|Current Research Grants|
COR Selected Publications
Chandhanarat Chandhanayingyong, Won Seok Song, Anny Hsu, Yuhree Kim, Francis Y. Lee*: Extraskeletal myxoid chondrosarcomas: Oncologic Outcomes (Pending).
Heon Goo Lee, Anny Hsu, Chandhanarat Chandhanayingyong, Seok Hyun Kweon, Hesham Tawfeek, Daniel S. Oh, Francis Y. Lee*: PTH inhibits production of pro-osteoclastogenic cytokines and inflammatory osteolysis in vitro and in vivo.(Pending).
Francis Y. Lee*, Maya Mikami, Heon Goo Lee, Saqib Nizami, Hiroshi Minematsu, Anny Hsu, Hanying Bai, Chandhanarat Chandhanayingyong, Yuhree Kim, Hesham Tawfeek, Daniel S. Oh, Francis Y. Lee: Calreticulin is a novel anti-osteoclastogenic protein. (Pending).
Heon Goo Lee, Anny C. Hsu, Chandhanarat Chandhanayingyong, Seok Hyun Kweon, Hesham Tawfeek, Daniel S. Oh, Francis Y. Lee*: PTH inhibits production of pro-osteoclastogenic cytokines and inflammatory osteolysis in vitro and in vivo.(Pending).
Heon Goo Lee, Anny C. Hsu, Yuhree Kim, Chandhanarat Chandhanayingyong, Saqib Nizami, Hana Goto, Daniel S. Oh, Hesham Tawfeek, Francis Y. Lee*: Combinatorial mechanical perturbation and metal particles amplify pERK signlaing and inflammatory cytokine production (In Preparation for American Journal of Physiology).
Kyung Ok Kim, Any C. Hsu, Neel Patel, Ester Kwak, Hana Goto, Saqib Nizami, Alan Chou, Hiroshi Minematsu, Francis Y. Lee*: Proteomic Identification of 14-3-3 as a regulator of pro-apoptotic protein in osteosarcoma. Sarcoma. June 2012 (In Press).
Son JS, Kim JM, Han M, Choi SH, Lee FY, Oh DO* (2011): Bone Regeneration of Tibial Segmental Defect Using Isotropic-Pore Structures Hydroxyapatite/Alumina Bi-Layered Scaffold: In Vivo Pilot Study, Journal of Long-Term Effects of Medical Implants, 21(2): 159-167.
Minematsu H, Shin MJ, Celil Aydemir AB, Kim KO, Nizami SA, Chung GJ, Lee FY: Nuclear presence of nuclear factor of activated T cells (NFAT) c3 and c4 is required for Toll-like receptor-activated innate inflammatory response of monocytes/macrophages. Cell Signal. 2011 Nov;23(11):1785-93. Epub 2011 Jun 25. PubMed PMID: 21726630.
Noh KC, Kim KO, Staples JR, Patel N, Minematsu H, Nair K, Lee FY: Targeting Inflammatory Pathways in Osteosarcoma. Journal of Bone and Joint Surgery (Am). 2011 Apr 20; 93(8):723-32. PubMed PMID: 21508279.
Shahryarinejad A, Gardner TR, Cline JM, Levine WN, Bunting HA, Brodman MD, Ascher-Walsh CJ, Scotti RJ, Vardy MD: Effect of hormone replacement and selective estrogen receptor modulators (SERMs) on the biomechanics and biochemistry of pelvic support ligaments in the cynomolgus monkey (Macaca fascicularis). Am J Obstet Gynecol. 2010 ,May;202(5):485.e1-9.
Seo SW, Lee D, Minematsu H, Kim AD, Shin M, Cho SK, Kim DW, Yang J, Lee FY. Targeting extracellular signal-regulated kinase (ERK) signaling has therapeutic implications for inflammatory osteolysis. Bone. 2010 Mar:46(3):695-702. Epub 2009 Nov 4. PubMed PMID: 19895919; PubMed Central PMCID: PMC2823832.
Nowak DD, Gardner TR, Bigliani LU, Levine WN, Ahmad CS: Interobserver and Intraobserver Reliability of the Walch Classification in Primary Glenohumeral Arthritis. Journal of Shoulder and Elbow Surgery, 19: 180-183, 2010.
Mills J, Matos T, Charytonowicz E, Hrick T, Castillo-Martin M, Remotti F, Lee FY, Matushansky I. Characterization and comparison of the properties of sarcoma cell lines in vitro and invivo. Human Cell, 2009 Nov;22(4):85-93. PubMed PMID: 19874397.
Aydemir AB, Minematsu H, Gardner TR, Kim KO, Ahn JM, Lee FY: Nuclear factor of activated T cells mediates fluid shear stress-and tensile strain-induced Cox2 in human and murine bone cells. Bone. 2010 Jan;46(1):167-75. Epub 2009 Sep 11. PubMed PMID: 19748606; PubMed Central PMCID: PMC2818272.
Kim DW, Kim KO, Shin MJ, Ha JH, Seo SW, Yang J, Lee FY: siRNA-Based Targeting of Antiapoptotic Genes Can Reverse Chemoresistance in P-glycoprotein Expressing Chondrosarcoma Cells. J Molecular Cancer, 2009 May 15;8:28.
Seo SW, Cho SK, Storer SK, Lee FY: Zoledronate reduces unwanted bone resorption in intercalary bone allografts. Int Orthop., 2009 Apr 3, PubMed PMID: 19343345.
Guterl CC, Gardner TR, Rajan V, Ahmad CS, Hung CT, Ateshian GA: Two-Dimensional Strain Fields on the Cross-Section of the Human Patellofemoral Joint Under Physiological Loading. Journal of Biomechanics, 42: 1275-1281, 2009.
Caligaris M, Canal CE, Ahmad CS, Gardner TR, Ateshian GA: Investigation of the Frictional Response of Osteoarthritic Human Tibiofemoral Joints and the Potential Beneficial Tribological Effect of Healthy Synovial Fluid. Osteoarthritis and Cartilage, 17: 1327-1332, 2009.
Ahmad CS, Vorys GC, Covey A, Levine WN, Gardner TR, Bigliani LU: Rotator Cuff Repair Fluid Extravasation Characteristics are Influenced by Repair Technique. Journal of Shoulder and Elbow Surgery,18:976-981, 2009.
Moffat KL, Doty S, Spalatzi J, Levine WN, Lu H: Novel Nanofiber-based Scaffold for Rotator Cuff Repair and Augmentation. Tissue Engineering, 2009, 15:115-126.
Kleweno CP, Jacir AM, Gardner TR, Ahmad CS, Levine WN: Biomechanical Evaluation of Anterior Cruciate Ligament Femoral Fixation Techniques. American Journal of Sports Medicine, 37:339-345, 2009.
Chambers A, Prince D, Greisberg J: Apoptosis and Nitric Oxide in Chondrocyte Following Trauma. J of Trauma. In press.
Tang P, Gauvin J, Muriuki M, Pfaeffle JH, Imbriglia JE, Goitz RJ: Comparison of the “Contact Mechanics” of the Intact and Proximal Row Carpectomy Wrist: J Hand Surg, 34A:660-670, 2009.
Sanjeev Suratwala, Samuel K. Cho, Jonathan Van Rattle, Sang H Park, Sung W Seo, Seong-Sil chang, Thomas R. Gardner, Lee, FY: Enhancement of periprosthetic bone quality with topical hydroxyapatite-bisphosphonate composite: An Experimental Study. The Journal of Bone and Joint Surgery, 90A(10):2189-2195, 2008.
Tuan RS, Lee FY, Konttinen YT, Wilkinson JM, Smith RL: What are the local and systemic biologic reactions and mediators to wear debris, and what host factors determine or modulate the biologic response to wear particles? Journal of American Academy of Orthopaedic Surgeons, 16(S):42-48, 2008.
Ahmad CS, Gardner T, Bell J, Levine WN: Biomechanical Performance of Rotator Cuff Repairs with Humeral Rotation: A New Rotator Cuff Repair Failure Model. Am J Sports Med, Apr 9, 2008 [Epub ahead of print].
Gonzalez-Lomas G, Kippe MA, Brown GA, Ding A, Gardner TR, Levine WN, Ahmad CS: In-Situ Trans-Tendon Repair Outperforms Tear Completion and Repair for Partial Articular-Sided Supraspinatus Tendon Tears. Journal of Shoulder and Elbow Surgery, 17: 722-728, 2008.
Kowlosky MS, Dellenbaugh SG, Erlichman DB, Gardner TR, Levine, WN, Ahmad CS: Evaluation of Suture Abrasion Against Rotator Cuff Tendon and Proximal Humerus Bone. Arthroscopy, 24:329-334, 2008.
Ahmad CS, Kleweno C, Jacir A, Bell JE, Gardner TR, Levine WN, Bigliani LU: Biomechanical Performance of Rotator Cuff Repairs with Humeral Rotation: A New Rotator Cuff Repair Failure Model. American Journal of Sports Medicine, 36:888-92, 2008.
Celil Aydemir AB, Lee S, Won Kim D, Gardner TR, Prince D, Mok Ahn J, Lee FY: Calcineurin/NFATc axis mediated fluid shear stress-induced COX-2 expression in human mesenchymal cells. The Annals of New York Academy of Science,1117:138-42; Nov, 2007.
Seo SW, Aydemir A, Minematsu H, Lee FY: ERK Signaling Regulates M-CSF Expression Induced by Titanium Nanoparticles in MC3T3-E1 Murine Calvarial Pre-Osteoblastic Cells. The Annals of New York Academy of Science, 1117:151-8; Nov, 2007.
Minematsu H, Seo S, Aydemir A, Lee FY: Calcomeirom/NFATC1 Axis Regulates UHMWPE Wear Particle-Induced Cytokine Expression in Macrophages: The Annals of New York Academy of Science, 1117:143-50; Nov, 2007.
Park MC, Jun BJ, Park CJ, Ahmad CS, Elattrache NS, Lee TQ: The Biomechanical Effects of Dynamic External Rotation on Rotator Cuff Repair Compared to Testing With the Humerus Fixed. American Journal of Sports Medicine, 35:1931-9, 2007.
Ahmad CS, DiSipio K, Gardner TR, Levine WN, Bigliani LU: Factors Affecting Dropped Biceps Deformity After Tenotomy of the Long Head of the Biceps Tendon. Arthroscopy, 23:537-41, 2007.
Ahmad CS, Wing DE, Gardner T, Levine WN, Bigliani LU: Biomechanical evaluation of subscapularis repair used during shoulder arthroplasty. J Shoulder and Elbow Surg,16 (3 Suppl):S59-6.4; May-June, 2007.
Kim DW, Seo SW, Cho S, Chang SS, Lee HW, Lee SE, Block JA, Hei TK, Lee FY: Targeting of cell survival genes using small interfering RNAs (siRNAs) enhances radiosensitivity of Grade II chondrosarcoma cells. Journal of Orthopaedic Research, 25(6):820-8; March 7, 2007.
Park MC, Elattrache, NS, Tibone JE, Ahmad CS, Jun BJ, Lee TQ: Part I: Footprint Contact Characteristics for a “Transosseous-Equivalent” Rotator Cuff Repair Technique Compared to a Double-Row Technique. Journal of Shoulder and Elbow Surgery, 16:461-8, 2007.
Spalazzi JP, Doty SB, Moffat KL, Levine WN, Lu HH: Development of controlled matrix heterogeneity on a triphasic scaffold for orthopaedic interface tissue engineering: Tissue Engineering, 12: 3497-3508, 2006.
Lee FY, Sinicropi S, Vitale MG, Lee FS, Roye DP, Choi IH: Treatment of congenital pseudarthrosis of tibia with recombinant human bone morphogenetic protein-7: A prospective study. Journal of Bone and Joint Surgery, 88(3):627-33; Mar,2006.
Kim YS, Bigliani LU, Fujisawa M, Murakami K, Chang SS, Lee HJ, Lee FY, Blaine TA: Stromal cell-derived factor 1 (SDF-1, CXCL12) is increased in subacromial bursitis and downregulated by steroid and nonsteroidal anti-inflammatory agents. Journal of Orthopaedic Research, 24: 1756-64; June, 2006.
Ahmad CS, Wing D, Gardner TR, Levine WN, Bigliani LU: Biomechanical Evaluation of Subscapularis Repairs Used During Total Shoulder Replacement. Journal of Shoulder and Elbow Surgery, 16:s59-64, 2006.
Kim DW, Lee HJ, Karmin J, Lee SE, Chang SS, Tolchin B, Lin S, Cho SK, Kwon A, Ahn JM, and Lee FY: Mechanical Loading Differentially Regulates Membrane-Bound and Soluble RANKL Availability in MC3T3-E1 Cells. Annals of New York Academy of Science, Vol 1068, pp568-572, April, 2006.
Park M, Cadet E, Levine, WN, Bigliani LU, Ahmad CS: Comparison of Rotator Cuff Tendon Pressure Against the Tuberosity in Suture Anchor and Transosseous Suture Rotator Cuff Repairs. American Journal of Sports Medicine, 33:1154-9, 2005.
Lee FY, Kim DW, Karmin JA, Hong D, Chang SS, Fujisawa M, Takayanagi H, Bigliani LU, Blaine TA, Lee HJ: mu -calpain regulates RANKL-supported osteoclastogenesis via NF-kappa B activation in raw 264.7 cells. Journal of Biological Chemistry, 280(33):29929-36; June 13, 2005.
Yu J, Chang SS, Suratwala S, Chung W, Abdelmessieh P, Lee HJ, Yang J, Lee FY: Zoledronate induces apoptosis in stromal cells of unicameral bone cyst. Journal of Orthopaedic Research, 23(5):1004-122005; May 24, 2005.
Blaine TA, Kim YS, Voloshin I, Chen D, Murakami K, Chang SS, Winchester R, Lee FY, O'Keefe RJ, Bigliani LU: The molecular pathophysiology of subacromial bursitis in rotator cuff disease. J Shoulder Elbow Surg, 14(1 Suppl S):84S-89S; Jan-Feb, 2005.
Liao T, Yurgelun M, Chang SS, Murakami K, Zhang HZ, Parisien MV, Blaine TA, Kim W, Winchester RJ, Lee FY: Recruitment of osteoclast precursors by stromal cell derived factor-1 in giant cell tumor of bone. Journal of Orthopaedic Research, 23(1):203-9; Jan, 2005.
Yoon AJ, Parisien M, Feldman F, Lee FY: Extranodal Rosai-Dorfman disease of bone, subcutaneous tissue and paranasal sinus mucosa: Case report and review of the literature. Skeletal Radiology, 34(10):653-7; Oct, 2005.
Delloye C, Suratwala S, Valentin-Opran A, Cornu O, Lee FY: Treatment of Allograft Nonunions with Recombinant Human Bone Morphogenetic Proteins (rhBMP): Early Clinical Results. ACTA Orthopaedica Belgica, 70:591-597, 2004.
Chang SS, Suratwala S, Jung KM, Doppelt J, Zhang HJ, Blaine TA, Kim TW, Winchester RJ, Lee FY: Bisphosphonate may reduce recurrence in GCT by inducing apoptosis. Clinical Orthopaedics and Related Research, September, 426:103-109, 2004.
Lee FY, Hornicek FJ, Dick HM, Mankin HJ: Synovial chondromatosis of the foot. Clinical Orthopaedic and Related Research, April, 423:186-190, 2004.
Ahmad CS, Groh M, Arnouk J, Gardner TR, Levine WN: Mechanical properties of soft tissue femoral fixation devices for ACL reconstruction. Am J Sports Med, 32: 1-10, 2004.
Vitale MG, Choe JC, Hwang MW, Bauer RM, Hyman JE, Lee FY, Roye DP: Postoperative Use of Ketorolac Tromethamine in Children Undergoing Scoliosis Surgery. The Spine Journal, 3:55-62; 2003.
Lee FY, Storer SK, Hazan EJ, Gebhardt MC, Mankin HJ: Repair of bone allograft fracture using bone morphogenetic protein-2 in an animal experimental model. Clinical Orthopaedics and Related Research, April, 397:119-126, 2002.
Lee FY, Zawadsky M, Parisien M, Ho M, Murty VV, Jayaraman T, Dick HM: A novel translocation (9;12)(q22;q24) in secondary chondrosarcoma arising from hereditary multiple exostosis. Cancer Genetics and Cytogenetics, 132(1)68-70; 2002.
Lee FY, Hazan EJ, Gebhardt MC, Mankin HJ. An experimental model for allograft fracture repair. Journal of Orthopaedic Research, 18:303-306, 2000.
Ramappa AJ, Lee FY, Tang P, Carlson JR, Gebhardt MC, Mankin HJ: Chondroblastoma of bone. Journal of Bone and Joint Surgery, 82A:1140-1145, 2000.
Lee FY, Mankin HJ, Gebhardt MC, Springfield D, Fondren G, Jennings LC, Rosenberg A. Outcome analysis of chondrosarcoma. Journal of Bone and Joint Surgery, (Am) 81A: 326-338, 1999.
Lee FY, Rho JY, Harten R, Parsons JR, Behrens FF. Micromechanical Properties of Primary Spongiosa and Epiphyseal Trabecular Bone. Journal of Pediatric Orthopaedics, 18: 582-585, 1998.
Lee FY, Behrens FF, DeFouw DO, and Einhorn TA: Programmed Removal of Chondrocytes During Enchondral Fracture Healing. Journal of Orthopaedic Research, 16(1), 144-149, 1998.
Lee FY, Gebhardt MC, Keel SB, Rosenthal DI. Orthopaedic-Pathology-Radiology Conference. A discrete soft tissue mass in the distal thigh of 29-year–old male. Clinical Orthopaedics and Related Research, 357: 247-250, 1998.
Benevenia J, Lee FY, Buechel FF, Parsons JR: Aggressive Granulomatous Lesion following Total Knee Replacement Arthroplasty. Journal of Biomedical Materials Research Applied Biomaterials, 43(4):473-477, 1998.
Seong SC, Matsumura T, Lee FY, Whelan MC, Li XQ and Trippel SB: Insulin-like growth factor I regulation of Swarm rat chondrosarcoma chondrocytes in culture. Experimental Cell Research, 211:238-244, 1994.
Kim YM, Lee SH, Lee FY, Koo KH and Cho KH: Morphologic and biomechanical study of avascular necrosis of the femoral head. Orthopaedics, 14:1111-1116, 1991.
Active Research Awards
Orthopaedic Research & Education Foundation Resident Clinician Scientist Training Grant
Anny Hsu, M.D., Principal Investigator
Enhancement of Dynamic Biomechanical Properties of Structural Allograft with BMP2 Loaded Nanospheres
Period: 7/01/12 - 6/30/13
American Foundation for Surgery of the Hand
Peter Tang, M.D., MPH, Principal Investigator
An Evaluation of Inflammation, Histology, and Function in Nerve Regeneration
Period: 9/01/11 - 8/31/12
Department of Defense
Francis Y. Lee, M.D., Ph.D. -Principal Investigator
Ready-to-Use Tissue Constructs for Military Bone and Cartilage Trauma
Period: 9/30/10 - 10/29/14
National Institutes of Health (NIH)
The Medical Advisory Committee for Major League Baseball has awarded Dr. Christopher S. Ahmad, director of the Biomechanics Laboratory and team physician for the New York Yankees, a grant for research investigating "The Effect of Timing of Plasma-Rich Protein (PRP) Injections on Muscle Healing". The study will evaluate the efficacy of PRP to accelerate muscle tissue repair and regeneration at the site of injury.
Period: 12/01/10 - 11/30/11
National Institutes of Health (NIH)
AO North America Resident Trauma Research Support Award
Orthopaedic Research and Education Foundation
Orthopaedic Research and Education Foundation
Orthopaedic Research & Education Foundation 2008 - 2009
Ra'Kerry K. Rahman, M.D.
Orthopaedic Research and Scientific Foundation 2008 - 2009
Peter Tang, M.D.