. 103:1037-44.

Bertuglia, S., Ichimura, H., Fossati, G., Parthasarathi K., Leoni, F., Modena, D., Cremonesi, P., Bhattacharya, J., and Mascagni, P. 2007. ITF1697, a stable Lys-Pro–containing peptide, inhibits Weibel Palade body exocytosis induced by ischemia/reperfusion and pressure elevation. Mol Med. 13:615-24.

Kuebler, W.M., Parthasarathi, K., Lindert, J., and Bhattacharya, J. 2007. Real-time lung microscopy. J Appl Physiol. 102:1255-64.

Bhattacharya, J. 2007. Interpreting the lung microvascular filtration coefficient. Am J Physiol Lung Cell Mol Physiol. 79:357-66

Chatterjee, S., Baeter, S., and Bhattacharya, J. 2007. Endothelial and epithelial signaling in the lung. Am J Physiol Lung Cell Mol Physiol, 293: L517-19.

Ichimura, H., Parthasarathi, K., Issekutz, AC., and Bhattacharya, J. 2005. Pressure-induced leukocyte margination in lung postcapillary venules. Am J Physiol Lung Cell Mol Physiol. 289:L407-12.

Safdar, Z., Yiming, M., Grunig, G., and Bhattacharya, J. 2005. Inhibition of Acid-induced Lung Injury by Hyperosmolar Sucrose in Rats. Am J Respir Crit Care Med. 172:1002-7.

Paik D.C., Fu, C., Bhattacharya, J., and Tilson, M.D. 2004. Ongoing angiogenesis in blood vessels of the abdominal aortic aneurysm. Exp Mol Med. 36:524-33.

Boitano, S., Safdar, Z., Welsh, D.G., Bhattacharya, J., and Koval, M. 2004. Related Articles, Links Cell-cell interactions in regulating lung function. Am J Physiol Lung Cell Mol Physiol. 287:L455-9. Review.

Ichimura, H., Parthasarathi, K., Quadri, S., Issekutz A.C., and Bhattacharya, J. 2003. Mechano-oxidative coupling by mitochondria induces proinflammatory responses in lung capillaries. J. Clin. Invest. 111: 691-699.

Quadri, S., Bhattacharjee, M., Parthasarathi, K., Tanita, T., and Bhattacharya, J. 2003. Endothelial barrier strengthening by activation of focal adhesion kinase. J. Biol. Chem. 278:13342-9.

Safdar, Z., Wang, P., Ichimura, H., Issekutz, A.C., Quadri, S., and Bhattacharya. J. 2003. Hyperosmolarity enhances the lung capillary barrier. J. Clin. Invest. 112:1541-9.

Bhattacharya, S., Sen, N., Yiming, M., Patel, R., Parthasarathy, K., Quadri, S., Issekutz, A., and Bhattacharya, J. 2003. High tidal volume ventilation induces proinflammatory signaling in rat lung endothelium. Am J Respir Cell Mol Biol. 28:218-24.

Parthasarathi, K., Ichimura, H., Quadri, S., Issekutz, A., and Bhattacharya, J. 2002. Mitochondrial reactive oxygen species regulate spatial profile of proinflammatory responses in lung venular capillaries. J. Immunol. 169:7078-7086.



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