F A C U L T Y   P R O F I L E 

Harrison

HARRISON, NEIL L, PH.D.
Professor of Anesthesiology and Pharmacology

Biophysics/Ion Channels, Synapses & Circuits.

Office: Presbyterian Hospital | 5th Floor | P&S 7 (labs)
Telephone: 212.304.6459
Fax: 212.305.8780
Email:
nh2298@cumc.columbia.edu


Current Research
The Harrison lab is interested in all aspects of neuronal excitability and synaptic transmission with a focus on the role of ion channels in mediating changes in neuronal activity. We also have a special interest in neuronal responses to alcohol, in response to short-term exposure and the process of neuroadaptation to prolonged alcohol drinking. Our work uses behavioral, electrophysiological and molecular methods to study this problem in a mouse model of adolescent binge drinking.



Selected Publications

McCracken L. Lowes D., Salling M.C., Vollmer C., Odean N., Betz H., Harris R.A. and Harrison N.L. (2017) Glycine receptor α2 and α3 subunits mediate tonic and glycine-activated currents in brain. Proceedings of the National Academy of Sciences, in Press.

Harrison N.L., Skelly M.J., Grosserode E., Lowes D.C., Zeric T., Phister S. and Salling M.C. (2017)
 Effects of acute alcohol on neuronal excitability in the CNS. Neuropharmacology, 122, 36-45.

Yocum G.T., Turner D.L., Danielsson J., Barajas M.B., Zhang Y., Xu D., Harrison N.L., Homanics G.E., Farber D.L. and Emala C.W. (2017)
γ-Aminobutyric acid A receptor α4 subunit knockout enhances lung inflammation in a murine asthma model. American Journal of Physiology, Lung, 313, L406-415.

Avegno E., Salling M.C., Mrejeru A., Bjorklund A., Barnett A., Sulzer D. and Harrison N.L. (2016) Adolescent drinking in mice enhances alcohol sensitivity of a subset of dopaminergic neurons in the ventral tegmental area. Neuropharmacology, 110, 386-395. 19371619

Canetta S., Bolkan S., Song L-J., Sahn R., Harrison N.L., Brown A. and Kellendonk C. (2016) Prenatal maternal immune activation alters prefrontal GABAergic transmission and anxiety-related behaviors in adult offspring. Molecular Psychiatry, 21, 956-968.

Bekdash R. and Harrison N.L. (2015) Down-regulation of Gabra4 expression during alcohol withdrawal is mediated by specific microRNAs in cultured mouse cortical neurons. Brain and Behavior, 5, e00355.

Dixon C., Harrison N.L., Lynch J.W. and Keramidas A. (2015). Zolpidem and eszopiclone prime α1β2γ2 GABAA receptors for longer duration of activity. British Journal of Pharmacology, 172, 3522-3536.

Gallos G., Yocum G., Siviski M., Yim P., Fu X.W., Poe M., Cook J., Harrison N.L. and Emala C. (2015) Selective targeting of the α5 subunit of GABAA receptors relaxes airway smooth muscle and inhibits cellular calcium handling. American Journal of Physiology: Lung Cellular and Molecular Physiology, 308, L931-942.

Mrejeru A., Avegno E., Marti-Prats L., Sulzer D. and Harrison N.L. (2015) A subset of ventral tegmental area dopamine neurons responds to acute ethanol in naïve mice Neuroscience, 290, 649-658.

Coutts D.J. and Harrison N.L. (2015) Acetaldehyde, not ethanol, impairs myelin formation and viability in primary mouse oligodendrocytes. Alcohol: Clinical and Experimental Research, 39, 455-462.

Gallo E., Salling M.C., Harrison N.L., Javitch J.A. and Kellendonk C. (2015) Upregulation of dopamine D2 receptors in the nucleus accumbens indirect pathway increases locomotion but does not reduce alcohol consumption. Neuropsychopharmacology, 40, 1609-1618.

Salling M.C. and Harrison N.L. (2014) Strychnine-sensitive glycine receptors on pyramidal neurons in layers 2/3 of the mouse prefrontal cortex are tonically activated. Journal of Neurophysiology, 112, 1169-1178.

Varodayan F.P., and Harrison N.L. (2013) HSF1 transcriptional activity mediates alcohol induction of VAMP2 and GABA release. Frontiers in Integrative Neuroscience, 7, 89: 1-8.

Pignataro L., Varodayan F.P., Tannenholz L.E., Protiva P. and Harrison N.L. (2013) Brief alcohol exposure alters transcription in astrocytes via the heat shock pathway. Brain and Behavior, 3, 114-133.

Mintz C.D., Barrett K., Smith S.C., Benson D. and Harrison N.L. (2013) Anesthetics interfere with axon guidance in developing mouse neocortical neurons via a GABAA receptor mechanism. Anesthesiology, 118, 825-33.

Ganat Y., Calder E., Kriks S., Nelander J., Tu E., Jia F., Battista D., Harrison N.L., Parmar M., Tomishima M., Rutishauser U. and Studer L. (2012) Identification of embryonic stem cell-derived midbrain dopaminergic neurons for engraftment. Journal of Clinical Investigation, 122, 2928-2939.

Cazorla M., Shegda M., Harrison N.L. and Kellendonk C. (2012) Striatal D2 receptors regulate dendritic morphology of medium spiny neurons via Kir2 channels. Journal of Neuroscience, 32, 2398-2409.

The lab has published extensively for more than thirty years, with many papers in high impact journals up to the present. https://scholar.google.com/citations?user=RfGMy94AAAAJ&hl=en