Presynatic regulation of transmitter release (dopamine and glutamate)
Mosharov, E., and Sulzer, D. (2005).
Detailed algorithms for detection and analysis of exocytic events recorded by amperometry.
Nature Methods, 2:651-658. pdf
here is the supplementary material for that paper
Giraudo, C.G., Hu, C., You, D. Slovic, A.M., Mosharov, E., Sulzer, D., Melia, T.J., Rothman, J.E. (2005)
SNAREs can promote complete fusion and hemifusion as alternative outcomes.
Journal of Cell Biology, 2005, 170:249-260 pdf
Staal, R.G.W., Mosharov, E.V., Sulzer, D.
Dopamine neurons release transmitter via a flickering fusion pore
Nature Neuroscience 2004 7:341-346 pdf
here is a commentary on the above paper by Mark Wightman
Bamford, N.S., Zhang, H., Schmitz, Y., N.P. Wu, Cepdea, C., Levine, M.S., Schmauss, C., Zakharenko, S.S., Zablow, L., Sulzer, D.
Heterosynaptic dopamine neurotransmission selects sets of corticostriatal terminals
Neuron 2004 42, 653-663 pdf
here is a commentary on the above paper by Fu-Ming Zhou and John Dani
Zhang, H., and Sulzer, D.
Frequency-dependent modulation of dopamine release by nicotine
Nature Neuroscience, 2004 7, 581-582 pdf
here is an article on the above paper, including related studies and sociocultural analysis from Nature Medicine
Hui Zhang and David Sulzer
Glutamate spillover in the striatum depresses dopaminergic transmission by
activating Group I metabotropic glutamate receptors
Journal
of Neuroscience 2003 23:10585-10592 pdf
Eugene V. Mosharov, Liang-Wei
Gong, Bhavanna Khanna, David Sulzer, and Manfred Lindau
Intracellular patch electrochemistry: regulation of cytosolic catecholamines
in chromaffin cells
Journal
of Neuroscience 2003 23:5835-5845 pdf
Yvonne Schmitz,Marianne
Benoit-Marand, Francois Gonon, and David Sulzer
Presynaptic regulation of dopaminergic neurotransmission (Review)
Journal of Neurochemistry, 2003 87:273-289 pdf
Schmitz, Y., Schmauss, C.,
and Sulzer, D.
Altered dopamine release and uptake in mice lacking D2 receptors
Journal of Neuroscience 2002 15:8002-2009 pdf
Pothos, E., Mosharov, E.,
Liu, K.P., Setlik, W., Baldini, G., Gershon, M.D., Tamir, H., Sulzer, D
Stimulation-dependent regulation of secretory vesicle pH, volume, and quantal
size
Journal of Physiology 2002 542:453-476 pdf
David Sulzer and Emmanuel
N Pothos
Presynaptic mechanisms that regulate quantal size (Review)
Reviews in the Neurosciences 2000 11:150-212 pdf
Pothos, E., Larsen, K.,
Liu, Y.J. Edwards, R.H., and Sulzer, D.,
Synaptic vesicle transporter expression regulates vesicle phenotype and quantal
size
Journal of Neuroscience 2000 20:7297- 7308 pdf
Abelovich, A., Schmitz,
Y., Farinas, I., Choi-Lundberg, D., Ho, W.-H., Verdugo, J.M.G., Armanini, M.,
Ryan, A., Hynes, M., Phillips, H., Sulzer, D., Rosenthal, A.
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal
dopamine system
Neuron, 2000 25:239-252 pdf
Colliver, T., Hess, E.,
Pothos, E.N., Sulzer, D., and Ewing, A.G.
Quantitative and statistical analysis of the shape of amperometric spikes recorded
from two populations of cells
Journal of Neurochemistry, 2000 74:1086-1097 pdf
David Sulzer and Robert
Edwards
Vesicles: equal in neurotransmitter concentration but not in volume (Commentary)
Neuron, 2000 28: 5-7 pdf
Emmanuel N Pothos, Serge
Przedborski, Viviana Davila, Yvonne Schmitz, and David Sulzer
D2-Like Dopamine Autoreceptor Activation Reduces Quantal Size in PC12 Cells
Journal of Neuroscience, 1998 18: 5575-5585
pdf
David Sulzer, Myra P Joyce,
Ling Lin, Daron Geldwert, Suzanne N Haber, Toshiaki Hattori, and Stephen Rayport
Dopamine Neurons Make Glutamatergic Synapses In Vitro
Journal of Neuroscience, 1998 18: 4588-4602 pdf
Emmanuel N Pothos, Viviana
Davila, and David Sulzer
Presynaptic Recording of Quanta from Midbrain Dopamine Neurons and
Modulation of the Quantal Size
Journal of Neuroscience, 1998 18: 4106-4118 pdf
Physiology of midbrain dopamine neurons
Chuhma,N., Zhang, H., Mustine, J., Sulzer, D., Hen, R., Rayport, S.G.
Dopamine neurons mediate a fast excitatory signal via glutamatergic neurotransmission.
Journal of Neuroscience, 2004 24:972-981. pdf
Viviana Davila,Zhen Yan, Liviu C. Craciun, Diomedes Logothetis, and David Sulzer
D3 Dopamine Autoreceptors Do Not Activate G-Protein-Gated Inwardly Rectifying Potassium Channel Currents in Substantia Nigra Dopamine Neurons
Journal of Neuroscience, 2003, 23:5693-5697 pdf
David Sulzer and Aurelio
Galli
Transporter currents are promoted from curiosity to physiology (Review)
Trends in Neuroscience, 2003 26: 173-6
pdf
David Sulzer and Stephen
Rayport
Dale's principle and glutamate corelease from ventral dopamine neurons (REVIEW)
Amino Acids 2000, 19:45-52 pdf
David Sulzer, Myra P Joyce,
Ling Lin, Daron Geldwert, Suzanne N Haber, Toshiaki Hattori, and Stephen Rayport
Dopamine Neurons Make Glutamatergic Synapses In Vitro
Journal of Neuroscience, 1998 18: 4588-4602
pdf
Stephen Rayport, David Sulzer,
Wei-Xi Shi, Saswana Sawasdikosol, Jacqueline Monaco, Diedre Batson, and Geetha
Rajendran
Identified postnatal mesolimbic dopamine neurons in culture: morphology
and electrophysiology
Journal of Neuroscience, 1992 12: 4264-4280 pdf
Psychostimulant drug mechanisms of action
David Sulzer, Mark Sonders, Nathan W. Poulsen, and Aurelio Galli
Mechanisms of neurotransmitter release by amphetamines: a review
Progress in Neurobiology, 2005 75:406-433. pdf
Eugene V. Mosharov, Liang-Wei
Gong, Bhavanna Khanna, David Sulzer, and Manfred Lindau
Intracellular patch electrochemistry: regulation of cytosolic catecholamines
in chromaffin cells
Journal of Neuroscience, 2003 23:5835-5845 pdf
Kristin Larsen, Edward Fon,
Terry G. Hastings, Robert H. Edward, R.H., and David Sulzer
Methamphetamine -induced degeneration of dopaminergic
neurons involves autophagy and upregulation of dopamine synthesis
Journal of Neuroscience, 2002 22:8951-8960 pdf
Yvonne Schmitz,Y., C. Justin
Lee, Claudia Schmauss, Francois Gonon, and David Sulzer
Amphetamine distorts synaptic dopamine overflow: effects on vesicular stores,
D2 autoreceptors, and uptake
Journal of Neuroscience, 2001 21: 5916-5924 pdf
Edward Fon, Emmanuel N Pothos,
Bao-Cun Sun, Nigel Killeen, David Sulzer and Robert H Edwards
Vesicular transport regulates monoamine storage and release but Is not essential
for amphetamine action
Neuron 19: 1271-1283. pdf
David Sulzer, Ta-Kung Chen,
Yau-Yi Lau, Helle Kristensen, Stephen Rayport, and Andrew Ewing
Amphetamine redistributes dopamine from synaptic vesicles to the
cytosol and promotes reverse transport
Journal of Neuroscience, 1995 15: 4102-4108 pdf
Joseph F Cubells, Stephen
Rayport, Geetha Rajendran, and David Sulzer
Methamphetamine neurotoxicity involves vacuolation of endocytic
organelles and dopamine-dependent intracellular oxidative stress
Journal of Neuroscience, 1994 14: 2260-2271 pdf
David Sulzer and Stephen
Rayport
Amphetamine and other psychostimulants reduce pH gradients in midbrain
dopaminergic neurons and chromaffin granules: a mechanism of action
Neuron, 1990 5: 797-808 [Abstract only]
Parkinson's Disease and neurodegeneration
Ana Maria Cuervo, Leo Stefanis, Ross Fredenburg, Peter Lansbury, David Sulzer
Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy
Science 2004 305:1292-5 pdf
Stan Fahn and David Sulzer
Neurodegeneration and neuroprotection in Parkinson's Disease
NeuroRx
2004 1:139-154 pdf
Luigi Zecca, Fabio Zucca,
Henrik Wilms and David Sulzer
Neuromelanin of the substantia nigra: a neuronal black hole with protective
and toxic characteristics
TRENDS in Neurosciences, 2003, 26:216-220 pdf
Larsen,
K., and Sulzer, D.
Autophagy in neurons: a review
Histology & Histopathology, 2002, 17:897-908 pdf
Luigi Zecca, Ruggero Fariello,
Peter Riederer, David Sulzer, Alberto Gatti, Davide Tampellini
The absolute concentration
of nigral neuromelanin, assayed by a new sensitive method, increases throughout
the life and is dramatically decreased in Parkinson's disease
FEBS Letters, 2002, 510: 216-220 pdf
David Sulzer
Alpha-synuclein and cytosolic dopamine; stabilizing a bad situation (Commentary)
Nature Medicine,
2001, 12: 1280-1282 pdf
Stefanis,
L., Larsen, K.E., Rideout, H.J., Sulzer, D., and Greene, L.A.
Expression of A53T mutant, but not wild type, alpha-synuclein in PC12 cells
induces alterations of the ubiquitin-dependent degradation system, loss of dopamine
release, and autophagic cell death
Journal of Neuroscience, 2001 21, 9549-9560 pdf
Petersen, A., Behr, G.G.,
Larsen, K., Romero, N., Przedborski, S., Brundin, P., Sulzer, D.
An expanded CAG repeat in exon 1 of the Huntington's Disease gene promotes
dopamine-mediated autophagy and death in striatal neurons
Hum. Mol. Genet., 2001 10:1243-54 pdf
Zecca, L., Tampellini, D.,
Gerlach, M., Riederer, P., Fariello, R.G., and Sulzer, D. (2001)
Substantia nigra neuromelanin: structure, synthesis and molecular behaviour
(Review)
J. Clinical Pathol. 2001 54:414-418 pdf
Sulzer, D., Bogulavsky,
J., Larsen, K.E., Karatekin, E., Kleinman, M., Turro, N., Kranz, D., Edwards,
R., Greene, L.A., Zecca, L.
Neuromelanin synthesis sequesters cytosolic catecholamines not accumulated
by synaptic vesicles
Proc Natl Acad Sci USA, 2000 97:11869-11874. pdf
Abelovich, A., Schmitz,
Y., Farinas, I., Choi-Lundberg, D., Ho, W.-H., Verdugo, J.M.G., Armanini, M.,
Ryan, A., Hynes, M., Phillips, H., Sulzer, D., Rosenthal, A.
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal
dopamine system
Neuron, 2000 25:239-252. pdf
David Sulzer and Luigi Zecca
Intraneuronal dopamine-quinone biosynthesis: a review
Neurotoxicity
Research, 2000 1:181-195 pdf
Kholidov, N.G., Neystat,
M., Oo, T.F., Larsen, K.E., Sulzer, D., and Burke, R.E.
Increased expression of rat synuclein 1 in the substantia nigra
compacta identified by mRNA differential display in a model of developmental
target injury
Journal of Neurochemistry, 1999: 73:2586-2599. pdf
Mena, M.A., Davila, V.,
Bogaluvsky, J., and Sulzer, D.
L-DOPA potentiates NGF-induced outgrowth and quantal dopamine release in
PC12 neurites.
Molecular Pharmacol., 1998 54:678-686. pdf
Robert E Burke, Megan Antonelli,
and David Sulzer
Glial Cell Line-Derived Neurotrophic Growth Factor Inhibits Apoptotic
Death of Postnatal Substantia Nigra Dopamine Neurons in Primary Culture
Journal of Neurochemistry, 1998 71, 517-525. pdf
Maria Angeles Mena, Viviana
Davila, and David Sulzer
Neurotrophic Effects of L-DOPA in Postnatal Midbrain Dopamine Neuron/Cortical
Astrocyte Cocultures
Journal of Neurochemistry, 1997 69, 1398-1408. pdf
Serge Przedborski, Uzma
Khan, Vladimir Kostic, Elaine Carlson, Charles J Epstein, and David Sulzer
Increased Superoxide Dismutase Activity Improves Survival of Cultured
Postnatal Midbrain Neurons
Journal of Neurochemistry, 1996, 67, 1383-1392 pdf