The Robert E. Carroll and Jane Chace Carroll Laboratories
Project Report (September 25, 2013 – Columbia Orthopaedics)
Phase I of the development plan for the Dr. Robert E. Carroll and Jane Chace Carroll Laboratories concluded with a bang. An informal ground-breaking ceremony on September 23rd featured Drs. Louis U. Bigliani and Francis Y. Lee initiating the renovation stage by shattering a laboratory wall.
Phase I goals were met with great success. The vision of a musculoskeletal clinical and translational research center was shared with colleagues from throughout the NY Presbyterian Hospital / Columbia University complexes. The enthusiastic response resulted in a May 10th Musculoskeletal Symposium on Current Trends in Musculoskeletal Medicine & Science spearheaded by Drs. Lee and Bigliani. Guest speakers represented the fields of orthopaedic surgery, medicine, genetics and development, pathology and cell biology, hematology and oncology, endocrinology, rheumatology and regenerative medicine. The symposium’s overall message was one of fostering collaborative clinical and translational musculoskeletal research that would ultimately improve patient outcomes. The NYPress, NY Presbyterian’s monthly magazine featured an article on the symposium entitled “Expanding Collaborations in Musculoskeletal Medicine.”
The department of orthopaedic surgery had a stellar year for research funding awards from private foundations and government agencies. In particular, Dr. Francis Lee received an established investigator award from the Musculoskeletal Transplant Foundation and renewal of two NIH R01 awards. Dr. Charla Fischer received a NIH supplements award through mentor, Dr. Francis Lee’s parent NIH grant.
Dr. Lee’s recognition as an NIH principal investigator and mentor and Dr. Bigliani’s roles as departmental chairman and president of ColumbiaDoctors have helped to establish the department’s leadership position in the field of musculoskeletal research. More than 50 Principal Investigators with 60 NIH awards are conducting musculoskeletal system-related research spanning basic, translational, and clinical aspects at Columbia University Medical Center / Presbyterian Hospital.
The Dr. Robert E. Carroll and Jane Chace Carroll Laboratories will provide a solid foundation for cultivating a multidisciplinary musculoskeletal research center. This past July, Drs. Lee and Bigliani collaborated with more than 60 investigators for a P30 Center grant submission to the NIH. The long-term objectives of the P30 grant echo the Dr. Robert E. Carroll and Jane Chace Carroll Laboratories’ goal to develop a musculoskeletal research center that will provide rapidly evolving state-of-the-art core services to enhance collaborations for creative interdisciplinary research.
As we enter the renovation period, we will continue to develop collaborative relationships with our colleagues to advance clinical and translational musculoskeletal research. In addition, we will seek funding opportunities through private foundations, government awards and fund-raising activities. We eagerly welcome the next phase of development and look forward to a new era in musculoskeletal research.
2013 AAOS/OREF/ORS Clinician Scholar Development Program
Dr. Francis Y. Lee, Professor of Orthopaedic Surgery and Vice Chair of Research at Columbia University Medical Center served as a moderator for the September 26-28, 2013 AAOS/OREF/ORS Clinician Scholar Development Program (CSDP) at the Hyatt Rosemont Hotel, Rosemont, Illinois. This year’s program was chaired by Dr. Mathias Bostrom, Academic Director and Residency Program Director at the Hospital for Special Surgery. Faculty members represented leaders in the field of orthopaedic research and included; Denis R. Clohisy, MD, University of Minnesota, Regis O’Keefe, MD, PhD, University of Rochester, William Robb, MD, Illinois Bone & Joint Institute, Marjolein van der Meulen, PhD, Cornell University, Michael Yaszemski, MD, PhD, Mayo Clinic, James S. Panagis, MD, MPH, National Institute of Arthritis & Musculoskeletal & Skin Diseases, Kurt Spindler, MD, Vanderbilt University, Richard Terek, MD, Brown University, Peter C. Amadio, MD, Mayo Clinic, Kristy L. Weber, MD, University of Pennsylvania, MAJ Benjamin Kyle Potter, MD, Walter Reed National Military Medical Center, Nancy Pleshko, PhD, Temple University, Larry Suva, PhD, University of Arkansas, Kevin J. Bozic, MD, MBA, University of California, San Francisco, and Ken Yamaguchi, MD, Washington University, St. Louis. There was a wonderful turnout and this year’s participants were selected through a competitive selection process. The program participants represented early career attendings, residents and faculty from across the country. This year’s workshop sessions included the following topics:
Beginning Your Career as a Clinician Scientist (Scholar)
Orthopaedic Research Bench or Bedside
Navigating Grants and Securing Research Funding
Interaction Between Department Chairs and Clinician Scholars
Orthopaedic Organizations: Opportunities and Mentorship
Dr. Eric Makhni, (PGY4 Resident), Columbia University, participated in the Clinician Scholar Development Program. Dr. Makhni stated that “The program was masterfully taught, providing didactics regarding several aspects of pursuing a successful career as a clinician-scholar in orthopaedic surgery, including development of a focused research program to build upon, relentless pursuit of external funding in order to create a sustainable research program, navigating the promotion ladder within academic medicine, and finally how to balance it all with commitments to family, self and institution.” Upon reviewing the program, Dr. Makhni said, “The CSDP experience has been profound and inspiring on multiple levels. I have met many peers from across the country who, are blindly committed to leaving meaningful impacts on the current state of understanding in orthopaedic medicine. I also have heard from those who have achieved this impact, and the various struggles that can be expected on the way. More importantly, however, it has afforded me an opportunity to critically introspect my own career trajectory, motivating me to set out clear goals with respect to commitment to sound, meaningful research and clear delineation of a focused research program so that I may one day, leave my own imprint on the field of orthopaedic medicine.”
Eric Makhni, MD & Francis Y. Lee, MD, PhD
Charla R. Fischer, MD, NIH Investigator
Francis Y. Lee, MD, PhD, NIH Mentor & Principal Investigator
Dr. Fischer and Dr. Lee are the Recipients of the National Institutes of Health Supplements Award to Promote Diversity in Health-Related Research
Dr. Charla R. Fischer, Assistant Professor of Clinical Orthopaedic Surgery and Dr. Francis Y. Lee, Professor with Tenure and Vice Chair of Research received an NIH Research Supplements award to promote Diversity in Health-Related Research. Dr. Fischer is a practicing spine surgeon with a particular interest in treating the aging spine. This interest has led her to study bone biology related to osteoclastogenesis and osteolysis. Dr. Fischer is mentored by Dr. Francis Y. Lee, Professor of Orthopaedic Surgery. Dr. Lee is a musculoskeletal tumor and pediatric orthopaedic surgeon. Dr. Lee’s current research programs on bone inflammation, regeneration and cancers are funded by the Department of Defense, NIAMS, NIBIB, OREF, and Musculoskeletal Transplant Foundation. Dr. Lee is the PI of the NIH parent grant for Dr. Fischer’s Supplement award. Dr. Lee is examining the anti-inflammatory function of specific proteins. Dr. Fischer will expand Dr. Lee’s experimental base to examine the osteoporotic spine. Dr. Lee has been mentoring junior faculty, orthopaedic residents (Columbia Orthopaedics Translational Research in Orthopaedics Pre-Residency Fellowship) and P&S students interested in pursuing clinical and translational research.
Francis Y. Lee, MD, PhD
Columbia University Senator 2013 – 2015
Dr. Francis Y. Lee, Professor of Orthopaedic Surgery and Vice Chair of Research, has been reelected to serve the Columbia University Senate as a tenured faculty member. This is his second term as a senate member. The Columbia Senate is a university-wide legislature that represents faculty, students and other constituencies. The Senate passes policy on a wide range of issues that affect the entire University. Dr. Lee is a Chair for the Research Policy and External Relations Committee and a member of the Columbia University Budget Review Committee. Dr. Lee is a musculoskeletal tumor and pediatric orthopaedic surgeon. He is initialing personalized medicine using genomic studies in the field of musculoskeletal oncology. As a NIH-funded researcher, he analyzes current clinical challenges through translational research programs.
Current Trends in Musculoskeletal Medicine & Science
May 10th 1:00pm - 6:00pm
Columbia University Medical Center / New York Presbyterian Hospital
650 W. 1168th St., William Black Building, Alumni Auditorium, Main Floor
Columbia Orthopaedics is honored to host this wonderful opportunity for promoting scientific and clinical collaboration across departments, specialties and campuses in a relaxed and informal setting. Collectively, our scientists, clinicians and engineers seek to advance knowledge in the areas of bone biology, bone mechanics, tissue regeneration and bone disease processes. Our guest speakers are highly regarded in their fields.
Dr. Francis Y. Lee Awarded 4th NIH R01 Grant
National Institute of Arthritis & Musculoskeletal & Skin Diseases
Francis Y. Lee, M.D., Ph.D., Professor of Orthopaedic Surgery, Vice-Chairman for Research and Director of the Center for Orthopaedic Research has received a $1.7M award from the National Institute of Arthritis & Musculoskeletal & Skin Diseases.
This award represents a 5 year competitive renewal of Dr. Lee’s second R01 grant, “ERK Signaling in Inflammatory Bone Loss.” Dr. Lee's long-term goals for this project are to develop new pharmacologic methods for preserving and enhancing bone mass that will address the future needs of the increasing elderly population. Other research projects are focused on the development of novel therapeutic strategies that will enhance bone health, regulate bone loss, prevent cancer spread to bone and improve orthopaedic implant integration and healing.
Dr. Lee specializes in bone tumors, soft tissue sarcomas, metastatic bone cancers, and pediatric orthopaedic disorders. As an exemplary orthopaedic surgeon scholar, he serves as both researcher and mentor to students, postdoctoral fellows, residents and junior faculty internally and nationally through AAOS/ORS/OREF mentoring programs.
|Francis Y. Lee, MD|
Orthopaedic Research & Education Foundation (OREF) / DePuy
Resident Research Project Grant
The Orthopaedic Research & Education Foundation proudly supports orthopaedic residents to develop clinically relevant research interests.
Dr. Thomas R. Hickernell, the Translational Research in Orthopaedics (TRIO) fellow of the Center for Orthopaedic Research (COR) has received a Resident Research Project Grant from the OREF for his proposal “Investigation of the mechanism of action and a novel therapeutic application of a caspase 1 inhibitor in the setting of inflammatory osteolysis.” The study’s long range goal is to preserve and enhance bone quality in diverse conditions that lead to pathologic inflammatory osteolysis.
|Thomas Hickernell, MD|
Mentor, Dr. Francis Y. Lee, Director of COR and Vice-Chair for Research, oversees the TRIO program, a six year research residency track with year one dedicated to research. The research year includes guidance on the fundamentals of grant proposal development and grant application processes. In addition to his role as mentor to residents, post-doctoral research fellows and students, Dr. Lee is an active proponent for the AAOS/OREF/ORS Clinician Scholar Development Programs sponsored by the American Academy of Orthopaedic Surgeons, the Orthopaedic Research & Education Foundation and the Orthopaedic Research Society.
|Francis Y. Lee, MD|
Dr. Francis Y. Lee Receives
2012 Established Investigator Award
The Musculoskeletal Transplant Foundation (MTF) has been supporting orthopaedic transplant science and bioconstructive research through its Peer-reviewed granting program since 1991. The MTF is pleased to announce that Dr. Francis Y. Lee has been awarded the 2012 Established Investigator Award for $300,000. Dr. Lee’s proposal Bio-Logical Modification of Structural Bone Allografts was ranked as the best proposal in 2012 and in recognition, Dr. Lee is the recipient of the prestigious J.R. Neff Award. As the seventh recipient of the J.R. Neff award Dr. Lee joins a select group of musculoskeletal researchers. Dr. Lee’s long range goal for the MTF grant award is to improve clinical performance of massive structural bone allografts.
The MTF award advances Dr. Lee’s reputation as a successful musculoskeletal clinician scientist. He is just one of a handful of orthopaedic surgeons to have received NIH R01 funding and most recently, Dr. Lee obtained his third NIH grant. Dr. Lee’s research is focused on the development of novel therapeutic strategies that will enhance bone health, regulate bone loss, prevent cancer spread to bone and improve orthopaedic implant integration and healing.
As a clinician, Dr. Lee specializes in bone tumors, soft tissue sarcomas, metastatic bone cancers, and pediatric orthopaedic disorders. He is the Vice Chair for Research, Chief of the Musculoskeletal Tumor Service and the Director of the Center for Orthopaedic Research. He serves as mentor to junior faculty, residents, postdoctoral researchers and students at Columbia University and nationally through AAOS/ORS/OREF mentoring programs. He is a review panelist for the National Institutes of Health and a committee member for the American Board of Orthopaedic Surgery.
The 2013 Annual ORS Meeting, San Antonio, Texas
January 26th—January 29th
Center for Orthopaedic Research ORS Presentations
Spotlight Session: Sarcoma, January 26, 2013 from 11:00 AM to 12:30 PM Room 214
Session 004 Paper #: 0023 Presentation: 12:10 PM to 12:20 PM
Paper Title: Re-expression of silenced Ewing’s sarcoma genes in tumor cell lines by an engineered bone microenvironment.
Authors: Aranzazu Villasante(1); Richard Friedman(2); Francis Lee(3); Gordana Vunjak-Novakovic(1)
Podium Presentation January 27, 2013 from 4:00 PM to 5:00 PM Session Number: 024 Session Title: Osteoporosis II: Therapy Presentation Time: 4:30 PM to 4:40 PM Paper #: 0142 Room: Ballroom C2 Paper Title: rhCalregulin is a potent inhibitior of inflammation-associated osteoclastogenesis Authors: Francis Lee(1); Heon Goo Lee(1); Saqib Nizami(1); Hiroshi Minematsu(1); Lee Song(1); Hesham Tawfeek(1); Hicham Drissi(2); Hana Goto(1); Daniel Oh(1); Maya Mikami(1)
Poster Session Number & Title: PS1--057 PS1 Cancer, Tumors Poster #: 1181
Title: In vivo Three-Dimensional (3D) Bioluminescence Tomography in Murine Osteosarcoma Models Allows Real-Time Monitoring of Tumor Volume, Chemotherapeutic Response and Metastasis
Chandhanarat Chandhanayingyong, MD
Poster Session Number & Title: PS2--059 PS2 Biomaterials Poster #: 1226 Title: Engineered Scaffold with Micro Capillary Channels for Tissue Engineering Daniel S. Oh, PhD
Poster Session Number & Title: PS2 Bone: Tissue Engineering, Repair & Biomechanics Poster #:1551
Title: Effectiveness of PCL-HA Scaffold on the Osteoconduction of Critical Size Canine Tibial Segmental Defects
Han Ying Bai, PhD, Francis Y. Lee, MD, Jeremy Mao, MD, Thomas Gardner, MCE
2012 AAOS/OREF/ORS Clinician Scholar Development Program
Dr. Francis Y. Lee, Columbia Orthopaedics, Vice Chair of Research and Chief of the Tumor and Bone Disease Service, successfully hosted the October 7-9, 2012, AAOS/OREF/ORS Clinician Scholar Development Program (CSDP) at the Rosemont Hyatt Hotel, Illinois. Dr. Lee is an orthopaedic surgeon with clinical expertise in musculoskeletal tumors and pediatric orthopaedics. He has simultaneously developed a clinical practice and successful departmental research program; securing 3 NIH R01 grants, 1 DOD grant, as well as foundation grants totaling nine million dollars. Dr. Lee has been the CSDP Chair since 2010.
Sixteen faculty were invited to attend the CSDP meeting. Faculty included Dr. Bostrom (Academic Program Director at HSS), Dr. Thomas Einhorn (Chair, Boston University), Dr. Denis Clohisy (Chair, U Minnesota), Dr. Randy Rosier (Past Chair, U Rochester), Dr. John Healey (Chief, Sloan Kettering Cancer Center, Tumor Society President), Dr. Bechtold (ORS President), Dr. Peter Amadio (Associate Dean, Mayo Clinic), Dr. Mike Yaszemski (Brig General, Mayo Clinic), Dr. Kristy Weber (Johns Hopkins U, President Elect Tumor Society), Dr. Richard Terek (Brown U, Presidential Line, Tumor Society), and others. There were 29 participants consisting of residents, fellows and junior faculty, who were chosen through a competitive selection process.
Dr. Oladapo Babatunde (Columbia Orthopaedics, PGY4 Resident) attended the workshop as a recipient of the AAOS traveling award. According Dr. Babatunde, “The CSDP is an extremely valuable and amazing opportunity to learn from and interact with leaders in the orthopaedic research community. Not only did the program motivate everyone in attendance, but it also highlighted the importance and need for orthopaedic surgeons to be committed to advancing research in our field. The program also illustrated ways of initiating and developing individual academic programs.”
Program topics included Academic Promotion, Compensation Model, Departmental Infrastructure, Grantsmanship, Clinical Trials, Career Paths, Collaboration, and Balancing Life. Dr. Lee said “On October 8, 2012, Dr. Shinya Yamanaka received a Nobel Prize in Medicine. He introduced a revolutionary concept on induced Pleuripotent Stem (iPS) cells. iPS technology will surely benefit many patients suffering from incurable diseases. I listened to his lecture 3 years ago and learned that he was an orthopaedic surgeon in Japan. Dr. Yamanaka’s research career began during his orthopaedic residency. This year’s workshop has been truly meaningful as I remarked on Dr. Yamanaka during the program introduction. I mentioned that he surely will receive a Nobel prize one day and then I heard the announcement.” “So far, 200 orthopaedic surgeons, about 1% of AAOS members, including three orthopaedic surgeons from Columbia University Medical Center (CUMC) have attended this course. It is time we as orthopaedic surgeons implement meaningful research strategies to conduct NIH and DOD funded research at CUMC.”
Dr. Oladapo Babatunde & Dr. Francis Y. Lee
Dr. Francis Y. Lee Awarded 3rd NIH R01 Grant
Columbia Orthopaedics is pleased to announce that Francis Y. Lee, M.D., Ph.D., Vice-Chairman for Research has obtained his third NIH Grant. The National Institute of Biomedical Imaging and Bioengineering (NIBIBE) has awarded a $1.44 million, four year competitive renewal of Dr. Lee’s first R01 grant, “Mechanobiological Mechanism for Inflammatory Bone Loss.” This is a noteworthy accomplishment as Dr. Lee is just one of a handful of active orthopaedic surgeons to have received R01 funding. This award will provide insight on the anti-inflammatory function of a hydrogel-based drug delivery system in the setting of inflammatory osteolysis. Dr. Lee specializes in bone tumors, soft tissue sarcomas, metastatic bone cancers, and pediatric orthopaedic disorders. As an exemplary orthopedic surgeon scholar, he serves as both researcher and mentor to students, postdoctoral fellows, residents and junior faculty internally and nationally through AAOS/ORS/OREF mentoring programs. He also serves on NIH review panels and ABOS committees.
|Francis Y. Lee, MD|
Grant Writing Workshop (GWW)
Francis Y. Lee, MD, PhD – Chair
Strategies for Success: Tools for Investigators in Challenging Times.
May 17-18, 2012, Long Beach California
For more than 15 years, the Orthopaedic Research Society (ORS), Orthopaedic Research and Education Foundation (OREF) and American Academy of Orthopaedic Surgeons (AAOS) have offered the Grant Writing Workshop. Through this workshop, new investigators have developed the skills and strategies to successfully secure funding for clinical, translational and basic research.
(Attendees, The historic Queen Mary, Long Beach, California, May 2012)
The ORS/OREF/AAOS Grant Writing Workshop (GWW) held at Long Beach, California on May 17-18, 2012 was a huge success. Dr.
Francis Y. Lee, Vice-Chair of Research and Associate Professor of Orthopaedic Surgery at Columbia University Medical Center has been chairing
this premiere educational workshop since 2011. Dr. Lee, an active orthopaedic clinician-scientist has maintained a high-caliber research program
through funding of two concurrent NIH R01 grants and a Department of Defense Grant. He is one of less than a dozen orthopaedic surgeons with
NIH R01 grants. While the NIH has released reports that NIH funding success is at the lowest rate ever, former workshop attendees have demonstrated a success rate of 40%, a reflection of the high educational content and academic caliber of the attendees’ grant proposals.
More than 50 orthopaedic surgeons and scientists attended the recent GWW. Of special note is the report that there are about 25 orthopaedic
attendings, fellows and residents, who are pursuing scholarly tracts through clinical trials and translational research. "There seems to be an increasing interest in translational research by orthopaedic surgeons over the past few years," stated Dr. Lee. The workshop was led by 17 faculty members consisting of 6 orthopaedic surgeons (Drs. Francis Y. Lee, Chair, Columbia University, Mathias Bostrom, Hospital for Special Surgery, Ted Miclau, UC San Francisco, James Luck, UCLA, Ranjan Gupta, UC Irvine and Kurt P. Spindler, MD, Vanderbilt University Sports Medicine), renowned basic scientists and representatives of funding agencies. This year, the workshop format was changed to diversify grant application strategies and to promote networking among orthopaedic surgeons and scientists.
Dr. Lee is committed to mentoring and encouraging young orthopaedic investigators to seek NIH funding grants, the gold standard for tenure appointments at many institutions. Dr. Lee will lead another GWW in Baltimore next May, 2013.
Orthopaedic Research & Education Foundation (OREF)
Resident Clinician Scientist Training Grant
Dr. Anny Hsu, COR's Research Fellow and Department of Orthopaedic Surgery Resident, has received the OREF's Resident Clinician Scientist Training Grant for her proposal "Enhancement of Dynamic Biomechanical Properties of Structural Allograft with BMP2 Loaded Nanospheres." The OREF has a long history of supporting independent peer-reviewed musculoskeletal research and education. The $20,000 grant is awarded at the national level and is a prestigious honor.
Anny Hsu, MD
According to mentor, Dr. Francis Y. Lee, Director of COR and Vice-Chair for Research, "Dr. Hsu is an exceptionally talented young researcher with a promising future as a clinician-scientist. We are very proud of Anny's accomplishments."
Dr. Lee is taking great pride in Anny's achievements, as she is the first COR Resident Research Fellow. The Translational Research Fellow in Orthopaedics (TRIO) program was initiated in July 2011. The TRIO program offers an additional 1Y track for musculoskeletal research prior to beginning the Columbia University Orthopaedic Surgery Residency Program. In addition to his passion for research, Dr. Lee is an active proponent for the Orthopaedic Clinician Scholar Development programs sponsored by the American Academy of Orthopaedic Surgeons, The Orthopaedic Research and Education Foundation and the Orthopaedic Research Society.
Francis Y. Lee, MD
The Orthopaedic Research Society Annual Meeting will be held in San Francisco, California, February 4-7, 2012.
The Center for Orthopaedic Research, Department of Orthopaedic Surgery, Columbia University Medical Center will present the following abstracts:
Title: Non-Specific Cathepsin B Inhibitor CA-074Me Inhibits Osteoclastogenesis via c-FOS Upregulation Blockade
Presenters/Authors: Neel Patel, Francis Y. Lee, MD
Title: Physiochemical Dual Action Bone-like Scaffold – Pilot Study in Canine Model
Presenters/Authors: Daniel S. Oh, PhD; Francis Y. Lee, MD; Anny C. Hsu, MD; Han-Ying Bai, PhD; Saqib Nizami; Hanna Goto; Hesham Tawfeek, MD; Columbia University; Jongmin Kim, PhD; Seokhwa Choi, PhD; Chungbuk National University, Korea
Title: Constitutive activity of Nuclear Factor of Activated T Cells (NFAT) facilitates LPS-induced mRNA elongation of TNF in Monocyte/Macrophage-lineage cells
Presenters/Authors: Hiroshi Minematsu, PhD; Mike Shin; Ayse Celil-Aydemir, PhD; Kyung-Ok Kim, PhD; Saqib Nizami; Francis Lee, MD
Title: The ERK Pathway Links Actin Remodeling for Phagocytosis of Metal Particle and Inflammatory Gene Expression in Osteoprogenitor Cells
Presenters/Authors: Heon-Goo Lee; Hiroshi Minematsu, PhD; Hana Goto; Anny Hsu, MD; Alan Chou; Saqib Nizami, Francis Lee, MD
Title: Tendon-Bone Healing in a Rat Cannulation Model
Presenters/Authors: David M. Levy; Comron Saifi, MD; Jennifer L. Perri; Sue Coyle; Carlos Aponte; Renwen Zhang, MD, PhD; Thomas R. Gardner; Christopher S. Ahmad, MD
Title: Effect of Incomplete Reaming on Glenoid Loosening in total Shoulder Arthroplasty: A Finite Element Analysis
Presenters/Authors: Charlie Yongpravat; Thomas R. Gardner; Louis U. Bigliani, MD; William N. Levine, MD; Christopher S. Ahmad, MD
The American Academy of Orthopaedic Surgeons, the Orthopaedic Research and Education Foundation and the Orthopaedic Research Society brought together aspiring clinician-researchers and an esteemed faculty of clinician-scientists for a national Clinician Scholar Development Program during October 2011, in Rosemont, Illinois. The ultimate goal of orthopaedic clinical and basic science research is to seek new avenues of knowledge that ultimately will impact patient care. The meeting was chaired by Dr. Francis Y. Lee, Columbia University Medical Center. Faculty speakers included Dr. Thomas Sculco, Hospital for Special Surgery, Surgeon-in-Chief; Dr. Denis Clohisy, University of Minnesota, Orthopaedic Surgery Chair; as well as many other spectacular leaders in the field of orthopaedic research. The instructional forum provided an exciting platform for scientific exchange.
The American Foundation for Surgery of the Hand has awarded Dr. Peter Tang, a $20,000 grant for "An Evaluation of Inflammation, Histology, and Function in Nerve Regeneration.
Dr. Tang specializes in operative and nonoperative treatment of all problems of the upper extremity and hand. He is an active researcher with a focus on wrist biomechanics and nerve regeneration. He is the recipient of numerous grant awards and his research has been presented at national orthopaedic meetings.
The Center for Orthopaedic Research Welcomes New Faculty
We are pleased to announce the addition of two new faculty members:
Daniel S. Oh, Ph.D., Assistant Professor of Orthopaedic Science - Dr. Oh received his Ph.D. in Materials Science and Engineering at Yeungnam University, Gyeongsan, South Korea. He comes to us from the University of Texas at San Antonio. Dr. Oh's research is focused on the design and development of multifunctional hybrid scaffolds for optimization of bone regeneration in large segmental defects.
Hesham Tawfeek, M.D., Assistant Professor of Orthopaedic Science - Dr. Tawfeek received his M.D. at El-Minia University, El-Minia, Egypt. He comes
to us from Emory University School of Medicine, Atlanta, Georgia. Dr. Tawfeek's research is focused on the cellular and molecular mechanisms that lead to bone formation and resorption.
Francis Y. Lee, MD, PhD Columbia University Senator 2011 - 2012
“The Columbia University Senate is a University-wide legislature, representing faculty, students, and other constituencies. It makes policy on a range of issues that affect the entire University or more than one school, including educational programs and priorities, the budget, academic freedom and tenure, the conduct of research, the libraries, information technology, Columbia's external relations, student sexual misconduct, rules governing political demonstrations, and the welfare of faculty, students, and research officers. Trustee concurrence is required for acts of the Senate.
RESEARCH WORKSHOP - Sponsored by the American Academy of Orthopaedic Surgeons, Orthopaedic Research Society and the Orthopaedic Research and Education Foundation.
Dr. Francis Y. Lee shared his experience with the federal grant application process in a two-day intensive workshop sponsored by the American Academy of Orthopaedic Surgeons (AAOS), Orthopaedic Research Society (ORS), and the Orthopaedic Research and Education Foundation (OREF) in Florida.
Among the faculty were James Panigis, MD, NIH Scientific Review Officer; Jonathan Forsberg, MD, VA and DOD representative; and biologist Mary Goldring, PhD, Hospital for Special Surgery, NY. The faculty members covered topics such as; the grant review processes for the NIH, DOD and Department of Veterans Affairs; designing translational and clinical research studies; presenting preliminary data; handling budgets and statistics; addressing reviewers' feedback; and planning for continued funding.
RESEARCH WORKSHOP - Department of Orthopaedic Surgery, Columbia University Medical Center
The Center for Orthopaedic Research hosted an Inaugural Research Workshop for the Department of Orthopaedic Surgery's research fellows, students and staff. The program brought clinicians, scientists, fellows and students together in an atmosphere of clinical and scientific exchange. Our participants shared their research experiences and achievements. All in all the Research Workshop proved to be quite successful and plans are in place to move forward with a new department tradition.
The Orthopaedic Research Society Annual Meeting was held in Long Beach California, January 13-16, 2011.
The Center for Orthopaedic Research, Department of Orthopaedic Surgery, Columbia University Medical Center presented the following abstracts:
Aydemir, AB; Minematsu, H; Lee, HG; Mikami, M; Lee, FY: NFAT and MAPK Signaling Converge on Osterix Regulation to Mediate Mechanotransduction in Osteoprogenitor Cells.
Lee, HG; Minematsu, H; Aydemir, AB, Kim, KO; Patel, N; Chung, KJ; Jacobs, CR; Hung, CT; Lee, FY: Phagocytosis of LPS Free-Wear Particles Induces Pro-Inflammatory and Pro-Osteoclastogenic Cytokine Gene Expression via Phosphorylation of ERK in Osteoprogenitor Cells.
Kim, KO; Onishi, AC; Hincker, AM; Patel, NR; Kwak, E; Staples, JRW; Nizami, S; Nair, K; Minematsu, H; Aydemir, ABC; Schiff, JC; Lee, FY: Proteomic Identification of 14-3-3ε, a Novel Regulator of Apoptotic Protein Bim, in Human Osteosarcoma Cell.
The Medical Advisory Committee for Major League Baseball has awarded Dr. Christopher S. Ahmad, director of the Biomechanics Laboratory and team physician for the New York Yankees, a $50,000 grant award for research investigating 'The Effect of Timing of Plasma-Rich Protein (PRP) Injections on Muscle Healing'. The study will evaluate the efficacy of PRP to accelerate muscle tissue repair and regeneration at the site of injury.
AAOS Clinician Scientist Development Program Webinars
Interested in a career as a clinician scientist? Participate in these FREE 90 minute live events for tips and tools on how to balance your surgical practice and research career. Presented by experienced clinician scientists.
Register: Contact AAOS Customer Service (toll free) at 800-626-6726 from 8:00 am to 5:00pm CT. From outside the US, call +1-847-823-7186. Online: www.aaos.org/3849 or www.aaos.org/3850. Follow registration instructions.
Module 1: Translational Research, CS Timeline, and Work/Life Balance
Course #3849 - Wednesday, November 3rd - 5:00pm ET
Course Director - Francis Y. Lee, MD, PhD
Dept. Orthopaedic Surgery, Columbia University, New York, NY
Module 2: Clinical Research, Benefits, Risks and Resources
Course #3850 - Wednesday, November 10th - 5:00pm ET
Course Director - Theodore Miclau, MD
Dept. Orthopaedic Surgery, University of California, San Francisco, CA
Francis Y. Lee, MD, PhD, Associate Professor of Orthopaedic Surgery and Vice-Chair for Research, Jeremy Mao, DDS, PhD, Edward V. Zegarelli Professor of Dental Medicine and Andreas Hielscher, PhD, Associate Professor of Biomedical Engineering have received a four year grant of $3.1M from the Department of Defense for the research project "Ready-to-Use Tissue Constructs for Military Trauma Bone and Cartilage Defects." This grant exemplifies successful multi-disciplinary collaboration across campuses (CU Medical Center, CU College of Dental Medicine, CU Dept. of Biomedical Engineering). The collective efforts of Dr. Lee, orthopaedic clinician-scientist, Dr. Mao, tissue engineering expert and Dr. Hielscher, 3D optical tomography (OT) imaging authority will examine the potential of ready-to-use tissue constructs with optimal growth factors for regeneration of massive cartilage/bone defects resulting from military combat related injuries.
Dr. Francis Y. Lee hosted a free benefit concert for cancer patients, families and friends to support Musculoskeletal Cancer research. The evening of Italian Opera Arias presented tenor Luciano Lamonarca, singer Valentina Popa and pianist Asami Tamura. The evening's emcee, Nicole Muller is a bone cancer survivor and Dr. Lee's patient. The evening successfully highlighted COR's bone cancer efforts and goals to improve patient outcomes for children and adults faced with musculoskeletal cancer.
Orthopaedic Cancer Facts:
Francis Y. Lee, M.D., Ph.D.
The Orthopaedic Research Society has announced this year’s selected podium and poster presenters for the 56th annual meeting, March 2010 in New Orleans. The Center for Orthopaedic Research and the Department of Orthopaedic Surgery, Columbia University Medical Center are well represented.
Molecular Biomedical Engineering
Aydemir, AB; Minematsu, H ; Gardner, TR ; Kim, KO; Lee, FY: NFAT2 physically interacts with Osterix in response to physiologic mechanical stimulation in human mesenchymal stem cells during osteoblast differentiation - Poster
Blaine, T A; Cote, M A; Ortega, S.; Lee, F Y; Bigliani, L U; Chen, Q: CXCR4 blockade (AMD 3100 and T140 analog) inhibits SDF-1a expression and cell migration in human subacromial bursa cells - Podium
Blaine, T A; Cote, M A; Proto, A; Lee, F Y; Bigliani, L U: Pro-Inflammatory Cytokines Stimulate Stromal Derived Factor-1 (SDF-1α) Expression in Cultured Synoviocytes from Human Subacromial Bursa - Poster
Fong J; Gunja, N; Kim, KO; Lee FY; Hung CT: Comparison of Doxorubicin Resistance of an Osteosarcoma Cell Line in Two and Three Dimensional Cultures – Poster
Kim, KO; Aydemir, AB; Minematsu, H ; Lee, HG ; Gardner, TR ; Ahn JM ; Lee, FY: Transactivation of Cox2 promoter region by NFAT2 in human mesenchymal stem cells in response to tensile strain – Podium
Kim KO, Persaud T, Schiff J, and Lee FY: ERK ½ Inhibition Increases BH3 Domain Proapototic Protein BIM and Apoptosis in osteosarcoma cells - Poster
Lee, HG; Shin, M J; Kim, KO; Patel, N; Aydemir AB; Mikami, M; Minematsu, H; Hung, CT; Lee, FY - Mechanical Perturbations and Metal Particles Exaggerate Bone Resorption and Inflammation in MC3T3E1 Cells - Podium
Minematsu, H; Shin, M J; Aydemir, ABC; Lee, FY: Nuclear Factor of Activated T Cells (NFAT) regulates innate inflammatory response by Monocyte / Macrophage-lineage cells - Podium
Nair K, Patel N; Staples R, Lee FY: Hyaluronan Gel as a Drug Delivery Vector in Murine Calavarial Osteolysis Models: A New Methodology for Induction of Inflammatory Bone Resorption - Poster
Noh, K C; Staples, JRW; Kim, KO; Patel, N; Kim, D; Cha, T; Seo, SW; Yin, B; Lee, FY: Targeting MAPK/ERK Inflammatory Pathway as a Novel Adjuvant Therapy for Osteosarcoma In vivo – Poster Presentation
Patel, N; Kwak E; Mikami, M; Lee, FY: Cathepsin B Inhibitor CA-074 Me Inhibits Osteoclastogenesis In Vivo and Promotes Calcineurin Cleavage in Murine Bone Marrow-derived Monocyte/macrophage Progenitor Cells - Podium
Patel, N; Lee, JH; Nair, K; Lee, HG; Mikami, M; Staples, JRW, Hielscher, AH Lee, FY Heparin-Regulated controlled release of BSA-Doxorubicin conjugate promotes sarcoma apoptosis: A novel site specific method for treating solid tumors. – Poster
Schiff JC, Kim KO, Lee FY: Paclitaxel induces apoptosis in human osteosarcoma cells – Poster
Shin, MJ; Minematsu, H; Aydemir, ABC; Lee, FY: Constitutive activity of Nuclear Factor of Activated T Cells (NFAT) is essential for LPS-induced Proinflammatory Cytokine Expression in Monocyte/Macrophage-lineage cells - Poster
Staples, JRW; Patel, N; Nair K; Jentry, H; Minematsu, H; Lee FY: Inhibition of
Osteolysis in Mouse Calvarial Bones via Osteoblast Specific ERK1/2 Inhibition In Vivo – Poster
Fabian, LM; Cassilly, R; Mkparu, A; Gardner, TR; Nwachukwu B; Ahmad, CS; Levine, WN; Teres Minor Hypertrophy Associated with Massive Rotator Cuff Tears Correlates with Active Forward Elevation and Outcomes - Poster
Choi JK; Gardner TR; Yoon, E; Morrison TA; Macaulay W; Geller, JA: A Biomechanical Study in Fixation Techniques on Comminuted Vancouver B1 Periprosthetic Femur Fractures – Poster
Gardner, TR; Cassilly, RT; Jin, B; Ahmad CS; Bigliani, LU; Levine, WN The Effect of Hormone Replacement Therapy on Elongation of the Macaque IGHL – Poster
Moffat, KL; Cassilly, RT; Subramony, SD: Dargis, BR; Liu, XS; Guo, XE; Doty, SB; Levine, WN, Lu, HH - In Vivo Evaluation of a Bi-Phasic Nanofiber-Based Scaffold for Integrative Rotator Cuff Repair – Podium
Yongpravat, C; Dyrszka, MD; Nowak, DD; Gardner, TR; Bigliani LU; Levine, WN; Ahmad, CS: Volume Removed During Total Shoulder Arthroplasty Using 3D Computer Simulation – Poster
Dae Won Kim, MD, recent COR research fellow has accepted an Assistant Professor appointment with Rush University Medical Center, Chicago, Illinois.
Anuli Mparu, MD, Shoulder, Elbow and Sports Medicine, research student 2007-2008, is the winner of the New England Orthopaedic Society 1st Place Kilfoyle Award Competition.
The Department of Orthopaedic Surgery hosted a Multidisciplinary Musculoskeletal Symposium in tribute to Dr. Lee’s research efforts. The scientific program included prominent guest speakers from the University of Pennsylvania School of Medicine as well as from Columbia University departments of Genetics and Biology, Medicine and Pharmacology, Biomedical Engineering and Orthopaedic Surgery. It is hoped that this will be the first of many multidisciplinary musculoskeletal scientific exchanges.
Dr. Francis Y. Lee associate professor of orthopaedic surgery and director of the Center for Orthopaedic Research has been honored by the Trustees of Columbia University with a tenure appointment in recognition of his outstanding research accomplishments. Dr. Lee has successfully obtained research funding from the NIH as well as private foundations. He is one of a select few Columbia University clinician-scientists to warrant the distinction of a tenure appointment.
It is a pleasure to announce that Louis Amorosa, M.D., PGY 3, has been awarded the Resident Trauma Research Support grant from the AO North America Foundation for his proposal The Effect of Mesenchymal & Hematopoietic Stem Cells Loaded into a Tricalcium Phosphate Scaffold in a Rat Femoral Nonunion Model.
Congratulations to Marc Dyrszka on placing first place for the best orthopaedic and best overall poster at the 50th Annual National Student Research Forum sponsored by the AMA, Galveston, TX, for Predicting Outcomes of Total Shoulder Arthroplasty Using 3-D Computer Simulations.
We are proud to announce that the National Institutes of Health has awarded Francis Y. Lee, M.D., Ph.D. his second R01 research grant. This is an amazing accomplishment as Dr. Lee is just one of a handful of orthopaedic surgeons to have received R01 funding. The newly awarded grant project will focus on the specific targeting of biomolecular pathways which induce inflammatory bone loss in response to biomaterials. It is hoped that this will lead to the development of clinical effective and safe treatments for inflammatory bone loss due to osteoarthritis, rheumatoid arthritis and orthopaedic and periodontal implants. Additional research projects are currently investigating the molecular mechanisms behind sarcoma bone destruction and chemoresistance.
Dr. Francis Y. Lee is an Associate Professor of Orthopaedic Surgery, College of Physicians and Surgeons, Columbia University. He is the Department of Orthopaedic Surgery’s Vice Chair for Research and the Director of the Center for Orthopaedic Research. Dr. Lee is an orthopaedic surgeon specializing in bone tumors, soft tissue sarcomas, metastatic bone cancers and pediatric orthopaedic surgery. He serves as both researcher and mentor to postdoctoral fellows, residents and students. He is the author or co-author of more than forty-five peer reviewed publications.
Congratulations to Ryan Cassilly on placing first for the best overall clinical science presentation for MRI Evaluation of Teres Minor Hypertrophy and Functional Status in Patients with Massive Rotator Cuff Tears at the 35th Annual Eastern-Atlantic Student Research Forum held in Miami, Florida, February 25 -28 and sponsored by the AMA Foundation.