F A C U L T Y P R O F I L E
WIT, ANDREW L., PH.D.
Mechanisms for arrhythmias caused by cardiac disease .
Office: Physicians & Surgeons | Floor 7th | Room 446
Andrew L Wit Ph.D. retired in June 2011 after 41 years on the faculty of the Department of Pharmacology. Dr. Wit’s research during this time focused on the electrical mechanisms of cardiac arrhythmias. His major contributions provided experimental data that defined the mechanisms of arrhythmias caused by cardiac ischemia and infarction. Some of these seminal publications are listed below.
Dr. Wit was appointed as Emeritus Professor and will continue to participate in the teaching programs of the department. He is the organizer and director of a graduate student course on Systems Pharmacology that presents mechanisms of the effects of drugs used in medical therapy, on the different physiological systems.
1. Friedman PL, Stewart JR, Fenoglio JJ Jr, Wit AL: Survival of subendocardial Purkinje fibers after extensive myocardial infarction in dogs; In vivo and in vitro correlations. Circulation Research 33:597-611, 1973.
2. Friedman PL, Stewart JR, Wit AL: Spontaneous and induced cardiac arrhyth¬mias in Purkinje fibers surviving experimental myocardial infarction in dogs. Circulation Research 33:612-625, 1973.
3. Friedman PL, Fenoglio JJ Jr, Wit AL: Time course for reversal of electro¬physiological and ultrastructural abnormalities in subendocardial Purkinje fibers surviving extensive myocardial infarction in dogs. Circulation Research 36:127-144, 1975
4. Fenoglio JJ Jr, Albala A, Silva FG, Friedman PL, Wit AL: Structural basis of ventricular arrhythmias in human myocardial infarction: A hypothesis. Human Pathology 7:547-563, 1976.
5. Karagueuzian HS, Fenoglio JJ Jr, Weiss MB, Wit AL: Protracted ventricular tachycardia induced by premature stimulation of the canine heart after coronary artery occlusion and reperfusion. Circulation Research 44:833-845, 1979.
6. Wit AL, Allessie MA, Bonke FIM, Lammers W, Smeets J, Fenoglio JJ Jr: Electrophysiological mapping to determine the mechanism of experimental ventri¬cular tachycardia initiated by premature impulses. American Journal of Cardiology 49:166-185, 1982.
7. Fenoglio JJ Jr, Pham TD, Harken AH, Horowitz LN, Josephson ME and Wit AL: Recurrent sustained ventricular tachycardia: Structure and ultrastructure of suben¬docardial regions in which tachycardia originates. Circulation 68:518-533, 1983.
8. Gardner PI, Ursell PC, Fenoglio JJ Jr, Wit AL: Electrophysiologic and anatomic basis for fractionated electrograms recorded from chronically ischemic and infarcted regions of the heart. Circulation 72:596-611, 1985.
9. Ursell PC, Gardner PI, Albala A, Fenoglio JJ Jr, Wit AL: Structural and electrophysiological changes in the epicardial border zone of canine myocardial infarcts during infarct healing. Circulation Research 56:436-451, 1985.
10. Dillon S, Allessie M, Ursell PC, Wit AL: Influence of anisotropic tissue structure on reentrant circuits in the subepicardial border zone of subacute canine infarcts. Circulation Research 63:182-206, 1988
11. Kline R, Hanna M, Dresdner KP, Wit AL: Time course of changes in intracellular K, Na, and pH of subendocardial Purkinje cells during the first 24 hours after coro¬nary occlusion. Circulation Research 70:566-575, 1992.
12. Peters NS, Coromilas J, Severs NJ, Wit AL: Disturbed connexin43 gap junction distribution correlates with the location of reentrant circuits in the epicardial border zone of healing canine infarcts that cause ventricular tachycardia. Circulation 95:988-996, 1997.
13. Yao J-A, Hussain W, Patel P, Peters NS, Boyden P, Wit AL. Remodeling of gap junctional channel function in epicardial border zone of healing canine infarcts. Circulation Research 92:437-443, 2003.
14. Ciaccio EJ, Ashikaga A, Kaba Riyaz A, Cervantes D, Hopenfeld B, Wit AL, PetersNS,McVeigh ER, Garan H, Coromilas J. Model of reentrant ventricular tachycardia based on infarct border zone geometry predicts reentrant circuit features as determined by activation mapping. Heart Rhythm 4: 1034-1045, 2007