Selected Publications Selected Abstracts
arrowCurrent Research Grants

COR Selected Publications

Books & Chapters

Chandhanarat Chandhanayingyong, Thomas Hickernell, Francis Y. Lee: Spine Tumors. Spine, Baccaro Ed., 2014 (in press).

Lee FY, Seo SW, Kim HS: Chapter 4. Molecular Basis of Sarcoma. Orthopaedic Basic Science, 2013.

Lee FY, Zuscik M, Chen Di, Drissi H: Chapter 1. Molecular and Cellular Biology. Orthopaedic Basic Science, 2013.

Orthopaedic In-Training Examination, Basic Science, AAOS, 2006-2008.

Orthopaedic Basic Science Self Assessment Examination, AAOS, 2007.

Seo SW, F Remotti, Lee FY: Chondrosarcoma, Orthopaedic Knowledge Update, Musculoskeletal Oncology, 2007.

Seo SW, Moon YL, Lee FY: Benign Cystic Lesions. Essentials of Orthopaedic Surgery, 2007.

Hyman J, Lee FY, Roye DP: Orthopaedic Surgery, Chapter, Pediatric Secrets, Ed, 2002.

Carol Morris, Lee FY and Gebhardt MC: Benign Bone Tumors, Chapter, Operative Orthopaedic Surgery, Ed. Chapman M, Williams and Wilkins, 2000.

Publications

Jocelyn Traina Compton and Francis Y. Lee*: Current Concept Review. Osteocytes: Emerging Roles and Orthopaedic Implications. Journal of Bone and Joint Surgery (Am). 2014 (in press).

Chandhanarat Chandhanayingyong and Francis Y. Lee*: Molecular signature and clinical outcomes of extraskeletal myxoid chondrosarcoma. Journal of Bone and Joint Surgery (Am). 2014 (in press).

Jocelyn Compton, Francis Y. Lee*: Function of osteocytes and sclerostin. Current Concept Review. Journal of Bone and Joint Surgery (Am). 2014 (in press).

Yuhree Kim, Emily Stein, Fabrizzio Remotti, Francis Y. Lee*: Tumor-induced osteomalacia. Journal of Bone and Joint Surgery (Am) Case Connector. 2014 (in press).

Daniel S. Oh*, Yoon Hyuk Kim, Danaa Ganbat, Myung-Ho Han, Phillip Lim, Jung-Ho Back, Francis Y. Lee, Hesham Tawfeek. Bone marrow absorption and retention properties of engineered scaffolds with micro-channels and nano-pores for tissue engineering: a proof of concept. Ceramics International. 2014 (in press).

Amorosa L, CH Lee, Aydemir A, Nizami S,Hsu A, Patel N, Gardner T, Navalgund A, Kim DG, Park SH, Mao JJ, Lee FY*: Physiologic load-bearing characteristics of autografts, allografts, and polymer-based scaffolds in a critical size segmental defect of a long bone: an experimental study. International Journal of Nanomedicine. 2013, 8:1-7

Rosa M. Guzzo, Jason Gibson, Ren-He Xu, Francis Y. Lee, Hicham Drissi*: Efficient differentiation of human iPSC-derived mesenchymal stem cells to chondroprogenitor cells. Journal of Cellular Biochemistry, 2013 Feb; 114(2):480-90. doi: 10.1002/jcb.24388

Lee HG, Hsu A, Goto H, Nizami S, Lee JH, Cadet ER, Tang P, Shaji R, Chandhanayingyong C, Kweon SH, Oh DS, Tawfeek HA, Lee FY*. Aggravation of Inflammatory Response by Co-Stimulation with Titanium Particles and Mechanical Perturbations in Osteoblast- and Macrophage- like Cells. American Journal of Physiology 2012 Dec 19. {Epub ahead of print} PMID: 23255578}

Confavreux CB, Borel O, Lee F, Vax G, Guyard M, Fadat C, Carlier MC, Chapurlat R, Karsenty G*. Osteoid osteoma is an osteocalcinoma affecting glucose metabolism. Osteoporosis Int. 2012 May;23(5): 1645-50. Epub 2011 Jun 17. PubMed PMID: 21681611.

Yuhree Kim, Saqib Nizami, Hana Goto, Francis Y. Lee*: Giant Cell tumor of Bone. Clinics in Orthopaedic Surgery,, 2012, Jun:4(2):107-16.

Chandhanarat Chandhanayingyong, M.D., Scott Thompson, M.D., Fabrizzio Remotti, M.D., Francis Y Lee, M.D., Ph.D.*: Disseminated Osteolytic Embolic Lesions from Atrial Myxoma. Journal of Bone and Joint  Surgery, 2012.

  • Chandhanarat Chandhanayingyong, Yuhree Kim, J. Robert Staples, Cody Hahn, Francis Y. Lee*: MAPK/ERK Signaling in Osteosarcomas, Ewing Sarcomas and Chondrosarcomas: Therapeutic Implications and Future Directions. Sarcoma, June 2012 .
  • Blaine TA*, Cote MA, Proto A, Mulcahey M, Lee FY, Bigliani LU. Interleukin-1ß stimulates stromal-derived factor-1 α expression in human subacromial bursa. J Orthop Res. 2011 Nov;29(11):1695-9. doi: 10.1002/jor.21416. Epub 2011 Apr 11. PubMed PMID: 21484857.
  • Tekabe Y, Klose A, Nizami S, Luma J, Lee FY, Johnson L*: New application of optical agent to image angiogenesis in hindlimb ischemia. J Biophotonics. 2011 Nov;4(11-12):859-65. Epub 2011 Oct 27.

Son JS, Kim JM, Han M, Choi SH, Lee FY, Oh DO* (2011): Bone Regeneration of Tibial Segmental Defect Using Isotropic-Pore Structures Hydroxyapatite/Alumina Bi-Layered Scaffold: In Vivo Pilot Study, Journal of Long-Term Effects of Medical Implants, 21(2): 159-167.

  • Lee HG, Minematsu H, Hsu AC, Nizami S,  Chung KJ,  Lee FY*: Actin and ERK1/2-CEBP-beta signaling mediates phagocytosis-induced innate immune response of osteoprogenitor cells. Biomaterials. 2011 Dec;32(35):9197-206. Epub 2011 Sep 6.

Minematsu H, Shin MJ, Celil Aydemir AB, Kim KO, Nizami SA, Chung GJ, Lee FY: Nuclear presence of nuclear factor of activated T cells (NFAT) c3 and c4 is required for Toll-like receptor-activated innate inflammatory response of monocytes/macrophages. Cell Signal. 2011 Nov;23(11):1785-93. Epub 2011 Jun 25. PubMed PMID: 21726630.

  1. Onishi AC, Hincker AM, Lee FY. Surmounting chemotherapy and radioresistance in chondrosarcoma: molecular mechanisms and therapeutic targets. Sarcoma. 2011, Epub 2010 Dec 30. PubMed PMID: 21234363..

Noh KC, Kim KO, Staples JR, Patel N, Minematsu H, Nair K, Lee FY: Targeting  Inflammatory Pathways in Osteosarcoma. Journal of Bone and Joint Surgery (Am). 2011 Apr 20; 93(8):723-32. PubMed PMID: 21508279.

Shahryarinejad A, Gardner TR, Cline JM, Levine WN, Bunting HA, Brodman MD, Ascher-Walsh CJ, Scotti RJ, Vardy MD: Effect of hormone replacement and selective estrogen receptor modulators (SERMs) on the biomechanics and biochemistry of pelvic support ligaments in the cynomolgus monkey (Macaca fascicularis). Am J Obstet Gynecol. 2010 ,May;202(5):485.e1-9.

Seo SW, Lee D, Minematsu H, Kim AD, Shin M, Cho SK, Kim DW, Yang J, Lee FY. Targeting extracellular signal-regulated kinase (ERK) signaling has therapeutic implications for inflammatory osteolysis. Bone. 2010 Mar:46(3):695-702. Epub 2009 Nov 4. PubMed PMID: 19895919; PubMed Central PMCID: PMC2823832.

Nowak DD, Gardner TR, Bigliani LU, Levine WN, Ahmad CS: Interobserver and Intraobserver Reliability of the Walch Classification in Primary Glenohumeral Arthritis. Journal of Shoulder and Elbow Surgery, 19: 180-183, 2010.

Mills J, Matos T, Charytonowicz E, Hrick T, Castillo-Martin M, Remotti F, Lee FY, Matushansky I. Characterization and comparison of the properties of sarcoma cell lines in vitro and invivo. Human Cell, 2009 Nov;22(4):85-93. PubMed PMID: 19874397.

Aydemir AB, Minematsu H, Gardner TR, Kim KO, Ahn JM, Lee FY: Nuclear factor of activated T cells mediates fluid shear stress-and tensile strain-induced Cox2 in human and murine bone cells. Bone. 2010 Jan;46(1):167-75. Epub 2009 Sep 11. PubMed PMID: 19748606; PubMed Central PMCID: PMC2818272.

Kim DW, Kim KO, Shin MJ, Ha JH, Seo SW, Yang J, Lee FY: siRNA-Based Targeting of Antiapoptotic Genes Can Reverse Chemoresistance in P-glycoprotein Expressing Chondrosarcoma Cells. J Molecular Cancer, 2009 May 15;8:28.

Seo SW, Cho SK, Storer SK, Lee FY: Zoledronate reduces unwanted bone resorption in intercalary bone allografts. Int Orthop., 2009 Apr 3, PubMed PMID: 19343345.

  • Jobin CM, Kippe MA, Gardner TR, Levine WN, Ahmad CS: Distal Biceps Tendon Repair: A Cadaveric Analysis of Suture Anchor and Interference Screw Restoration of the Anatomic Footprint.  American Journal of Sports Medicine, 37: 2214-2221, 2009.
  • Cadet ER, Vorys GC, Rahman R, Park SH, Gardner TR, Lee FY, Levine WN, Bigliani LU, Ahmad CS: Improving Bone Density at the Rotator Cuff Footprint Increases Supraspinatus Tendon Failure Stress in a Rat Model. Journal of Orthopaedic Research, 28: 308-314, 2009.
  • Ahmad CS, Jobin C, Kippe M, Gardner T, Levine WN: Distal Biceps Tendon Repair: A Cadaveric Analysis of Suture Anchor and Interference Screw Restoration of the Anatomic Footprint. Am J Sports Med 2009, 37(11):2214-21.
  • Ahmad CS, Galano GJ, Christian Vorys G, Covey AS, Gardner TR, Levine WN: Evaluation of Glenoid Capsulolabral Complex Insertional Anatomy and Restoration with Single and Double Row Capsulolabral Repairs. Journal of Shoulder and Elbow Surgery, 18: 948-954, 2009.
  • Nowak DD, Bahu MJ, Gardner TR, Dyrska MD, Levine WN, Bigliani LU, Ahmad CS: Simulation of Surgical Glenoid Resurfacing Using Three-dimensional Computed Tomography of the Arthritic Glenohumeral Joint: The Amount of Glenoid Retroversion That Can Be Corrected. Journal of Shoulder and Elbow Surgery, 18:680-688, 2009.

Guterl CC, Gardner TR, Rajan V, Ahmad CS, Hung CT, Ateshian GA: Two-Dimensional Strain Fields on the Cross-Section of the Human Patellofemoral Joint Under Physiological Loading. Journal of Biomechanics, 42: 1275-1281, 2009.

Caligaris M, Canal CE, Ahmad CS, Gardner TR, Ateshian GA: Investigation of the Frictional Response of Osteoarthritic Human Tibiofemoral Joints and the Potential Beneficial Tribological Effect of Healthy Synovial Fluid. Osteoarthritis and Cartilage, 17: 1327-1332, 2009.

Ahmad CS, Vorys GC, Covey A, Levine WN, Gardner TR, Bigliani LU: Rotator Cuff Repair Fluid Extravasation Characteristics are Influenced by Repair Technique. Journal of Shoulder and Elbow Surgery,18:976-981, 2009.

Moffat KL, Doty S, Spalatzi J, Levine WN, Lu H: Novel Nanofiber-based Scaffold for Rotator Cuff Repair and Augmentation. Tissue Engineering, 2009, 15:115-126.

Kleweno CP, Jacir AM, Gardner TR, Ahmad CS, Levine WN: Biomechanical Evaluation of Anterior Cruciate Ligament Femoral Fixation Techniques. American Journal of Sports Medicine, 37:339-345, 2009.

Chambers A, Prince D, Greisberg J: Apoptosis and Nitric Oxide in Chondrocyte Following Trauma. J of Trauma. In press.

Tang P, Gauvin J, Muriuki M, Pfaeffle JH, Imbriglia JE, Goitz RJ: Comparison of the “Contact Mechanics” of the Intact and Proximal Row Carpectomy Wrist: J Hand Surg, 34A:660-670, 2009.

Sanjeev Suratwala, Samuel K. Cho, Jonathan Van Rattle, Sang H Park, Sung W Seo, Seong-Sil chang, Thomas R. Gardner, Lee, FY: Enhancement of periprosthetic bone quality with topical hydroxyapatite-bisphosphonate composite: An Experimental Study. The Journal of Bone and Joint Surgery, 90A(10):2189-2195, 2008.

Tuan RS, Lee FY, Konttinen YT, Wilkinson JM, Smith RL: What are the local and systemic biologic reactions and mediators to wear debris, and what host factors determine or modulate the biologic response to wear particles? Journal of American Academy of Orthopaedic Surgeons, 16(S):42-48, 2008.

Ahmad CS, Gardner T, Bell J, Levine WN: Biomechanical Performance of Rotator Cuff Repairs with Humeral Rotation: A New Rotator Cuff Repair Failure Model. Am J Sports Med, Apr 9, 2008 [Epub ahead of print].

Gonzalez-Lomas G, Kippe MA, Brown GA, Ding A, Gardner TR, Levine WN, Ahmad CS: In-Situ Trans-Tendon Repair Outperforms Tear Completion and Repair for Partial Articular-Sided Supraspinatus Tendon Tears. Journal of Shoulder and Elbow Surgery, 17: 722-728, 2008.

Kowlosky MS, Dellenbaugh SG, Erlichman DB, Gardner TR, Levine, WN, Ahmad CS: Evaluation of Suture Abrasion Against Rotator Cuff Tendon and Proximal Humerus Bone. Arthroscopy, 24:329-334, 2008.

Ahmad CS, Kleweno C, Jacir A, Bell JE, Gardner TR, Levine WN, Bigliani LU: Biomechanical Performance of Rotator Cuff Repairs with Humeral Rotation: A New Rotator Cuff Repair Failure Model. American Journal of Sports Medicine, 36:888-92, 2008.

Celil Aydemir AB, Lee S, Won Kim D, Gardner TR, Prince D, Mok Ahn J, Lee FY: Calcineurin/NFATc axis mediated fluid shear stress-induced COX-2 expression in human mesenchymal cells. The Annals of New York Academy of Science,1117:138-42; Nov, 2007.

Seo SW, Aydemir A, Minematsu H, Lee FY: ERK Signaling Regulates M-CSF Expression Induced by Titanium Nanoparticles in MC3T3-E1 Murine Calvarial Pre-Osteoblastic Cells. The Annals of New York Academy of Science, 1117:151-8; Nov, 2007.

Minematsu H, Seo S, Aydemir A, Lee FY: Calcomeirom/NFATC1 Axis Regulates UHMWPE Wear Particle-Induced Cytokine Expression in Macrophages: The Annals of New York Academy of Science, 1117:143-50; Nov, 2007.

Park MC, Jun BJ, Park CJ, Ahmad CS, Elattrache NS, Lee TQ: The Biomechanical Effects of Dynamic External Rotation on Rotator Cuff Repair Compared to Testing With the Humerus Fixed. American Journal of Sports Medicine, 35:1931-9, 2007.

Ahmad CS, DiSipio K, Gardner TR, Levine WN, Bigliani LU: Factors Affecting Dropped Biceps Deformity After Tenotomy of the Long Head of the Biceps Tendon. Arthroscopy, 23:537-41, 2007.

Ahmad CS, Wing DE, Gardner T, Levine WN, Bigliani LU: Biomechanical evaluation of subscapularis repair used during shoulder arthroplasty. J Shoulder and Elbow Surg,16 (3 Suppl):S59-6.4; May-June, 2007.

Kim DW, Seo SW, Cho S, Chang SS, Lee HW, Lee SE, Block JA, Hei TK, Lee FY: Targeting of cell survival genes using small interfering RNAs (siRNAs) enhances radiosensitivity of Grade II chondrosarcoma cells. Journal of Orthopaedic Research, 25(6):820-8; March 7, 2007.

Park MC, Elattrache, NS, Tibone JE, Ahmad CS, Jun BJ, Lee TQ: Part I: Footprint Contact Characteristics for a “Transosseous-Equivalent” Rotator Cuff Repair Technique Compared to a Double-Row Technique. Journal of Shoulder and Elbow Surgery, 16:461-8, 2007.

Spalazzi JP, Doty SB, Moffat KL, Levine WN, Lu HH: Development of controlled matrix heterogeneity on a triphasic scaffold for orthopaedic interface tissue engineering: Tissue Engineering, 12: 3497-3508, 2006.

Lee FY, Sinicropi S, Vitale MG, Lee FS, Roye DP, Choi IH: Treatment of congenital pseudarthrosis of tibia with recombinant human bone morphogenetic protein-7: A prospective study. Journal of Bone and Joint Surgery, 88(3):627-33; Mar,2006.

Kim YS, Bigliani LU, Fujisawa M, Murakami K, Chang SS, Lee HJ, Lee FY, Blaine TA: Stromal cell-derived factor 1 (SDF-1, CXCL12) is increased in subacromial bursitis and downregulated by steroid and nonsteroidal anti-inflammatory agents. Journal of Orthopaedic Research, 24: 1756-64; June, 2006.

Ahmad CS, Wing D, Gardner TR, Levine WN, Bigliani LU: Biomechanical Evaluation of Subscapularis Repairs Used During Total Shoulder Replacement. Journal of Shoulder and Elbow Surgery, 16:s59-64, 2006.

Kim DW, Lee HJ, Karmin J, Lee SE, Chang SS, Tolchin B, Lin S, Cho SK, Kwon A, Ahn JM, and Lee FY: Mechanical Loading Differentially Regulates Membrane-Bound and Soluble RANKL Availability in MC3T3-E1 Cells. Annals of New York Academy of Science, Vol 1068, pp568-572, April, 2006.

Park M, Cadet E, Levine, WN, Bigliani LU, Ahmad CS: Comparison of Rotator Cuff Tendon Pressure Against the Tuberosity in Suture Anchor and Transosseous Suture Rotator Cuff Repairs. American Journal of Sports Medicine, 33:1154-9, 2005.

Lee FY, Kim DW, Karmin JA, Hong D, Chang SS, Fujisawa M, Takayanagi H, Bigliani LU, Blaine TA, Lee HJ: mu -calpain regulates RANKL-supported osteoclastogenesis via NF-kappa B activation in raw 264.7 cells. Journal of Biological Chemistry, 280(33):29929-36; June 13, 2005.

Yu J, Chang SS, Suratwala S, Chung W, Abdelmessieh P, Lee HJ, Yang J, Lee FY: Zoledronate induces apoptosis in stromal cells of unicameral bone cyst. Journal of Orthopaedic Research, 23(5):1004-122005; May 24, 2005.

Blaine TA, Kim YS, Voloshin I, Chen D, Murakami K, Chang SS, Winchester R, Lee FY, O'Keefe RJ, Bigliani LU: The molecular pathophysiology of subacromial bursitis in rotator cuff disease. J Shoulder Elbow Surg, 14(1 Suppl S):84S-89S; Jan-Feb, 2005.

Liao T, Yurgelun M, Chang SS, Murakami K, Zhang HZ, Parisien MV, Blaine TA, Kim W, Winchester RJ, Lee FY: Recruitment of osteoclast precursors by stromal cell derived factor-1 in giant cell tumor of bone. Journal of Orthopaedic Research, 23(1):203-9; Jan, 2005.

Yoon AJ, Parisien M, Feldman F, Lee FY: Extranodal Rosai-Dorfman disease of bone, subcutaneous tissue and paranasal sinus mucosa: Case report and review of the literature. Skeletal Radiology, 34(10):653-7; Oct, 2005.

Delloye C, Suratwala S, Valentin-Opran A, Cornu O, Lee FY: Treatment of Allograft Nonunions with Recombinant Human Bone Morphogenetic Proteins (rhBMP): Early Clinical Results. ACTA Orthopaedica Belgica, 70:591-597, 2004.

Chang SS, Suratwala S, Jung KM, Doppelt J, Zhang HJ, Blaine TA, Kim TW, Winchester RJ, Lee FY: Bisphosphonate may reduce recurrence in GCT by inducing apoptosis. Clinical Orthopaedics and Related Research, September, 426:103-109, 2004.

Lee FY, Hornicek FJ, Dick HM, Mankin HJ: Synovial chondromatosis of the foot. Clinical Orthopaedic and Related Research, April, 423:186-190, 2004.

Ahmad CS, Groh M, Arnouk J, Gardner TR, Levine WN: Mechanical properties of soft tissue femoral fixation devices for ACL reconstruction. Am J Sports Med, 32: 1-10, 2004.

Vitale MG, Choe JC, Hwang MW, Bauer RM, Hyman JE, Lee FY, Roye DP: Postoperative Use of Ketorolac Tromethamine in Children Undergoing Scoliosis Surgery. The Spine Journal, 3:55-62; 2003.

Lee FY, Storer SK, Hazan EJ, Gebhardt MC, Mankin HJ: Repair of bone allograft fracture using bone morphogenetic protein-2 in an animal experimental model. Clinical Orthopaedics and Related Research, April, 397:119-126, 2002.

Lee FY, Zawadsky M, Parisien M, Ho M, Murty VV, Jayaraman T, Dick HM: A novel translocation (9;12)(q22;q24) in secondary chondrosarcoma arising from hereditary multiple exostosis. Cancer Genetics and Cytogenetics, 132(1)68-70; 2002.

Lee FY, Hazan EJ, Gebhardt MC, Mankin HJ. An experimental model for allograft fracture repair. Journal of Orthopaedic Research, 18:303-306, 2000.

Ramappa AJ, Lee FY, Tang P, Carlson JR, Gebhardt MC, Mankin HJ: Chondroblastoma of bone. Journal of Bone and Joint Surgery, 82A:1140-1145, 2000.

Lee FY, Mankin HJ, Gebhardt MC, Springfield D, Fondren G, Jennings LC, Rosenberg A. Outcome analysis of chondrosarcoma. Journal of Bone and Joint Surgery, (Am) 81A: 326-338, 1999.

Lee FY, Rho JY, Harten R, Parsons JR, Behrens FF. Micromechanical Properties of Primary Spongiosa and Epiphyseal Trabecular Bone. Journal of Pediatric Orthopaedics, 18: 582-585, 1998.

Lee FY, Behrens FF, DeFouw DO, and Einhorn TA: Programmed Removal of Chondrocytes During Enchondral Fracture Healing. Journal of Orthopaedic Research, 16(1), 144-149, 1998.

Lee FY, Gebhardt MC, Keel SB, Rosenthal DI. Orthopaedic-Pathology-Radiology Conference. A discrete soft tissue mass in the distal thigh of 29-year–old male. Clinical Orthopaedics and Related Research, 357: 247-250, 1998.

Benevenia J, Lee FY, Buechel FF, Parsons JR: Aggressive Granulomatous Lesion following Total Knee Replacement Arthroplasty. Journal of Biomedical Materials Research Applied Biomaterials, 43(4):473-477, 1998.

Seong SC, Matsumura T, Lee FY, Whelan MC, Li XQ and Trippel SB: Insulin-like growth factor I regulation of Swarm rat chondrosarcoma chondrocytes in culture. Experimental Cell Research, 211:238-244, 1994.

Kim YM, Lee SH, Lee FY, Koo KH and Cho KH: Morphologic and biomechanical study of avascular necrosis of the femoral head. Orthopaedics, 14:1111-1116, 1991.

Active Research Awards

National Institutes of Health

Francis Y. Lee, M.D., Ph.D., Principal Investigator

ERK Signaling in Inflammatory Bone Loss

Period: 2/01/13 - 1/31/18 (Competitive Renewal)

National Institutes of Health

Francis Y. Lee, M.D., Ph.D., Principal Investigator/Mentor

Charla  R. Fischer, M.D., Investigator

ERK Signaling in Inflammatory Bone Loss

Research Supplement to Promote Diversity in Health Related Research

Period: 2/01/14 - 1/31/17

National Institutes of Health

Francis Y. Lee, M.D., Ph.D., Principal Investigator

Mechanobiological Mechanism for inflammatory bone loss

Period:   2/01/13 - 1/31/18 (Competitive Renewal)

Musculoskeletal Transplant Foundation

Francis Y. Lee, M.D., Ph.D., Principal Investigator

Biological Modification of Allografts

Period: 2/01/13 - 1/31/16

Department of Defense

Francis Y. Lee, M.D., Ph.D. -Principal Investigator

USAMRAA

Ready-to-Use Tissue Constructs for Military Bone and Cartilage Trauma

Period:  9/30/10 - 10/29/14

Orthopaedic Research & Education Foundation

Orthopaedic Resident Clinician Scientist Development Award

Thomas Hickernell, M.D., Resident Principal Investigator

Investigation of the Mechanism of Action & a Novel Therapeutic Application of a Caspase 1 Inhibitor in the Setting of Inflammatory Osteolysis

Period:  7/01/13 - 6/30/14

Orthopaedic Research & Education Foundation Resident Clinician Scientist Training Grant

Anny Hsu,  M.D., Principal Investigator

Enhancement of Dynamic Biomechanical Properties of Structural Allograft with BMP2 Loaded Nanospheres

Period: 7/01/12 - 6/30/13

American Foundation for Surgery of the Hand

Peter Tang, M.D., MPH, Principal Investigator

An Evaluation of Inflammation, Histology, and Function in Nerve Regeneration

Period:  9/01/11 - 8/31/12

National Institutes of Health (NIH)
Francis Y. Lee, M.D., Ph.D., Principal Investigator
National Institute of Biomedical Imaging and Biomedical Engineering (NIBIB)
ERK signaling in inflammatory bone loss
Period: 4/01/2009 – 1/31/2013

The Medical Advisory Committee for Major League Baseball has awarded Dr. Christopher S. Ahmad, director of the Biomechanics Laboratory and team physician for the New York Yankees, a grant for research investigating "The Effect of Timing of Plasma-Rich Protein (PRP) Injections on Muscle Healing". The study will evaluate the efficacy of PRP to accelerate muscle tissue repair and regeneration at the site of injury.

Period:  12/01/10 - 11/30/11

National Institutes of Health (NIH)
Francis Y. Lee, M.D., Ph.D., Principal Investigator
National Institute of Biomedical Imaging and Biomedical Engineering (NIBIB)
Mechanobiological Mechanism of Inflammatory Bone Loss
Period: 6/01/07 – 2/28/12

AO North America Resident Trauma Research Support Award
Louis Amorosa, M.D.

The Effects of Mesenchymal and Hematopoietic Stem Cells Loaded into a Tricalcium Phosphate Scaffold in a Rat Femoral Nonunion Model
Period: 6/01/09 – 3/31/11

Orthopaedic Research and Education Foundation
Zimmer Orthopaedic Career Development Award
Peter Tang, M.D., Principal Investigator
Contact Biomechanics after Scaphoid Excision, Four-Corner Fusion
Period: 7/01/08 – 6/30/09

Orthopaedic Research and Education Foundation
Career Development Award (Peer-Reviewed)
Francis Y. Lee, Principal Investigator
The Calcineurin/Nuclear Factor of Activated T Cells in Ultrahigh Molecular Weight Polyethylene (UHMWPE) Wear Particle
Period: 7/01/06 – 6/30/09

Orthopaedic Research & Education Foundation 2008 - 2009


Depuy Orthopaedic Resident Educational Grants


Lan Chen, M.D.

Antiapoptotic Gene Silencing Using Human Mesenchymal Stem Cell Delivery of Small Interfering RNA (siRNA) as Adjuvant Therapy for Osteosarcomas


Lauren M. Fabian, M.D.
Radiographic Evaluation of Teres Minor Hypertrophy and Functional Status in Patients with Rotator Cuff Tears


Ra'Kerry K. Rahman, M.D.
The Effects of Bisphosphonates on Greater Tuberosity Bone Density and Rotator Cuff Attachment Properties in the Osteoporotic Rat Model

Orthopaedic Research and Scientific Foundation 2008 - 2009


Christopher S. Ahmad, M.D.

The Effects of Reversing Ovariectomy-Induced Osteopenia at Greater Tuberosity with Bisphosphonates (Zometa) and Estradiol at a Supraspinatus Tendon Repair Site in a Rat Model


William N. Levine, M.D.
Thomas Gardner, M.C.E.
The Effects of Hormone Replacement Therapy on the Biomechanics of the Macaque Glenohumeral Joint as an Animal Model of the Human Shoulder

Peter Tang, M.D.
Contact biomechanics of the Intact and Scaphoid Excision, Four Bone Fusion (4BF) Wrist


Robert Strauch, M.D., Christopher Ahmad, M.D., Francis Lee, M.D.
Yelena Akelina, D.V.M.
Computerized Gait Analysis Track-DigiGait for small laboratory animals


Francis Y. Lee, M.D., Ph.D.
Musculoskeletal Stem Cell Initiative & Molecular Imaging Infrastructure Grant
Shared Equipment Infrastructure Grant