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      Assistant Professor

My laboratory is investigating the biology of the human LINE-1 retrotransposable element. These DNA elements are members of a family of DNA elements that have been present in eukaryotic genomes for over 600 million years. They are capable of making new copies of themselves and inserting into new genomic loci. By amplifying themselves in this way, LINE-1 elements have come to make up about 15% of human DNA.

We have developed a new assay that is designed to compare the genomic DNA from different individuals or from different tissues from the same individuals and to identify loci that have LINE-1 insertions in some but not all of the samples. We are using this technique to: 1. study the structure of the human genome, 2. answer questions about human history and evolution, and 3. to investigate the role of human LINE-1 elements in the development of cancer.

      Division of Molecular Medicine
      Ph9-405
      Ph. 212-305-2174
      Fax: 212-342-5316
      Email: gs314@columbia.edu

1976B.A., Cornell University, Ithaca, NY .
1983M.D., Ph.D., Albert Einstein College of Medicine, Bronx, NY
1998-presentAssistant Professor, Department of Medicine, Division of Molecular Medicine, Columbia University, New York City,
1997-1998Medical Director, Program in Cancer Genetics, Center for Medical Genetics
1993- 1998Senior Staff Fellow, - FDA, Center for Biologics Evaluation and Research, Division of Cellular and Gene Therapies
1990-1992Fellow in Clinical Medical Genetics - National Institutes of Health
1990-1992Senior Staff Fellow - National Cancer Institute, NIH, Laboratory of Dr. Maxine Singer
1987-1990Medical Staff Fellow - National Cancer Institute, NIH, Lab of Dr. Maxine Singer
1986-1987PRAT Fellow - National Institute of Diabetes and Digestive Diseases, NIH
1983-1986Intern and Resident in Internal Medicine - Albert Einstein Medical Center, Bronx, NY
1996-1998Member, National Action Plan On Breast Cancer, Hereditary Susceptibility Working Group
1999Project Award, Office of Clinical Trials, Columbia-Presbyterian Medical Center
1999Pilot Project Award, Herbert Irving Comprehensive Cancer Center, Columbia-Presbyterian Medical Center
1998Visiting Professor, Scranton-Temple Residency Program
1997NIH Directors Award
1994-1996Directors Targeted Research Award, FDA, Center for Biologics Evaluation and Research
1995ASBMB High School Science Teacher Fellowship Sponsor
1990U.S. Patent Number 4,901,381. Issued Feb. 20
1986-1988Pharmacology Research Associate Fellow, NIH
1976-1983NIH Medical Scientist Training Program Fellow
1976B.A. with Distinction in All Subjects, Cornell University
1975Alvan T. - Viola D. Fuller American Cancer Society Junior Research Fellowship
1973-1977N.Y.S. Cornell Regents Scholarship Award
1972Winner, National Westinghouse Science Talent Search
American College of Medical Genetics
American Society of Human Genetics
American Association for the Advancement of Science
American Society for Biochemistry and Molecular Biology (Elected Member, 1993)
American Society for Microbiology
Human Genome Organization

Swergold, G.D. Identification, Characterization, and Cell Specificity of a Human LINE-1 Promoter. Mol. Cell. Biol., 10: 6718-6729. 1990.

Goldfarb, L.G., Brown, P., McCombie, W.R., Goldgaber, D., Swergold, G.D., Wills, P.R., Cerenakova, L., Baron, H., Gibbs Jr., C.J., and D.C. Gajdusek. Transmissible Familial Creutzfeldt-Jakob Disease Associated With Five, Seven, and Eight Extra Octapeptide Coding Repeats in the PRNP Gene. Proc. Nat. Acad. Sci., USA, 88:10926-10930. 1991.

Holmes, S., M.F. Singer, and G.D. Swergold. Studies on p40, the Leucine Zipper containing Protein Encoded by the First Open Reading Frame of an Active Human Transposable Element.. J. Biol. Chem.. 267: 19765-19768. 1992.

Goldfarb, Lev, et. al.. Fatal Familial Insomnia and Familial Creutzfeldt -Jakob disease: disease phenotype determined by a DNA polymorphism. Science 258: 806-808. 1992.

Becker, K., G.D. Swergold, K. Ozato, and R.E. Thayer. Binding of the ubiquitous nuclear transcription factor YY1 to a cis regulatory sequence in the human LINE-1 transposable element. Human Molecular Genetics. 2: 1697-1702. 1993

Singer, M.F., V. Krek, J.P. McMillan, G.D. Swergold, and R.E. Thayer. (1993) LINE-1: a human transposable element. Gene 135: 183-188. 1993

Rothenberg, K., B. Fuller, M. Rothstein, T. Duster, M.J. Ellis Kahn, R. Cunningham, K. Hudson, M.-C. King, P. Murphy, G. Swergold, and F. Collins. Genetic Information and the Workplace: Legislative Approaches and Policy Challenges. Science 275:1755-1757, 1997.

Sassaman, D.M., B.A. Dombroski, J.V. Moran, M.L. Kimberland, T.P. Naas, R.J. DeBerardinis, G.D. Swergold, and H.H. Kazazian Jr., Characterization of five novel active L1 elements allows an estimate of the number of active L1 elements in the human genome. Nature Genetics 16:37-43, 1997.

Deininger, P. L., S.T. Sherry, G. Risch, C. Donaldson, M.B. Robichaux, H. Soodyall, T. Jenkins, F. Sheen, G. Swergold, M. Stoneking and M.A. Batzer (In Press) Interspersed repeat insertion polymorphisms for studies of human molecular anthropology. In "Genomic Diversity: Applications in Human Population Genetics", S. S. Papiha, R. Deka and R. Chakraborty (Eds.), Plenum Press, New York, NY.

Fuller, B. P., M. J. Ellis Kahn, P.A. Barr, L. Biesecker, E. Crowley, J. Garber, M. K. Mansoura, P. Murphy, J. Phillips, K. Rothenberg, M. Rothstein, J. Stopfer, G. Swergold, B. Weber, F. S. Collins, and K. L. Hudson. Privacy in Genetics Research. Science, 285:1359-1361, 1999.

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Updated: March 17, 2000