This interdisciplinary training program in the molecular and genetic basis of cardiac arrhythmias is designed to provide training to post doctoral fellows with either M.D. or Ph.D. degrees to enable them to become independent researchers and leaders in the field as we enter a period of post genomic medical science. The overall aim of the program is to train researchers who will be well-grounded in molecular and cellular biology, but who also are trained in cardiovascular systems physiology/pharmacology in order to integrate the cellular and subcellular mechanisms (genotype) with the basis of human disease expressed at the systems level (phenotype).
Trainees may select mentors from a list of faculty each of whom directs a well-funded research laboratory specializing in one of these areas. Didactic training in all areas is provided to all trainees and, depending on the background of each applicant, tailored course work is recommended to ensure that, upon completion of the training period, each trainee is well-equipped to carry out independent research in an area of his or her choice. Trainees are eligible for this program after receiving M.D., Ph.D., or M.D./Ph.D. degrees. Candidates are selected by committee and training programs are designed around individual needs. The primary training facilities are the research laboratories and other core facilities of the participating laboratories as well as those of other faculty and institutes and specialized research centers at of the Health Sciences Complex of Columbia University.
Training Faculty and Areas of Research:
Electrophysiology: cell to system
Michael R. Rosen, M.D.
Translational approaches to cardiac electrophysiology and electrophysiology of the in situ heart
Penelope A Boyden, Ph.D.
Electrical basis of abnormal heart rhythm: unique animal and cellular models.
Andrew Wit, Ph.D.
Electrophysiology of the murine heart: systems and cellular approaches
Signal transduction in the heart:
Susan F. Steinberg, M.D.
The cardiac actions the G protein-coupled adrenergic receptor and protease-activated receptors (PARs) in cardiomyocytes.
Jonathan Javitch, M.D./Ph.D.
G-protein coupled receptors: the structural bases for pharmacological specificity, signal transduction, and oligomerization. Catecholamine transporters: the structural bases for substrate transport, cocaine binding, and oligomerization.
Genetics and Arrhythmias:
Wendy K Chung, M.D/Ph.D
Molecular genetics of human disease.
Robert S. Kass, Ph.D.
Molecular mechanisms of inherited cardiac arrhythmias: structure, function, systems.
Rene Hen, Ph.D.
Genetically-altered mice: novel procedures for systems pharmacology
Calcium handling proteins and arrhythmias:
Andrew R. Marks, M.D.
Molecular biology of intracellular calcium release channels and their relevance to human disease.
Steven M. Marx, M.D.
Ion channels as macromolecular complexes
Geoffrey S. Pitt, M.D/Ph.D
Molecular mechanisms of calcium-dependent regulation of electrical activity in the heart.
Pacemakers and the Heart:
Richard B. Robinson Ph.D.
Cellular electrophysiology: molecular mechanisms of pacing in the heart.
Steven A. Siegelbaum, Ph.D.
Structure and function of pacemaker channels in heart and brain: structural basis of channel regulation.
An-Suei Yang, Ph.D.
Computational biology: predicting protein structure.
Appointments ordinarily are made for two years and commence in July.
Stipends range from $34,200 to $50, 800 depending on the number of years of postdoctoral experience.
For further information, address inquires to the Program Director:
Robert S. Kass, Ph.D.
Department of Pharmacology
College of Physicians and Surgeons
630 West 168th Street
New York, NY 10032
Columbia University is an equal opportunity employer.