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AGING, MEMORY AND DEMENTIA




» Memory Disorders

» Taub Institute for Research in Alzheimer Disease
This group provides in-patient consultation services for patients with cognitive and behavioral disorders and staffs the Memory Disorders Clinic at the Psychiatric Institute. Residents are encouraged to elect rotations on this service. Research interests in behavioral disorders and dementia primarily focus on degenerative diseases such as Parkinson disease, Alzheimer disease, Huntington disease, and stroke. Neurologic, psychiatric and neuropsychologic functions are assessed. Current projects include studies of dementia in Parkinson disease, use of brain imaging in dementia, clinical trials, and epidemiology of Alzheimer disease and related disorders; natural history of HIV; cognitive performance in children with complex metabolic disorders. Aging and dementia rounds are held weekly at Columbia University Medical Center and monthly at Harlem Hospital Center. The research activities of the Division of Aging and Dementia are integrated closely with those of the Sergievsky Center, and all divisional faculty hold appointments in the Sergievsky Center.

Karen S. Marder


Division Director
Investigations of genetic influences in families of probands with early-onset compared to late-onset Parkinson disease. Multicenter investigation of risk factors for the development of dementia in HIV. Clinical trials of new therapeutic agents in Huntington disease. Longitudinal study of subjects at risk for developing Huntington disease.

Karen L. Bell


Development of new clinical treatments for Alzheimer disease. Currently conducting research for the prevention of Alzheimer disease in individuals with mild cognitive impairment. Other research interests include understanding barriers that minorities face in receiving clinical care for dementia and cognitive loss, and developing mechanisms to recruit minorities into clinical research.

Sandra Bell-McGinty


Clinical neuropsychology. Assessment of memory and behavior dysfunction, and evaluations for Alzheimer's disease and other dementia disorders.

Elise Caccappolo


Clinical neuropsychology. Assessment of memory and behavior dysfunction, and evaluations for Alzheimer's disease and other dementia disorders.

Lucien Côté


Epidemiology and genetics of Parkinson's disease. Studies of depression and dementia in Parkinson's disease.

Lawrence S. Honig


Dr. Honig performs both basic and clinical research involving various aspects of Alzheimer disease, dementia and cognitive dysfunction. His laboratory research focusses on biomarkers in neurodegenerative disease including studies of gene expression in Lewy Body Disease, frontotemporal dementias, and Alzheimer disease, as well as work on genetic and epigenetic markers, the latter involving role of telomeres in biological aging. His clinical research includes both NIH funded research and pharmaceutical company funded clinical trials. He is the director of the Clinical Core of the NIA/NIH-funded Alzheimer Disease Research Center (ADRC) at Columbia University. He is the principal site investigator in a number of ongoing clinical drug trials aimed at Alzheimer disease, as well as in several clinical trials involving molecular neuroimaging.

Edward Huey


Investigations into the neuroanatomical and genetic bases of behavioral, emotional, and cognitive symptoms in frontotemporal dementia and related disorders. Interested in the overlap of neurological and psychiatric disorders. Also interested in developing and testing treatments for frontotemporal dementia and related disorders.

Jennifer Manly


Epidemiology and genetics of Parkinson's disease. Studies of depression and dementia in Parkinson's disease.

Richard Mayeux


Gertrude H. Sergievsky Professor of Neurology, Psychiatry, and Epidemiology
Chair & Neurologist-in-Chief, Department of Neurology
Director, Gertrude H. Sergievsky Center
Co-director, Taub Institute for Research on Alzheimer's Disease and the Aging Brain
Epidemiology and genetics of Alzheimer disease and Parkinson disease.
(see Sergievsky Center)

James M. Noble


Dr. Noble's research interests focus on understanding the steps leading to the disparity of dementia among this country's minority populations. Specific projects involve potential neuropathologic links between stroke and dementia, as well as epidemiologic and serologic exploration of associations between dementia and inflammation, particularly periodontitis. In addition, Dr. Noble has developed a cultural arts program for dementia patients and their caregivers in an effort to improve caregiver burden and is working with multidisciplinary educational programs to improve stroke and health literacy in minority communities.

Nicole Schupf


Risk factors for accelerated aging and Alzheimer's disease in adults with Down syndrome; Risk factors and biomarkers of risk for late onset Alzheimer's disease.

Scott Small


Correlations of memory and changes in the hippocampal formation using functional magnetic resonance imaging in normal aging and in Alzheimer disease. Parallel studies in transgenic mice.

Yaakov Stern


Dr. Stern is using cognitive experimental and fMRI neuroimaging approaches to understand why some people are more susceptible to aging and disease pathology than others.
 

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