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      Professor of Medicine and Anatomy and Cell Biology

      PH 8 East 101-B
      Division of Molecular Medicine
      622 West 168th Street
      New York, NY 10032
      Ph.: (212) 305-9430
      Fax: (212) 305-4834
      Email: iat1@columbia.edu

1975B.S., Undergraduate: Tufts University, Medford, MA
1981M.D., Ph.D. (Biochemistry), Washington University, St. Louis, MO
1981-1983Internship/Residency: Internal Medicine, Columbia-Presbyterian Medical Center, New York, NY
1983-1985Clinical Fellowship: Endocrinology/Metabolism, Columbia-Presbyterian Medical Center, New York, NY
1983-1985Research Fellowship: Laboratory of Dr. Alan Tall, Department of Medicine, Columbia University, New York, NY
1988-1992

Assistant Professor of Anatomy & Cell Biology, Columbia University College of Physicians and Surgeons, New York , NY

1992-1997

Associate Professor of Medicine and Anatomy & Cell Biology (Tenured), Columbia University College of Physicians and Surgeons, New York , NY

1997-present

Professor of Medicine and Anatomy & Cell Biology (Tenured), Columbia University College of Physicians and Surgeons, New York , NY

1974Phi Beta Kappa, Tufts University, Medford, MA
1975Summa cum laude, Tufts University, Medford, MA
1977Letter of Commendation, Washington School of medicine, St. Louis, MO
1981Mosby Scholarship Book Award, Washington University School of Medicine, St. Louis MO
1981Alpha Omega Alpha, Washington University School of Medicine, St. Louis MO
1985-1987Pfizer Research Award for Young Faculty
1988-1993Silberberg Assistant Professorship of Medicine, Columbia University
1988-1993American Heart Association Established Investigator Award
Invited speaker to Gordon Research Conferences (1988, 1989, 1994, 1996, 1997, 1999, 2001, 2002)
Aspen Research Conference (1989, 1992, 1998, 2000); Deuel Research Conference (1997, 2002)
1997International Symposium on Atherosclerosis (1997, 2000); session chair in satellite symposium of International Congress of Biochemistry and Molecular Biology
1997Satellite symposium of the American Society for Biochemistry and Molecular Biology (1998); Keystone Conference on Cellular and Molecular Events in the Pathogenesis of Atherosclerosis (2001)
1990Doctor Harold and Golden Lamport Research Award
1992Elected to the American Society for Clinical Investigation
1992-1996Scientific Board of the Stanley J. Sarnoff Endowment for Cardiovascular Science, Inc.
1995-2000Editorial Board of Journal of Biological Chemistry
1996-presentElected to Interurban Clinical Club
1988-presentElected to American Association of Physicians
2001-2006Deputy Editor, Journal of Clinical Investigation
Arteriosclerosis Council (Council on Arteriosclerosis, Thrombosis, and Vascular Biology as of 1997)
American Heart Association; appointed member of the Membership/Credentials Committee (1990-1992, 1997-1999) and Program Committee (1992-1994)
American Society of Biochemists and Molecular Biologists
American Association for the Advancement of Science
American Society for Cell Biology
New York Lipid Club
American Society for Clinical Investigation
North American Vascular Biology Organization
Interurban Clinical Club
American Association of Physicians
Academic appointments
1985-1992Assistant Professor of Medicine, Columbia University College of Physicians and Surgeons, New York, NY
1988-1992Assistant Professor of Anatomy & Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY
Associate Professor of Medicine and Anatomy & Cell Biology (Tenured), Columbia
July 1992-Feb. 1997University College of Physicians and Surgeons, New York, NY
March, 1997-presentProfessor of Medicine and Anatomy & Cell Biology (Tenured), Columbia University College of Physicians and Surgeons, New York, NY
Hospital appointments
1985-1992Assistant Attending Physician of Medicine, Columbia-Presbyterian Medical Center, New York, NY
1992-presentAssociate Attending Physician of Medicine, Columbia-Presbyterian Medical Center, New York, NY
1997-presentAttending Physician of Medicine, Columbia-Presbyterian Medical Center, New York, NY

      Anthem
      Cambridge
      CIGNA
      Comm Premier Plus
      HIP
      Medichoice
      NPPN
      Oxford POS
      PHCS
      Prudential
NewYork-Presbyterian Hospital
Internal Medicine, Endocrinology & Metabolism

Marathe, S., Schissel, S.L., Yellin, M.J., Beatini, N., Mintzer, R., Williams, K.J., and Tabas, I. (1998) Human vascular endothelial cells are a rich and regulatable source of secretory sphingomyelinase.  Implications for early atherogenesis and ceramide-mediated cell signaling.  J. Biol. Chem. 273:4081-4088.

Schissel, S.L., Keesler, G.A., Schuchman, E.H., Williams, K.J., and Tabas. I. (1998) The cellular trafficking and zinc-dependency of secretory and lysosomal sphingomyelinase, two products of the acid sphingomyelinase gene.  J. Biol. Chem.  273:18250-18259.

Buton, X., Mamdouh, Z., Ghosh, R., Du, H., Kuriakose, G., Beatini, N., Grabowski, G.A., Maxfield, F.R., and Tabas, I. (1999) Unique cellular events occurring during the initial interaction of macrophages with matrix-retained or methylated aggregated LDL.  Prolonged cell-surface contact during which LDL-cholesteryl ester hydrolysis exceeds LDL-protein degradation.  J. Biol. Chem.  274:32132-32121.

Yao , P.M. and Tabas, I. (2000) Free cholesterol loading of macrophages induces apoptosis involving the Fas pathway.  J. Biol. Chem. 275:23807-23813.

Wong, M-L., Xie, B., Beatini, N., Phu, P., Marathe, S., Johns, A., Hirsch, E., Williams, K.J., Licinio, J., and Tabas, I. (2000)  Acute systemic inflammation up-regulates secretory sphingomyelinase in vivo:  a possible new link between inflammatory cytokines and atherogenesis.  Proc. Natl. Acad. Sci. U.S.A 97:8681-8686.

Marathe, S., Miranda, S.R.P., Devlin, C., Johns, A., Kuriakose, G., Williams, K.J., Schuchman, E.H., and Tabas, I. (2000) Creation of a mouse model for non-neurological (type B) Niemann-Pick mouse model by stable, low-level expression of lysosomal sphingomyelinase in the absence of secretory sphingomyelinase:  relationship between brain intra-lysosomal enzyme activity and central nervous system function.  Hum. Molec. Gen.  9:1967-1976.

Zhang, D., Tang, W., Yao , P.M., Yang, C., Xie, B., Jackowski, S., and Tabas, I. (2000) Macrophages deficient in CTP:phosphocholine cytidylyltransferase-a are viable under normal culture conditions but are highly susceptible to free cholesterol-induced death. Molecular genetic evidence that the induction of phosphatidylcholine biosynthesis in free cholesterol-loaded macrophages is an adaptive response.  J. Biol. Chem.  275:35368-35376.

Sakr, S., Eddy, R.J., Barth, H., Wang, F., Greenberg, S., Maxfield, F.R., and Tabas, I. (2001) The uptake and degradation of matrix-bound lipoproteins by macrophages require an intact actin cytoskeleton, Rho family GTPases, and myosin ATPase activity.  J. Biol. Chem. 276:37649-37658.

  Yao , P.M. and Tabas, I. (2001) Free cholesterol loading of macrophages is associated with widespread mitochondrial dysfunction and activation of the mitochondrial apoptosis pathway.  J. Biol. Chem. 276:42468-42476.

Leventhal, A.R., Chen, W., Tall, A.R., and Tabas, I. (2001) Acid sphingomyelinase-deficient macrophages have defective cholesterol efflux and trafficking.  J. Biol. Chem. 276:44976-44983.


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Updated: December 20, 2001