TIRAR: 2007-2012

Training in Interdisciplinary Research on Antimicrobial Resistance (TIRAR)

Grant # T90 NR010824
Title: TRAINING IN INTERDISCIPLINARY RESEARCH TO REDUCE ANTIMICROBIAL RESISTANCE (TIRAR)
Director: Elaine Larson, RN, PhD, Professor of Therapeutic and Pharmaceutical Research, Columbia University School of Nursing
Co-Director: Richard H. Kessin, PhD, Professor of Pathology and Cell Biology, College of Physicians & Surgeons of Columbia University
Funder: National Institute of Nursing Research, National Institutes of Health
Dates: 9/18/07 - 6/30/12
Funding: $1,034,545

Under the founding direction of Kristine Gebbie, DrPH, RN, and Aaron Mitchell, PhD, the TIRAR training grant was designed to prepare biomedical researchers and others in interdisciplinary research with a focus on the prevention and control of antimicrobial resistance. With their initial leadership and later under the direction of Elaine Larson, PhD, RN, and Richard Kessin, PhD, TIRAR supported seven pre-doctoral and six post-doctoral trainees from the fields of nursing, epidemiology, medicine, pharmacy, microbiology, and biomedical informatics. Trainees participated in two specially designed didactic courses (“Building Interdisciplinary Research Models” and “Global Antimicrobial Resistance”), completed supervised interdisciplinary field experiences, and worked with their faculty mentors on antimicrobial resistance research projects in their primary disciplines. TIRAR trainees have gone on to pursue a variety of endeavors after completing the program, including faculty and postdoctoral appointments at Columbia University, Duke University, and The Ohio State University, research positions at the National Institutes of Health, and clinical research positions at major medical centers. Examples of the work completed by TIRAR trainees while in the program are listed below.

Adjalley SH, Johnston GL, Li T, Eastman RT, Ekland EH, Eappen AG, Richman AG, Sim BK, Lee MC, Hoffman SL, Fidock DA. Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue. Proc Natl Acad Sci U S A 2011;108:E1214-23.
http://www.ncbi.nlm.nih.gov/pubmed/22042867

Apte M, Landers T, Furuya Y, Hyman S, Larson E. Comparison of two computer algorithms to identify surgical site infections. Surg Infect 2011;12:459-64.
http://www.ncbi.nlm.nih.gov/pubmed/22136489

Bright TJ, Furuya EY, Kuperman GJ, Cimino JJ, Bakken S. Development and evaluation of an ontology for guiding appropriate antibiotic prescribing. J Biomed Inform 2012;45:120-8.
http://www.ncbi.nlm.nih.gov/pubmed/22019377

Bright TJ, Furuya EY, Kuperman GJ, Bakken S. Creating an ontology for an antibiotic prescribing decision support system. AMIA Annu Symp Proc 2008:888.
http://www.ncbi.nlm.nih.gov/pubmed/18998876

Clock SA, Cohen B, Behta M, Ross B, Larson EL. Contact precautions for multidrug-resistant organisms: current recommendations and actual practice. Am J Infect Control 2010;38:105-11.
http://www.ncbi.nlm.nih.gov/pubmed/19913329

Cohen B, Clock SA, Larson E, Behta M, Ross B, Saddul R, Vawdrey DK. Documentation of contact precautions in an electronic health record. J Nurs Care Qual 2011;26:252-9.
http://www.ncbi.nlm.nih.gov/pubmed/21623181

Conway LJ, Pogorzelska M, Larson EL, Stone PW. Adoption of policies to prevent catheter-associated urinary tract infections in United States intensive care units. Am J Infect Control 2012 [Epub ahead of print.]
http://www.ncbi.nlm.nih.gov/pubmed/22317857

Conway LJ, Larson EL. Guidelines to prevent catheter-associated urinary tract infection: 1980-2010. Heart Lung 2011 [Epub ahead of print.]
http://www.ncbi.nlm.nih.gov/pubmed/21925731

Coulibaly YL, Dembele B, Diallo AA, Lipner E, Doumbia SS, Coulibaly SY, et al. A randomized trial of doxycycline for Mansonella perstans infection. N Engl J Med 2009;361:1448-58.
http://www.ncbi.nlm.nih.gov/pubmed/19812401

Cunningham-Rundles S, Ahrne S, Johann-Liang R, Abuav R, Dunn-Navarra AM, Grassey C, Bengmark S, Cervia JS. Effect of probiotic bacteria on microbial host defense, growth, and immune function in human immunodeficiency virus type-1 infection. Nutrients 2011;3:1042-70.
http://www.ncbi.nlm.nih.gov/pubmed/22292110

Dunn-Navarra AM, Cohen B, Stone PW, Pogorzelska M, Jordan S, Larson E. Relationship between systems-level factors and hand hygiene adherence. J Nurs Care Qual 2010. [Epub ahead of print.]
http://www.ncbi.nlm.nih.gov/pubmed/20489659

Eastman RT, Dharia NV, Winzeler EA, Fidock DA. Piperaquine resistance is associated with a copy number variation on chromosome 5 in drug-pressured Plasmodium falciparum parasites. Antimicrob Agents Chemother 2011;55:3908-16.
http://www.ncbi.nlm.nih.gov/pubmed/21576453

Eastman RT, Fidock DA. Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria. Nat Rev Microbiol 2009;7:864-74.
http://www.ncbi.nlm.nih.gov/pubmed/19881520

Furuya EY, Larson E, Landers T, Jia H, Ross B, Behta M. Challenges of applying the SHEA/HICPAC metrics for multidrug-resistant organisms to a real-world setting. Infect Control Hosp Epidemiol 2011;323-32.
http://www.ncbi.nlm.nih.gov/pubmed/21460483

Landers T, Apte M, Hyman S, Furuya Y, Glied S, Larson E. A comparison of methods to detect urinary tract infections using electronic data. Jt Comm J Qual Patient Saf 2010;36:411-7.
http://www.ncbi.nlm.nih.gov/pubmed/20873674

Landers TF, Ferng YH, McLoughlin JW, Barrett AE, Larson E. Antibiotic identification, use, and self-medication for respiratory illnesses among urban Latinos. J Am Acad Nurse Pract 2010;22:488-95.
http://www.ncbi.nlm.nih.gov/pubmed/20854641

Landers T, McWalters J, Behta M, Bufe G, Ross B, Vawdrey DK, Larson E. Terms used for isolation practices by nurses at an academic medical center. J Adv Nurs 2010;66:2309-19.
http://www.ncbi.nlm.nih.gov/pubmed/20722801

Landers TF, Cohen B, Wittum TE, Larson EL. A review of antibiotic use in food animals: perspective, policy, and potential. Public Health Rep 2012;127:4-22.
http://www.ncbi.nlm.nih.gov/pubmed/22298919

Larson EL, Cohen B, Gebbie K, Clock S, Saiman L. Interdisciplinary research training in a school of nursing. Nurs Outlook 2011;59:29-36.
http://www.ncbi.nlm.nih.gov/pubmed/21256360

Larson EL, Landers TF, Begg MD. Building interdiscip;inary research models: a didactic course to prepare interdisciplinary scholars and faculty. Clin Transl Sci 2011;4:38-41.
http://www.ncbi.nlm.nih.gov/pubmed/21348954

Lat A, Clock SA, Wu F, Whittier S, Della-Latta P, Fauntleroy K, Jenkins SG, Saiman L, Kubin CJ. Comparison of polymyxin B, tigecycline, cefepime, and meropenem MICs for KPC-producing Klebsiella pneumoniae by broth microdilution, Vitek 2, and Etest. J Clin Microbiol 2011;49:1795-8.
http://www.ncbi.nlm.nih.gov/pubmed/21367993

Malcolm, B. The rise of methicillin-resistant staphylococcus aureus in U.S. correctional populations. J Correct Health Care 2011;17:254-65.
http://www.ncbi.nlm.nih.gov/pubmed/21571749

Miko BA, Cohen B, Conway L, Gilman A, Seward SL Jr, Larson E. Determinants of personal and household hygiene among college students in New York City, 2011. Am J Infect Control 2012. [Epub ahead of print.]
http://www.ncbi.nlm.nih.gov/pubmed/22464037

Moskowitz SM, Garber E, Chen Y, Clock SA, Tabibi S, Miller AK, Doctor M, Saiman L. Colistin susceptibility testing: evaluation of reliability for cystic fibrosis isolates of Pseudomonas aeruginosa and Stenotrophomonas maltophilia. J Antimicrob Chemother 2010;65:1416-23.
http://www.ncbi.nlm.nih.gov/pubmed/20430789

Patel S, Landers T, Larson E, Zaoutis T, Delamora P, Paul DA, Wong-McLaughlin J, Ferng YH, Saiman L. Clinical vignettes provide an understanding of antibiotic prescribing practices in neonatal intensive care units. Infect Control Hosp Epidemiol 2011;32:597-602.
http://www.ncbi.nlm.nih.gov/pubmed/21558773

Ross B, Marine M, Chou M, Cohen B, Chaudhry R, Larson E, Landers T, Behta M. Measuring compliance with transmission-based isolation precautions: comparison of paper-based and electronic data collection. Am J Infect Control 2011;39:839-43.
http://www.ncbi.nlm.nih.gov/pubmed/21737176

Scanfeld D, Scanfeld V, Larson EL. Dissemination of health information through social networks: twitter and antibiotics. Am J Infect Control 2010;38:182-8.
http://www.ncbi.nlm.nih.gov/pubmed/20347636

Stone PW, Glied SA, McNair PD, Matthes N, Cohen B, Landers TF, Larson EL. CMS changes in reimbursement for HAIs: setting a research agenda. Med Care 2010;48:433-9.
http://www.ncbi.nlm.nih.gov/pubmed/20351584

Uchida M, Stone PW, Conway LJ, Pogorzelska M, Larson EL, Raveis VH. Exploring infection prevention: policy implications from a qualitative study. Policy Polit Nurs Pract 2011;12:82-9.
http://www.ncbi.nlm.nih.gov/pubmed/22042614

Valderramos SG, Scanfeld D, Uhlemann AC, Fidock DA, Krishna S. Investigations into the role of the Plasmodium falciparum SERCA (PfATP6) L263E mutation in artemisinin action and resistance. Antimicrob Agents Chemother 2010;54:3842-52.
http://www.ncbi.nlm.nih.gov/pubmed/20566762