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Selected Publications
Search
PubMed for articles
Jahangir Iqbal, Kezhi Dai, Tracie Seimon, Rivka Jungreis, Miho Oyadomari, George Kuriakose, David Ron, Ira Tabas, and M. Mahmood Hussain. (2008) IRE1b Inhibits Chylomicron Production by Selectively Degrading MTP mRNA. Cell Metabolism. 7, 1–11, May 2008. [PDF
reprint]
Edward Thorp, Dongying Cui, Dorien M. Schrijvers, George Kuriakose and Ira Tabas. (2008) Mertk Receptor Mutation Reduces Efferocytosis Efficiency and Promotes Apoptotic Cell Accumulation and Plaque Necrosis in Atherosclerotic Lesions of Apoe -/- Mice. Arterioscler. Thromb. Vasc. Biol. published online May 1, 2008. [PDF
reprint]
Wah-Seng Lim, Jenelle M. Timmins, Tracie A. Seimon, Anthony Sadler, Frank D., Kolodgie, Renu Virmani and Ira Tabas. (2008) Signal Transducer and Activator of Transcription-1 Is Critical for Apoptosis in Macrophages Subjected to Endoplasmic Reticulum Stress In Vitro and in Advanced Atherosclerotic Lesions In Vivo. Circulation 117:940-951. [PDF
reprint]
Thorp, E., Kuriakose, G., Shah, Y.M., Gonzalez, F.J., Tabas, I. (2007) Pioglitazone increases macrophage apoptosis and plaque necrosis in advanced atherosclerotic lesions of non-diabetic LDL receptor-null mice. Circulation 116:2182-2190. [PDF
reprint]
Cui D, Thorp E, Li Y, Wang N, Yvan-Charvet L, Tall AR, Tabas I. Pivotal Advance: Macrophages become resistant to cholesterol-induced death after phagocytosis of apoptotic cells. J Leukoc Biol. 2007 Nov;82(5):1040-50. [PDF
reprint]
Tabas, I. , Williams, K.J., Borén,
J. (2007) Subendothelial
Lipoprotein Retention as the Initiating Process
in Atherosclerosis: Update and Therapeutic
Implications. Circulation 116(16):1832-44.
[PDF
reprint]
Tabas, I. (2007) A
Two-Carbon Switch to Sterol-Induced Autophagic
Death. Autophagy 3 (1):38–41.
[PDF
reprint]
Seimon, T.A., Obstfeld, A., Moore,
K.J., Golenbock, D.T., Tabas, I. (2006)
Combinatorial pattern recognition receptor
signaling alters the balance of life and
death in macrophages. Proc.
Natl. Acad. Sci. U.S.A.
103 (52):19794–19799. [PDF
reprint]
Bao, L., Yankun, L., Deng, S.,
Landry, D., Tabas, I. (2006) Sitosterol-containing
Lipoproteins Trigger Free Sterol-induced
Caspase-independent Death in ACAT-competent
Macrophages. J. Biol. Chem. 281 (44):33635–33649.
[PDF
reprint]
Li, Y., Gerbod-Giannone, M.,
Seitz, H., Cui, D., Thorp, E.,
Tall, A.R.,
Matsushima, G.K., Tabas, I. (2005) Cholesterol-induced
Apoptotic Macrophages Elicit an Inflammatory
Response in Phagocytes, Which Is Partially
Attenuated by the Mer Receptor. J. Biol.
Chem. 281 (10):6707–6717. [PDF
reprint]
Maxfield, F.R., Tabas, I. (2005)
Role of cholesterol and lipid organization
in
disease. Nature 438:36-45. [PDF
reprint]
Tabas, I. (2005) Consequences
and Therapeutic Implications of Macrophage
Apoptosis in Atherosclerosis:
The Importance of Lesion Stage and Phagocytic
Efficiency. Arterioscler Thromb Vasc Biol. 25:2255-2264.
[PDF reprint]
DeVries-Seimon, T, Li Y, Mei Yao,
P, Stone, E, Wang, Y, Davis, R, Flavell,
R, Tabas, I. (2005) Cholesterol-induced macrophage
apoptosis requires ER stress pathways and
engagement of the type A scavenger receptor. J.
Cell Biol. 171 (1):61-73. [PDF
reprint]
Li Y, Schwabe, R,
DeVries-Seimon, T, Mei Yao, P, Gerbod-Giannone,
M, Tall, A, Davis, R,
Flavell, R, Brenner, D, and Tabas,
I. (2005) Free Cholesterol-loaded Macrophages
Are an Abundant Source of Tumor Necrosis Factor-alpha
and Interleukin-6. J. Biol. Chem. 280
(23):21763–21772. [PDF
reprint]
Wong, M-L., Xie, B., Beatini, N.,
Phu, P., Marathe, S., Johns, A., Hirsch, E., Williams,
K.J., Licinio, J., and Tabas, I. (2000) Acute
systemic inflammation up-regulates secretory sphingomyelinase
in vivo: a possible new link between inflammatory
cytokines and atherogenesis. Proc. Natl. Acad.
Sci. U.S.A. 97:8681-8686.
Marathe, S., Miranda, S.R.P., Devlin,
C., Johns, A., Kuriakose, G., Williams, K.J.,
Schuchman, E.H., and Tabas, I. (2000) Creation
of a mouse model for non-neurological (type B)
Niemann-Pick mouse model by stable, low-level
expression of lysosomal sphingomyelinase in the
absence of secretory sphingomyelinase: relationship
between brain intra-lysosomal enzyme activity
and central nervous system function. Hum.
Molec. Gen. 9:1967-1976.
Zhang, D., Tang, W., Yao, P.M., Yang, C., Xie,
B., Jackowski, S., and Tabas, I. (2000) Macrophages
deficient in CTP:phosphocholine cytidylyltransferase-a
are viable under normal culture conditions but
are highly susceptible to free cholesterol-induced
death. Molecular genetic evidence that the induction
of phosphatidylcholine biosynthesis in free cholesterol-loaded
macrophages is an adaptive response. J. Biol. Chem. 275:35368-35
Sakr, S., Eddy, R.J., Barth, H.,
Wang, F., Greenberg, S., Maxfield, F.R., and Tabas,
I. (2001) The uptake and degradation of matrix-bound
lipoproteins by macrophages require an intact
actin cytoskeleton, Rho family GTPases, and myosin
ATPase activity. J. Biol. Chem. 276:37649-37658.
Yao, P.M. and Tabas, I. (2001) Free cholesterol
loading of macrophages is associated with widespread
mitochondrial dysfunction and activation of the
mitochondrial apoptosis pathway. J. Biol. Chem.
276:42468-42476.
Leventhal, A.R., Chen, W., Tall,
A.R., and Tabas, I. (2001) Acid sphingomyelinase-deficient
macrophages have defective cholesterol efflux
and trafficking. J. Biol. Chem. 276:44976-44983.
[view pdf]
Tabas, I. (2002) Cholesterol in
health and disease. J. Clin. Invest. 110:583-590.
[view pdf]
Tabas, I. (2002) Consequences of cellular cholesterol
accumulation. J. Clin. Invest. 110:955-911. [view
pdf]
Devlin, C.M., Kuriakose, G., Hirsch,
E., and Tabas, I. (2002) Genetic alterations of
interleukin-1 receptor antagonist in mice markedly
affect non-HDL lipoprotein cholesterol levels
and foam cell lesion size. Proc. Natl. Acad.
Sci. U.S.A. 99: 6280-6285.
Feng, B. and Tabas, I. (2002) ABCA1-mediated
cholesterol efflux is defective in free cholesterol-loaded
macrophages. Mechanism involves enhanced ABCA1
degradation in a process requiring full npc1 activity.
J. Biol. Chem. 277:43271-43280. [view
pdf]
Feng, B, Yao, P.M., Li, Y., Devlin,
C., Zhang, D., Harding, H., Sweeney, M., Rong,
J.X., Kuriakose, G., Fisher, E.A., Marks, A.R.,
Ron, D., Tabas, I. (2003) The endoplasmic reticulum
is the site of cholesterol-induced cytotoxicity
in macrophages. Nature Cell Biology 5:781-792.
[view pdf]
Feng, B., Zhang, D., Kuriakose,
G., Devlin, C.M., Kockx, M., and Tabas, I. (2003)
Niemann-Pick C heterozygosity confers resistance
to lesional necrosis and macrophage apoptosis
in murine atherosclerosis. Proc. Natl. Acad.
Sci. U.S.A. 100:10423-10428. [view
pdf]
Patel, M., Morrow, J., Maxfield,
F.R., Strickland, D.K., Greenberg, S., and Tabas,
I. (2003) The cytoplasmic domain of LDL receptor-related
protein, but not that of the LDL receptor, triggers
phagocytosis. J. Biol. Chem. 278: 44799-44807
[view pdf]
Leventhal, A.R., Leslie, C.C., and
Tabas, I. (2004) Suppression of macrophage eicosanoid
synthesis by atherogenic lipoproteins is profoundly
affected by cholesterol-fatty acyl esterification
and the Niemann-Pick C pathway of lipid trafficking.
J. Biol. Chem. 279:8084-8092. [view
pdf]
Li, Y., Ge, M., Ciani, L., Kuriakose,
G., Westover, E.J., Dura, M., Covey, D.F., Freed,
J.H., Maxfield, F.R., Lytton, J., and Tabas, I.
(2004) Enrichment of Endoplasmic Reticulum with
Cholesterol Inhibits SERCA2b Activity in Parallel
with Increased Order of Membrane Lipids. J.
Biol. Chem. 279:37030–37039. [view
pdf]
Tabas, I (2004) Apoptosis and plaque
destabilization in atherosclerosis: the role of
macrophage apoptosis induced by cholesterol. Cell
Death Diff. 11:S12-S16. [view
pdf]
Tabas, I. (2004) Sphingolipids and
Atherosclerosis: A Mechanistic Connection? A Therapeutic
Opportunity? Circulation. 110:3400-3401. [view
pdf]
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