» The Stroke Center
» The Northern Manhattan Study (NOMAS)
Clinical Research Programs
Randolph S. Marshall
Behavioral and physiologic investigation of early hemispheric ischemia in patients undergoing therapeutic carotid balloon test occlusions. Evaluation of visual-spatial dysfunction using behavioral and functional imaging methodologies.
Mitchell S. Elkind
Stroke risk factors and prevention. Focus on different inflammatory markers and infections, such as C. pneumoniae and periodontal disease, as potential causes of atherosclerosis and ischemic stroke. Use of high-resolution duplex doppler ultrasonography as a measure of stroke risk. Clinical trials of neuroprotectants and surgical hemicraniectomy for acute stroke, and antiplatelet and of other therapies for stroke prevention.
John W. Krakauer
» The Motor Performance Laboratory
The Motor Performance Laboratory is a research facility dedicated to the study of the neural basis of limb movement control in health and neurologic disease.
Ronald M. Lazar
Clinical and imaging studies of post-stroke language impairment (aphasia) and the development of novel pharmacological and behavioral therapies for language recovery. New emphasis on charting recovery during the acute stroke period and establishing the efficacy for early intervention.
Research is focused on clinical, radiologic and pathologic correlations of clinical stroke syndromes; doppler studies and cerebral hemodynamics of large-artery disease; arteriovenous malformations (AVMs); studies of the course and outcome of stroke and its various subtypes; cardiac and hematologic risk factors of stroke; and modification of stroke outcome by specific therapies tested in multi-center trials.
Cerebral Localization Laboratory
Ronald M. Lazar, Randolph S. Marshall
A clinical research unit dedicated to investigation of the behavioral outcomes of strokes and related vascular diseases. Computerized assessment of stroke patients' behaviors, functional magnetic resonance imaging, superselective arterial amobarbital (Wada) testing, and transcranial doppler ultrasonography allow measurement of cerebral plasticity with the principal focus on the brain's abilities to compensate for injury.
Joanne R. Festa
Research focuses on the neurocognitive outcomes of stroke and related vascular diseases such as heart failure, carotid disease, and AVMs. Design and conduct neurocognitive outcomes research in multi-center clinical trials.
Basic Research Laboratory
E. Sander Connolly
Mechanisms of ischemic injury. Cellular and molecular neuroprotective mechanisms and new therapeutic strategies.