Integrated Program in
Cellular, Molecular and Biophysical Studies
Ronald Liem (Pathology, Cell Biology, Neurobiology): Cell and molecular biology of the neuronal cytoskeleton and its involvement in neurodegenerative diseases.
Lorraine Symington (Microbiology): Genetics and biochemistry of DNA recombination and repair in yeast.
A | B | C | D
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- Larry Abbott (Neurobiology): Computational modeling and mathematical analysis of neurons and neural networks.
- Asa Abeliovich (Pathology, Neurobiology): The molecular mechanisms of neurodegeneration and the function and survival of dopamine receptors.
- Qais D. Al-Awqati (Physiology): Studies of the molecular mechanisms that determine epithelial differentiation.
- Konstantina Alexandropoulos (Pharmacology): Signal transduction in T lymphocytes: Role of Src kinases, adapter proteins and low molecular weight GTPases in thymocyte development and T cell activation.
- Ottavio Arrancio (Pathology): Mechanisms underlying changes of synaptic function associated with cognitive impairment.
- Richard Axel (Biochemistry, Pathology, Neurobiology): Defining the logic of olfactory perception; how individual sensory neurons express a specific receptor and how the brain distinguishes which receptors have been activated.
- Richard Baer (Pathology): The mechanisms of cancer development by characterizing genetic defects.
- Arthur Bank (Genetics, Medicine): Regulation of human globin gene expression in hematopoietic cells; gene transfer in animals.
- Jonathan Barasch (Cell Biology): Developmental and cell biology of kidney organogenesis.
- Timothy H.
Bestor (Genetics): Nuclear organization; DNA methyltransferases; epigenetic effects in gene expression.
- J. Chloe Bulinski (Cell Biology, Pathology): Function of the cytoskeleton during the cell cycle and during differentiation.
- Harmen Bussemaker (Biological Sciences): Analysis of complete genome sequences ranging from prokaryotes to human, and the modeling of the regulatory network of the cell based on genome-wide mRNA expression data and protein-DNA binding profiles.
- Kathryn L. Calame (Microbiology, Biochemisty): Transcriptional regulatory cascades required for terminal differentiation of B lymphocytes and monocyte/macrophages.
- Andrea Califano (Biomedical Informatics): Reverse engineering of metabolic amd gene regulatory networks using dynamical and statistical predictive models that can be validated experimentally.
- Marian B. Carlson (Genetics, Microbiology): Transcriptional and developmental responses to nutrient stress in yeast.
- Fred Chang (Microbiology): Molecular genetics of cytokinesis in fission yeast.
- Angela M. Christiano (Genetics): Molecular basis of inherited skin and hair disorders in humans and mice.
- Raphael Clynes (Microbiology): Fc Receptors in tumor immunity and autoimmunity.
- Virginia Cornish (Pharmacology, Chemisty): Development of in vivo selection strategies for proteins with novel catalytic properties.
- Franklin D. Costantini (Genetics): Molecular basis of inductive interactions during mammalian embryogenesis and organogenesis.
- Riccardo Dalla-Favera (Pathology, Genetics): Molecular genetics of cancer; molecular pathogenesis of lymphoma and leukemia; genetic control in lymphoid tissue development.
- William Dauer (Pharmacology, Neurobiology): Studies of the fundamental molecular and cellular mechanisms of diseases that disrupt normal motor control, with a focus on Parkinson's disease and dystonia.
- Gilbert Di Paolo (Pathology): Role of phosphoinositides in organelle trafficking, cytoskeletal dynamics and disease-related processes.
- Jane Dodd (Physiology, Neurobiology): Neuronal differentiation and axonal patterning in the developing vertebrate central nervous system.
- Fiona Doetsch (Pathology, Neurobiology): The nature and function of stem cells for adult neurogenesis.
- Jonathan Dworkin (Microbiology): Cell Biology of protein localization and chromosome segregation in Bacillus subtilis.
- Argiris Efstratiadis (Genetics): Role of growth factors in mammalian embryogenesis; mechanism of parental imprinting; physical mapping of human chromosome 13.
- Qing Fan (Pharmacology): Structural studies of cell surface receptors.
- David Fidock (Microbiology): Antimalarial chemotherapy, resistance, pathogenesis, immunomodulation; Plasmodium falciparum parasite biology.
- David Figurski (Microbiology): Molecular genetics of promiscuous bacterial plasmids; pathogenesis of Actinobacillus actinomycetemocomitans.
- Jean Gautier (Genetics): Maintenance of genetic integrity: DNA replication and response to DNA damage.
- Michael D. Gershon (Cell Biology, Neurobiology): Structure and function of monoaminergic synapses; structure, function, and development of the enteric nervous system.
- Stephen P. Goff (Biochemisty, Microbiology): Retroviral replication; tyrosine kinase oncogenes.
- Joseph Gogos (Physiology, Neurobiology): Assembly and maintenance of sensory maps in the brain; animal models for genes predisposing to psychiatric disorders.
- Daniel Goldberg (Pharmacology, Neurobiology): Cellular and molecular mechanisms of axon growth and synapse formation.
- Michael Goldberg (Neurobiology): The physiology of cognitive processes; visual attention, spatial perception and decision making.
- James E. Goldman (Pathology, Neurobiology): Glial differentiation in mammalian CNS development; progenitors in the adult CNS; cytoskeletal abnormalities and stress proteins in neurological disorders.
- Maxwell Gottesman (Biochemistry, Microbiology): Regulation of transcription termination in E. coli and bacteriophage; role of cAMP in cell cycle progession and signal transduction in eukaryotes; vitamin A metabolism in the mouse.
- Steven M. Greenberg (Pharmacology, Medicine): Macrophage signal tranduction; role of low molecular weight GTPases in innate immunity.
- Eric Greene (Biochemistry): Total internal reflection fluorescence microscopy (TIRFM) to study the molecular machinery involved in the recombination and repair of damaged DNA.
- Lloyd A. Greene (Pathology, Neurobiology): Molecular mechanisms governing neuronal differentiation and survival.
- Alla Grishok (Biochemistry): Contribution of short RNAs to regulation of gene expresion through chromatin; epigenetic phenomena in C. elegans.
- Iva Greenwald (Biochemistry): Cell-cell interactions, signal transduction, and cell fate choice; genetic and molecular studies of C. elegans development.
- Wes Grueber (Neurobiology, Physiology): Mechanisms of dendritic morphogenesis and patterning.
- Hua Gu (Microbiology): Lymphocyte development and differentiation.
- Wei Gu (Pathology): P53 in tumor suppression and aging; acetylation and deacetylation of p53 in tumorigenesis; mammalian Sir2a in stress response and aging; ubiquitination and deubiquitination in the regulation of p53 stability.
- Gregg G. Gundersen (Cell Biology, Pathology): The regulation and function of the microtubule cytoskeleton.
- Renč Hen (Pharmacology, Neurobiology): Contribution of specific serotonin receptors to pathological states such as depression and anxiety, using knock-out mice.
- Christopher Henderson (Pathology, Neurobiology): Motor neuron development and pathology.
- Wayne Hendrickson (Biochemistry): Structural biology of macromolecules; diffraction and computational methods.
- Oliver Hobert (Biochemistry): Genetic programs that control neural development in C. elegans.
- Barry Honig (Biochemistry): Computational biology, bioinformatics, prediction of protein structure and function.
- Antonio Iavarone (Pathology): Molecular genetics of tumors derived from the nervous system. The role of Id proteins in cell cycle regulation and differentiation.
- Jonathan A. Javitch (Pharmacology): Structural bases for pharmacological specificity and signal transduction in G-protein coupled receptors.
- Thomas Jessell (Biochemistry, Neurobiology): Molecular mechanisms of neuronal differentiation, axon guidance, and cell recognition in vertebrate development.
- Laura Johnston (Genetics): Control of cell growth and cell division.
- Eric R. Kandel (Neurobiology, Biochemistry): Cell and molecular mechanisms of associative and non-associative learning in invertebrates and vertebrates.
- Arthur Karlin (Biochemistry): Molecular mechanisms of receptor function.
- Gerard Karsenty (Genetics): Genetic and molecular bases of skeletogenesis, physiology and diseases.
- Robert S. Kass (Pharmacology, Neurobiology): Regulation and expression of ion channel proteins in normal and genetically altered cardiac cells.
- Richard H. Kessin (Cell Biology): Genetic capacity of Dictyostelium discoideum to study proteo-lytic mechanisms and regulation.
- Tae-Wan Kim (Pathology, Neurobiology): Presenilin biology and molecular mechanism of Alzheimer's disease.
- Jan Kitajewski (Pathology): Wnt and Notch genes in tumorigenesis and vascular development.
- John Koester (Neurobiology): How cellular and circuit proper ties of neurons control behavior in the autonomic nervous system of Aplysia.
- Anna Lasorella (Pathology): Molecular biology of pediatric tumors. The Rb-Id2 pathway in development and cancer.
- Rudolph Leibel (Pediatrics, Nutrition): Molecular genetic analysis of human obesity.
- Ronald Liem (Pathology, Cell Biology, Neurobiology): Cell and molecular biology of the neuronal cytoskeleton and its involvement in neurodegenerative diseases.
- W. Ian Lipkin (Pathology): Immunopathogenesis and infectious diseases.
- Thomas Ludwig (Cell Biology): Molecular functions of breast cancer susceptibility genes BRCA1 and BRCA2; mouse models of mammary tumorigenesis.
- Amy MacDermott (Physiology, Neurobiology): Mechanisms underlying synaptic transmission and modulation of synaptic transmission in spinal cord dorsal horn.
- Richard S. Mann (Biochemistry, Neurobiology): Control of pattern formation by homeotic genes and their downstream targets in Drosophila.
- Yinghui Mao (Cell Biology and Pathology): Kinetochore microtubule attachment, chromosome movement, and mitotic checkpoint during mitosis.
- Andrew Marks (Physiology): Molecular biology of intracellular calcium release channels and their relevance to human disease.
- Carol A. Mason (Pathology, Cell Biology, Neurobiology): Molecular mechanisms of axon guidance and synaptogenesis.
- Brian McCabe (Neurobiology, Physiology): Molecular genetics of synaptic development and plasticity.
- Cathy Mendelsohn (Pathology, Urology): Molecular pathways controlling development of urogenital tract.
- Kenneth Miller (Neurobiology, Physiology): Theory and modeling of the function, circuitry and development of the cerebral cortex and the thalamus.
- Aaron Mitchell (Microbiology): Molecular genetics of meiosis and its regulation in yeast.
- Rebecca Morris (Pathology, Dermatology): Identificatiion, isolation, and functional analysis of keratinocyte stem cells in adult skin and hair follicles. Identification of novel stem cell regulatory genes and their role in skin tumor susceptibility.
David M. Owens (Pathology, Dermatology): The contributions of stem cells and differentiated cells to epidermal cancer.
- Arthur G. Palmer III (Biochemistry): Structure, function, and dynamics of proteins, fluctuations in chemical and biological systems; and nuclear magnetic resonance and fluorescence spectroscopies.
- Virginia E. Papaioannou (Genetics): Genetic control of mammalian development in the peri-implantation period; determination of cell lineages and the role of oncogenes in normal development, using embryonic stem-cell technology.
- Ramon Parsons (Pathology): The genetics of breast cancer tumorigenesis.
- Dana Pe'er (Biological Sciences, Computational Biology): Computational systems biology, the organization, function and evolution of molecular networks.
- Liza A. Pon (Cell Biology): Cytosketetal control of organelle movements and segregation during cell division.
- Serge Przedbrodski (Pathology, Neurobiology): Study of toxin-induced damage to neurotransmitter systems pertinent to movement disorders such as Parkinson’s disease and amyotrophic lateral sclerosis.
- Ning Qian (Physiology, Neurobiology): Computational modeling of visual information processing; visual psychophysics of perceptual learning.
- Vincent Racaniello (Microbiology): Molecular biology of poliovirus and its cellular receptor.
- Adam Ratner (Pediatrics, Microbiology): Bacterial pathogenesis and innate immunity.
- Boris Reizis (Microbiology): Stem cell maintenance and dendritic cell development.
- Richard B. Robinson (Pharmacology): Developmental regulation of cardiac ion channel function and autonomic signaling cascades.
- Burkhard Rost (Biochemistry): Bioinformatics. Goals: sequence analysis, prediction of protein structure and function. Means: statistics and artificial intelligence.
- James Rothman (Physiology): Elucidating the underlying mechanisms of transport within cells
- Rodney Rothstein (Genetics): Control of genome stability; functional genomics; yeast as a model for human disease; yeast genetics; mechanisms of genetic recombination.
- Peter Scheiffele (Physiology, Neurobiology): Molecular mechanisms of synapse formation.
- Christian Schindler (Microbiology): Role of the JAK-STAT pathway in cytokine signal tranduction.
- Eric A. Schon (Genetics): Molecular genetics of neurological and neuromuscular disorders with focus on mitochondrial genetics and diseases.
- Lawrence Shapiro (Biochemistry): Structural information obtained from X-ray crystallography to direct biochemical studies of biological problems, particularly involving neuronal cell adhesion and neural patterning.
- Michael L. Shelanski (Pathology): Role of cytoskeleton, cell cycle machinery, and proteases in neuronal degeneration.
- Howard Shuman (Microbiology): Molecular basis of ATP-driven transporters and host-pathogen interactions.
- Steven Siegelbaum (Pharmacology): Studies of the structure and function of ion channels.
- Ann-Judith Silverman (Cell Biology, Neurobiology): Migration of neuronal and immune systems cells into the CNS.
- Samuel C. Silverstein (Physiology, Medicine): Polymorphonuclear mononuclear phagocytes, lymphocytes, platelets and endothelial cells in innate immunity and diseases.
- Saul Silverstein (Microbiology): Control of gene expression in human herpes and papillomavirus infected cells.
- Ila Singh (Pathology): High resolution functional mapping of retroviral genes.
- Scott Small (Neurobiology): Correlations of memory and changes in the hippocampal formation using fMRI imaging in normal aging and in Alzheimer's disease; parallel studies in transgenic mice.
- Janet Sparrow (Pathology, Cell Biology): Cell biology of retinal disorders.
- Gary Struhl (Genetics, Neurobiology): Molecular nature and mode of action of spatial information responsible for organizing cell and body patterns in Drosophila.
- Gloria Su (Pathology, Otolaryngology): Molecular genetics of head and neck squamous cell carcinoma (HNSCC) and pancreatic ductal adenocarcinoma.
- Lori Sussell (Genetics): Transcriptional regulation of pancreatic islet differentiation and development in the mouse embryo.
- Lorraine Symington (Microbiology): Genetics and biochemistry of DNA recombination and repair in yeast.
- Ira Tabas (Cell Biology, Medicine): Cellular and molecular processes related to arterial wall biology and atherogenesis.
- Gareth Tibbs (Pharmacology, Anesthesiology): Molecular mechanism and functions of HCN encoded ih pacemaker ion channels -molecular rhythm generators.
- Andrew Tomlinson (Genetics, Neurobiology): The cellular and molecular bases of cellular communication during the development of the fruit fly Drosophila melanogaster.
- Benjamin Tycko (Pathology): Molecular biological studies on genomic imprinting in human and mouse systems; molecular genetics of pediatric tumors; molecular genetics of Alzheimer's disease.
- Richard Vallee (Pathology, Cell Biology, Neurobiology): Microtubule motor proteins. Motor proteins in axonal transport, brain developmental disease, and synaptic function.
- Dennis Vitkup (Biomedical Informatics): Reconstructing biological networks, understanding the evolution of biological networks and developing efficient methods to simulate networks.
- Hynek Wichterle (Pathology, Neurobiology): The use of stem cells to study the development and function of the nervous system.
- Debra J.Wolgemuth (Genetics, Nutrition): Molecular developmental genetics of mammalian gametogenesis and embryogenesis; regulation of the cell cycle during germ cell mitosis and meiosis.
- Howard J. Worman (Cell Biology, Medicine): The studies of the inner nuclear membrane and its proteins.
- Ming Zhou (Physiology, Cellular Biophysics): Molecular physiology and biophysics of potassium channel modulations.
- Yongrui Zhou (Microbiology): Mechanisms of lymphoid organogenesis.
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