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Endocrinology
Research Activities
We maintain cross-disciplinary collaborations with:
- The Naomi Berrie Diabetes Center
- The Comprehensive Adolescent Bariatric Surgery Program
- Columbia Center for Childrens Environmental Health
Research Highlights
- Studies of alternations in androgen metabolism, growth factors and insulin sensitivity in children at risk for Metabolic Syndrome and Type 2 diabetes
- Initiation of new treatments for growth failure and disordered puberty (including adrenarche and PCOS)
- Studies assessing the effect of bariatric surgery in morbidly obese adolescents
- Evaluation of body composition in children, including assessment of visceral fat content of muscle cells and organs
- Studies of endocrine dysfunction and obesity related to environmental endocrine disruptors
- New treatment modalities for type 1 and type 2 diabetes
- Studies assessing the effect of exercise, nutrition, and education in the prevention of IR and obesity
Current Grants
Training Grant in Pediatric Endocrinology; Principal Investigator Sharon Oberfield, MD.
(NIH/NIDDK T32DK065522)
Medical Student Research Training Grant (3T32 DK065522-06SI); Mentor - Sharon E. Oberfield, MD (NIH/NIDDK)
Alterations in Androgen Metabolism, Growth Factors in Insulin Sensitivity in Premature Adrenarche, Obesity and Polycystic Ovary Syndrome; Principal Investigator Sharon Oberfield, MD (private funding)
Early-life Phthalate Exposure, Thyroid Function and Child Cognitive Development; Co-Investigator Sharon Oberfield, MD. (NIH 2R01ES012543)
Assessing the Effects of Pre and Postnatal Exposure to Organophosphorus; Co-Investigator Sharon Oberfield, MD. (NIH R01ES015579)
The Impact in Morbidly Obese Adolescents of LAGB on Gherlin, PYY, CKK, Leptin, and Insulin; Empire Clinical Investigators Program - Investigator Shula Lerner, MD
Diabetes and Endocrinology Research Center; Prinicpal Investigator Dominic Accili, MD.
(NIH/NIDDK IP30 DK6068)
Preventing Type 2 Diabetes in School Based Settings "The Road Project" AMDEC/STARR Foundation Corp.- Site principal investigator Ilene Fennoy, MD, Principal Investigator - Michael Rosenbaum
A number of clinical trials and natural history studies relating to type 1 and type 2 Diabetes are conducted at the Naomi Berrie Diabetes Center; Site Prinicpal Investigator Robin Goland, MD with Drs. Gallagher, Leibel, Softness and Fennoy participating as co-investigators. These include:
- Trial to reduce autoimmunity in the Genetically at risk; Robin Goland, MD, Site PI (TRIGR) NIH/NIDDK UO1HD042444-07
- Treatment Options for Type 2 Diabetes in Adolescents and Youth; Natasha Leibel, MD, Co-Investigator (NIH/NIDDK U01DK061230-04)
- Environmental Determinants of Diabetes in the Young TEDDY (NIH/NIDDK U01KD6390); Barney Softness, MD, Co-Prinicipal Investigator
- TODAY Trial (Treatment Options for Type 2 Diabetes in Adolescents and Youth (NIH/NIDDK U01DK06123040); Natasha Leibel, MD, Co-Investigator and Ilene Fennoy, MD, (Consultant)
- Multiple Trial Net Consortium Studies: (NIH/NIDDK U01DK6045), TN-05/ DE14260, 401DK61035 TN-01/DE14260, U01DK61035 TN-07/ DE14260, 401DK61035 TN-02/D14260; Co. Prinicipal Investigators Robin Goland, MD/ Mary Pat Gallagher, MD.
Effects of Rituximab on the Program's of Type 2 Diabetes in New Onset subjects
Oral Insulin for Prevention of Diabetes in Relatives at Risk for Type 1 Diabetes
Natural History study of the Development of Type 2 Diabetes
New onset of Type 1 Diabetes Mycophenolane Mofetil-Saclizumab Clinical Trial
Open-Label, Parallel Group Study to Evaluate the Efficacy of Preprandial Human Insulin Inhalation Powder (HIIP) Compared to Preprandial Injectable Insulin Patients with Type 1 Diabetes Mellitus, Eli-Lilly; Site Principal Investigator Mary Pat Gallagher, MD
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