Selected Publications

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Devlin, C., Pipalia, N.H., Liao, X., Schuchman, E.H., Maxfield F.R., and Tabsa, I .(2010) Improvement in Lipid and Protein Trafficking in NPC1 Cells by Correction of a Secondary Enzyme Defect. Traffic, (Accepted Article) doi: 10.1111/j.1600-0854.2010.01046.x [pdf reprint]

Tabas, I., Tall, A,. and Accili,D. (2010) The Impact of Macrophage Insulin Resistance on Advanced Atherosclerotic Plaque Progression. Circ. Res. 106; 58-67 DOI: 10.1161/CIRCRESAHA.109.208488 [pdf reprint]

Tabas, I. (2009) Macrophage death and defective inflammation resolution in atherosclerosis. Nature Reviews Immunology, published online; DOI: 10.1038/nri2675. [pdf reprint]

Thorp, E. and Tabas, I. (2009) Mechanisms and consequences of efferocytosis in advanced atherosclerosis. Journal of Leukocyte Biology. 86, 1089-1095. [pdf reprint]

Woo, C.W., Cui, D., Arellano, J., Dorweiler, B., Harding, H., Fitzgerald, K.A., Ron, D., and Tabas, I. (2009) Adaptive suppression of the ATF4–CHOP branch of the unfolded protein response by toll-like receptor signalling. Nature Cell Biology, published online; DOI: 10.1038/ncb1996. [pdf reprint]

Tabas, I. (2009) Macrophage Apoptosis in Atherosclerosis: Consequences on Plaque Progression and the Role of Endoplasmic Reticulum Stress Antioxid. Redox Signal. 11, 2333–2339. [pdf reprint]

Timmins, J.M., Ozcan,L., Seimon,T.A., Li,G., Malagelada,C., Backs,J., Backs,T., Bassel-Duby,R., Olson, E.N., Anderson, M.E., and Tabas, I. (2009) Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways. Journal of Clinical Investigation. 119(10):2925-2941. [pdf reprint]

Li, G., Mongillo, M., Chin, K-T., Harding, H., Ron, D., Marks, A.R., and Tabas, I.A. (2009) Role of ERO1-α–mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress–induced apoptosis. Journal of Cell Biology. 186(6):783-792. [pdf reprint]

Thorp, E., Li, G., Seimon, T. A., Kuriakose G., Ron D., Tabas, I.A. (2009) Reduced Apoptosis and Plaque Necrosis in Advanced Atherosclerotic Lesions of Apoe-/- and Ldlr-/- Mice Lacking CHOP. Cell Metabolism. 9:474–481. [pdf reprint]

Seimon T.A., Wang Y., Han S., Senokuchi T., Schrijvers D.M., Kuriakose G., Tall A.R., Tabas, I.A. (2009) Macrophage deficiency of p38α MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in mice. The Journal of Clinical Investigation. 119(4):886-898. [pdf reprint]

Manning-Tobin, J.J., Moore, K.J., Seimon, T.A., Bell, S.A., Sharuk, M., Alvarez-Leite, J.I., de Winther, M.P.J., Tabas, I., and Freeman, M.W. (2009) Loss of SR-A and CD36 Activity Reduces Atherosclerotic Lesion Complexity Without Abrogating Foam Cell Formation in Hyperlipidemic Mice. Arterioscler. Thromb. Vasc. Biol. 29:19-26. [pdf reprint]

Li, Y., Zhang, Y., Dorweiler, B., Cui, D., Wang, T., Woo, C.W., Brunkan, C.S. , Wolberger, C., Imai, S., and Tabas, I. (2008) Extracellular Nampt Promotes Macrophage Survival via a Nonenzymatic Interleukin-6/STAT3 Signaling Mechanism. J. Biol. Chem. 283(50):34833–34843. [PDF reprint]

Thorp, E., Li, Y., Bao, L., Yao, P.M., Kuriakose, G., Rong, J., Fisher, E.A. and Tabas, I. (2008) Increased Apoptosis in Advanced Atherosclerotic Lesions of Apoe-/-Mice Lacking Macrophage Bcl-2. Arterioscler. Thromb. Vasc. Biol. [PDF reprint]

Devlin, C.M., Leventhal, A.R., Kuriakose, G., Schuchman, E.H., Williams, K.J., and Tabas, I. (2008) Atheromata and Accelerates Lesion ProgressionAcid Sphingomyelinase Promotes Lipoprotein Retention Within Early. Arterioscler. Arterioscler. Thromb. Vasc. Biol. 28:1723-1730. [PDF reprint]

Iqbal, J., Dai, K., Seimon, T.A., Jungreis, R., Oyadomari, M., Kuriakose, G., Ron, D., Tabas, I., and Hussain M.M. (2008) IRE1b Inhibits Chylomicron Production by Selectively Degrading MTP mRNA. Cell Metabolism. 7:1–11. [PDF reprint]

Thorp, E., Cui, D., Schrijvers, D.M., Kuriakose, G. and Tabas, I. (2008) Mertk Receptor Mutation Reduces Efferocytosis Efficiency and Promotes Apoptotic Cell Accumulation and Plaque Necrosis in Atherosclerotic Lesions of Apoe -/- Mice. Arterioscler. Thromb. Vasc. Biol. [PDF reprint]

Lim, W-S., Timmins, J.M., Seimon, T.A., Sadler, A., Kolodgie, F.D., Virmani, R., Tabas, I. (2008) Signal Transducer and Activator of Transcription-1 Is Critical for Apoptosis in Macrophages Subjected to Endoplasmic Reticulum Stress In Vitro and in Advanced Atherosclerotic Lesions In Vivo. Circulation 117:940-951. [PDF reprint]

Thorp, E., Kuriakose, G., Shah, Y.M., Gonzalez, F.J., Tabas, I. (2007) Pioglitazone increases macrophage apoptosis and plaque necrosis in advanced atherosclerotic lesions of non-diabetic LDL receptor-null mice. Circulation 116:2182-2190. [PDF reprint]

Cu,i D., Thorp E., Li, Y., Wang, N., Yvan-Charvet, L., Tall AR, Tabas, I. (2007) Pivotal Advance: Macrophages become resistant to cholesterol-induced death after phagocytosis of apoptotic cells. J Leukoc Biol. 82(5):1040-50. [PDF reprint]

Tabas, I. , Williams, K.J., Borén, J. (2007) Subendothelial Lipoprotein Retention as the Initiating Process in Atherosclerosis: Update and Therapeutic Implications. Circulation 116(16):1832-44. [PDF reprint]

Tabas, I. (2007) A Two-Carbon Switch to Sterol-Induced Autophagic Death. Autophagy 3 (1):38–41. [PDF reprint]

Seimon, T.A., Obstfeld, A., Moore, K.J., Golenbock, D.T., Tabas, I. (2006) Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages. Proc. Natl. Acad. Sci. U.S.A. 103 (52):19794–19799. [PDF reprint]

Bao, L., Yankun, L., Deng, S., Landry, D., Tabas, I. (2006) Sitosterol-containing Lipoproteins Trigger Free Sterol-induced Caspase-independent Death in ACAT-competent Macrophages. J. Biol. Chem. 281 (44):33635–33649. [PDF reprint]

Li, Y., Gerbod-Giannone, M., Seitz, H., Cui, D., Thorp, E., Tall, A.R., Matsushima, G.K., Tabas, I. (2005) Cholesterol-induced Apoptotic Macrophages Elicit an Inflammatory Response in Phagocytes, Which Is Partially Attenuated by the Mer Receptor. J. Biol. Chem. 281 (10):6707–6717. [PDF reprint]

Maxfield, F.R., Tabas, I. (2005) Role of cholesterol and lipid organization in disease. Nature 438:36-45. [PDF reprint]

Tabas, I. (2005) Consequences and Therapeutic Implications of Macrophage Apoptosis in Atherosclerosis: The Importance of Lesion Stage and Phagocytic Efficiency. Arterioscler Thromb Vasc Biol. 25:2255-2264. [PDF reprint]

DeVries-Seimon, T, Li Y, Mei Yao, P, Stone, E, Wang, Y, Davis, R, Flavell, R, Tabas, I. (2005) Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor. J. Cell Biol. 171 (1):61-73. [PDF reprint]

Li Y, Schwabe, R, DeVries-Seimon, T, Mei Yao, P, Gerbod-Giannone, M, Tall, A, Davis, R, Flavell, R, Brenner, D, and Tabas, I. (2005) Free Cholesterol-loaded Macrophages Are an Abundant Source of Tumor Necrosis Factor-alpha and Interleukin-6. J. Biol. Chem. 280 (23):21763–21772. [PDF reprint]

Wong, M-L., Xie, B., Beatini, N., Phu, P., Marathe, S., Johns, A., Hirsch, E., Williams, K.J., Licinio, J., and Tabas, I. (2000) Acute systemic inflammation up-regulates secretory sphingomyelinase in vivo: a possible new link between inflammatory cytokines and atherogenesis. Proc. Natl. Acad. Sci. U.S.A. 97:8681-8686.

Marathe, S., Miranda, S.R.P., Devlin, C., Johns, A., Kuriakose, G., Williams, K.J., Schuchman, E.H., and Tabas, I. (2000) Creation of a mouse model for non-neurological (type B) Niemann-Pick mouse model by stable, low-level expression of lysosomal sphingomyelinase in the absence of secretory sphingomyelinase: relationship between brain intra-lysosomal enzyme activity and central nervous system function. Hum. Molec. Gen. 9:1967-1976.

Zhang, D., Tang, W., Yao, P.M., Yang, C., Xie, B., Jackowski, S., and Tabas, I. (2000) Macrophages deficient in CTP:phosphocholine cytidylyltransferase-a are viable under normal culture conditions but are highly susceptible to free cholesterol-induced death. Molecular genetic evidence that the induction of phosphatidylcholine biosynthesis in free cholesterol-loaded macrophages is an adaptive response. J. Biol. Chem. 275:35368-35

Sakr, S., Eddy, R.J., Barth, H., Wang, F., Greenberg, S., Maxfield, F.R., and Tabas, I. (2001) The uptake and degradation of matrix-bound lipoproteins by macrophages require an intact actin cytoskeleton, Rho family GTPases, and myosin ATPase activity. J. Biol. Chem. 276:37649-37658.

Yao, P.M. and Tabas, I. (2001) Free cholesterol loading of macrophages is associated with widespread mitochondrial dysfunction and activation of the mitochondrial apoptosis pathway. J. Biol. Chem. 276:42468-42476.

Leventhal, A.R., Chen, W., Tall, A.R., and Tabas, I. (2001) Acid sphingomyelinase-deficient macrophages have defective cholesterol efflux and trafficking. J. Biol. Chem. 276:44976-44983. [view pdf]

Tabas, I. (2002) Cholesterol in health and disease. J. Clin. Invest. 110:583-590. [view pdf]

Tabas, I. (2002) Consequences of cellular cholesterol accumulation. J. Clin. Invest. 110:955-911. [view pdf]

Devlin, C.M., Kuriakose, G., Hirsch, E., and Tabas, I. (2002) Genetic alterations of interleukin-1 receptor antagonist in mice markedly affect non-HDL lipoprotein cholesterol levels and foam cell lesion size. Proc. Natl. Acad. Sci. U.S.A. 99: 6280-6285.

Feng, B. and Tabas, I. (2002) ABCA1-mediated cholesterol efflux is defective in free cholesterol-loaded macrophages. Mechanism involves enhanced ABCA1 degradation in a process requiring full npc1 activity. J. Biol. Chem. 277:43271-43280. [view pdf]

Feng, B, Yao, P.M., Li, Y., Devlin, C., Zhang, D., Harding, H., Sweeney, M., Rong, J.X., Kuriakose, G., Fisher, E.A., Marks, A.R., Ron, D., Tabas, I. (2003) The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages. Nature Cell Biology 5:781-792. [view pdf]

Feng, B., Zhang, D., Kuriakose, G., Devlin, C.M., Kockx, M., and Tabas, I. (2003) Niemann-Pick C heterozygosity confers resistance to lesional necrosis and macrophage apoptosis in murine atherosclerosis. Proc. Natl. Acad. Sci. U.S.A. 100:10423-10428. [view pdf]

Patel, M., Morrow, J., Maxfield, F.R., Strickland, D.K., Greenberg, S., and Tabas, I. (2003) The cytoplasmic domain of LDL receptor-related protein, but not that of the LDL receptor, triggers phagocytosis. J. Biol. Chem. 278: 44799-44807 [view pdf]

Leventhal, A.R., Leslie, C.C., and Tabas, I. (2004) Suppression of macrophage eicosanoid synthesis by atherogenic lipoproteins is profoundly affected by cholesterol-fatty acyl esterification and the Niemann-Pick C pathway of lipid trafficking. J. Biol. Chem. 279:8084-8092. [view pdf]

Li, Y., Ge, M., Ciani, L., Kuriakose, G., Westover, E.J., Dura, M., Covey, D.F., Freed, J.H., Maxfield, F.R., Lytton, J., and Tabas, I. (2004) Enrichment of Endoplasmic Reticulum with Cholesterol Inhibits SERCA2b Activity in Parallel with Increased Order of Membrane Lipids. J. Biol. Chem. 279:37030–37039. [view pdf]

Tabas, I (2004) Apoptosis and plaque destabilization in atherosclerosis: the role of macrophage apoptosis induced by cholesterol. Cell Death Diff. 11:S12-S16. [view pdf]

Tabas, I. (2004) Sphingolipids and Atherosclerosis: A Mechanistic Connection? A Therapeutic Opportunity? Circulation. 110:3400-3401. [view pdf]

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