Lucille P. Markey Charitable Trust

sponsor of

Basic and Clinical Research Career Tracks in Internal Medicine at

Columbia-Presbyterian Medical Center

 


Alan Tall, M.D.
.
Tilden Weger Bieler Professor of Medicine
P&S 8-401
212-305-4899
art1@columbia.edu

Faculty Page
www.alantall.org
Division of Molecular Medicine

 

Research Interests

 

 

Research Activities

The laboratory is carrying out research on the molecular mechanisms responsible for human diseases. The approach is to use molecular, genomic and cellular approaches to investigate basic aspects of the pathogenesis of atherosclerosis. A major focus is on molecular mechanisms of cellular cholesterol efflux, mediated by the interaction of extracellular apoA-I with the lipid transporter ABCA1. We are carrying out studies on the transcriptional regulation of ABCA1 gene expression, and regulation of the degradation of ABCA1 protein. This has led to the elucidation of a class of transcription factors (LXRs) that co-ordinately regulate cellular cholesterol efflux and reverse cholesterol transport.

 

 

Selected Publications

1. Jiang XC, Bruce C, Mar J, Lin M, Ji Y, Francone OL and Tall AR. Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high density lipoprotein levels. J Clin Invest. 103:907 914, 1999.

2. Rubin EM, Tall AR. Perspectives for vascular genomics. Nature. 2000 Sep 14;407(6801):265-9.

3. Costet P, Luo Y, Wang N, Tall AR. Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. J Biol Chem. 2000 Sep 8;275(36):28240-5.

4. Welch CL, Bretschger S, Latib N, Bezouevski M, Guo Y, Pleskac N, Liang C-P, Barlow C, Dansky H, Breslow JL, Tall AR. Localization of atherosclerosis susceptibility loci to chromosomes 4 and 6 using the Ldlr knockout mouse model. PNAS. 2001 Jul 3;98(14): 7946-51.

5. Luo Y, Liang CP, Tall AR.: The orphan nuclear receptor LRH-1 potentiates the sterol-mediated induction of the human CETP gene by liver X receptor. J Biol Chem. 2001 Jul 6;276(27):24767-73.

6. Jiang, XC, Qin, S, Qiao, C, Kawano, K, Lin, M, Xiao, X, Tall, AR. Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency. Nat. Med. 2001 Jul;7(7):847-52.

7. Tall AR, Costet P, Wang N. Regulation and mechanisms of macrophage cholesterol efflux. J Clin Invest. 2002 Oct;110(7):899-904.

8. Tall AR. Exercise to reduce cardiovascular risk - how much is enough? N Engl J Med. 2002 Nov 7;347(19):1522-4.

9. Wang N, Chen W, Linsel-Nitschke P, Martinez L, Agerholm-Larsen B, Silver DL, Tall AR. A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I. J Clin Invest. 2003 Jan;111(1):99-107.

 

 
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