Molecular Biomedical Engineering

Dr Francis Lee
Francis Y. Lee, M.D., Ph.D.

The Molecular Biomedical Engineering Laboratory, under the direction of orthopaedic surgeon Dr. Francis Y. Lee, is currently spearheading novel research projects that fuse molecular biological and engineering fundamentals to advance the understanding of biological operating systems in order to develop biology based technologies with the potential to transform clinical outcomes. A clinician-scientist, Dr. Lee has specific interests in the pathogenesis of bone destruction, inflammatory bone loss, and sarcoma research. Together with his talented research team, the Molecular Biomedical Engineering lab is researching the development of new pharmacologics to prevent bone loss, bone graft substitutes for bone tumors, innovative implants that resist inflammatory bone loss, and stem cell delivery mechanisms for sarcoma treatment.

Dr. Lee has been awarded four NIH R01 grants, funding from the Department of Defense and numerous awards from prestigious research foundations. He is the Vice-Chair of Research for the Dept. of Orthopaedic Surgery, Director of the Center for Orthopaedic Research, Chief of Tumor and Bone Disease and an Associate Professor of Orthopaedic Surgery with tenure. In addition, Dr. Lee is an active participant in the peer review process for the NIH and the Orthopaedic Research and Education Foundation. He is an effective mentor for medical students, residents, PhD candidates, fellows and faculty in the field of musculoskeletal research.

The definitive goal of Molecular Biomedical Engineering is to improve overall bone health by developing novel therapeutic strategies to enhance bone formation, regulate bone loss, reduce fractures, prevent cancer spread to the bone, improve orthopaedic implant integration, promote healing, and decrease health care burden.