Doctoral Training and Teaching Faculty

Domenico Accili, M.D., Professor of Medicine
M.D. 1983, University of Rome, Italy

Dr. Accili's research is focused on the pathogenesis of insulin resistance and its role in type 2 diabetes. Current interests include a genetic approach to dissecting the integrated physiology of insulin action using transgenic and knockout mice. The main thrust of this work is to understand how different tissues contribute to the pathogenesis of type 2 diabetes. In addition, the laboratory is interested in how insulin regulates gene transcription. He is studying the role of forkhead transcription factors in insulin action, and especially in linking peripheral insulin action and pancreatic beta cell function. He has shown that the forkhead transcription factor Foxo1 plays an important role in regulating insulin-dependent suppression of hepatic gluconeogenesis. Foxo1 is also emerging as the insulin-regulated transcription factor that regulates adipogenesis and myogenesis. Moreover, it plays a key role in the development and function of beta cells, as well as in insulin and leptin signaling in the arcuate nucleus of the hypothalamus.

Kitamura T. Kitamura Y. Nakae J. Giordano A. Cinti S. Kahn CR. Efstratiadis A. Accili D. Mosaic analysis of insulin receptor function.  Journal of Clinical Investigation 113:209-19, 2004.

Accili D, Arden KC. FoxOs at the crossroads of cellular metabolism, differentiation, and transformation.  Cell 117:421-6, 2004.

Hribal ML, Nakae J, Kitamura T, Shutter JR, Accili D. Regulation of insulin-like growth factor-dependent myoblast differentiation by Foxo forkhead transcription factors. J Cell Biol 162:535-41, 2003.

..TOP..