Domenico Accili, M.D.
Diabetes, insulin action, pancreatic endocrine stem cells, genetics
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Qais Al-Awqati M.B., Ch.B.
Epithelial Cell Biology, Kidney Development, Stem Cells.
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Arthur Bank, M.D.
Human globin gene regulation and gene therapy
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Jonathan Barasch, M.D.
Identification of growth factors that induce the formation of nephrons from mesenchymal progenitor cells.
Conversion of mesenchyme into epithelia. Identification of renal stem cells.
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William S. Blaner, Ph.D.
Retinoid (vitamin A and its metabolites) metabolism and actions.
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David A. Brenner, M.D.
Dr. Brenner’s laboratory is interested in studying intracellular signaling in the liver under normal and
pathophysiological states. They use animal models of human diseases including transgenic mice combined with
cultures of primary and immortalized cells to study in particular the role of NFkB and JNK.
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Anne-Marie B. Brillantes, M.D.
Genetic basis of type 1 and Type 2 Diabetes Mellitus with specific emphasis on the cellular and molecular
biology of the pancreatic beta cell.
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Paolo Colombo, M.D.
We conduct translational (clinical/basic) studies to determine the expression of pro-inflammatory genes in the
vascular endothelium of patients with diabetes and of patients with heart failure. Using a novel approach,
endothelial cells are biopsied from peripheral vessels of patients, and then characterized by real time PCR,
Flow Cytometry and immunofluorescent analysis.
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Jeanine D'Armiento, M.D., Ph.D.
We are interested in the role of matrix metalloproteases in disease and the inhibition of these enzymes as
potential therapy in destructive lung diseases.
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Phillip Factor, D.O., F.C.C.P.
Dr. Factor’s clinical research interests include the treatment of acute lung injury and prevention of
complications of mechanical ventilation.
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Anthony W. Ferrante, Jr., M.D., Ph.D.
Large increases in fat mass lead to obesity and adversely alter blood pressure, insulin sensitivity,
serum lipid profiles and cardiac function. The research in our laboratory focuses on identifying cellular
and molecular mechanisms by which changes fat mass alter medically important traits, including insulin
sensitivity and cardiac mass.
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Pamela U. Freda M.D.
Clinical studies of patients with pituitary tumors. Current research is investigating new approaches to the
evaluation of disease status and treatment of acromegaly.
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Ali Gharavi, M.D.
I am interested in the molecular genetics of renal diseases, in particular glomerular disorders in humans
and rodent models.
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Henry N. Ginsberg, M.D.
I am interested in the molecular and cellular regulation hypertriglyceridemia, particularly in patients and
animal models of insulin resistance and diabetes.
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Ira J. Goldberg
Lipid uptake by tissues, atherosclerosis
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Kevan Herold, M.D.
The research interests of my laboratory and clinical staff are to understand the mechanisms of autoimmune
disease, in particular, autoimmune diabetes, and develop novel approaches to treatment of this as well as
other autoimmune diseases.
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Hong Jiang, M.D., Ph.D.
My research interest is to study the regulation of peripheral immune responses; especially the
immuno-regulatory pathway mediated by the Qa-1 restricted regulatory CD8+ T cells.
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Andrew K. Joe, M.D.
My research focuses on evaluating cancer prevention agents and identifying surrogate tumor markers for use
in targeted clinical chemoprevention. I have ongoing translational, patient-oriented projects, in which I am
investigating Barrett’s Esophagus and African-American Breast Cancer.
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Judith Korner, M.D., Ph.D.
My research interests are focused on the hypothalamic regulation of energy homeostasis and the development
of treatments for obesity. I am interested in the molecular mechanisms by which several hormones discovered
over the past few years control food intake. I am studying the neuroendocrine changes that occur with weight
loss in both rodent models and obese humans.
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Donald W. Landry, M.D., Ph. D.
Medical application of artificial enzymes. Pathogenesis of vasodilatory shock.
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Rudolph L. Leibel, M.D.
Molecular genetics of obesity and type 2 diabetes
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Franklin Lowy, M.D.
Research involves the pathogenesis and transmission of Staphylococcus aureus.
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Jeremy Luban, M.D.
HIV-1 Replication and Pathogenesis
Anti-HIV-1 Immune Response and Vaccine Development
Regulation of CD4+ T Cell Effector Function
Transplant Rejection and Cyclosporine Mechanism of Action
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Andrew Marks, M.D.
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Rachel L. Miller, M.D.
Our work concentrates on mechanisms for the onset of asthma. One large research focus involves studying
a birth cohort from Northern Manhattan, determining the importance of environmental allergen and pollutant
exposure to the onset of allergies, asthma, and Th2 immune responses. A second research focus is determining
whether in utero sensitization to environmental antigens occurs. To answer this question, we are using
tetramer technology to detect and immunophenotype influenza matrix protein and hemaggluttin specific T
cells among offspring born to mothers vaccinated with the influenza vaccine during pregnancy. Additional
areas of research include studying the relationship between Th2 polarization during pregnancy and asthma
outcomes, and identifying novel genetic polymorphisms important to the asthma phenotype.
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Jane H. Morse, M.D.
The main goal has been the identification of genes that cause pulmonary arterial hypertension (PAH) and
how these genes contribute to the pathophysiology of the disease and its clinical subsets. These studies
have focussed on patients with sporadic and familial primary pulmonary hypertension, PAH with connective
tissue diseases, HIV-infection and congenital systemic to pulmonary shunts, although all types of PAH are
included.
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Juan A. Oliver, M.D.
In the laboratory: Analysis of molecular mechanisms involved in renal vascular development; isolation of
growth factors and adhesion molecules involved in this process.
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Charles A. Powell, M.D.
Dr. Powell’s primary clinical and research interest is lung cancer.
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Christian Schindler, M.D., Ph.D.
The role cytokine signal transduction plays in innate and adaptive immunity with a focus on the JAK-STAT
pathway.
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Milan Stojanovic, Ph.D.
My primary research interest is in the construction of autonomous therapeutic and diagnostic molecular
devices based on nucleic acids.
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Ira Tabas, M.D., Ph.D.
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Alan Tall, M.D.
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Sharon Wardlaw, M.D.
Neuroendocrine control of pituitary function. Hypothalamic regulation of energy homeostasis.
Neuroendocrine-immune interactions.
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Carrie Welch, Ph.D.
We are using a mouse genetics approach to identify new genes underlying susceptibility to atherosclerosis
and thrombosis.
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Howard J. Worman, M.D.
Our laboratory is interested in determining how mutations in proteins of the inner nuclear membrane cause a
wide variety of inherited diseases, including muscular dystrophy, cardiomyopathy, partial lipodystrophy and
Hutchinson-Gildford progeria syndrome.
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Yi-Hao Yu, M.D. Ph.D.
Lipid and energy metabolism, insulin resistance, and diabetes
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