Zhang Y, Mena P, Romanov G, Lin JS, Smiley ST, and Bliska JB. 2012. A protective epitope in type III effector YopE is a major CD8 T cell antigen during primary infection with Yersinia pseudotuberculosis. Infect Immun 80:206-14.

Varshney AK, Wang X, Cook E, Dutta K, Scharff MD, Goger MJ, and Fries BC. 2011. Generation, characterization, and epitope mapping of neutralizing and protective monoclonal antibodies against staphylococcal enterotoxin B-induced lethal shock. J Biol Chem 286:9737-47.

Wrammer J, Koutsonanos D, Li GM, Edupuganti S, Sui J, Morrissey M, McCausland M, Skountzou I, Hornig M, Lipkin WI, Mehta A, Razavi B, Del Rio C, Zheng NY, Lee JH, Huang M, Ali Z, Kaur K, Andrews S, Amara RR, Wang Y, Das SR, O'Donnell CD, Yewdell JW, Subbarao K, Marasco WA, Mulligan MJ, Compans R, Ahmed R, and Wilson PC. 2011. Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection. J Exp Med 208:181-93.

Vaccines

Pica N, Hai R, Krammer F, Wang TT, Maamary J, Eggink D, Tan GS, Krause JC, Moran T, Stein CR, Banach D, Wrammert J, Belshe RB, Garcia-Sastre A, and Palese P. 2012. Hemagglutinin stalk antibodies elicited by the 2009 pandemic influenza virus as a mechanism for the extinction of seasonal H1N1 viruses. Proc Natl Acad Sci USA 109:2573-8.

Wang TT, Parides MK, and Palese P. 2012. Seroevidence for H5N1 influenza infections in humans: meta-analysis. Science 335:1463.

Schwartz JA, Buonocore L, Suguitan AL, Jr. Hunter M, Marx PA, Subbarao, K, and Rose JK. 2011. Vesicular stomatitis virus-based H5N1 avian influenza vaccines induce potent cross-clade neutralizing antibodies in rhesus macaques. J Virol 85:4602-5.

Diagnostics and Pathogen Discovery

Forrester NL, Palacios G, Tesh RB, Savji N, Guzman H, Sherman M, Weaver SC and Lipkin, WI. 2012. Genome-scale phylogeny of the alphavirus genus suggests a marine origin. J Virol 86:2729-38.

Kapoor A, Simmonds P, Gerold G, Qaisar N, Jain K, Henriquez JA, Firth C, Hirschberg DL, Rice CM, Shields S,  and Lipkin WI. 2012. Characterization of a canine homolog of hepatitis C virus. Proc Natl Acad Sci USA 108:11608-13.

Tokarz R, Kapoor V, Wu W, Lurio J, Jain K, Mostashari F, Briese T, and Lipkin WI. 2011. Longitudinal molecular microbial analysis of influenza-like illness in New York City, May 2009 through May 2010.Virol J 8:288.

Therapeutics

Porotto M, Palmer SG, Palermo LM and Moscona A. 2012. Mechanism of fusion triggering by human parainfluenza virus type III: communication between viral glycoproteins during entry. J Biol Chem 287:778-93.

Talekar A, Pessi A, Glickman F, Sengupta U, Briese T, Whitt MA, Mathieu C, Horvat B, Moscona A, and Porotto M. 2012. Rapid screening for entry inhibitors of highly pathogenic viruses under low-level biocontainment. PLoS One 7:e30538.

Zheng Y, Sanchez-San Martin C, Qin ZL, and Kielian M. 2011. The domain I-domain III linker plays an important role in the fusogenic conformational change of the alphavirus membrane fusion protein. J Virol 85:6334-42.

Innate Immunity

Meng X, Schoggins J, Rose L, Cao J, Ploss A, Rice CM and Xiang Y. 2012. C7L family of poxvirus host range genes inhibits antiviral activities induced by type I interferons and interferon regulatory factor 1. J Virol 86:4538-47.

Schoggins JW, Wilson SJ, Panis M, Murphy MY, Jones CT, Bieniasz P, and Rice CM. 2011 .A diverse range of gene products are effectors of the type I interferon antiviral response. Nature 472:481-5.

Leung LW, Park MS, Martinez O, Valmas C, Lopez CB, and Basler CF. 2011. Ebolavirus VP35 suppresses IFN production from conventional but not plasmacytoid dendritic cells. Immunol Cell Biol 89:792-802.

Microbial Pathogenesis

Mukherjee S, Liu X, Arasaki K, McDonough J, Galan JE, and Roy CR. 2011. Modulation of Rab GTPase function by a protein phosphocholine transferase. Nature 477:103-6.

Newton HJ and Roy CR. 2011. The Coxiella burnetii Dot/Icm system creates a comfortable home through lysosomal renovation. MBio 2:e00226-11.

Feng Z, Kallifidas D, and Brady SF. 2011. Functional analysis of environmental DNA-derived type II polyketide synthases reveals structurally diverse secondary metabolites. Proc Natl Acad Sci U S A 108:12629-34.

Developmental Projects

Yi Z, Sperzel L, Nurnberger C, Bredenbeek PJ, Lubick KJ, Best SM, Stoyanov CT, Law LM, Yuan Z, Rice CM, and MacDonald MR. 2011. Identification and characterization of the host protein DNAJC14 as a broadly active flavivirus replication modulator PLoS Pathog 7:e1001255

Bublitz DC, Noah CE, Benach J, and Furie MB. 2010. Francisella tularensis suppresses the proinflammatory response of endothelial cells via the endothelial protein C receptor. J Immunol 185:1124-31.

Yang YY, Grammel M, Raghavan AS, Charron G, and Hang HC. 2010. Comparative analysis of cleavable azobenzene-based affinity tags for bioorthogonal chemical proteomics. Chem Biol 24:1212-22.

New Opportunities

Gavrilovskaya IN, Gorbunova EE, and Mackow ER. 2010. Pathogenic hantaviruses direct the adherence of quiescent platelets to infected endothelial cells. J Virol 84:4832-9.

Matthys VS, Gorbunova EE, Gavrilovskaya IN, and Mackow ER. 2010. Andes virus recognition of human and Syrian hamster beta3 integrins is determined by an L33P substitution in the PSI domain. J Virol 84:352-60.

Novikova M, Kazakov T, Vondenhoff GH, Semenova E, Rozenski J, Metlytskaya A, Zukher I, Tikhonov A, Van Aerschot A, and Severinov K. 2010. MccE provides resistance to protein synthesis inhibitor microcin C by acetylating the processed form of the antibiotic. J Biol Chem 285:12662-9.

Career Development

Lara-Tejero M, Kato J, Wagner S, Liu X, and Galan JE. 2011. A sorting platform determines the order of protein secretion in bacterial Type III Systems. Science 4:1189-91.

Steel J, Palese P, and Lowen AC. 2010. Transmission of a 2009 pandemic influenza virus shows a sensitivity to temperature and humidity similar to that of an H3N2 seasonal strain. J Virol 85:1400-2.

Wang P, Arjona A, Zhang Y, Sultana H, Dai J, Yang L, LeBlanc PM, Doiron K, Saleh M and Fikrig E. 2010. Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I. Nat Immunol 11:912-9.