Biochemistry and Molecular Cell Biology I, II* The course Web page can be found at Courseworks

Course number: G6300X

Offered: Fall, each year. *The second part of this course is offered in the Spring. Dr. Gilbert Di Paolo is the course director.

Instructors: Eric Greene and Larry Shapiro
Prerequisite: College Biochemistry, Biology and Chemistry
Content:This course is for all first year Ph.D. students and provides them with a unified curriculum that covers many of the topics that students need to know to successfully carry out research in biological sciences. The topics include basic biochemical principles, processes common to all eukaryotic cells such as transcription, translation and the cell cycle, and mechanisims of cell-cell signaling.
4.5 points per semester

Biochemistry of Nucleic and Protein Synthesis.

Course number: G4026Y
Offered: Spring, each year.
Instructor: P.R. Srinivasan
Prerequisite: A basic course in biochemistry or biology or permission of the instructor.
Content: Structure and organization of chromatin, nucleic acid hybridization and sequence complexity of DNA, DNA and RNA sequencing methods, current views of replication and repair, transcription and translation, regulation of nucleic acid and protein synthesis, recombinant DNA techniques, gene transfer, and gene duplication. Discussion of original papers and evaluation of experimental procedures and conclusions. Lectures preceded by an hour-long optional conference. (Given at the Morningside Campus.)
3 points

Course number: G6275Y
Offered: Spring, Odd numbered years
Instructor: W. Hendrickson
Prerequisite: Biophysical Chemistry G4170 or the instructors’ permission.
Content: Diffraction theory and applications to protein, nucleic acid, and membrane structures. Topics include electron microscopy, x-ray diffraction, protein crystallography, electron and neutron diffraction and electron microscopy.
4.5 points

Course number: G4021X
Offered:Fall, Each year.
Instructor: Alvin I. Krasna
(Primarily for students in departments other than biochemistry).
Prerequisite: General and organic chemistry.
Content: An integration, from a dynamic point of view, of cellular constituents with the chemical processes of living systems: chemistry and function, mode of synthesis and degradation by the cell, the characterization and role of particular enzymes and coenzymes in these reactions, and the mechanisms of oxidation and energy production. Nucleic acids, replication, and the genetic code. (Given at the Morningside campus.)
3 points

Course number: G6045Y
Offered: Spring, Odd numbered years.
Instructor: A. Karlin
Prerequisites: Biochemistry and Molecular Biology (G6300X); Molecular Biophysics (G4250).
Content: Molecular structure and function of membrane proteins; general principles and common threads.
3 points

Course number: G4250X
Offered: Fall, each year
Instructors: B. Honig and Staff.
Prerequisite: Basic physical and organic chemistry and the instructor’s permission.
Content: Primarily intended to satisfy the requirements of graduate students. Methods and principles involved in studying the structure and function of proteins, nucleic acids, membranes and their macromolecular assemblies. Noncovalent forces and conformational analysis; ultracentrifugation, viscometry, circular dichroism, fluorescence, magnetic resonance, conformational changes in proteins and nucleic acids, topological properties of macromolecules.
4.5 points

Course number: G6270Y
Offered: Spring, Even numbered years.
Instructor: A. G. Palmer
Prerequisite: the instructor’s permission or Biophysical chemistry G4170.
Content: Theoretical principles and applications of NMR spectroscopy for the study of biological macromolecules, including proteins, nucleic acids and carbohydrates, in solution.
4 points

Course number: G6011X(Fall)-G6012Y(Spring)
Offered: Each year.
Instructor: Staff.
Prerequisite: Permission of the department.
Content: Practical experience in the use of biochemical methods, with the aim of preparing the student for research.
2 to 10 pts.

Course number: G6100X
Offered: Fall, even years.
Instructor: Oliver Hobert, Fiona Doetsch, Hynek Wichterle, Ben Ohlstein
Prerequisite: A basic course in molecular biology or permission of the instructor.
Content: The lecture series will comprise general lectures, analyses and discussions of primary literature on stem cell and lineage biology as well as student seminars. The themes to be presented include basic cell and molecular biological characterization of stem cells, regulation of self-replication versus lineage restriction and differentiation of cells, model systems used in studies of stem cells, and the relevance of tissue formation, regeneration and disease states.
3 points

Course number: G4024Y
Offered: Spring, Even numbered years.
Instructor: Staff
Prerequisite: Organic chemistry.
Content: The structure, dynamics, catalytic reactivity and biological function of DNA, RNA, and their derivatives.
4 points