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Selected Publications
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PubMed for articles
Devlin, C., Pipalia, N.H., Liao, X., Schuchman, E.H., Maxfield F.R., and Tabsa, I .(2010)
Improvement in Lipid and Protein Trafficking in NPC1 Cells by Correction of a Secondary Enzyme Defect. Traffic, (Accepted Article) doi: 10.1111/j.1600-0854.2010.01046.x [pdf reprint]
Tabas, I., Tall, A,. and Accili,D. (2010) The Impact of Macrophage Insulin Resistance on Advanced Atherosclerotic Plaque Progression. Circ. Res. 106; 58-67 DOI: 10.1161/CIRCRESAHA.109.208488 [pdf reprint]
Tabas, I. (2009) Macrophage death and defective inflammation resolution in atherosclerosis. Nature Reviews Immunology, published online; DOI: 10.1038/nri2675. [pdf reprint]
Thorp, E. and Tabas, I. (2009) Mechanisms and consequences of efferocytosis in advanced atherosclerosis. Journal of Leukocyte Biology. 86, 1089-1095. [pdf reprint]
Woo, C.W., Cui, D., Arellano, J., Dorweiler, B., Harding, H., Fitzgerald, K.A., Ron, D., and Tabas, I. (2009) Adaptive suppression of the ATF4–CHOP branch of the unfolded protein response by toll-like receptor signalling. Nature Cell Biology, published online; DOI: 10.1038/ncb1996. [pdf reprint]
Tabas, I. (2009) Macrophage Apoptosis in Atherosclerosis:
Consequences on Plaque Progression and the Role of Endoplasmic Reticulum Stress Antioxid. Redox Signal. 11, 2333–2339. [pdf reprint]
Timmins, J.M., Ozcan,L., Seimon,T.A., Li,G., Malagelada,C., Backs,J., Backs,T., Bassel-Duby,R., Olson, E.N., Anderson, M.E., and Tabas, I. (2009) Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways. Journal of Clinical Investigation. 119(10):2925-2941. [pdf reprint]
Li, G., Mongillo, M., Chin, K-T., Harding, H., Ron, D., Marks, A.R., and Tabas, I.A. (2009) Role of ERO1-α–mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress–induced apoptosis. Journal of Cell Biology. 186(6):783-792. [pdf reprint]
Thorp, E., Li, G., Seimon, T. A., Kuriakose G., Ron D., Tabas, I.A. (2009) Reduced Apoptosis and Plaque Necrosis in Advanced Atherosclerotic Lesions of Apoe-/- and Ldlr-/- Mice Lacking CHOP. Cell Metabolism. 9:474–481. [pdf reprint]
Seimon T.A., Wang Y., Han S., Senokuchi T., Schrijvers D.M., Kuriakose G., Tall A.R., Tabas, I.A. (2009) Macrophage deficiency of p38α MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in mice. The Journal of Clinical Investigation. 119(4):886-898. [pdf reprint]
Manning-Tobin, J.J., Moore, K.J., Seimon, T.A., Bell, S.A., Sharuk, M., Alvarez-Leite, J.I., de Winther, M.P.J., Tabas, I., and Freeman, M.W. (2009) Loss of SR-A and CD36 Activity Reduces Atherosclerotic Lesion Complexity Without Abrogating Foam Cell Formation in Hyperlipidemic Mice. Arterioscler. Thromb. Vasc. Biol. 29:19-26. [pdf reprint]
Li, Y., Zhang, Y., Dorweiler, B., Cui, D., Wang, T., Woo,
C.W., Brunkan, C.S. , Wolberger, C., Imai, S., and Tabas, I. (2008) Extracellular Nampt Promotes Macrophage Survival via a Nonenzymatic Interleukin-6/STAT3 Signaling Mechanism. J. Biol. Chem. 283(50):34833–34843. [PDF reprint]
Thorp, E., Li, Y., Bao, L., Yao, P.M., Kuriakose, G., Rong, J., Fisher, E.A. and Tabas, I. (2008) Increased Apoptosis in Advanced Atherosclerotic Lesions of Apoe-/-Mice Lacking Macrophage Bcl-2. Arterioscler. Thromb. Vasc. Biol. [PDF reprint]
Devlin, C.M., Leventhal, A.R., Kuriakose, G., Schuchman, E.H., Williams, K.J., and Tabas, I. (2008) Atheromata and Accelerates Lesion ProgressionAcid Sphingomyelinase Promotes Lipoprotein Retention Within Early. Arterioscler. Arterioscler. Thromb. Vasc. Biol. 28:1723-1730. [PDF
reprint]
Iqbal, J., Dai, K., Seimon, T.A., Jungreis, R., Oyadomari, M., Kuriakose, G., Ron, D., Tabas, I., and Hussain M.M. (2008) IRE1b Inhibits Chylomicron Production by Selectively Degrading MTP mRNA. Cell Metabolism. 7:1–11. [PDF
reprint]
Thorp, E., Cui, D., Schrijvers, D.M., Kuriakose, G. and Tabas, I. (2008) Mertk Receptor Mutation Reduces Efferocytosis Efficiency and Promotes Apoptotic Cell Accumulation and Plaque Necrosis in Atherosclerotic Lesions of Apoe -/- Mice. Arterioscler. Thromb. Vasc. Biol. [PDF
reprint]
Lim, W-S., Timmins, J.M., Seimon, T.A., Sadler, A., Kolodgie, F.D., Virmani, R., Tabas, I. (2008) Signal Transducer and Activator of Transcription-1 Is Critical for Apoptosis in Macrophages Subjected to Endoplasmic Reticulum Stress In Vitro and in Advanced Atherosclerotic Lesions In Vivo. Circulation 117:940-951. [PDF
reprint]
Thorp, E., Kuriakose, G., Shah, Y.M., Gonzalez, F.J., Tabas, I. (2007) Pioglitazone increases macrophage apoptosis and plaque necrosis in advanced atherosclerotic lesions of non-diabetic LDL receptor-null mice. Circulation 116:2182-2190. [PDF
reprint]
Cu,i D., Thorp E., Li, Y., Wang, N., Yvan-Charvet, L., Tall AR, Tabas, I. (2007) Pivotal Advance: Macrophages become resistant to cholesterol-induced death after phagocytosis of apoptotic cells. J Leukoc Biol. 82(5):1040-50. [PDF
reprint]
Tabas, I. , Williams, K.J., Borén,
J. (2007) Subendothelial
Lipoprotein Retention as the Initiating Process
in Atherosclerosis: Update and Therapeutic
Implications. Circulation 116(16):1832-44.
[PDF
reprint]
Tabas, I. (2007) A
Two-Carbon Switch to Sterol-Induced Autophagic
Death. Autophagy 3 (1):38–41.
[PDF
reprint]
Seimon, T.A., Obstfeld, A., Moore,
K.J., Golenbock, D.T., Tabas, I. (2006)
Combinatorial pattern recognition receptor
signaling alters the balance of life and
death in macrophages. Proc.
Natl. Acad. Sci. U.S.A.
103 (52):19794–19799. [PDF
reprint]
Bao, L., Yankun, L., Deng, S.,
Landry, D., Tabas, I. (2006) Sitosterol-containing
Lipoproteins Trigger Free Sterol-induced
Caspase-independent Death in ACAT-competent
Macrophages. J. Biol. Chem. 281 (44):33635–33649.
[PDF
reprint]
Li, Y., Gerbod-Giannone, M.,
Seitz, H., Cui, D., Thorp, E.,
Tall, A.R.,
Matsushima, G.K., Tabas, I. (2005) Cholesterol-induced
Apoptotic Macrophages Elicit an Inflammatory
Response in Phagocytes, Which Is Partially
Attenuated by the Mer Receptor. J. Biol.
Chem. 281 (10):6707–6717. [PDF
reprint]
Maxfield, F.R., Tabas, I. (2005)
Role of cholesterol and lipid organization
in
disease. Nature 438:36-45. [PDF
reprint]
Tabas, I. (2005) Consequences
and Therapeutic Implications of Macrophage
Apoptosis in Atherosclerosis:
The Importance of Lesion Stage and Phagocytic
Efficiency. Arterioscler Thromb Vasc Biol. 25:2255-2264.
[PDF reprint]
DeVries-Seimon, T, Li Y, Mei Yao,
P, Stone, E, Wang, Y, Davis, R, Flavell,
R, Tabas, I. (2005) Cholesterol-induced macrophage
apoptosis requires ER stress pathways and
engagement of the type A scavenger receptor. J.
Cell Biol. 171 (1):61-73. [PDF
reprint]
Li Y, Schwabe, R,
DeVries-Seimon, T, Mei Yao, P, Gerbod-Giannone,
M, Tall, A, Davis, R,
Flavell, R, Brenner, D, and Tabas,
I. (2005) Free Cholesterol-loaded Macrophages
Are an Abundant Source of Tumor Necrosis Factor-alpha
and Interleukin-6. J. Biol. Chem. 280
(23):21763–21772. [PDF
reprint]
Wong, M-L., Xie, B., Beatini, N.,
Phu, P., Marathe, S., Johns, A., Hirsch, E., Williams,
K.J., Licinio, J., and Tabas, I. (2000) Acute
systemic inflammation up-regulates secretory sphingomyelinase
in vivo: a possible new link between inflammatory
cytokines and atherogenesis. Proc. Natl. Acad.
Sci. U.S.A. 97:8681-8686.
Marathe, S., Miranda, S.R.P., Devlin,
C., Johns, A., Kuriakose, G., Williams, K.J.,
Schuchman, E.H., and Tabas, I. (2000) Creation
of a mouse model for non-neurological (type B)
Niemann-Pick mouse model by stable, low-level
expression of lysosomal sphingomyelinase in the
absence of secretory sphingomyelinase: relationship
between brain intra-lysosomal enzyme activity
and central nervous system function. Hum.
Molec. Gen. 9:1967-1976.
Zhang, D., Tang, W., Yao, P.M., Yang, C., Xie,
B., Jackowski, S., and Tabas, I. (2000) Macrophages
deficient in CTP:phosphocholine cytidylyltransferase-a
are viable under normal culture conditions but
are highly susceptible to free cholesterol-induced
death. Molecular genetic evidence that the induction
of phosphatidylcholine biosynthesis in free cholesterol-loaded
macrophages is an adaptive response. J. Biol. Chem. 275:35368-35
Sakr, S., Eddy, R.J., Barth, H.,
Wang, F., Greenberg, S., Maxfield, F.R., and Tabas,
I. (2001) The uptake and degradation of matrix-bound
lipoproteins by macrophages require an intact
actin cytoskeleton, Rho family GTPases, and myosin
ATPase activity. J. Biol. Chem. 276:37649-37658.
Yao, P.M. and Tabas, I. (2001) Free cholesterol
loading of macrophages is associated with widespread
mitochondrial dysfunction and activation of the
mitochondrial apoptosis pathway. J. Biol. Chem.
276:42468-42476.
Leventhal, A.R., Chen, W., Tall,
A.R., and Tabas, I. (2001) Acid sphingomyelinase-deficient
macrophages have defective cholesterol efflux
and trafficking. J. Biol. Chem. 276:44976-44983.
[view pdf]
Tabas, I. (2002) Cholesterol in
health and disease. J. Clin. Invest. 110:583-590.
[view pdf]
Tabas, I. (2002) Consequences of cellular cholesterol
accumulation. J. Clin. Invest. 110:955-911. [view
pdf]
Devlin, C.M., Kuriakose, G., Hirsch,
E., and Tabas, I. (2002) Genetic alterations of
interleukin-1 receptor antagonist in mice markedly
affect non-HDL lipoprotein cholesterol levels
and foam cell lesion size. Proc. Natl. Acad.
Sci. U.S.A. 99: 6280-6285.
Feng, B. and Tabas, I. (2002) ABCA1-mediated
cholesterol efflux is defective in free cholesterol-loaded
macrophages. Mechanism involves enhanced ABCA1
degradation in a process requiring full npc1 activity.
J. Biol. Chem. 277:43271-43280. [view
pdf]
Feng, B, Yao, P.M., Li, Y., Devlin,
C., Zhang, D., Harding, H., Sweeney, M., Rong,
J.X., Kuriakose, G., Fisher, E.A., Marks, A.R.,
Ron, D., Tabas, I. (2003) The endoplasmic reticulum
is the site of cholesterol-induced cytotoxicity
in macrophages. Nature Cell Biology 5:781-792.
[view pdf]
Feng, B., Zhang, D., Kuriakose,
G., Devlin, C.M., Kockx, M., and Tabas, I. (2003)
Niemann-Pick C heterozygosity confers resistance
to lesional necrosis and macrophage apoptosis
in murine atherosclerosis. Proc. Natl. Acad.
Sci. U.S.A. 100:10423-10428. [view
pdf]
Patel, M., Morrow, J., Maxfield,
F.R., Strickland, D.K., Greenberg, S., and Tabas,
I. (2003) The cytoplasmic domain of LDL receptor-related
protein, but not that of the LDL receptor, triggers
phagocytosis. J. Biol. Chem. 278: 44799-44807
[view pdf]
Leventhal, A.R., Leslie, C.C., and
Tabas, I. (2004) Suppression of macrophage eicosanoid
synthesis by atherogenic lipoproteins is profoundly
affected by cholesterol-fatty acyl esterification
and the Niemann-Pick C pathway of lipid trafficking.
J. Biol. Chem. 279:8084-8092. [view
pdf]
Li, Y., Ge, M., Ciani, L., Kuriakose,
G., Westover, E.J., Dura, M., Covey, D.F., Freed,
J.H., Maxfield, F.R., Lytton, J., and Tabas, I.
(2004) Enrichment of Endoplasmic Reticulum with
Cholesterol Inhibits SERCA2b Activity in Parallel
with Increased Order of Membrane Lipids. J.
Biol. Chem. 279:37030–37039. [view
pdf]
Tabas, I (2004) Apoptosis and plaque
destabilization in atherosclerosis: the role of
macrophage apoptosis induced by cholesterol. Cell
Death Diff. 11:S12-S16. [view
pdf]
Tabas, I. (2004) Sphingolipids and
Atherosclerosis: A Mechanistic Connection? A Therapeutic
Opportunity? Circulation. 110:3400-3401. [view
pdf]
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