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The cellular and molecular biology of
macrophages during atherogenesis

The laboratory utilizes cell-culture models and induced mutant mice (i.e., transgenics and knockouts) to explore areas of macrophage cellular and molecular biology that are pertinent to the development of atherosclerosis. During atherogenesis, macrophages become loaded with cholesterol ("foam cell" formation), a process that plays a critical role in this disease process. In this context, the laboratory studies basic cellular processes involved in the uptake, intracellular trafficking, metabolism, and cell biological effects of cholesterol.

Ira Tabas, MD, PhD
Richard J. Stock Professor & Vice-Chairman of Research,
Department of Medicine, Columbia University
Professor of Medicine and Anatomy & Cell Biology
(in Physiology and Cellular Biophysics)
Deputy Editor-Journal of Clinical Investigation

Department of Medicine
Columbia University
630 West 168th Street
New York, NY 10032

Office: PH 8-East-105F
Laboratory: PH 9-405/406
Tel (office): 212-305-9430
Tel (lab): 212-305-5669
Fax: 212-305-4834
iat1@columbia.edu

What's New?

Oct. 2007: NIH Awards $10.8 Million to Columbia Researchers Investigating Connection between Diabetes & Heart Disease... learn more

Oct. 2007: Macrophages, apoptotic cells and cholesterol—strategies for survival: an interview with Dr. Ira Tabas... learn more

Dec. 2006: Columbia Researchers Identify Molecular Process That Could Lead to Arterial Plaque Rupture ...
learn more

 

 


Copyright © 2003 Ira Tabas, MD, PhD. All Rights Reserved.