Endocrinology

Research Activities

• The Naomi Berrie Diabetes Center
• The Comprehensive Adolescent Bariatric Surgery Program
• Columbia Center for Children’s Environmental Health

Research Highlights

• Studies of alternations in androgen metabolism, growth factors and insulin sensitivity in children at risk for Metabolic Syndrome and Type 2 diabetes
• Initiation of new treatments for growth failure and disordered puberty (including adrenarche and PCOS)
• Studies assessing the effect of bariatric surgery in morbidly obese adolescents
• Evaluation of body composition in children, including assessment of visceral fat content of muscle cells and organs
• Studies of endocrine dysfunction and obesity related to environmental endocrine disruptors
• New treatment modalities for type 1 and type 2 diabetes
• Studies assessing the effect of exercise, nutrition, and education in the prevention of IR and obesity

Current Grants

Training Grant in Pediatric Endocrinology; Principal Investigator – Sharon Oberfield, MD. (NIH/NIDDK T32DK065522)

Medical Student Research Training Grant (3T32 DK065522-06SI); Mentor - Sharon E. Oberfield, MD (NIH/NIDDK)

Alterations in Androgen Metabolism, Growth Factors in Insulin Sensitivity in Premature Adrenarche, Obesity and Polycystic Ovary Syndrome; Principal Investigator – Sharon Oberfield, MD (private funding)

Early-life Phthalate Exposure, Thyroid Function and Child Cognitive Development; Co-Investigator – Sharon Oberfield, MD. (NIH 2R01ES012543)

Assessing the Effects of Pre and Postnatal Exposure to Organophosphorus; Co-Investigator – Sharon Oberfield, MD. (NIH R01ES015579)

The Impact in Morbidly Obese Adolescents of LAGB on Gherlin, PYY, CKK, Leptin, and Insulin; Empire Clinical Investigators Program - Investigator – Shula Lerner, MD

Diabetes and Endocrinology Research Center; Prinicpal Investigator – Dominic Accili, MD. (NIH/NIDDK IP30 DK6068)

Preventing Type 2 Diabetes in School Based Settings "The Road Project" – AMDEC/STARR Foundation Corp.- Site principal investigator – Ilene Fennoy, MD, Principal Investigator - Michael Rosenbaum

A number of clinical trials and natural history studies relating to type 1 and type 2 Diabetes are conducted at the Naomi Berrie Diabetes Center; Site Prinicpal Investigator – Robin Goland, MD with Drs. Gallagher, Leibel, Softness and Fennoy participating as co-investigators. These include:

• Trial to reduce autoimmunity in the Genetically at risk; Robin Goland, MD, Site PI (TRIGR) NIH/NIDDK UO1HD042444-07
• Treatment Options for Type 2 Diabetes in Adolescents and Youth; Natasha Leibel, MD, Co-Investigator (NIH/NIDDK U01DK061230-04)
• Environmental Determinants of Diabetes in the Young – TEDDY (NIH/NIDDK U01KD6390); Barney Softness, MD, Co-Prinicipal Investigator
• TODAY Trial (Treatment Options for Type 2 Diabetes in Adolescents and Youth (NIH/NIDDK U01DK06123040); Natasha Leibel, MD, Co-Investigator and Ilene Fennoy, MD, (Consultant)
• Multiple Trial Net Consortium Studies: (NIH/NIDDK U01DK6045), TN-05/ DE14260, 401DK61035 TN-01/DE14260, U01DK61035 TN-07/ DE14260, 401DK61035 TN-02/D14260; Co. Prinicipal Investigators – Robin Goland, MD/ Mary Pat Gallagher, MD.

New onset of Type 1 Diabetes Mycophenolane Mofetil-Saclizumab Clinical Trial

Open-Label, Parallel – Group Study to Evaluate the Efficacy of Preprandial Human Insulin Inhalation Powder (HIIP) Compared to Preprandial Injectable Insulin Patients with Type 1 Diabetes Mellitus, Eli-Lilly; Site Principal Investigator – Mary Pat Gallagher, MD