F A C U L T Y P R O F I L E
HARRISON, NEIL L, PH.D.
Biophysics/Ion Channels, Synapses & Circuits.
Office: Presbyterian Hospital | 5th Floor | Room
The Harrison lab is interested in the effects of alcohol and other drugs on synaptic transmission, neuronal excitability and gene expression in the brain. We study these problems at a variety of levels including whole animal, brain slice and cell cultures, using behavioral, electrophysiological and molecular techniques.
We also collaborate with the Kellendonk and Sulzer labs on projects of joint interest, and share a journal club with these labs.
1. Pignataro L., Miller A.,, Ma L., Midha S., Protiva P., Herrera D.G. and Harrison N.L. (2007) Alcohol regulates gene expression in neurons via activation of heat shock factor 1. Journal of Neuroscience, 27, 12957-12966.
2. Keramidas A., Harrison N.L. (2008).
Agonist-dependent single channel current and gating in alpha4beta2delta and alpha1beta2gamma2S GABA-A receptors.
J Gen Physiol,131,163-81.
3. Jia F., Chandra D., Homanics G.E. and Harrison N.L. (2008)
Ethanol modulates synaptic and extrasynaptic GABAA receptors in the thalamus.
Journal of Pharmacology and Experimental Therapeutics, 326, 475-482.
4. Pignataro L., Varodayan F.P., Tannenholz L.E. and Harrison N.L. (2009)
The regulation of neuronal gene expression by alcohol.
Pharmacology and Therapeutics, 124, 324-335.
5. Keramidas A. and Harrison N.L. (2010).
The activation mechanism of α1β2γ2 and α3β3γ2 GABAA receptors.
Journal of General Physiology, 135, 59-75.
6. Blednov Y.A., Borghese C., McCracken M.L., Benavidez J.M., Geil C.R., Ostendorff-Kahanek E., Werner DF, Iyer S., Swihart A., Harrison, N.L., Harris R.A. and Homanics, G.E. (2011)
Loss of ethanol conditioned taste aversion and motor stimulation in knock-in mice with ethanol-insensitive α2-containing GABAA receptors.
Journal of Pharmacology and Experimental Therapeutics, 336:145-154.
Varodayan F.P., Pignataro L. and Harrison N.L. (2011)
Alcohol regulates synaptotagmin-1 expression in neurons via activation of heat shock factor 1.
Neuroscience, in Press.