| Lucille P. Markey Charitable Trust sponsor of Basic and Clinical Research Career Tracks in Internal Medicine at Columbia-Presbyterian Medical Center |
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Research Interests Molecular genetics of obesity and type 2 diabetes
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Research Activities The Division of Molecular Genetics –headed by Dr. Leibel - has material and personnel resources permitting the analysis of the genetic basis for monogenic or complex medical and physiological phenotypes in humans or rodents. Research activities are designed to approach the biology of energy homeostasis and type 2 diabetes mellitus on a broad investigative front in both humans and rodents. However, members of his group are also interested in molecular genetic analysis of human subjects with unusual and/or potentially revealing medical or physiological phenotypes (see clinical activities below). The Division’s laboratories are also the Molecular Biology/Molecular Genetics and Genomics Core Laboratories of the New York Obesity Research Center and the Columbia University Diabetes Endocrinology Reseach Center (DERC).
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Selected Publications Ferrante, A, Jr., Thearle, M., Liao, T., Leibel, R.L. Effects of Leptin Deficiency and Short-Term Repletion on Hepatic Gene Expression in Genetically Obese Mice. Diabetes. 50:2268-2278, 2001. Rosenbaum, M., E.M. Murphy, S.B. Heymsfield, D.E. Matthews, R.L. Leibel. Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones. J. Clin. Endocrinol. Metab. 87:2391-2394, 2002. Zhang, Y., Guo, K-Y.,
Diaz, P.A., Heo, M., Leibel, R.L. Determinants of leptin
gene expression in fat depots of lean mice. Am. J. Physiol. 282:R226-R234,
2002. Rosenbaum, M., K. Vandenborne, J. Leigh, R. Goldsmith, J.A. Simoneau, J. Hirsch, K. Segal, R.L. Leibel. Effects of weight perturbation on skeletal muscle work efficiency & fuel utilization. Amer. J. Physiol.. 285:R183-92. 2003
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