MOTOR NEURON CENTER FOR BIOLOGY & DISEASE
» Columbia MDA/ALS Research Center
» Columbia Motor Neuron Center
The Center provides a multidisciplinary team approach for patients with ALS and their families. Comprehensive services include access to medical and psychosocial management, innovative therapeutic clinical trials, basic and clinical research, and expertise in palliative and biomedical care.
THE H. HOUSTON MERRITT CENTER FOR NEUROMUSCULAR AND MITOCHONDRIAL DISORDERS
Molecular Biochemistry Laboratory
» Laboratory of Molecular Neurogenetics
Biochemical and DNA investigations of human metabolic myopathies, including disorders of glycogen metabolism, lipid metabolism, and mitochondrial function.
Molecular Genetics Laboratories
Eric A. Schon
Molecular genetic studies of neuromuscular disorders. Current work includes analysis of respiratory chain genes (cytochrome c oxidase), mutations of mitochondrial DNA in human disease, and in vitro gene therapy.
Molecular biology of neuromuscular disorders. Identification of causative mutations in autosomal disorders affecting the mitochondria. Mouse models of mitochondrial diseases. Development of therapies for mitochondrial diseases.
Research involving the ultrastructure of membrane systems in normal and diseased human muscle. Procedures utilized involve transmission electron microscopy, immunocytochenustry, and in situ hybridization.
Tissue Culture Laboratory
Morphological, biochemical, molecular genetic and electrophysiological analyses of mitochondrial encephalomyopathies using transmitochondrial cybrids, skeletal myoblasts, cardiomyocytes, and neuronal cells. Studies of tissue-specific effects of mutations associated with these diseases on normal development and function; and cell culture models for devising potential therapeutic strategies.
Muscle and Nerve Pathology Laboratory
Arthur P. Hays
Morphologic studies of diabetic and other neuropathies and motor neuron diseases.